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Kawaguchi T.,QSai Co. | Nanbu P.N.,Institute of Whole Body Metabolism | Kurokawa M.,QSai Co.
Biological and Pharmaceutical Bulletin | Year: 2012

Prolylhydroxyproline (Pro-Hyp), which is derived from collagen hydrolysate, has been shown to be beneficial for skin and joint health. However, little is known about the distribution of Pro-Hyp in these tissues. In the present study, we investigated the biodistribution of orally administered [ 14C]Pro- Hyp in rats. Whole-body autoradiography at 30 min after administration of [ 14C]Pro-Hyp showed that radioactivity is widely distributed in tissues including skin and articular cartilage, with the highest level of radioactivity observed in the gastric and intestinal walls. Incorporation of radioactivity into cells known to respond to Pro-Hyp such as dermal fibroblasts, synovial cells, chondrocytes, osteoblasts, and osteoclasts was observed. The chemical form of [ 14C]Pro-Hyp-derived radioactivity detected in the tissues was investigated by thin layer chromatography. The radioactive constituents in cartilage extract were two proline-modified peptides (56%), intact Pro-Hyp (5%), and two nonpeptide metabolites (28%). Similar results were obtained for skin and bone marrow. Plasma analysis at 3 to 30 min post-dose suggested that the majority of Pro-Hyp is modified in its proline residue by a first-pass effect without peptide bond hydrolysis. In conclusion, we demonstrated that Pro-Hyp is partly distributed in observed tissues including skin and cartilage in its intact form, which might be responsible for its biological functions. © 2012 The Pharmaceutical Society of Japan.


Kato E.,Hokkaido University | Kushibiki N.,Hokkaido University | Inagaki Y.,Q'sai Co. | Kurokawa M.,Q'sai Co. | Kawabata J.,Hokkaido University
Bioscience, Biotechnology and Biochemistry | Year: 2017

Type 2 diabetes mellitus (T2DM) is a common global health problem. Prevention of this disease is an important task, and functional food supplements are considered an effective method. We found potent pancreatic α-amylase inhibition in Astilbe thunbergii root extract (AT) and confirmed that AT treatment in a T2DM rat model reduces post-starch administration blood glucose levels. Activity-guided isolation revealed procyanidin (AT-P) as the α-amylase inhibitory component with IC50 = 1.7 μg/mL against porcine pancreatic α-amylase. Structure analysis of AT-P revealed it is a B-type procyanidin comprised of four types of flavan-3-ols, some with a galloyl group, and catechin attached as the terminal unit. The abundant AT-P content and its comparable α-amylase inhibition to acarbose, the anti-diabetic medicine, suggest that AT is a promising food supplement for diabetes prevention. © 2017 Japan Society for Bioscience, Biotechnology, and Agrochemistry.


Kato E.,Hokkaido University | Uenishi Y.,Hokkaido University | Inagaki Y.,Qsai Co. | Kurokawa M.,Qsai Co. | Kawabata J.,Hokkaido University
Bioscience, Biotechnology and Biochemistry | Year: 2016

Dipeptidyl peptidase-IV (DPP-IV) is a protease responsible for the degradation of the incretin hormone. A number of DPP-IV inhibitors have been approved for use in the treatment of type 2 diabetes. While these inhibitors are effective for this treatment, methods for the prevention of this disease are also required as diabetes patient numbers are currently increasing rapidly worldwide. We screened the DPP-IV inhibitory activities of edible plant extracts with the intention of using these extracts in a functional food supplement for the prevention of diabetes. Rose (Rosa gallica) bud extract powder was a promising material with high inhibitory activity. In this study, seven ellagitannins were isolated as active compounds through activity-guided fractionations, and their DPP-IV inhibitory activities were measured. Among them, rugosin A and B showed the highest inhibitory activities and rugosin B was shown as the major contributing compound in rose bud extract powder. © 2016 Japan Society for Bioscience, Biotechnology, and Agrochemistry.


Patent
Qsai Co. | Date: 2014-12-16

[Theme] An object is to provide a collagen-containing composition for oral ingestion wherein the resulting peptide-type Hyp is effectively transferred into the blood. [Means for solving the problem] A water-insoluble complex comprising a water-soluble collagen peptide complexed with theaflavins and/or epicatechin.


Trademark
Qsai Co. | Date: 2016-03-11

Glucosamine; dietary supplements containing glucosamine.


Trademark
Qsai Co. | Date: 2015-07-10

Dietary and nutritional supplements; Dietary food supplements; Dietary supplements; Food supplements; Health food supplements; Nutritional supplements; Powdered nutritional supplement concentrate.


Trademark
QSAI Co. | Date: 2016-06-08

Dietary supplements for humans.


