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Rabta, Tunisia

Bouziri A.,Pediatric Intensive Care Unit | Khaldi A.,Pediatric Intensive Care Unit | Louati H.,Childrens Hospital of Tunis | Menif K.,Pediatric Intensive Care Unit | And 2 more authors.
Annals of Thoracic Surgery | Year: 2010

Multilocular thymic cysts are rare benign acquired lesions of the neck and mediastinum. In children, multilocular thymic cysts are usually symptomatic after the age of 2 years and produce few symptoms. We report an unusual case of a multilocular thymic cyst diagnosed in a 3-month-old girl, causing severe respiratory failure. We believe that this unusual presentation has not been previously reported in the literature. © 2010 The Society of Thoracic Surgeons. Source

Sbai M.A.,MT Maamouri Hospital | Benzarti S.,MT Maamouri Hospital | Bouzaidi K.,MT Maamouri Hospital | Sbei F.,MT Maamouri Hospital | Maalla R.,Rabta Hospital
International Journal of Mycobacteriology | Year: 2015

The tuberculosis of the hand and the wrist is a rare entity. Affecting the scapholunate joint is exceptional. It is usually diagnosed at an advanced stage of carpal destruction, due to slowly development of the symptoms. We report the case of a 58-year-old female, presenting as wrist pain for 3. months. Clinical study showed a local swelling in the left wrist, the mobility of the wrist was normal but painful at the end of motion. The diagnosis of osteoarticular tuberculosis was suspected after radiological and biological study then confirmed after histological study. Antibacillary chemotherapy during 12. months promoted healing and good outcome. © 2015 Asian-African Society for Mycobacteriology. Source

Kallel L.,Rabta Hospital | Ayadi I.,Laboratory of Biochemistry | Matri S.,Rabta Hospital | Fekih M.,Rabta Hospital | And 7 more authors.
European Journal of Gastroenterology and Hepatology | Year: 2010

Objectives Fecal calprotectin seems to have a diagnostic precision in predicting relapse in quiescent ulcerative colitis patients. However, the data remain controversial in Crohn's disease. The aim of this study was to prospectively evaluate the role of fecal calprotectin as a predictive marker for 1-year follow-up in patients with asymptomatic Crohn's disease. Methods Fifty-three Crohn's disease patients in clinical remission were consecutively included providing at the beginning of the study a single stool sample as well as a blood sample and regularly followed-up for 12 months. Fecal calprotectin level was measured using a commercially available enzyme-linked immunoassay. Results Among 53 patients, 10 (18.9%) developed clinical relapse during the 12-month follow-up period. Median fecal calprotectin level was significantly higher in relapse group patients compared with that in nonrelapse group (380.5 vs. 155μg/g, P<0.001). With a cutoff value of 340μg/g fecal calprotectin gave sensitivity of 80% and specificity of 90.7% in predicting clinical relapse. Fecal calprotectin level greater that 340μg/g gave an 18-fold higher risk to develop relapse (log rank P<0.001) and was found to be an independent predictive factor of relapse (P=0.02). Conclusion Fecal calprotectin seems to be a reliable marker of relapse in quiescent Crohn's disease patients. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins. Source

Mehri S.,University of Sfax | Baudin B.,Saint Antoine Hospital | Mahjoub S.,University of Sfax | Zaroui A.,Rabta Hospital | And 4 more authors.
Genetic Testing and Molecular Biomarkers | Year: 2010

Introduction: The role of the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme gene (ACE) on acute myocardial infarction (AMI) is controversial. Objectives: To assess the effect of the ACE I/D polymorphism on AMI compared with the healthy controls and its relationship with serum ACE activity in a Tunisian population. Design and Methods: A total of 119 patients with AMI were compared with 238 healthy controls from the same geographical area. ACE genotyping was determined by polymerase chain reaction, and serum ACE activity was measured with N-[3-(2-furylacryloyl]-L-phenylalanyl-L-glycyl-L- glycine as substrate. Results: The ACE I/D polymorphism was significantly different between patients and controls (p< 0.0001). The frequencies of the DD genotype and the D allele were statistically higher in patients with AMI as compared with the controls and were associated with increased risk of AMI (DD vs. ID and II: odds ratio=4.27, p< 0.0001, 95% confidence interval=2.65-6.86; D vs. I: odds ratio=3.15, p< 0.0001, 95% confidence interval=2.26-4.40). This association was independent of other cardiovascular risk factors but dyslipidemia (p=0.002) that was not represented in AMI patients with II genotype and in a lower extent with hypertension (p< 0.05). Serum ACE activity was significantly higher in AMI patients with ACE DD genotype compared with the subjects with ID or II genotype (p=0.034) and was not correlated with other cardiovascular risk factors. Conclusions: ACE DD genotype associated with higher serum ACE activity is increased in the studied population and might be clinically useful as markers to assess risk for AMI. © 2010, Mary Ann Liebert, Inc. Source

Kallel A.,Research Laboratory | Abdessalem S.,Rabta Hospital | Sediri Y.,Research Laboratory | Mourali M.S.,Rabta Hospital | And 4 more authors.
Clinical Biochemistry | Year: 2012

Objectives: The aim of the present study was to investigate the association between CCR2-Val64Ile and CCR5-δ32 variants and the estimation of haplotypes with MI in a sample of the Tunisian population. Design and methods: A total of 290 unrelated MI patients and 282 healthy controls were studied. The CCR2-Val64Ile and CCR5-δ32 variants were analyzed by PCR-RFLP. Results: Subjects carrying at least one copy of the CCR5-deletion allele were significantly more common in the control group, suggesting an atheroprotective effect (adjusted OR = 0.44, 95% CI = 0.28-0.72, p = 0.001). Haplotype analysis showed that MI patients had significantly less 64Val-Del haplotype (9.9% vs. 21.3%, OR = 0.30, 95% CI = 0.21-0.43, p < 0.001) and 64Ile-Ins haplotype (12.3% vs. 16.7%, OR = 0.58, 95% CI = 0.42-0.80, p < 0.001). Conclusion: A protective effect of the CCR5-δ32 polymorphism against MI in the Tunisian population was found. © 2012. Source

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