RadAnal Ltd.

Budapest, Hungary

RadAnal Ltd.

Budapest, Hungary

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Osvath S.,Frederic Joliot Curie National Research Institute for Radiobiology and Radiohygiene | Molnar Z.,RadAnal Ltd | Groska J.,RadAnal Ltd | Vajda N.,RadAnal Ltd
Journal of Radioanalytical and Nuclear Chemistry | Year: 2016

A radioanalytical method for separation and determination of 125Sb has been developed. This method is based on retention of fluoric complexes of antimony on anion exchange resin and γ-ray spectrometry. Using this method, 70(±17) % recovery was achieved and detection limit of 125Sb was reduced by ca. one order of magnitude compared to direct γ-ray spectrometry. Activity concentrations determined in evaporator concentrates of a nuclear power plant are presented. Reliability of results was confirmed by comparing the measured 125Sb/137Cs activity ratios with calculated ones. © 2015, Akadémiai Kiadó, Budapest, Hungary.


Vajda N.,RadAnal Ltd | Stefanka Z.S.,Hungarian Atomic Energy Authority | Szeles E.,Hungarian Academy of Sciences | Molnar Z.S.,RadAnal Ltd
Journal of Radioanalytical and Nuclear Chemistry | Year: 2011

A combined radioanalytical method for determination of 93Zr and 237Np (as well as other actinoids) in radioactive wastes has been developed. Analytes were co-precipitated on iron(II)-hydroxide, separated and purified on UTEVA columns, and detected by inductively coupled plasma mass spectrometry. According to Zr and Np, 65 and 75% yields were achieved, respectively. © 2010 Akadémiai Kiadó, Budapest, Hungary.


Vajda N.,RadAnal Ltd. | Kim C.-K.,International Atomic Energy Agency
Applied Radiation and Isotopes | Year: 2010

A great number of analytical methods have been developed and applied for the determination of 90Sr and 89Sr in environmental and nuclear samples using various measuring techniques, i.e. beta counting, liquid scintillation spectrometry and mass spectrometry. This paper is intended to give an overview about the development of the radiochemical procedures for the separation of strontium and/or yttrium including the classical procedure based on a series of semi-selective precipitations, the ion exchange and solvent extraction procedures and the recently developed extraction chromatographic ones offering high selectivity. An outlook to the procedures under development aiming the technological separation of strontium from radioactive wastes and process solutions is also given. Nuclear measuring techniques and mass spectrometric techniques will be comparatively evaluated. © 2010 Elsevier Ltd.


Ligor M.,Nicolaus Copernicus University | Studzinska S.,Nicolaus Copernicus University | Horna A.,Radanal Ltd. | Buszewski B.,Nicolaus Copernicus University
Critical Reviews in Analytical Chemistry | Year: 2013

An alternative to other universal detection methods like refractive index (RI), low wavelength or ultraviolet (UV), and evaporative light scattering detection (ELSD), chemiluminescent nitrogen detection is a relatively new method based upon aerosol charging and involves Corona-charged aerosol detection (Corona-CAD). Some reports show that the sensitivity of this method is lower than that of fluorescence detection. Others confirm approximately five times higher sensitivity than conventional UV absorbance detection for selected analytes. This is the reason that Corona-CAD can be widely used for the determination of nonvolatile or semivolatile compounds, including: lipids, oligosaccharides, carbohydrates, proteins, steroids, surfactants, polymers, peptides, and others. The response of Corona-CAD is independent of chemical properties of the analyte. This article reviews applications of Corona-CAD and principles of the aerosol charging method as well as advantages and disadvantages of the method. The modern solution using an ultra detector, which brings charged aerosol detection to UHPLC, is also discussed. © 2013 Copyright Taylor and Francis Group, LLC.


Vajda N.,RadAnal Ltd | Molnar Zs.,RadAnal Ltd | Szeles E.,Hungarian Academy of Sciences | Stefanka Zs.,Hungarian Academy of Sciences
Journal of Radioanalytical and Nuclear Chemistry | Year: 2010

The majority of long-lived radionuclides produced in the nuclear fuel cycle can be regarded as "difficult-to-measure" nuclides, hence chemical separation is needed before the nuclear measurement of them. A combined radiochemical procedure that enables the simultaneous determination of some "difficult-to-measure" nuclides in medium and low level radioactive wastes has been developed in our laboratory. Recently, this method has been extended for determination of 237Np and 93Zr. 237Np and 93Zr are pre-concentrated by co-precipitation on iron(II) hydroxide and zirconium oxide, separated by extraction chromatography using UTEVA, and measured by inductively coupled plasma mass spectrometry (ICP-MS). As even traces of polyatomic ions and isotopes at m/z 237 or 93 cause considerable interferences during ICP-MS detection, a purification step by extraction chromatography was needed. Analyzing real samples (evaporation concentrates of a nuclear power plant) 66-99% and 31-99% chemical yields were achieved for Np and Zr, respectively. © 2010 Akadémiai Kiadó, Budapest, Hungary.


