Radboud Umc

Nijmegen, Netherlands

Radboud Umc

Nijmegen, Netherlands

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PubMed | Radboud UMC, UniversitatsSpital Zurich, Alderhey Childrens Hospital, Childrens Hospital and 38 more.
Type: Comparative Study | Journal: Molecular genetics and metabolism | Year: 2015

Dietary management of 418 adult patients with galactosaemia (from 39 centres/12 countries) was compared. All centres advised lactose restriction, 6 restricted galactose from galactosides fruits and vegetables and 12 offal. 38% (n=15) relaxed diet by: 1) allowing traces of lactose in manufactured foods (n=13) or 2) giving fruits, vegetables and galactosides (n=2). Only 15% (n=6) calculated dietary galactose. 32% of patients were lost to dietetic follow-up. In adult galactosaemia, there is limited diet relaxation.


Srinivasan R.,Intel Corporation | Mohan A.,Honeywell | Srinivasan P.,Radboud UMC
Proceedings of the 2016 Smart City Security and Privacy Workshop, SCSP-W 2016 | Year: 2016

With advancements in wireless technologies, location based services (LBS) have become ubiquitous and are fundamental to services that provide emergency response to those that enhance the quality of daily life. Location tracking applications include traffic congestion management, waste management, indoor navigation in malls/airports, receiving coupons/advertisements by retailers, applications to allow parents to track their children, providing centimeter-level guidance to visually impaired users in indoor environments etc. Location tracking also enables applications in device-free situations - intrusion detection by means of tracking people and their movements through walls, monitoring the heartbeat of a person(ex: elderly citizen) through walls etc. In conjunction with location based services, the development of the Internet of Things (IoT) provides rich contextual information which is key to the scalability of smart cities. Managing these technologies along with establishing effective countermeasures against security and privacy concerns of individual citizens as well as service providers and government agencies is essential for their adoption. In this paper we envision a feature of the emergency response system of a smart city whereby critical contextual information from the emergency site is made available to the emergency service provider to enable effective first response strategy. We use the example of a smart building with an infrastructure that consists of an indoor hybrid wireless environment for identifying individuals, tracking their location, monitoring vital statistics and measuring ambient conditions. This information is critical to rescue teams and paramedics. We provide an architecture that addresses the security and privacy issues associated with the highly sensitive information generated by this system. © 2016 IEEE.


Lam J.,Rice University | Lu S.,Rice University | Lee E.J.,Rice University | Trachtenberg J.E.,Rice University | And 8 more authors.
Osteoarthritis and Cartilage | Year: 2014

Objective: To investigate the ability of cell-laden bilayered hydrogels encapsulating chondrogenically and osteogenically (OS) pre-differentiated mesenchymal stem cells (MSCs) to effect osteochondral defect repair in a rabbit model. By varying the period of chondrogenic pre-differentiation from 7 (CG7) to 14 days (CG14), the effect of chondrogenic differentiation stage on osteochondral tissue repair was also investigated. Methods: Rabbit MSCs were subjected to either chondrogenic or osteogenic pre-differentiation, encapsulated within respective chondral/subchondral layers of a bilayered hydrogel construct, and then implanted into femoral condyle osteochondral defects. Rabbits were randomized into one of four groups (MSC/MSC, MSC/OS, CG7/OS, and CG14/OS; chondral/subchondral) and received two similar constructs bilaterally. Defects were evaluated after 12 weeks. Results: All groups exhibited similar overall neo-tissue filling. The delivery of OS cells when compared to undifferentiated MSCs in the subchondral construct layer resulted in improvements in neo-cartilage thickness and regularity. However, the addition of CG cells in the chondral layer, with OS cells in the subchondral layer, did not augment tissue repair as influenced by the latter when compared to thecontrol. Instead, CG7/OS implants resulted in more irregular neo-tissue surfaces when compared to MSC/OS implants. Notably, the delivery of CG7 cells, when compared to CG14 cells, with OS cells stimulated morphologically superior cartilage repair. However, neither osteogenic nor chondrogenic pre-differentiation affected detectable changes in subchondral tissue repair. Conclusions: Cartilage regeneration in osteochondral defects can be enhanced by MSCs that are chondrogenically and osteogenically pre-differentiated prior to implantation. Longer chondrogenic pre-differentiation periods, however, lead to diminished cartilage repair. © 2014 Osteoarthritis Research Society International.


