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Thirumangalam, India

Raut S.,UK National Institute for Biological Standards and Control | Daniels S.,UK National Institute for Biological Standards and Control | Gartner P.,Quality Control | Hunfeld A.,Paul Ehrlich Institute | And 3 more authors.

Summary: Factor-Eight-Inhibitor-Bypassing-Activity (FEIBA) is a bypassing-agent used to control spontaneous bleeding or cover surgical interventions in Haemophiliacs who develop neutralizing antibodies against FVIII/FIX. The market lot-release of FEIBA is dependent on specific clot-based assays, carried out by both the manufacturer and regulatory authorities, relative to manufacturer's in-house standards, which are produced on a small-scale and are replaced frequently. We sought to standardize the FEIBA assay by developing a FEIBA primary standard which would be internationally available in sufficiently large quantities, with a predicted lifetime of many years. A collaborative study involving the manufacturer and three regulatory authorities, was carried out in which a candidate material, sample B (06/172), was calibrated by assays relative to the manufacturer's in-house FEIBA standards (C and D). All laboratories used their routine validated methods (16 APTT-assays, 8 ACTIN-FS-assays and 27 DAPTTIN-assays). Intra-laboratory geometric coefficients of variation (GCVs) for candidate B ranged from 3% to 29% (GCVs <9% from majority of labs). Assessment of inter-laboratory variability gave overall GCV values of 6.9% and 4.4% relative to standards C and D, respectively, for all methods. There was good agreement in potency estimation between laboratories using each of the three methods, with the overall potencies by the three methods differing by less than 10% of the overall mean, giving an overall combined potency of 28.0 units per ampoule. All participants agreed that candidate B (06/172) be established as the 1st NIBSC Working Standard for FEIBA with an assigned potency of 28.0 units per ampoule, based on combined results for both methods, relative to either standard C or D. © 2012 Blackwell Publishing Ltd. Source

Alagic-Dzambic L.,Bosnalijek d.d. Sarajevo | Omerovic S.,Quality Control | Dzambic M.,Bosnalijek d.d. Sarajevo
International Journal of Pharmacy and Technology

Rosuvastatin or 7- [4-(4-fluorophenyl)-6-(1-methylethyl) -2 - (methylsulfonyl-methyl-amino)-pyrimidin-5-yl] -3,5- dihydroxy-hept-6-enoic acid is the newest drug of the statin on the market. On the market is since 2003., in a form of the calcium salt. Also, rosuvastatin is marked as superstatinin reduction of cholesterol. Compared to the others hipolipemic drugs, statins shows others pleitropic effects. It means that they show analgesic, anti-inflammatory, antioxidant, antibacterial and antifungal activity. The presence of the pyrimidine ring in the molecule of rosuvastatin justifies above mentioned pharmacological actions. This paper presents a diffusion method, as a screening method for potential antimicrobial and antifungal effects of rosuvastatin. The test was perform against five different American Type Culture Collection (ATCC): Pseudomonas aeruginosa (ATCC 9027), Esherichia coli (ATCC 8739), Candida albicans (ATCC 10231), Staphylococcus aureus (ATCC 6538) and Staphylococcus epidermidis (ATCC 12228). © 2015, International Journal Of Pharmacy and Technology. All rights reserved. Source

Kamalakkannan S.,Bharathidasan University | Rajendran R.,Research and Development | Venkatesh R.V.,Quality Control | Clayton P.,Oxford Brookes University | Akbarsha M.A.,Bharathidasan University
Journal of Nutrition and Metabolism

There is evidence that the principles present in the widely consumed Indian food plant C. fimbriata extract (CFE) suppress appetite, and provide antiobesogenic and metabolic benefits. The Diet-Induced Obesity (DIO) rat model was used to investigate CFE's anorexigenic effects. Rats were randomly divided into three groups: (i) untreated control (C), (ii) control for cafeteria diet (CA), and (iii) cafeteria diet fed + CFE treated. Rats in the test group received cafeteria diet and CFE from day one onwards. CFE was administered by gavage at three doses (25, 50, 100 mg/Kg BW per day) for 90 days. The antiobesogenic effects of CFE were evaluated by monitoring changes in feed intake, body weight, serum lipid and hormonal (leptin) profiles, fat pads, and liver weight. Antiatherosclerotic effects were measured by histology. CFE induced significant and dose-dependent inhibition of food intake, with dose-related prevention of gains in body weight, liver weight, and fat pad mass. Alterations in serum lipid profiles associated with weight gain were similarly inhibited, as were the typical increases in serum leptin levels. These data substantiate CFE's reported anorexigenic effects. CFE treatment also conferred protection against atherogenesis. We conclude that CFE possesses antiobesogenic and antiatherosclerotic properties. © 2010 Soundararajan Kamalakkannan et al. Source

Bagyalakshmi M.,Quality Control | Andal L.,Velammal College of Engineering and Technology | Deepan Chakravarthi A.V.,Velammal College of Engineering and Technology
International Journal of Applied Engineering Research

Durable concrete pavement is one that achieves reasonably under the unprotected environmental condition during its service life span. Concrete requires to slight or zero conservation at normal environment. Copper slag is one of the materials which is considered as waste materials in the production of copper, which can be used as partial replacement of fine aggregates in concrete. This paper presents the results of an experimental study on various durability tests on concrete pavement containing copper slag as partial replacement of sand. In this report, M30 grade of concrete was designed and tests were conducted with different percentage of copper slag as fine aggregate in concrete. The objective of this study is to classify the possibilities of utilizing the copper slag in concrete to obtain an improved durability properties of concrete. The obtained test results were indicated that the replacement of natural sand by copper slag waste up to 50% will result in durable concrete. © Research India Publications. Source

News Article | November 17, 2015
Site: http://www.techtimes.com/rss/sections/environment.xml

Officials in Hawaii announced that the state will produce a comprehensive coral reef management plan amidst the second year of widespread bleaching in Hawaiian waters. The state's Department of Land and Natural Resources hopes to implement a management plan by 2016. Dr. Bruce Anderson from the DNLR explained that the rate of coral bleaching in parts of Hawaii has become unprecedented, and that the reefs are at much higher risk of dying. "We need to ensure our reefs are as healthy and resilient as possible to maximize the chances of recovery," said Anderson. The department's current action was prompted by an appeal from the State Office of Environmental Quality Control (OEQC) in October to temporarily stop the collection of herbivore fish for display in aquariums. The commercial use of these species does not contribute significantly to the health of coral reefs in the state. However, Suzanne Case, chair of the DNLR, explained that the taking of commercial aquarium fish does not occur, to any great extent, off most of the Hawaiian Islands. The fishery is mainly focused in West Hawaii, she said. According to Case, data suggests the herbivores, which consists of 92 percent of the catch, have increased over the years and are now more numerous there than any in other place in the Hawaiian archipelago. She also explained that no parrotfish are collected by aquarium collectors in West Hawaii. Aquatic Biologist Dr. William Walsh said that species of fish that help the reefs, such as the parrot fish, are the ones that are collected least for aquariums. He said protection of these species is vital, and the state's management plan should address the issue. He also believes that an aquarium fishing ban is not the right solution. Anderson said that coral reef resilience and recovery is very complex, so the management plan will have to address site-specific stressors. Case added that within the management plan, they hope to reiterate steps that every Hawaii resident and visitor can take to help our coral reefs. Meanwhile, in October this year, the National Oceanic and Atmospheric Administration reported a massive bleaching was occurring worldwide.

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