Qiqihar Medical University

www.qqhrmu.cn
Heping, China

Qiqihar Medical University is an institution for higher education, founded in 1946 and located in Qiqihar city of Heilongjiang province in northeast China. Wikipedia.

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Liu L.,Qiqihar Medical University
Journal of Chemical and Pharmaceutical Research | Year: 2014

Descriptive analysis, correlation analysis and regression analysis for randomly selected items are carried out by means of Matlab software. In order to get further analysis of quantitative data of integrated course teaching in English, in terms of it, English teaching process is cognized and improved. Finally, for the main result in this paper, the constructive suggestions for teaching are put forwards. The integrated teaching is closely associated with the implementation of the new curriculum goal of "knowledge and skill, process and method, emotion attitude and values", what’s more, students are taught in terms of arousing students' autonomous learning enthusiasm, and students' learning process perspective, and they are guided torethink, evaluate the feedback learning process timely. The integrated teaching breaks the traditional model, establishes multi-directional communication mode, forms a three-dimensional network of information exchange, reflects the thought of students being the principal part of learning, and highlights the students' self-learning which promotes students’ learning first, and then learning well to help them know how to learn and how to explore. For this, teacher-centered idea is transformed into student-centered one. In the process of teaching students’ thinking process is fully demonstrated, which can mobilize completely students’ the enthusiasm and initiative for the course so as to create the conditions for students to learn, improve the quality of learning and student disciplinary literacy. Thus, either their personality or their all-round quality can gain development, so that students learn easily, teachers teach well, both of whom can benefit from teaching. Integration teaching reduces the implicit waste teaching class, greatly improving the teaching efficiency and class realization rate. © 2014, Journal of Chemical and Pharmaceutical Research. All rights reserved.


Yu C.-L.,Qiqihar Medical University | Zhao X.-M.,Qiqihar Medical University | Niu Y.-C.,Qiqihar Medical University
Molecular Neurobiology | Year: 2016

Prenatal lead exposure is associated with poor intellectual development in children. However, there are few breakthroughs in therapeutic intervention of developmental lead neurotoxicity. The aim of this study is to evaluate the hypothesis that ferulic acid-mediated promotion of neurite outgrowth following lead exposure might mainly result from its antioxidant capability by extracellular signal-regulated kinases 1 and 2 (ERK1/2) activation of nuclear factor erythroid 2-related factor 2 (Nrf2). Exposure of PC12 cells to lead acetate inhibits neurite outgrowth and causes oxidative stress as measured by ROS, LPO, GSH/GSSG, and NAD+/NADH. FA treatment significantly, although not completely, protected the cells against lead acetate-induced neurite outgrowth inhibition. The effects of FA could be blocked by PD98059, zinc protoporphyrin (Zn-PP), and Nrf2 shRNA. In addition, FA induced heme oxygenase 1 (HO-1) gene expression, enhanced antioxidant response element (ARE) promoter activity, promoted ERK1/2 phosphorylation, and Nrf2 translocation in PC12 cells exposed to lead acetate. ERK1/2 locate upstream of Nrf2 and regulate Nrf2-dependent HO-1 expression in antioxidative effects of FA. Our results suggest that FA is a promising candidate for treatment of developmental lead neurotoxicity. These promising findings warrant future investigation evaluating the FA-mediated potentiation of neurite outgrowth following lead exposure in vivo. © 2015, Springer Science+Business Media New York.


Sun Y.,Qiqihar Medical University | Liu J.,Qiqihar Medical University | Kennedy J.F.,University of Birmingham
Carbohydrate Polymers | Year: 2010

Response surface methodology (RSM) was used to optimize the extraction conditions of polysaccharides from the roots of Codonopsis pilosula. A central composite design (CCD) was used for experimental design and analysis of the results to obtain the optimal processing parameters. Four independent variables such as extraction temperature (°C), ratio of water to raw material, extraction time (h), and number of extraction (n) were investigated. The experimental data obtained were fitted to a second-order polynomial equation using multiple regression analysis and also analyzed by appropriate statistical methods. The 3-D response surface and the contour plots derived from the mathematical models were applied to determine the optimal conditions. The optimum extraction conditions were as follows: extraction temperature 94 °C, ratio of water to raw material 9, extraction time 2.5 h, and number of extraction 5. Under these conditions, the experimental percentage value was 15.2 ± 0.28, which is well in close agreement with value predicted by the model. © 2010 Elsevier Ltd. All rights reserved.