PubMed | University of Houston, Radboud umc, Kyoto University and Rice University
Type: Journal Article | Journal: Osteoarthritis and cartilage | Year: 2014

To investigate the ability of cell-laden bilayered hydrogels encapsulating chondrogenically and osteogenically (OS) pre-differentiated mesenchymal stem cells (MSCs) to effect osteochondral defect repair in a rabbit model. By varying the period of chondrogenic pre-differentiation from 7 (CG7) to 14 days (CG14), the effect of chondrogenic differentiation stage on osteochondral tissue repair was also investigated.Rabbit MSCs were subjected to either chondrogenic or osteogenic pre-differentiation, encapsulated within respective chondral/subchondral layers of a bilayered hydrogel construct, and then implanted into femoral condyle osteochondral defects. Rabbits were randomized into one of four groups (MSC/MSC, MSC/OS, CG7/OS, and CG14/OS; chondral/subchondral) and received two similar constructs bilaterally. Defects were evaluated after 12 weeks.All groups exhibited similar overall neo-tissue filling. The delivery of OS cells when compared to undifferentiated MSCs in the subchondral construct layer resulted in improvements in neo-cartilage thickness and regularity. However, the addition of CG cells in the chondral layer, with OS cells in the subchondral layer, did not augment tissue repair as influenced by the latter when compared to the control. Instead, CG7/OS implants resulted in more irregular neo-tissue surfaces when compared to MSC/OS implants. Notably, the delivery of CG7 cells, when compared to CG14 cells, with OS cells stimulated morphologically superior cartilage repair. However, neither osteogenic nor chondrogenic pre-differentiation affected detectable changes in subchondral tissue repair.Cartilage regeneration in osteochondral defects can be enhanced by MSCs that are chondrogenically and osteogenically pre-differentiated prior to implantation. Longer chondrogenic pre-differentiation periods, however, lead to diminished cartilage repair.


PubMed | Maastricht University, MUMC and Radboud University Nijmegen
Type: Journal Article | Journal: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology | Year: 2016

Pre-eclampsia (PE) is associated with both postpartum structural asymptomatic heart disease (i.e. heart failure Stage B (HF-B)) and conventional cardiovascular (CV) risk factors. We aimed to evaluate the extent to which PE, adjusted for conventional CV risk factors, is associated independently with asymptomatic cardiac abnormalities postpartum.In this cross-sectional cohort study, 107 formerly pre-eclamptic women and 41 women with uneventful previous pregnancy (controls) were invited for CV risk assessment 4-10 years postpartum. This included cardiac ultrasound, blood pressure (BP) measurement and evaluation of metabolic syndrome determinants. Asymptomatic structural and functional cardiac abnormalities were classified as HF-B, according to the American Heart Association guidelines. Prehypertension was defined as systolic BP of 120-139 mmHg and/or diastolic BP of 80-89 mmHg. Univariate and multivariate regression analyses were performed to calculate associations of PE and conventional risk factors with HF-B.The prevalence of asymptomatic HF-B was approximately 3.5-fold higher in the PE group compared with controls (25% vs 7%, P < 0.01); 67% of this group had concentric remodeling and 22% had mildly impaired ejection fraction. After adjustment for postpartum interval, hypertension and high-density lipoprotein, PE was significantly associated with HF-B (adjusted odds ratio, 4.4 (95% CI, 1.0-19.1)). Moreover, in the formerly pre-eclamptic group, prehypertension was associated significantly with HF-B (odds ratio, 4.3 (95% CI, 1.4-12.7)), while metabolic syndrome determinants were not.PE is associated with a four-fold increased female-specific risk of asymptomatic cardiac abnormalities. Prehypertension apparently increases this risk significantly, while metabolic syndrome determinants do not. Copyright 2016 ISUOG. Published by John Wiley & Sons Ltd.


Bosch S.L.,Radboud Umc | Nagtegaal I.D.,Radboud Umc
Recent Results in Cancer Research | Year: 2014

High local recurrence rates were a major problem in rectal cancer treatment, with between 30 and 50 % of patients affected, resulting in a very poor quality of life and short survival of patients with rectal cancer. In recent years, prognosis of rectal cancer has markedly improved, due to innovations in surgical treatment in combination with neoadjuvant therapy. Quality evaluation of surgical procedures has become the standard; constant high quality of surgery is one of the major successes in rectal cancer over the last decade. Continuous monitoring of surgical procedures is a new role for the pathologist. Completeness of excision, resection margins, but also numbers of lymph nodes have been firmly established as quality indicators. © 2014 Springer International Publishing Switzerland.


