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Ma J.,Chonnam National University | Lee K.,Chonnam National University | Ban J.,Chonnam National University | Ban J.,R and nter for Ti and Special Alloys of | And 11 more authors.
Journal of Nanoscience and Nanotechnology | Year: 2013

An effective loading method of the recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) on the implant surface is essential for promoting bone formation. However, the studies comparing the effectiveness of loading methods for rhBMP-2 are insufficient. The objective of this study was to investigate the sustained rhBMP-2 delivery on the functionalized nanotubular surface. rhBMP-2 loading method on functionalized nanotubular surface was divided into 3 groups; coating and dry method, vacuum method, lyophilization method. A total of 10 ug rhBMP-2 was loaded into functionalized nanotubular titanium implant surfaces (3.75 mm in diameter and 7 mm in length). The releasing time of rhBMP-2 was evaluated at 1, 5, 7 days. The data were statistically analyzed with one-way ANOVA and a Post Hoc Bonferroni test. A sustained release pattern was observed in each groups and the amount of rhBMP-2 loaded was the highest in the lyophilization group. The results suggest that lyophilization method is effective method to load rhBMP-2 on the functionalized nanotubular surface and the functionalized nanotubular surface could be a sustainable useful carrier of rhBMP-2. Copyright © 2013 American Scientific Publishers All rights reserved. Source


Ban J.,Chonnam National University | Ban J.,R and nter for Ti and Special Alloys of | Kang S.,Chonnam National University | Kim J.,Chonnam National University | And 11 more authors.
Journal of Nanoscience and Nanotechnology | Year: 2015

This study was to investigate the effects of micro-nano titanium implant surface on the osseointegration. A total of 36 screw-shaped implants were used. The implant surfaces were classified into 3 groups (n = 12): machined surface (M group), nanosurface which is nanotube formation on the machined surface (MA group) and nano-micro surface which is nanotube formation on the RBM surface (RA group). Anodic oxidation was performed at a 20 V for 10 min with 1 M H3 PO4 and 1.5 wt% HF solutions. The implants were installed on the humerus on 6 beagles. After 4 and 12 weeks, the morphometric analysis with micro CT (skyscan 1172, SKYSCAN, Antwerpen, Belgium) was done. The data were statistically analyzed with two-way ANOVA. Bone mineral density and bone volume were significantly increased depending on time. RA group showed the highest bone mineral density and bone volume at 4 weeks and 12 weeks significantly. It indicated that nano-micro titanium implant surface showed faster and more mature osseointegration. Copyright © 2015 American Scientific Publishers All rights reserved. Source

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