Vajda N.,RadAnal Ltd. | Kim C.-K.,International Atomic Energy Agency
Journal of Radioanalytical and Nuclear Chemistry | Year: 2010

A great number of analytical methods have been developed and applied for the determination of 241Am isotope in environmental and nuclear samples using various measuring techniques, i.e. alpha and gamma spectrometry, liquid scintillation counting and mass spectrometry. This paper is intended to give an overview about the development of the radiochemical procedures for the separation of americium starting with a brief description of the analytical procedures from the "historic" times, followed by a more detailed discussion of the recent developments from the middle of 1990s till 2009 and giving an outlook to the procedures under development aiming the technological separation of americium from radioactive wastes and process solutions for purposes of partitioning of minor actinides. Nuclear measuring techniques and mass spectrometric techniques will be comparatively evaluated. © 2010 Akadémiai Kiadó.


Vajda N.,RadAnal Ltd. | Kim C.-K.,International Atomic Energy Agency
Journal of Radioanalytical and Nuclear Chemistry | Year: 2010

A great number of analytical methods have been developed and applied for the determination of plutonium isotopes in environmental and nuclear samples using alpha spectrometry. This paper is intended to give an overview about the development of the radiochemical procedures for the separation of plutonium starting with a brief description of the "historic" procedures from the early times of nuclear industry followed by a more detailed discussion of the recent developments from the nineties till 2008. Nuclear measuring techniques i.e. semiconductor alpha spectrometry and liquid scintillation counting are critically discussed. Capabilities of these techniques are compared with those of mass spectrometric techniques. © 2009 Akadémiai Kiadó, Budapest, Hungary.


Karady M.,Palacky University | Novak O.,Palacky University | Horna A.,RADANAL Ltd. | Horna A.,Tomas Bata University in Zlin | And 2 more authors.
Electroanalysis | Year: 2011

On-line LC-EC/ESI-MS has been established as a fast and simple method to mimic some types of oxidation reaction of various drugs and to study the formation and structure of the resulting products. This technique has been applied to a 2,6,9-trisubstituted purine, R-roscovitine, which is known to be an inhibitor of some cyclin-dependent kinases (CDKs) and a potential anticancer drug. Oxidation of R-roscovitine in an electrochemical cell (EC), operated under various conditions, resulted in appearance of 6 major products. These were further analyzed by high-resolution mass spectrometry, their structures were elucidated by accurate mass measurement and compared to previously identified R-roscovitine in vitro/in vivo metabolites. Although none of the observed products was structurally identical to those identified previously in vitro/in vivo, all of them, except for the methoxylated products, resembled similarity due to appearing through the same reaction type. R-roscovitine in the EC cell underwent N-dealkylation of the isopropyl moiety, hydroxylation of the aromatic side-chain, dihydroxylation, methoxylation and dimer formation. The hydroxylation product was identified as Olomoucine II, a R-roscovitine derivative, which displays 10-times higher CDK-inhibiting activity than R-roscovitine and the occurrence of which, as R-roscovitine product, has not yet been observed in vitro/in vivo. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Nagy P.,Hungarian Trade Licensing Office | Vajda N.,Radanal Ltd. | Pinter T.,Paks Nuclear Power Plant | Fel K.,Hungarian Academy of Sciences
Journal of Radioanalytical and Nuclear Chemistry | Year: 2015

Activities of 134Cs, 137Cs and 135Cs were determined in primary coolant samples of VVER-440 reactors. 135Cs was measured by inductively coupled plasma mass spectrometry after radiochemical separation of Cs using AMP–PAN and Dowex-50 cation exchange resin columns. The burnup of the samples was calculated from the 134Cs/137Cs activity ratio while the thermal neutron flux was estimated from the 137Cs/135Cs mass ratio. Conclusions were drawn on the burnup and the thermal neutron flux of defective fuel elements. © 2015 Akadémiai Kiadó, Budapest, Hungary


Diopan V.,Mendel University in Brno | Shestivska V.,Mendel University in Brno | Zitka O.,Mendel University in Brno | Galiova M.,Masaryk University | And 9 more authors.
Electroanalysis | Year: 2010

The main aim of this paper is to utilize high performance liquid chromatography with electrochemical detection for determination of thiols content in plants tissues of lettuce treated with lead(II) ions (0, 0.5 and 1 mM). We used two HPLC-ED instruments: HPLC coupled with one channel amperometric detector and HPLC coupled with twelve channel coulometric detector to detect simultaneously twelve thiols. The detection limits of thiols measured by CoulArray detector were about two magnitudes lower in comparison to those measured by Coulochem III detector and were from tens to hundreds pM. Under the optimal conditions, we utilized HPLC-CoulArray detector for analysis of tissues from lettuce plants. In addition, distribution and accumulation of lead ions with high spatial resolution was monitored using laser induced breakdown spectroscopy. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

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