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Durandet A.,Metz National School of Engineering | Durandet A.,Brunel University | Ricci P.-L.,Metz National School of Engineering | Ricci P.-L.,Brunel University | And 5 more authors.
Lecture Notes in Engineering and Computer Science | Year: 2013

High Tibia Osteotomy (HTO) is an operation that requires full lower limb alignment assessment to plan bone cuts. This study is trying to introduce a pre HTO operative radiographic analysis method to improve measurement of the whole lower limb using anatomical and mechanical axes and the angles between them. The aim is to improve the reproducibility of the measurements, and not personalize them. Using the introduced method, the lower limb radiographic alignments of a 25 year old female patient with a varus knee deformity were analyzed pre and post operation using imaging from hip to ankle. Source

Spiliopoulos K.,National and Kapodistrian University of Athens | Markakis C.,National and Kapodistrian University of Athens | Tomos P.,National and Kapodistrian University of Athens | Gakiopoulou H.,National and Kapodistrian University of Athens | And 4 more authors.
Surgery Today | Year: 2015

Purposes: The objective of this study was to test the efficacy of an equine pericardial patch for repairing full-thickness defects of the stomach wall.Methods: Circular defects, 1.5 cm in diameter, were created on the anterior wall of the stomach of 12 female New Zealand rabbits. The defects were repaired by an equine pericardial patch. After euthanasia at different time intervals (3 days to 8 weeks) a macroscopic evaluation of the abdominal cavity (including adhesion scoring), mechanical testing and a histological examination of the stomach were performed.Results: The animals survived the surgical procedure and underwent an uneventful recovery until euthanasia. None of the patches failed. Adhesions were observed in all animals and were significant in 3/12 animals. Bursting pressure testing indicated that the repair was durable and that adequate strength to prevent patch failure was achieved by the second week. A histological examination showed gradual narrowing of the perforation site by mucosal and limited muscular regeneration.Conclusions: The equine pericardial patch was successfully used to repair a gastric defect in our experimental model, and it seems that it could have potential as a material suitable for further research concerning the repair of upper gastrointestinal defects. © 2014, Springer Japan. Source

Mathews C.J.,Queen Elizabeth Hospital Woolwich
Aging Health | Year: 2010

Infectious diseases contribute significantly to the disease burden in elderly people. Septic arthritis is an important cause of musculoskeletal infection with high morbidity and mortality arising from irreversible joint destruction and overwhelming sepsis. Prompt diagnosis and appropriate management of suspected joint sepsis are vital to a good prognosis. In the elderly, the diagnosis of sepsis is made difficult by atypical clinical presentations. In addition, antimicrobial therapy is complicated by multiple factors that contribute to the increased incidence of adverse events secondary to antibiotic treatment. This article reviews the clinical presentation, risk factors, etiology and management of septic arthritis in the elderly. © 2010 Future Medicine Ltd. Source

Navarini A.A.,Kings College London | Simpson M.A.,Kings College London | Weale M.,Kings College London | Knight J.,Campbell Family Mental Health Research Institute | And 69 more authors.
Nature Communications | Year: 2014

Acne vulgaris (acne) is a common inflammatory disorder of the cutaneous pilo-sebaceous unit. Here we perform a genome-wide association analysis in the United Kingdom, comparing severe cases of acne (n=1,893) with controls (n=5,132). In a second stage, we genotype putative-associated loci in a further 2,063 acne cases and 1,970 controls. We identify three genome-wide significant associations: 11q13.1 (rs478304, Pcombined =3.23 × 10 -11, odds ratio (OR)=1.20), 5q11.2 (rs38055, Pcombined =4.58 × 10-9, OR=1.17) and 1q41 (rs1159268, P combined =4.08 × 10-8, OR=1.17). All three loci contain genes linked to the TGFβ cell signalling pathway, namely OVOL1, FST and TGFB2. Transcripts of OVOL1 and TFGB2 have decreased expression in affected compared with normal skin. Collectively, these data support a key role for dysregulation of TGFβ-mediated signalling in susceptibility to acne. © 2014 Macmillan Publishers Limited. All rights reserved. Source

Mathews C.J.,Queen Elizabeth Hospital Woolwich
Medicine (United Kingdom) | Year: 2014

The joint is a common site of musculoskeletal infection in adults. Septic arthritis is the most serious, although not the most frequent, cause of a hot swollen joint or joints. The diagnosis rests principally on clinical suspicion. Investigation of suspected joint sepsis is urgent in order to avoid significant morbidity and mortality. This review will cover the aetiology, pathogenesis, clinical features, investigation and management of native joint sepsis in adults, and will highlight the gaps in the evidence base regarding its pharmacological management and suggest some areas for future research. It will briefly cover osteomyelitis, which is much more common in young children than it is in adults. © 2014 Published by Elsevier Ltd. Source

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