Rc Patel Institute Of Pharmaceutical Education And Research Shirpur

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Dhule, India
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Tharkar P.R.,Sgsps Institute Of Pharmacy | Tatiya A.U.,Rc Patel Institute Of Pharmaceutical Education And Research Shirpur | Surana S.J.,Rc Patel Institute Of Pharmaceutical Education And Research Shirpur | Bhajipale N.S.,Sgsps Institute Of Pharmacy
International Journal of PharmTech Research | Year: 2010

In the present study, the bark of Wrightia tinctoria was investigated for anti-inflammatory activity by carrageenan- induced rat paw oedema and cotton pellet induced granuloma method. The various extracts showed inhibition of rat paw oedema and percent granuloma changes at dose of 200mg/kg when compared to control group. The activity was compared with that of standard drug diclofenac sodium (13.5 mg/kg /b w, p.o).


Tharkar P.R.,Sgsps Institute Of Pharmacy | Tatiya A.U.,Rc Patel Institute Of Pharmaceutical Education And Research Shirpur | Shinde P.R.,Rc Patel Institute Of Pharmaceutical Education And Research Shirpur
International Journal of PharmTech Research | Year: 2010

Direct bioautography is a method to localize antibacterial activity on a chromatogram. Optimized direct bioautography is useful both for the analytical determination of the main compounds and for characterization of their antibacterial effects. In the present study, the hydro alcoholic extract of Emblica officinalis L. and Glycyrrhiza glabra was investigated for antifungal activity against Candida albicans (C. albicans) and Aspergillus niger (A. niger) conventionally and by direct bioautography. Zone of inhibition for G. glabra were 23.83 mm and E. officinalis 18.10 mm in diameter at conc.1mg/ml against C. albicans while zone of inhibition produced by G. glabra and E. officinalis were 26.41 mm and 10.28mm in diameter at 2 mg/ml respectively against A. niger. MIC range of 512-1024 ng/ml and 1024-2048 ng/ml for C. albicans. While 256-512 μg/ml and 1024-2048 μg/ml For A. niger respectively. In TLC bioautographic studies it shows the significant inhibitory effect against A. niger.


Chalikwar R.D.,Srtm University | Yadav A.V.,Krishna University | Chalikwar S.S.,Rc Patel Institute Of Pharmaceutical Education And Research Shirpur
Acta Pharmaceutica Sciencia | Year: 2011

A sustained release system for Diltiazem Hydrochloride designed to increase its residence time in the stomach without contact with the mucosa was achieved through the preparation of microballoons as gastro-retentive drug delivery system. Microballoons were prepared by the o/o emulsion solvent diffusion-evaporation method utilizing two different acrylic polymers like Drugcoat RS 100, Drugcoat RL 100 and one ethyl cellulose with three different ratios of polymers. The prepared microballoons were evaluated for polymer compatibility, percentage recovery, drug entrapment, micrometric properties, surface morphology, in vitro floatation ability, in vitro release studies, and release kinetics and stability study. Scanning electron microscopy confirmed their hollow structures for its buoyancy. All Formulations show good floatability and drug entrapment. Formulation F 6 containing drug and Drugcoat RS 100 (1:2) which showed appropriate balance between release rate and buoyancy could be advantageous in terms of increased bioavailability of Diltiazem Hydrochloride. The formulation was found to be physically and chemically stable as per ICH guidelines.


PubMed | Rc Patel Institute Of Pharmaceutical Education And Research Shirpur
Type: | Journal: Carbohydrate polymers | Year: 2014

The purpose of the present investigation was to prepare microspheres using xyloglucan as the polymer and to evaluate them for pulmonary delivery of Montelucast. Xyloglucan microspheres were prepared using spray-drying technique employing lactose monohydrate as carrier for dry powder inhalation. The formulation of microspheres was optimized using response surface methodology. Multiple response surface simultaneous optimizations using desirability approach were use to find optimal formulation. In vitro characterization of optimized microsphere formulation demonstrates its suitability as dry powder inhalation. It found to provide high and prolonged drug concentration within lungs after pulmonary administration in animal model.

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