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Alim I.,Quality Assurance Laboratory | Rafi M.,ICFAI University, Tripura
Biosciences Biotechnology Research Asia | Year: 2010

All organs and body structures are involved in the maintenance of homeostasis. In addition to the excretion of wastes, the kidneys play an especially vital role in regulating the volume and composition of body fluids. The role of the kidneys in the regulation of fluid and electrolyte balance is very significant and regulates the body's metabolic functions. Looking to the importance and the most significance role of this organ the investigations were carried out to evaluate serum creatinine level in the selected individual used as an index or a measure of renal function. Present study reports the distribution and correlates of serum Creatinine in a group of community-dwelling elderly individuals, aged 65 years and older. Study reveals that difference in the serum creatinine, plasma electrolytes levels and other hematological parameters values in the target group with respect of the healthy individuals.

Hashmi L.,Maulana Azad National Institute of Technology | Malik M.M.,Maulana Azad National Institute of Technology | Qureshi M.S.,Maulana Azad National Institute of Technology | Dubey R.N.,Maulana Azad National Institute of Technology | And 2 more authors.
AIP Conference Proceedings | Year: 2010

Synthesis of Silver Sulfide nanoparticles of various morphologies were successfully done through colloidal synthesis technique at relatively low temperature using Chitosan bio polymer as stabilizer. The effect of change in stabilizer concentration, reagent concentrations and reaction temperature at constant pH on morphology and optical properties of synthesized products are also studied. It was found that reagent concentration and temperature both played important role in change in morphology of synthesized product. The crystal structure studies of synthesized products were carried out by powder X-ray diffraction technique which reveals the formation of Acanthite monoclinic Ag2S crystal structure and SAD was taken for only two samples whose analysis using XRD was difficult. The optical properties and quantum confinement effect of the products were confirmed by means of spectroscopic measurements. Morphologies obtained were characterized by SEM. Further the functionality and effectiveness of stabilization process were established by Fourier transform infrared spectroscopy. © 2010 American Institute of Physics.

Alim I.,Quality Assurance Laboratory | Alim I.,ICFAI University, Tripura | Arora H.,Unique Post Graduate Science College | Rafi M.,ICFAI University, Tripura
Oriental Journal of Chemistry | Year: 2010

Safed Musil grows wild in thick forests and is a traditional medicinal plant. Mainly its tuberous roots are used in Ayurvedic medicines. Safed Musli has been named in the Atharva Veda as one of the divine herbs, offering cure for many ailments and health related problems. Because of its significant medicinal properties, Chlorophytum borivillianum, a variety of Safed Musli has got today maximum demand and commercial value. There are around 256 varieties of Chlorophytum in the world; in India, we have around 17 of them, of which, borivillianum has got a good market demand all over the world especially in the Gulf countries and the West. It would not be an exaggeration to call Safed Musli a unique, potent and versatile medicine discovered by the genius of ancient India. It is a rich source of over 25 alkaloids, vitamins, proteins, carbohydrates, steroids, saponins, potassium, calcium, magnesium, phenol, resins, polysaccharides etc. Safed Musliis an important ingredient of more than a hundred Ayurvedic, Allopathic, Homeopathic and Unani medicinal preparations. It is one of the chief ingredients of Ayurvedic "Chyawanaprash". As a (protein rich) food supplement, there is a tremendously growing International demand for processed Safed Musli. Here we report Indirect value addition of the raw material and also the processed products by incorporating some measurements during the time of handling and processing of raw material and Phytoformulation of herbal drug for purity and the strength. The present study also indicates towards assessing the metal contaminants as per AYUSH and WHO recommendations which has become mandatory for export purpose.

Gupta Y.,Singhania University | Alim I.,Quality Assurance Laboratory | Ahmad D.,Singhania University
Oriental Journal of Chemistry | Year: 2010

In the present study we report, the various processing parameters and formulations aspects for developing a pharmaceutical equivalent, stable, cost improved and quality improved formulation of floating tablet of Simvastatin comparable with innovator and optimize certain process parameters to get maximum yield of the product during large scale manufacturing. Being a Class Il drug, Simvastatin shows slow dissolution rate, limited oral absorption and high variability in pharmacological effects. Present study has been done for improving the absorption and its bioavailability in order to establish controlled floating drug delivery systems of Simvastatin. Four formulations were prepared by using of HPMC K4M and Ethyl cellulose as polymers and fixed amount of gas generating agent sodium bi carbonate and hydrophobic material bees wax by melt granulation technique and it was noticed that the prepared tablets constantly found to be buoyant for more than 8 hours in the released medium. In vitro drug release, kinetic data and related stability studies after optimization of promising formulation of selected drug are being done to exhibit diffusion dominant drug release and its stability may be attributed to that the present problem certainly will be helpful and surely will open an avenue for new trend of control drug delivery system.

Spaak J.,University of Toronto | Spaak J.,Karolinska Institutet | Tomlinson G.,University of Toronto | McGowan C.L.,University of Toronto | And 5 more authors.
American Journal of Physiology - Heart and Circulatory Physiology | Year: 2010

In healthy subjects a standard drink of either red wine (RW) or ethanol (EtOH) has no effect on muscle sympathetic nerve activity or on heart rate (HR), whereas two drinks increase both. Using time- and frequency-domain indexes of HR variability (HRV), we now tested in 12 subjects (24-47 yr, 6 men) the hypotheses that 1) this HR increase reflects concurrent dose-related augmented sympathetic HR modulation and 2) RW with high-polyphenol content differs from EtOH in its acute HRV effects. RW, EtOH, and water were provided on 3 days, 2 wk apart according to a randomized, single-blind design. Eight-minute segments were analyzed. One alcoholic drink increased blood concentrations to 36 ± 2 mg/dl (mean ± SE), and 2 drinks to 72 ± 4 (RW) and 80 ± 2 mg/dl (EtOH). RW quadrupled plasma resveratrol (P < 0.001). HR fell after both water drinks. When compared with respective baselines, one alcoholic drink had no effect on HR or HRV, whereas two glasses of both increased HR (RW, +5.4 ± 1.2; and EtOH, +5.7 ± 1.2 min-1; P < 0.001), decreased total HRV by 28-33% (P < 0.05) and high-frequency spectral power by 32-42% (vagal HR modulation), and increased low-frequency power by 28-34% and the ratio of low frequency to high frequency by 98-119% (sympathetic HR modulation) (all, P ≤ 0.01). In summary, when compared with water, one standard drink lowered time- and frequency-domain markers of vagal HR modulation. When compared with respective baselines, two alcoholic drinks increased HR by diminished vagal and augmented sympathetic HR modulation. Thus alcohol exerts dose-dependent HRV responses, with RW and EtOH having a similar effect. Copyright © 2010 the American Physiological Society.

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