Heilongjiang, China
Heilongjiang, China

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Zhuang Z.,Qiqihar First Hospital | Liu J.,Qiqihar First Hospital | Li F.,Peking University | Peng X.,Qiqihar First Hospital | Zhao X.,Biomedical Imaging Center
Chinese Journal of Medical Imaging Technology | Year: 2016

Objective: To evaluate the characteristics of high resolution MRI (HRMRI) in atherosclerotic plaques of low-grade and non-stenosis carotid arteries. Methods: A total of 103 patients with recent cerebrovascular symptoms and carotid plaques were underwent carotid HRMRI. Arteries with poor image quality or severe luminal stenosis (≥50%) were excluded. MR images were reviewed for qualitative and quantitative evaluation of plaque characteristics. The plaque burden and the compositional features between carotid arteries with low-grade stenosis (1%-49%) and without stenosis were compared. Results Totally 86 patients (155 carotid arteries) were recruited in this study. Of all patients, 155 carotid arteries including 24 with low-grade stenosis and 131 without stenosis were qualified for analysis. Statistically significant differences were found in lumen area ([53.40±15.29]mm2 vs [41.30±11.57]mm2, P<0.001) and maximum wall thickness ([2.16±0.90]mm vs [3.30±1.25]mm, P=0.014) between carotid arteries with low-grade stenosis and without stenosis. But no significant differences was found in wall area ([31.69±6.80]mm2 vs [32.80±9.33]mm2, P=0.581). The prevalence of middle and high risk plaques were 10.69%(14/131) and 6.11%(8/131) in carotid arteries without stenosis, 20.83% (5/24) and 20.83% (5/24) in carotid arteries with low-grade stenosis. The maximum wall thickness of carotid artery correlated positively with the degree of stenosis (r=0.430, P<0.001). Conclusion: Carotid arteries with low-grade stenosis and without stenosis are still at the risk to develop vulnerable plaque. Copyright © 2016 by the Press of Chinese Journal of Medical Imaging and Technology.


PubMed | Harbin Medical University, Shanghai JiaoTong University, Qiqihar First Hospital and Daqing First Hospital
Type: Journal Article | Journal: Genetics and molecular research : GMR | Year: 2014

Keshan disease (KSD), a potentially fatal cardiomyopathy, has very high incidence in some selenium-poor regions of China. KSD may be accompanied with a variety of arrhythmia, which is associated with mutations in the gene coding for cardiac voltage-gated sodium channel (SCN5A). The molecular mechanism of KSD is still largely obscure. We aimed to determine the association between the H558R polymorphism of SCN5A and KSD. We recruited 71 patients with KSD and 80 geographical region-matched control subjects in our study. Vital sign and electrocardiographic (ECG) measurements were performed for heart rate, systolic pressure, diastolic pressure, PR interval, QT interval, QRS duration, ST-T changes and complete right bundle branch block (CRBBB), and H558R polymorphism was genotyped using the polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) method and sequencing. A significant association was found between the H558R polymorphism of exon 12 and KSD. Allele C carriers had a decreased risk for KSD with an odds ratio of 0.332 [95% confidence interval (CI), 0.160-0.692] as well as for QRS prolongation in KSD patients with an odds ratio of 0.089 (95%CI, 0.022-0.361). Our results provide support to the association between H558R polymorphism and the decreased risk for KSD. H558R polymorphism might increase susceptibility to KSD, and SCN5A containing the polymorphism might be a predisposing gene for QRS prolongation.


