Mulligan L.M.,Queens University
Nature Reviews Cancer
The RET receptor tyrosine kinase is crucial for normal development but also contributes to pathologies that reflect both the loss and the gain of RET function. Activation of RET occurs via oncogenic mutations in familial and sporadic cancers-most notably, those of the thyroid and the lung. RET has also recently been implicated in the progression of breast and pancreatic tumours, among others, which makes it an attractive target for small-molecule kinase inhibitors as therapeutics. However, the complex roles of RET in homeostasis and survival of neural lineages and in tumour-associated inflammation might also suggest potential long-term pitfalls of broadly targeting RET. © 2014 Macmillan Publishers Limited. Source
Davies P.L.,Queens University
Trends in Biochemical Sciences
Antifreeze proteins (AFPs) were discovered in marine fishes that need protection from freezing. These ice-binding proteins (IBPs) are widespread across biological kingdoms, and their functions include freeze tolerance and ice adhesion. Consistent with recent independent evolution, AFPs have remarkably diverse folds that rely heavily on hydrogen- and disulfide-bonding. AFP ice-binding sites are typically flat, extensive, relatively hydrophobic, and are thought to organize water into an ice-like arrangement that merges and freezes with the quasi-liquid layer next to the ice lattice. In this article, the roles, properties, and structure-function interactions of IBPs are reviewed, and their relationship to ice nucleation proteins, which promote freezing at high subzero temperatures, is explored. © 2014 Elsevier Ltd. Source
Queen's University | Date: 2015-09-29
Provided are DC-bus voltage or DC-bus current controller methods and circuits, for a voltage or current source inverter. A mean value calculator provides an output signal comprising the mean value of the DC-bus voltage or current, which is used as a feedback signal in a closed loop of the voltage or current source inverter controller, such that a ripple in the DC-bus voltage or current is substantially prevented from entering the closed-loop. In some embodiments a droop controller, which may be adaptive, is used in the closed loop with reverse proportional gain. The adaptive droop controller may provide a constant or variable DC-bus voltage or current. Embodiments regulate the DC-bus voltage or current to an optimized value such that power losses for load and grid conditions are minimized or reduced, and voltage and current ripple is minimized. Embodiments may be used in voltage and current source inverters connected to the utility power distribution grid, in power generation systems, in distributed generation systems, and renewable energy systems.
Queen's University | Date: 2014-03-13
In one aspect the invention provides a reference device that enhances image-guided surgical interventions. The reference device is tracked by the imaging system and used to verify the accuracy of the intervention tool placement before and during the intervention. The reference device holds a reference sensor in a position aligned with patient anatomy, so that images are displayed in the correct orientation to the operator, aiding in target recognition and better navigation. Also provided are methods using the reference device and programmed computer media for implementing at least a part of the methods.
Queen's University | Date: 2014-03-13
A method, apparatus, and system are provided to monitor and characterize the dynamics of a phase change region (PCR) created during laser welding, specifically keyhole welding, and other material modification processes, using low-coherence interferometry. By directing a measurement beam to multiple locations within and overlapping with the PCR, the system, apparatus, and method are used to determine, in real time, spatial and temporal characteristics of the weld such as keyhole depth, length, width, shape and whether the keyhole is unstable, closes or collapses. This information is important in determining the quality and material properties of a completed finished weld. It can also be used with feedback to modify the material modification process in real time.