RA Chemical Pharma Ltd.

Balanagar, India

RA Chemical Pharma Ltd.

Balanagar, India
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Mohana Raghava Srivalli K.,Osmania University | Mohana Raghava Srivalli K.,RA Chemical Pharma Ltd | Lakshmi P.K.,Osmania University | Balasubramaniam J.,RA Chemical Pharma Ltd
Saudi Pharmaceutical Journal | Year: 2013

Lamotrigine is a BCS class II drug with pH dependent solubility. The bilayered gastric mucoadhesive tablets of lamotrigine were designed such that the drug and controlled release polymers were incorporated in the upper layer and the lower layer had the mucoadhesive polymers. The major ingredients selected for the upper layer were the drug and control release polymer (either HPMC K15M or polyox) while the lower MA layer predominantly comprised of Carbopol 974P. A 23 full factorial design was constructed for this study and the tablets were optimized for parameters like tablet size, shape, ex vivo mucoadhesive properties and unidirectional drug release. Oval tablets with an average size of 14mm diameter were set optimum. Maximum mucoadhesive bond strength of 79.3±0.91*103dyn/cm2 was achieved with carbopol when used in combination with a synergistic resin polymer. All the tested formulations presented a mucoadhesion time of greater than 12h. The incorporation of methacrylic polymers in the lower layer ensured unidirectional drug release from the bilayered tablets. The unidirectional drug release was confirmed after comparing the dissolution results of paddle method with those of a modified basket method. Model independent similarity and dissimilarity factor methods were used for the comparison of dissolution results. Controlled drug release profiles with zero order kinetics were obtained with polyox and HPMC K15M which reported t90% at 6th and 12th hours, respectively. The "n" value with polyox was 0.992 and that with HPMC K15M was 0.946 indicating an approximate case II transport. These two formulations showed the potential for oral administration of lamotrigine as bilayered gastric mucoadhesive tablets by yielding highest similarity factor values, 96.06 and 92.47, respectively, between the paddle and modified basket method dissolution release profiles apart from reporting the best tablet physical properties and maximum mucoadhesive strength. © 2012 King Saud University.


Rajesh Y.,RA Chemical Pharma Ltd | Balasubramaniam J.,RA Chemical Pharma Ltd | Bindu K.,International Specialty Products India Pvt Ltd | Sridevi R.,International Specialty Products India Pvt Ltd | And 2 more authors.
Acta Pharmaceutica | Year: 2010

Efavirenz (EFV) tablets of different doses were prepared by a wet granulation process using different superdisintegrants such as crosscarmellose sodium (CCS), sodium starch glycollate (SSG) and crosspovidone (CP) to evaluate the role of different disintegrants on the in vitro release of EFV. Further, the mode of addition of disintegrants on EFV dissolution from tablets containing 600 mg of the drug was evaluated by incorporating the disintegrants extragranularly (EG), intragranularly (IG) or distributing them equally (IG and EG). In vitro dissolution of the prepared tablets was conducted using the recommended medium and a dissolution medium developed in-house, which had the ability to discriminate between the formulations.The t50 and t 80 values were indicative of the fact that the drug release was faster from tablet formulations containing CP. CP was able to release the drug faster than the other two disintegrants in both dissolution media and the drug release was unaffected by the mode of CP addition.


Rajinikanth P.S.,International Medical University | Balasubramaniam J.,RA Chemical Pharma Ltd | Thilek Kumar M.,International Medical University | Rajesh Y.V.,International Medical University
International Journal of Drug Delivery | Year: 2012

The present study investigated the effect of spray drying raloxifene HCl (RHCL) with different classes of hydrophilic carriers (different grades of polyvinyl pyrrolidones) and cellulosic polymers) in order to determine the potential effect on dissolution rate and bioavailability of RHCL. Pre-formulation studies were conducted to select the appropriate carriers and drug:carrier ratio for preparing the spray dried compositions.The solid state interactions of the spray dried mixtures were evaluated by DSC & XRD. Preformulation studies revealed that amorphous compositions of RHCL could be obtained only with Plasdones (K12, K29/32 and S630). DSC studies showed that the crystalline nature of RHCL was significantly reduced on spray drying. Significant enhancement in dissolution rate was observed with the prepared spray dried compositions and out of the three grades of Plasdone, Plasdone K12 demonstrated the maximum enhancement in rate of release of RHCL. The pharmacokinetics of spray dried composition (1:1 RHCL: K12) and pure RHCL was evaluated following oral administration (25 mg/kg) in healthy female Sprague Dawley rats. The extent of the mean plasma exposures of RHCL was 7-fold higher in animals treated with spray dried mixture of RHCL, K12 (1:1) compared to animals treated with RHCL. Spray drying of RHCL with Plasdones, especially Plasdone K12, reduced drug crystallinity, increased the rate and extent of dissolution, and improved bioavailability.