Liu J.,Qiqihar Medical University | Sun Y.,Qiqihar Medical University
Carbohydrate Polymers | Year: 2011

An alkali-extractable and water-soluble polysaccharide (ABP-AW1) was isolated by 5% sodium hydroxide solution from the fruiting bodies of Agaricus blazei. ABP-AW1 (Mw = 50 kDa), was composed of Gal, Glc, Fuc, Ara and Man with the molar ratio of 29: 20: 6: 2: 2. According to the combination of chemical and instrumental analysis, the results indicated that ABP-AW1 had a backbone consisting of (1 → 6)-linked-β-d-galactopyranosyl, (1 → 6)-linked-β-d-glucopyranosyl and (1 → 3, 6)-linked-β-d- glucopyranosyl, which was terminated with (1→)-linked Fuc, Ara and Man residues at the O-3 position of (1 → 3, 6)-linked-β-d-glucopyranosyl in the proportion of 29: 10: 10: 6: 2:2. © 2011 Elsevier Ltd All rights reserved.


Xu L.,Qiqihar Medical University
Journal of Convergence Information Technology | Year: 2012

How to effectively extend WSN (Wireless sensor networks) survival time with the energy of the sensor node is focused in research on the WSN routing protocol all the time. This paper proposes a new routing algorithm called as COLEH (Clustering Optimized Low Energy Hierarchy) based on the clustering protocol, optimizes the cluster division based on the uneven clustering idea and selects the cluster head according to the residual energy of the node. The simulation results indicate that this routing algorithm can effectively balance the energy consumption of the nodes and extend the life of the whole network.


Panax ginseng C.A. Meyer, with thousands of years of history, has been known as a valuable traditional Chinese medicine. The plant has been valued for its important biological and chemical perspectives and its use in the treatment of a variety of pathological conditions and illnesses have been documented in ethnobotanical reports. Modern pharmacological experiments have proved that ginsenosides is the most active ingredients. Most recent interest has been focused on the ginsenosides to explore the pharmacological mechanisms of P. ginseng. Whereas it is difficult to make significant progress to elucidate the underlying mechanism by which P. ginseng take effect only by ginsenoside. As we know, ginseng contains multiple constituents, such as ginsenosides, essential oil, polysaccharides and peptides, and especially more and more attentions have been cast on ginseng polysaccharides by medical scientists and nutritionists due to their various important biological activities. Therefore the aim of present review is to give a comprehensive summary of information regarding the chemical constituents and biological effects of polysaccharides form the leaves, roots and fruits of P. ginseng to help us to take action for future study in this discipline. © 2011 Elsevier Ltd. All rights reserved.


Zhao S.,Qiqihar Medical University
Proceedings - 2016 8th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2016 | Year: 2016

By the methods of questionnaire and interview, the study investigates 395 non-English major college students self-efficiency, achievement goal orientation and self-regulated learning strategies, through correlation analysis and multiple regression analysis, analyzes the effects of individual factors on college English learners autonomous learning ability. The results show that individual factors, such as self-efficiency, achievement goal orientation, and self-regulated learning strategies influence each other, and they have reciprocal effects on students' autonomous learning ability. © 2016 IEEE.


Li G.,Qiqihar Medical University
Proceedings - 2016 8th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2016 | Year: 2016

Standard fuzzy c-means algorithm only considers gray information and noise tolerance ability is poor. In order to overcome the drawbacks of traditional fuzzy c-means algorithm, a kind of improved ant colony algorithm is used to optimize fuzzy c-means. Then a new kind of image segmentation algorithm is put forward based on improved fuzzy c-means method. The experiment results show that the proposed algorithm has better noise tolerance ability than traditional fuzzy c-means method. © 2016 IEEE.


Sun Y.-X.,Qiqihar Medical University | Kennedy J.F.,Institute of Advanced Science and Technology
Carbohydrate Polymers | Year: 2010

Four water-soluble purified polysaccharides (CRPsA-1, CRPsA-2, CRPsB-1 and CRPsB-2) were obtained from the fruiting bodies of Chroogomphis rutilus by DEAE Sepharose Fast Flow column chromatography and Sepharose 6 Fast Flow column chromatography. Their chemical and physical characteristics were determined by chemical methods, gas chromatography (GC) and high-performance size-exclusion chromatography (HPSEC). On the basis of hydroxyl radical assay, superoxide radical assay and Fe2+-chelating ability assay, the antioxidant activities of CRPsA-1, CRPsA-2, CRPsB-1 and CRPsB-2 were investigated. Among these fractions, CRPsB-1 and CRPsB-2 containing glucuronic acid had the higher scavenging effects on hydroxyl radicals and superoxide radicals, and more potent Fe2+-chelating activity than CRPsA-1and CRPsA-2 containing no glucuronic acid in a concentration-dependent manner. © 2010 Elsevier Ltd. All rights reserved.


Liu L.,Qiqihar Medical University
Proceedings - 2016 8th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2016 | Year: 2016

Combining with the characteristics and actual demand of medical English, network-based medical English autonomous learning platform is put forward. This platform adopts Browser/Server architecture and it is developed based on ASP.NET technology and SQL Server 2005 database. Overall architecture, function and database are designed in detail. The platform provides learning tool and learning resources for students. Teachers can also use the platform to enrich learning resources. After testing, it is concluded that this medical English teaching platform has good performance. © 2016 IEEE.

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