RA Chemical Pharma Ltd.

Balanagar, India

RA Chemical Pharma Ltd.

Balanagar, India

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Kannasani R.K.,RA Chemical Pharma Ltd | Peruri V.V.S.,Acharya Nagarjuna University | Battula S.R.,RA Chemical Pharma Ltd
Chemistry Central Journal | Year: 2012

Background: Structurally diverse aldehydes are successfully converted into acylals (1,1-diacetates) with acetic anhydride using NaHSO4-SiO2 as a mild, convenient and inexpensive catalyst under solvent-free conditions. The noteworthy features of the present system are shorter reaction times, and mild and solvent-free conditions. Furthermore, it offers chemoselective protection of aldehydes.Results: Both aromatic and aliphatic aldehydes reacts smoothly with acetic anhydride in presence of silica supported sodium hydrogen sulphate to afford the corresponding 1,1-diacetates in good to excellent yields. We studied competitive reactions for the acylation of aldehydes in the presence of ketones using silica supported sodium hydrogen sulphate as a catalyst. Using this catalytic system, the highly selective conversion of an aldehyde in the presence of ketone was observed.Conclusions: NaHSO4-SiO2 is a chemoselective and highly efficient catalyst for acylal formation from aldehydes. The advantages of this methodology over the reported methods is the availability of the starting materials, simplicity of acylation procedure, a clean work-up, a short reaction time, high yields and reusability. © 2012 PERURI et al.; licensee Chemistry Central Ltd.


Kumar K.R.,RA Chemical Pharma Ltd | Satyanarayana P.V.V.,Acharya Nagarjuna University | Reddy B.S.,RA Chemical Pharma Ltd
Chinese Journal of Chemistry | Year: 2012

Tetrahydropyranyl (THP) ethers have been efficiently and simply deprotected by using Silica supported sodium hydrogen sulphate (NaHSO 4-SiO 2) in methanol at room temperature to regenerate the parent alcohols in high yields. Tetrahydropyranyl (THP) ethers have been efficiently and simply deprotected by using silica supported sodium hydrogen sulphate (NaHSO 4-SiO 2) in methanol at room temperature to regenerate the parent alcohols in high yields. © 2012 SIOC, CAS, Shanghai & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Ravi Kumar K.,RA Chemical Pharma Ltd | Satyanarayana P.V.V.,Acharya Nagarjuna University | Srinivasa Reddy B.,RA Chemical Pharma Ltd
Asian Journal of Chemistry | Year: 2012

A Simple and efficient process for tetrahydropyranylation of alcohols and phenols has been developed by reacting with dihydropyran at room temperature in presence of catalytic amount of silica supported sodium hydrogen sulphate.


Ramineni S.,Chalapathi Institute of Engineering and Technology | Kannasani R.K.,RA Chemical Pharma Ltd | Kalikinidi N.R.,Indian Institute of Chemical Technology
Der Pharma Chemica | Year: 2016

DL-10-Camphorsulfonic acid (CAS. No- 5872-088-2) was found to be a convenient catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones through a one-pot three-component reaction of aldehydes, alkyl acetoacetate, and urea at 80°C under solvent-free conditions.


Kumar K.R.,RA Chemical Pharma Ltd | Satyanarayana P.V.V.,Acharya Nagarjuna University | Srinivasa Reddy B.,RA Chemical Pharma Ltd
Der Pharma Chemica | Year: 2012

Benzoxazole derivatives have been prepared through the reaction of 2-Amino phenols and aldehydes in the presence of catalytic amount of Silica supported sodium hydrogen sulphate (NaHSO 4-SiO 2) under refluxing in Dioxane solvent to obtained excellent yields.


Bathula S.B.,Jawaharlal Nehru Technological University Anantapur | Bathula S.B.,Alekhya Drugs Pvt Ltd | Mukkanti K.,Jawaharlal Nehru Technological University Anantapur | Venkatasubramanian H.,RA Chemical Pharma Ltd.
Der Pharma Chemica | Year: 2014

Michel addition of indoles with olefins in the presence of cellulose sulfuric acid as catalysts afford the corresponding 3-substituted indoles in excellent yields and short reaction times is described. The reaction work up is simple and the catalyst can be easily separated from the reaction mixture and reused in subsequent reaction.


Ramineni S.,Chalapathi Institute of Engineering and Technology | Kannasani R.K.,RA Chemical Pharma Ltd | Peruri V.V.S.,Acharya Nagarjuna University
Green Chemistry Letters and Reviews | Year: 2014

A simple and efficient method has been developed for the synthesis of benzoxazoles from 2-aminophenol and substituted aldehydes in the presence of a catalytic amount of zinc triflate in ethanol solvent at reflux temperature. © 2014 The Author(s). Published by Taylor & Francis.


Kumar K.R.,RA Chemical Pharma Ltd | Satyanarayana P.V.V.,Acharya Nagarjuna University | Srinivasa Reddy B.,RA Chemical Pharma Ltd
Journal of Chemistry | Year: 2013

An efficient protocol has been developed for the preparation of a library of benzoxazole, benzimidazole, and benzothiazole derivatives from reactions of acyl chlorides with o-substituted aminoaromatics in the presence of catalytic amount of silica-supported sodium hydrogen sulphate under solvent-free conditions. Simple workup procedure, high yield, easy availability, reusability, and use of ecofriendly catalyst are some of the striking features of the present protocol. © 2013 K. Ravi Kumar et al.


Srinivasulu R.,Chalapathi Institute of Engineering and Technology | Satyanarayana P.V.V.,Acharya Nagarjuna University | Ravi Kumar K.,RA Chemical Pharma Ltd
Russian Journal of General Chemistry | Year: 2013

Treatment of tetrahydropyranyl (THP) ethers with zinc triflate in methanol provides a simple and efficient process for deprotection of these ethers and the parent alcohols are obtained in excellent yields. © 2013 Pleiades Publishing, Ltd.


PubMed | RA Chemical Pharma Ltd
Type: Journal Article | Journal: Acta pharmaceutica (Zagreb, Croatia) | Year: 2010

Efavirenz (EFV) tablets of different doses were prepared by a wet granulation process using different superdisintegrants such as crosscarmellose sodium (CCS), sodium starch glycollate (SSG) and crosspovidone (CP) to evaluate the role of different disintegrants on the in vitro release of EFV. Further, the mode of addition of disintegrants on EFV dissolution from tablets containing 600 mg of the drug was evaluated by incorporating the disintegrants extragranularly (EG), intragranularly (IG) or distributing them equally (IG and EG). In vitro dissolution of the prepared tablets was conducted using the recommended medium and a dissolution medium developed in-house, which had the ability to discriminate between the formulations. The t50 and t80 values were indicative of the fact that the drug release was faster from tablet formulations containing CP. CP was able to release the drug faster than the other two disintegrants in both dissolution media and the drug release was unaffected by the mode of CP addition.

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