Patel Mahila Pharmacy College

Gujarat, India

Patel Mahila Pharmacy College

Gujarat, India
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Nakarani M.P.,Ganpat University | Patel P.R.,Ganpat University | Patel J.K.,Nootan Pharmacy College | Vaghani S.S.,Patel Mahila Pharmacy College
Latin American Journal of Pharmacy | Year: 2011

SUMMARY. In the present study, a simple, rapid and precise liquid chromatographic method was developed and validated for the determination of ezetimibe in its dosage form. Ezetimibe was separated in a 100 × 4.6 mm i.d., C18 column, 3 μm particle size, Luna phenomenex, using a mobile phase composition of water and acetonitrile (60:40 v/v). Column oven temperature was kept at 25 °C. The flow rate was 1.5 mL/min and the analyte monitored at 225 nm. The retention time of Ezetimibe was 8.47 min. The specificity of the method was determined by assessing interference from the placebo and by stress testing of the drug (forced degradation).The developed method was validated in terms of linearity, accuracy, precision, system suitability, limit of detection, limit of quantitation and solution stability. The proposed method was also applied successfully to the pharmaceutical dosage form self emulsified drug delivery without any interference by excipients.

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