Quality

Ascot, New Zealand
Ascot, New Zealand
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Sacks L.,Royal Physiotherapy Clinic | Yee K.,LifeMark Physiotherapy | Huijbregts M.,Quality | Miller P.A.,McMaster University | And 2 more authors.
Journal of Rehabilitation Medicine | Year: 2010

Objective: To evaluate the construct validity of the Activity Inventory of the Chedoke-McMaster Stroke Assessment and the Clinical Outcome Variables Scale (COVS), 2 measures of functional mobility. Design: A retrospective longitudinal study of 24 inpatients (mean age 83 years (standard deviation 7)) on a geriatric rehabilitation unit.Participants: The primary reasons for admission were de- conditioning (n=9) and hip fracture (n=7). Method: We tested hypotheses that Activity Inventory and COVS scores at admission and discharge, and change scores during hospital stay would correlate. Longitudinal construct validity was also estimated using effect size and standardized response mean. Results: Correlations between scores on each measure ranged from r=0.59-0.93 across subscales and total scales (p<0.01). The effect size of the Activity Inventory and the COVS was 1.53 and 1.43, respectively. The standardized response mean of the Activity Inventory and the COVS was 1.83 and 2.30, respectively. Conclusion: Although findings support the validity of both measures, the COVS appears more efficient and sensitive than the Activity Inventory to change in this population. A larger study is needed to confirm these findings. Journal Compilation © 2010 Foundation of Rehabilitation Information.


Sauron C.,University of Montréal | Jouvet P.,Pediatric Intensive Care | Pinard G.,Quality | Goudreault D.,Specialized Biochemistry Laboratory | And 3 more authors.
Acta paediatrica (Oslo, Norway : 1992) | Year: 2015

AIM: The safety of SwabCap alcohol impregnated disinfection caps was questioned in our unit because of malfunctions in luer access valves. We examined whether SwabCaps affected the integrity of two luer access valves and were associated with alcohol injected into the lines.METHODS: Our bench test study included seven circuits using SmartSite or CARESITE valves exposed to two environmental temperatures. Passive circuits consisted of a 96-hour contact system using SwabCap without other interventions. Active circuits consisted of nine sham injections during a 24-hour period, with the SwabCap replaced after each injection. The active control circuit used isopropyl alcohol impregnated pads to disinfect valves. Isopropyl alcohol was measured at the extremity of all active circuits by gas chromatography.RESULTS: The visual appearance of all SmartSite valves and 67% of the CARESITE valves was changed by SwabCap use. The mean isopropyl alcohol dosages were 52 mmol/L in the SmartSite and 8 mmol/L in the CARESITE at room temperature and 73 and 7 mmol/L, respectively, at 35°C. No alcohol was found in the control circuit.CONCLUSION: The SwabCap altered the valves' appearance and allowed significant amounts of isopropyl alcohol to be injected. It should not be used for neonates without further research. ©2015 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.


PubMed | Pediatric Intensive Care, Specialized Biochemistry Laboratory, Quality, University of Montréal and CHU Sainte Justine
Type: Journal Article | Journal: Acta paediatrica (Oslo, Norway : 1992) | Year: 2015

The safety of SwabCap alcohol impregnated disinfection caps was questioned in our unit because of malfunctions in luer access valves. We examined whether SwabCaps affected the integrity of two luer access valves and were associated with alcohol injected into the lines.Our bench test study included seven circuits using SmartSite or CARESITE valves exposed to two environmental temperatures. Passive circuits consisted of a 96-hour contact system using SwabCap without other interventions. Active circuits consisted of nine sham injections during a 24-hour period, with the SwabCap replaced after each injection. The active control circuit used isopropyl alcohol impregnated pads to disinfect valves. Isopropyl alcohol was measured at the extremity of all active circuits by gas chromatography.The visual appearance of all SmartSite valves and 67% of the CARESITE valves was changed by SwabCap use. The mean isopropyl alcohol dosages were 52 mmol/L in the SmartSite and 8 mmol/L in the CARESITE at room temperature and 73 and 7 mmol/L, respectively, at 35C. No alcohol was found in the control circuit.The SwabCap altered the valves appearance and allowed significant amounts of isopropyl alcohol to be injected. It should not be used for neonates without further research.


