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Beiko D.,Queens University | Pierre S.A.,Queensway Carleton Hospital | Leonard M.P.,University of Ottawa
Journal of Pediatric Urology | Year: 2011

Urethral hair and diverticula are well described long-term complications following urethroplasty or hypospadias repair. Endoscopic laser ablation is an uncommonly reported treatment option for a symptomatic hair-bearing urethra, and holmium laser hair epilation has not been previously reported in the literature. We report the first case of urethroscopic holmium laser ablation of urethral diverticular hair follicles and the outcome. © 2010 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved. Source


Fargo J.H.,U.S. National Cancer Institute | Fargo J.H.,Center for Cancer and Blood Disorders | Rochowski A.,Queensway Carleton Hospital | Giri N.,U.S. National Cancer Institute | And 3 more authors.
Cytogenetic and Genome Research | Year: 2014

Fanconi anemia (FA) is a rare inherited bone marrow failure syndrome (IBMFS). Affected individuals must be distinguished from relatives, patients with mosaicism must be identified, and patients with other IBMFS classified as non-FA. The diagnostic feature of FA is increased chromosomal breakage in blood lymphocytes cultured with diepoxybutane or mitomycin C. Here, we sought a method to uniquely identify patients with FA with mosaicism, using cells from participants in the National Cancer Institute IBMFS cohort. Lymphocytes were treated with diepoxybutane or mitomycin C, and metaphases scored for breaks and radials. Analyses included the percentage of cells with any aberration, breaks per cell, and breaks per aberrant cell. There were 26 patients with FA (4 mosaics), 46 FA relatives, and 62 patients with a non-FA IBMFS. By all analytic methods, patients with FA were abnormal compared with other groups. Those with FA mosaicism had more breakage than relatives or patients with non-FA IBMFS, but there was some individual overlap. The choices of clastogen are laboratory-dependent, but there was no method or analysis of lymphocytes that clearly distinguished all individuals mosaic for FA from relatives or patients with other IBMFS. Thus, genotyping remains the best method for providing absolute clarity. © 2014 S. Karger AG, Basel. Source


Baslyman M.,University of Ottawa | Rezaee R.,University of Ottawa | Amyot D.,University of Ottawa | Mouttham A.,Queensway Carleton Hospital | And 4 more authors.
Personal and Ubiquitous Computing | Year: 2015

Rising infection rates in health care cause complications for the patient, extended hospital stay, financial difficulties and even death. One of the crucial factors that reduce those infections is better hand hygiene. Due to the lack of automated systems that can help monitoring hand hygiene compliance, some hospitals use direct observations, surveys, dispensers usage measurements and other such methods to monitor the compliance of care providers. This paper presents an alternative system that takes advantage of emerging off-the-shelf infrastructures in hospitals and in particular of real-time location systems (RTLS) and automated hand sanitizer dispensers. Our RTLS-based hand hygiene monitoring and notification system (RHMNS) improves upon current methods by enabling interactions with care providers through notifications when they do not execute expected hand hygiene actions, even for fine-grained location situations such as moving between patients a multi-bed room. RHMNS supports two approaches that share the same infrastructure while differing in their way of deciding on missed hand hygiene opportunities. The activation-based approach, which offers better results than the time-based one, exploits new intelligent dispensers that send notifications on a wireless network when sanitizer is dispensed. RHMNS also provides informative reports about compliance and trends. Validation results based on a proof-of-concept deployment in a hospital bedroom and on a performance evaluation in a university laboratory suggest that it is feasible to have an RTLS-based system that is reliable, accurate, valid and adoptable, that considers the privacy of healthcare providers and that reminds healthcare providers of taking hand hygiene actions when required. © 2015 Springer-Verlag London Source


Nagaraju S.P.,Kasturba Medical College | Cohn A.,Queensway Carleton Hospital | Akbari A.,Ottawa Hospital Research Institute | Zimmerman D.L.,Ottawa Hospital Research Institute
BMC Nephrology | Year: 2013

Background: Anemia secondary to iron deficiency is common in patients with non-dialysis dependent chronic kidney disease (ND-CKD) but it is unclear if oral supplementation is as effective as intravenous (IV) supplementation in re-establishing iron stores. The purpose of this study was to determine if oral Heme Iron Polypeptide (HIP) is as effective as IV iron sucrose in the treatment of iron-deficiency anemia for patients with ND-CKD. Methods. Forty ND-CKD patients were randomized; 18 to HIP 11 mg orally 3 times per day and 22 to IV iron sucrose 200 mg monthly for 6 months. Baseline clinical and laboratory data were collected for all patients. The primary and secondary outcomes for the study were hemoglobin (Hgb) concentration and iron indices [ferritin and percentage transferrin saturation (TSAT)] at the end of 6 months respectively. Adverse events were also compared. Results: The baseline demographic characteristics and laboratory values were similar for the two groups. After 6 months of treatment, Hb in the HIP group was 117 g/L and 113 g/L in the IV sucrose group (p = 0.37). The TSAT at 6 months was not different between the two groups {p = 0.82}but the serum ferritin was significantly higher in the IV iron sucrose group {85.5 ug/L in HIP and 244 ug/L; p = 0.004}. Overall adverse events were not different between the groups. Conclusion: HIP is similar in efficacy to IV iron sucrose in maintaining hemoglobin in ND-CKD patients with no differences in adverse events over 6 months. It is unclear if the greater ferritin values in the IV iron sucrose group are clinically significant. Trial registration. ClinicalTrials.gov: NCT00318812. © 2013 Nagaraju et al.; licensee BioMed Central Ltd. Source


Beiko D.,Queens University | Zaza K.,Queens University | Power K.V.,Queensway Carleton Hospital | Robert Siemens D.,Queens University | Boag A.H.,Queens University
Journal of the Canadian Urological Association | Year: 2014

Isolated anterior urethral metastases from prostate cancer are rare. The pathogenesis of this form of loco-regional recurrence may be related to spread by instrumentation-induced implantation and could potentially then be associated with a better prognosis than metastatic disease secondary to a more malignant phenotype. We report a case of a 68-year-old man with high-risk prostate cancer, diagnosed at transurethral resection of prostate, who was originally treated with combination external beam radiotherapy and hormonal therapy. He re-presented 4 years after his original diagnosis with recurrent gross hematuria and cystourethroscopic biopsies of anterior urethral polyps revealing isolated recurrent prostatic adenocarcinoma. We present our this case and review the literature. © 2014 Canadian Urological Association. Source

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