Alghamdi H.S.,Radboud umc | Alghamdi H.S.,King Saud University | Bosco R.,Radboud umc | Both S.K.,Radboud umc | And 4 more authors.
Biomaterials | Year: 2014

The prevalence of osteoporosis will increase within the next decades due to the aging world population, which can affect the bone healing response to dental and orthopedic implants. Consequently, local drug targeting of peri-implant bone has been proposed as a strategy for the enhancement of bone-implant integration in osteoporotic conditions. In the present study, an established in-vivo femoral condyle implantation model in osteoporotic and healthy bone is used to analyze the osteogenic capacity of titanium implants coated with bisphosphonate (BP)-loaded calcium phosphate nanoparticles (nCaP) under compromised medical conditions. After 4 weeks of implantation, peri-implant bone volume (%BV; by μCT) and bone area (%BA; by histomorphometry) were significantly increased within a distance of 500μm from implant surfaces functionalized with BP compared to control implants in osteoporotic and healthy conditions. Interestingly, the deposition of nCaP/BP coatings onto implant surfaces increased both peri-implant bone contact (%BIC) and volume (%BV) compared to the deposition of nCaP or BP coatings individually, in osteoporotic and healthy conditions. The results of real-time PCR revealed similar osteogenic gene expression levels to all implant surfaces at 4-weeks post-implantation. In conclusion, simultaneous targeting of bone formation (by nCaP) and bone resorption (by BP) using nCaP/BP surface coatings represents an effective strategy for synergistically improvement of bone-implant integration, especially in osteoporotic conditions. © 2014 Elsevier Ltd.


Alghamdi H.S.,Radboud Umc | Alghamdi H.S.,King Saud University | Van Den Beucken J.J.J.P.,Radboud Umc | Jansen J.A.,Radboud Umc
Drug Discovery Today: Disease Models | Year: 2014

Osteoporosis is a highly relevant disease and associated with an increased risk of fragility fracture. Also, in patients with osteoporotic condition, unfavorable osseointegration of bone implants remains an issue of concern. Consequently, research in biomaterials is focusing on the therapeutic potential of locally released bioactive, anti-osteoporotic and anabolic drug-loaded implant coatings for osseointegration in osteoporotic conditions. For evaluation of the preclinical efficacy of drug-loaded implant coatings, various experimental models are available that focus on osseointegration and fracture healing in osteoporotic conditions. In view of this, the present review aims to highlight the biological effect of bioactive and pharmacological surface coatings on bone healing and osseointegration of bone implants in osteoporotic bone conditions using in vivo preclinical animal models. © 2014 Elsevier Ltd. All rights reserved.


PubMed | Radboud UMC and LUMC
Type: | Journal: Critical reviews in oncology/hematology | Year: 2016

Recurrent disease occurs in 12-37% of patients with vulvar squamous cell carcinoma (VSCC). Decisions about treatment of recurrent VSCC mainly depend on the location of the recurrence and previous treatment, resulting in individualized and consensus-based approaches. Most recurrences (40-80%) occur within 2 years after initial treatment. Currently, wide local excision is the treatment of choice for local recurrences. Isolated local recurrence of VSCC has a good prognosis, with reported 5-year survival rates of up to 60%. Groin recurrences and distant recurrences are less common and have an extremely poor prognosis. For groin recurrences, surgery with or without (chemo) radiotherapy is a treatment option, depending on prior treatment. For distant recurrences, there are only palliative treatment options. In this review, we give an overview of the available literature and discuss epidemiology, risk factors, and prognostic factors for the different types of recurrent VSCC and we describe treatment options and clinical outcome.


PubMed | Radboud Umc
Type: | Journal: Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer | Year: 2014

High local recurrence rates were a major problem in rectal cancer treatment, with between 30 and 50 % of patients affected, resulting in a very poor quality of life and short survival of patients with rectal cancer. In recent years, prognosis of rectal cancer has markedly improved, due to innovations in surgical treatment in combination with neoadjuvant therapy. Quality evaluation of surgical procedures has become the standard; constant high quality of surgery is one of the major successes in rectal cancer over the last decade. Continuous monitoring of surgical procedures is a new role for the pathologist. Completeness of excision, resection margins, but also numbers of lymph nodes have been firmly established as quality indicators.

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