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Montevideo, Uruguay

Santi E.,Quimica Inorganica DEC | Viera I.,Quimica Inorganica DEC | Mombru A.,Laboratorio Of Cristalografia | Castiglioni J.,Fisicoquimica DETEMA | And 2 more authors.
Biological Trace Element Research | Year: 2011

Five new copper and zinc heteroleptic complexes with saccharin and aminoacids with general stoichiometry Na 2[M(sac) 2(aa) 2]·nH 2O (M denotes Cu or Zn, sac the saccharinate ion, and aa the aminoacids) were synthesized and characterized by elemental and thermogravimetric analysis, conductimetric measurements and IR, Raman and UV-vis spectroscopies. In all the complexes, copper and zinc ions coordinated with the aminoacids through the terminal amine and carboxylate residues and with saccharin through the heterocyclic nitrogen atom. Besides, the superoxide dismutase-like activity of the heteroleptic copper complexes was evaluated and compared with the homoleptic copper amino acid complexes with the aim to observe the influence of the saccharin coordination. © 2011 Springer Science+Business Media, LLC.

Mondelli M.,Quimica Inorganica DEC | Pavan F.,Sao Paulo State University | De Souza P.C.,Sao Paulo State University | Leite C.Q.,Sao Paulo State University | And 4 more authors.
Journal of Molecular Structure | Year: 2013

Nowadays, the research for new and better antimicrobial compounds is an important field due to the increase of immunocompromised patients, the use of invasive medical procedures and extensive surgeries, among others, that can affect the incidence of infections. Another big problem associated is the occurrence of drug-resistant microbial strains that impels a ceaseless search for new antimicrobial agents. In this context, a series of heterocyclic- sulfonamide complexes with Co(II) was synthesized and characterized with the aim of obtaining new antimicrobial compounds. The structural characterization was performed using different spectroscopic methods (UV-Vis, IR, and EPR). In spite of the fact that the general stoichiometry for all the complexes was Co(sulfonamide)2·nH2O, the coordination atoms were different depending on the coordinated sulfonamide. The crystal structure of [Co(sulfamethoxazole)2(H2O)2]·H 2O was obtained by X-ray diffraction showing that Co(II) is in a slightly tetragonal distorted octahedron where sulfamethoxazole molecules act as a head-to-tail bridges between two cobalt atoms, forming polymeric chains. Besides, the activity against Mycobacterium tuberculosis, one of the responsible for tuberculosis, and the cytotoxicity on J774A.1 macrophage cells were evaluated. © 2012 Elsevier B.V. All rights reserved.

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