Bathula S.B.,Telangana University | Bathula S.B.,Alekhya Drugs Pvt. Ltd | Khagga M.,Telangana University | Venkatasubramanian H.,RA Chemical Pharma Ltd.
Letters in Organic Chemistry | Year: 2017

Background: Oxygen heterocycles exhibit diverse biological and pharmacological activities. In particular, benzofurans are available in a wide number of natural products and have drawn considerable attention over the last few years due to their profound physiological and biological properties. The aim of this paper describes a green methodology to synthesize this potent molecule with high selectivity by using ionic resin in PEG at room temperature. Methods: The methodology is very simple and easily accessible at room temperature. It uses low catalyst loadings and is recycled subsequently. In addition, detailed experimental procedure for the selected compounds including the spectral data are provided. Results: Among the various ionic resins attempted, Amberlyst-15® in PEG-400 was the choice of selection for the synthesis of 3-benzoyl-5-hydroxy benzofuran and naphtho[1,2-b]furan derivatives at room temperature in an environmentally friendly method. This catalyst system resulted in excellent yields in short reaction times and high selectivity. Conclusion: We have developed a green highly efficient and environmentally friendly protocol for the facile synthesis of 3-benzoyl-5-hydroxy benzofuran and naphtho[1,2-b]furan derivatives at room temperature in high yields (>90-95%) using nontoxic and inexpensive ion exchange resin Amberlyst-15®. The notable advantages of the catalyst approach enables the reactions with high selectivity, short reactions time and excellent yields without generating any waste and was reused. © 2017 Bentham Science Publishers.


Kannasani R.K.,RA Chemical Pharma Ltd | Peruri V.V.S.,Acharya Nagarjuna University | Battula S.R.,RA Chemical Pharma Ltd
Chemistry Central Journal | Year: 2012

Background: Structurally diverse aldehydes are successfully converted into acylals (1,1-diacetates) with acetic anhydride using NaHSO4-SiO2 as a mild, convenient and inexpensive catalyst under solvent-free conditions. The noteworthy features of the present system are shorter reaction times, and mild and solvent-free conditions. Furthermore, it offers chemoselective protection of aldehydes.Results: Both aromatic and aliphatic aldehydes reacts smoothly with acetic anhydride in presence of silica supported sodium hydrogen sulphate to afford the corresponding 1,1-diacetates in good to excellent yields. We studied competitive reactions for the acylation of aldehydes in the presence of ketones using silica supported sodium hydrogen sulphate as a catalyst. Using this catalytic system, the highly selective conversion of an aldehyde in the presence of ketone was observed.Conclusions: NaHSO4-SiO2 is a chemoselective and highly efficient catalyst for acylal formation from aldehydes. The advantages of this methodology over the reported methods is the availability of the starting materials, simplicity of acylation procedure, a clean work-up, a short reaction time, high yields and reusability. © 2012 PERURI et al.; licensee Chemistry Central Ltd.


Kumar K.R.,RA Chemical Pharma Ltd | Satyanarayana P.V.V.,Acharya Nagarjuna University | Reddy B.S.,RA Chemical Pharma Ltd
Chinese Journal of Chemistry | Year: 2012

Tetrahydropyranyl (THP) ethers have been efficiently and simply deprotected by using Silica supported sodium hydrogen sulphate (NaHSO 4-SiO 2) in methanol at room temperature to regenerate the parent alcohols in high yields. Tetrahydropyranyl (THP) ethers have been efficiently and simply deprotected by using silica supported sodium hydrogen sulphate (NaHSO 4-SiO 2) in methanol at room temperature to regenerate the parent alcohols in high yields. © 2012 SIOC, CAS, Shanghai & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Ravi Kumar K.,RA Chemical Pharma Ltd | Satyanarayana P.V.V.,Acharya Nagarjuna University | Srinivasa Reddy B.,RA Chemical Pharma Ltd
Asian Journal of Chemistry | Year: 2012

A Simple and efficient process for tetrahydropyranylation of alcohols and phenols has been developed by reacting with dihydropyran at room temperature in presence of catalytic amount of silica supported sodium hydrogen sulphate.


Ramineni S.,Chalapathi Institute of Engineering and Technology | Kannasani R.K.,RA Chemical Pharma Ltd | Kalikinidi N.R.,Indian Institute of Chemical Technology
Der Pharma Chemica | Year: 2016

DL-10-Camphorsulfonic acid (CAS. No- 5872-088-2) was found to be a convenient catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones through a one-pot three-component reaction of aldehydes, alkyl acetoacetate, and urea at 80°C under solvent-free conditions.


Kumar K.R.,RA Chemical Pharma Ltd | Satyanarayana P.V.V.,Acharya Nagarjuna University | Srinivasa Reddy B.,RA Chemical Pharma Ltd
Der Pharma Chemica | Year: 2012

Benzoxazole derivatives have been prepared through the reaction of 2-Amino phenols and aldehydes in the presence of catalytic amount of Silica supported sodium hydrogen sulphate (NaHSO 4-SiO 2) under refluxing in Dioxane solvent to obtained excellent yields.


Ramineni S.,Chalapathi Institute of Engineering and Technology | Kannasani R.K.,RA Chemical Pharma Ltd | Peruri V.V.S.,Acharya Nagarjuna University
Green Chemistry Letters and Reviews | Year: 2014

A simple and efficient method has been developed for the synthesis of benzoxazoles from 2-aminophenol and substituted aldehydes in the presence of a catalytic amount of zinc triflate in ethanol solvent at reflux temperature. © 2014 The Author(s). Published by Taylor & Francis.

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