Wu Y.,Shanghai Pudong New District Zhoupu Hospital | Hong X.,Harbin Medical University | Wang A.,Harbin Chest Hospital | Wei D.,Shanxi Medical University | And 3 more authors.
Heart Lung and Circulation | Year: 2016

Background: The aim is to compare effects of three different protocols of limb remote ischaemic preconditioning (LRIP) on ischaemia reperfusion injury in an acute left anterior descending artery (LAD) occlusion model rat. Methods: Forty adult male Wistar rats were randomly assigned into four groups: group A, control; group B, LRIP in bilateral upper-limb (BUL) IP; group C, LRIP in bilateral lower-limb (BLL) IP; group D, LRIP in bilateral upper and lower limbs (ULL) IP. The 60. min ligation and 180. min reperfusion in LAD were applied to all rats. Limb remote ischaemic preconditioning was performed using 5. min occlusion and 15. min reperfusion (six cycles). Heart rate, blood pressure and electrogastrography (EGG) were recorded. Creatine kinase isoenzyme (CK-MB) level and infarct size were measured. Results: Limb remote ischaemic preconditioning did not significantly affect heart rate, systolic blood pressure and arrhythmia score. However, LRIP significantly increased DBP value and decreased CK-MB levels and infarct size in group B, C, and D. Moreover, LRIP in ULL had a significantly better effect on reducing infarct size than LRIP in BUL and BLL. Conclusions: Limb remote ischaemic preconditioning at limbs could significantly reduce reperfusion injury in the heart. Moreover, LRIP in ULL indicated a better effect in reducing infarct size than LRIP in BUL and BLL. © 2016 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ).


PubMed | Shanghai Pudong New District Zhoupu Hospital, Harbin Chest Hospital, Harbin Medical University, Shanxi Medical University and 2 more.
Type: Journal Article | Journal: Heart, lung & circulation | Year: 2016

The aim is to compare effects of three different protocols of limb remote ischaemic preconditioning (LRIP) on ischaemia reperfusion injury in an acute left anterior descending artery (LAD) occlusion model rat.Forty adult male Wistar rats were randomly assigned into four groups: group A, control; group B, LRIP in bilateral upper-limb (BUL) IP; group C, LRIP in bilateral lower-limb (BLL) IP; group D, LRIP in bilateral upper and lower limbs (ULL) IP. The 60min ligation and 180min reperfusion in LAD were applied to all rats. Limb remote ischaemic preconditioning was performed using 5min occlusion and 15min reperfusion (six cycles). Heart rate, blood pressure and electrogastrography (EGG) were recorded. Creatine kinase isoenzyme (CK-MB) level and infarct size were measured.Limb remote ischaemic preconditioning did not significantly affect heart rate, systolic blood pressure and arrhythmia score. However, LRIP significantly increased DBP value and decreased CK-MB levels and infarct size in group B, C, and D. Moreover, LRIP in ULL had a significantly better effect on reducing infarct size than LRIP in BUL and BLL.Limb remote ischaemic preconditioning at limbs could significantly reduce reperfusion injury in the heart. Moreover, LRIP in ULL indicated a better effect in reducing infarct size than LRIP in BUL and BLL.


Zhang Z.-Y.,Harbin Medical University | Gao M.,Qiqihar First Hospital | Feng L.,Qiqihar First Hospital | Cao Y.-T.,Qiqihar Medical University | And 3 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2014

BACKGROUND: Edaravone as an antioxidant protective effect on nerve cells injured by hydrogen peroxide has been confirmed, but its protective effect on oxidative damage to bone marrow stromal cells has not been reported in-depth. OBJECTIVE: To investigate the regulatory effects of edaravone on oxidative injury to bone marrow stromal cells. METHODS: Bone marrow samples were extracted from the long bone of New Zealand rabbits by the method of washing the pulp cavity, then subjected to the density gradient centrifugation and adherent screening to obtain bone marrow stromal stem cells in vitro. The bone marrow stromal cells at 3 passage were divided into five groups: blank group, treated with low-glucose Dulbecco’s modified Eagle’s medium containing 10% fetal bovine serum and 1% double antibody; dexamethasone group, treated with cell culture medium containing 1×10- 7 mol/L dexamethasone; 50, 100, 300 mg/L edaravone groups, cultured in cell culture medium containing 1×10-7 mol/L dexamethasone and 50, 100, 300 mg/L edaravone, respectively. After culture, MTT method and flow cytometry were used to detect the proliferative level and cell cycle of cells. RESULTS AND CONCLUSION: Compared with the control and dexamethasone groups, edaravone significantly enhanced the cell proliferation. Edaravone played a protective role in bone marrow stromal cells. When the concentration was 50 mg/L, edaravone began to play a regulatory role (P < 0. 05), and this effect was certainly associated with the concentration of edaravone. When the concentration was up to 100 mg/L, edaravone showed a better protective role (P < 0. 01). However, with increasing concentration, this protective effect was not further increased, but decreased slightly. Results indicated that high-concentration dexamethasone can induce oxidative injury to bone marrow stromal cells, and edaravone can protect the cells against this oxidative damage by antioxidant role. © 2014, Chinese Journal of Tissue Engineering Research. All Rights Reserved.