Trademark
Qsai Co. | Date: 2014-08-11

Almond soaps; antibacterial skin soaps; antibacterial soap; anti-bacterial soap; aromatic body care products, namely, body lotion, shower gel, cuticle cream, shampoo, conditioner, non-medicated lip balm, soap, body polish, body and foot scrub and non-medicated foot cream; baby hand soap; bar soap; bath soaps; bath soaps in liquid, solid or gel form; beauty soap; body cream soap; cakes of toilet soap; cosmetic soaps; cream soaps; disinfectant soap; disinfecting perfumed soaps; granulated soaps; hand soaps; handmade soap bars; laundry soap; liquid bath soaps; liquid soap; liquid soap used in foot bath; liquid soaps; liquid soaps for hands, face and body; liquid soaps for hands and face; loofah soaps; medicated soap; medicated soaps; perfumed soap; perfumed soaps; skin soap; soap powder; soaps for hands and face; soaps for babies; soaps for body care; soaps for household use; soaps for personal use; soaps for toilet purposes; soaps made from goats milk; soaps made from aloe; toilet soap; toilet soaps; body and beauty care cosmetics; coloring preparations for cosmetic purposes; cosmetic creams; cosmetic creams for skin care; cosmetic hair dressing preparations; cosmetic hair regrowth inhibiting preparations; cosmetic hand creams; cosmetic masks; cosmetic massage creams; cosmetic milks; cosmetic nourishing creams; cosmetic oils; cosmetic oils for the epidermis; cosmetic preparations for skin renewal; cosmetic preparations against sunburn; cosmetic preparations for body care; cosmetic preparations for eye lashes; cosmetic preparations; cosmetic preparations for the hair and scalp; cosmetic preparations for protecting the skin from the suns rays; cosmetic preparations for skin care; cosmetic products in the form of aerosols for skincare; cosmetic products taken orally, namely, pills that induce bronzing of the skin; cosmetic skin fresheners; cosmetic sunscreen preparations; cosmetic sun-protecting preparations; cosmetics; cosmetics and cosmetic preparations; cosmetics and make-up; cosmetics in general, including perfumes; cosmetics in the form of milks, lotions and emulsions; cosmetics, namely, make up for compacts; cosmetics, namely, lip primer; cosmetics, namely, lip repairers; face creams and cleansers containing benzoyl peroxide for cosmetic purposes; face creams for cosmetic use; foams containing cosmetics and sunscreens; gels for cosmetic purposes; glitter for cosmetic purposes; impregnated cleaning pads impregnated with cosmetics; lip stains being cosmetics; lotions for cosmetic purposes; mask pack for cosmetic purposes; milk for cosmetic purposes; non-foaming cosmetic preparations for skin; non-foaming cosmetic preparations face; non-foaming cosmetic preparations for body; non-medicated cosmetic skin care preparations consisting of organic coconut virgin oil and coconut virgin oil; non- medicated hair treatment preparations for cosmetic purposes; nutritional oils for cosmetic purposes; oils for cosmetic purposes; cosmetic tissues pre-moistened with cosmetic lotions; cosmetic towelettes pre-moistened with cosmetic lotions; cosmetic wipes pre-moistened with cosmetic lotions; shea butter for cosmetic purposes; skin and body topical lotions, creams and oils for cosmetic use; skin conditioning creams for cosmetic purposes; skin fresheners being cosmetics; tissues impregnated with cosmetic lotions; wrinkle-minimizing cosmetic preparations for topical facial use; cleaning preparations for cleansing drains; cleansing preparations; cleansing creams being cosmetics; cleansing milk; cleansing milk for cosmetic purposes; cleansing milk for toilet purposes. disposable wipes impregnated with cleansing preparations for either personal hygiene or household use; facial cleansing grains; facial cleansing milk; pre-moistened towelettes impregnated with cleaning preparations for woman; skin cleansing cream; baby shampoo; hair care kits comprising non-medicated hair care preparations; hair rinses being shampoo-conditioners; hair shampoo; hair shampoos and conditioners; shampoos; shampoo-conditioners; hair rinses. Frozen, frosted, preserved, processed, dried, cooked or crystallized fruit and vegetables extracts for use in prepared meals or food; processed fruit- and nut-based food bars; frozen entrees consisting primarily of vegetables; prepared entrees consisting primarily of vegetables; packaged entrees consisting primarily of vegetables; frozen meals consisting primarily of vegetables; prepared meals consisting primarily of vegetables; packaged meals consisting primarily of vegetables; frozen vegetable-based entrees; prepared vegetable-based entrees; packaged vegetable-based entrees; frozen vegetables; preserved, frozen, dried or cooked vegetables; pre-sliced carrots; toddler- meals, namely, packaged entrees consisting primarily of vegetables toddler meals, namely, frozen entrees consisting primarily of vegetables; toddler meals, namely, prepared entrees consisting primarily of vegetables; vegetables, instant frozen; canned vegetables; processed vegetables and fruits. Non-alcoholic fruit extracts used in the preparation of beverages; non-alcoholic fruit juice beverages; non-carbonated, non-alcoholic frozen flavored beverages; syrups for making non-alcoholic beverages; beauty beverages, namely, fruit juices and soft drinks for energy supply; concentrated fruit juice; concentrates for making fruit juices; fruit drinks and fruit juices; fruit drinks and juices; fruit juice; fruit juice concentrates; fruit juices; fruit juices and fruit drinks; apple juice; grape juice; non-alcoholic beverages containing fruit juices; syrups for making whey-based beverages; whey beverages; prepared entrees consisting of fruit drinks and fruit juices, fruit-based beverages, non-alcoholic beverages containing fruit juices, non-alcoholic fruit extracts used in the preparation of beverages, non-alcoholic fruit juice beverages, vegetable juices, vegetable-fruit juices and smoothies being fruit beverages with fruit predominating; vegetable juice beverage; vegetable juices being beverages; vegetable-fruit juices.


Trademark
QSAI Co. | Date: 2014-09-18

Processed kale. Preparations for making beverages, namely, kale drinks.


PubMed | Qsai Co., Tokyo University of Science and Medical Corporation Kenshokai
Type: Journal Article | Journal: Biomedical reports | Year: 2016

Kale (

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