Penanda S.,Quimica Farmaceutica |
Scarone L.,Quimica Farmaceutica |
Manta E.,Quimica Farmaceutica |
Serra G.,Quimica Farmaceutica
Khimiya Geterotsiklicheskikh Soedinenii | Year: 2011
A rapid and efficient methodology to prepare 2,4'-bi-1,3-azoles as scaffolds for biologically active marine natural products is described. Hantzsch reaction and oxidative cyclodehydration of ß-hydroxyamides or thioamides were used to construct the azole rings. The obtained biheterocycles displayed no citotoxicity on HCT-15 cell line.