Birdsall M.A.,Fertility Associates | Peek J.C.,Quality | Valiapan S.D.,Fertility Associates
New Zealand Medical Journal | Year: 2015

AIM: To investigate whether the decline in sperm concentration in New Zealand sperm donors observed from 1987 to 2007 continued in the period 2008–2014. METHOD: A retrospective study from 2008 to 2014. The first semen sample of 285 men presenting as sperm donors in Auckland and Wellington was analysed for sperm concentration, seminal fluid volume and the percentage of motile sperm. These results were compared to results from 1987 to 2007 from the same clinics. RESULTS: The decline in semen volume and sperm concentration observed between 1987 and 2007 did not continue in 2008–2014. Sperm concentration decreased from 1987 until some time between 1997 and 2001, and has remained stable at an average of 62x106/ml between 2001 and 2014. Sperm motility declined significantly (8%) in the period 2008–2014, but there was no significant change over the total period studied, between 1987 and 2014. CONCLUSION: After a decline between 1987 and sometime during 1997–2001, the sperm concentration in men presenting as donors remained unchanged between 2002 and 2014, suggesting semen quality has not changed in New Zealand men over the last decade. © NZMA.


Sethu R.S.,Quality | Ng H.S.,Quality | Chan A.,Quality | Ong C.N.,Quality | Chan S.F.,Quality
Microelectronics Reliability | Year: 2015

Semiconductor bond pads made from aluminum and small percentages of copper is susceptible to galvanic corrosion. In galvanic corrosion, the cathode (copper precipitate) is usually protected by the aluminum oxide that covers the surface of aluminum which acts as the anode. However, when the aluminum oxide thickness is reduced by plasma cleaning, the precipitates can be exposed. When exposed precipitates come in contact with de-ionized water, galvanic corrosion takes place. Therefore, though plasma cleaning in general is supposed to improve semiconductor bond pad surface in preparation for package level interconnection, adding the plasma clean step just before a process with de-ionized water can cause bond pad corrosion through the galvanic reaction between the exposed precipitate (cathode) and the surrounding aluminum (anode). This paper aims to investigate the mechanism of corrosion and characterize corroded bond pads by using wire bond ball shear method. © 2015 Elsevier Ltd. All rights reserved.


Ng H.S.,Quality
2011 IEEE Symposium on Industrial Electronics and Applications, ISIEA 2011 | Year: 2011

Wire Bond Shear (WBS) test is a method for evaluating the strength of a ball bond, to complement wire pull test. In foundry, wafer-level (WLR) WBS provides a quick way to demonstrate the integrity of metal bond pad, backend scheme as well as bond or via design. This is a big challenge for WLR WBS outsourcing as many of the factors affecting shear strength lying on the wire bonding parameters and shear test setup. This paper presents the outsourcing experiences of WBS tests and good shear strength was achieved from the outsource laboratory. © 2011 IEEE.


PubMed | Eli Lilly and Company, Merck And Co., Chemistry and Manufacturing Controls, MicroConstants and 2 more.
Type: Journal Article | Journal: The AAPS journal | Year: 2016

Non-clinical dose formulations (also known as pre-clinical or GLP formulations) play a key role in early drug development. These formulations are used to introduce active pharmaceutical ingredients (APIs) into test organisms for both pharmacokinetic and toxicological studies. Since these studies are ultimately used to support dose and safety ranges in human studies, it is important to understand not only the concentration and PK/PD of the active ingredient but also to generate safety data for likely process impurities and degradation products of the active ingredient. As such, many in the industry have chosen to develop and validate methods which can accurately detect and quantify the active ingredient along with impurities and degradation products. Such methods often provide trendable results which are predictive of stability, thus leading to the name; stability indicating methods. This document provides an overview of best practices for those choosing to include development and validation of such methods as part of their non-clinical drug development program. This document is intended to support teams who are either new to stability indicating method development and validation or who are less familiar with the requirements of validation due to their position within the product development life cycle.


News Article | February 15, 2017
Site: www.prweb.com

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