Zhu Y.-P.,Qiqihar First Hospital | Zhao R.,Qiqihar First Hospital | Jiang D.-N.,Qiqihar First Hospital
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2010

BACKGROUND: To select a suitable hardener via evaluating the hardener performance in endoscopic esophageal varices treatment. METHODS: Papers published from January 1993 to October 2009 were searched with key words of "endoscopy, esophageal varix and hardener" both in English and Chinese. Documents with regard to hardeners in esophageal varices treatment were included; repetition studies or Metal analysis were excluded. Totally 17 documents were selected to discuss the performance of hardener in esophageal varices treatment. RESULTS: Plenty of hardeners could be selected with each advantage. The 1% aethoxysklerol exhibited good therapeutic effect with little adverse reaction, but cost much; the drawback of high ulcer rate of dehydrated alcohol restricted its application despite low cost; 5% sodium morrhuate showed its superiority in cost, hemostasis, as well as low adverse reaction. CONCLUSION: Hardeners have shown obvious hemostasis effect with complications in esophageal varices treatment. Thus, how to handle complications and enhancing hemostasis by combing hardeners with interventional therapy becomes a research focus.


Xin Z.,Qiqihar First Hospital
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2010

OBJECTIVE: To summarize the classification, features of artificial tracheal materials and application of tracheal stent in treating tracheal or bronchial stenosis, as well as the disposals for related complications. METHODS: The databases of PubMed (http://www.ncbi.nim.nih.gov/PubMed) and CNKI (www.cnki.net/index.htm) were searched by the first author using search words of "artificial trachea, tracheal stent" both in English and Chinese. Articles about classification, materials selection, as well as the application outcomes were involved, in the same field, papers published in authoritative articles during the last three years were selected preferentially, totally 10 documents were included in this study. RESULTS: The high molecular polymer trachea possessed biotype composite structures, which combined the merits of previous artificial trachea and exhibited advantages in preventing prosthesis slippage, displacement, air leakage, as well as bare or collapse. The net structure of nick-eltitanium alloy stent allowed the axial and coronary movement of metal wire which is suitable for irregular or scraggy surfaces, thus, it was widely used in treating benign or malignant tracheobronchial stenosis. CONCLUSION: With the development of tissue engineering, some progressive achievements, such as application of seed cells and tracheal epithelial cells in constructing tissue engineered trachea, have been obtained. However, whether these tissue engineered trachea can maintain its activity and plays normal physiologic function in vivo still needs to be explored.


Wang L.-Y.,Qiqihar University | Ding L.-M.,Qiqihar First Hospital | Huo S.-C.,Qiqihar University | Sun L.,Qiqihar University | Sun Z.,Qiqihar University
Journal of Natural Medicines | Year: 2013

Three new taxoids (1-3), along with three known taxoids (4-6), were isolated from a EtOAc extract of Taxus cuspidata seed. The structures of 1-3 were determined by analyses of spectroscopic data. © 2012 The Japanese Society of Pharmacognosy and Springer Japan.


Wang L.,Qiqihar University | Wang L.,Northeast Petroleum University | Qin H.,Qiqihar University | Ding L.,Qiqihar First Hospital | And 5 more authors.
Journal of Surfactants and Detergents | Year: 2014

A class of novel cationic Gemini imidazolium surfactants containing amide groups as the spacer were synthesized from ethylenediamine and 1-bromoalkane(C8, C10, C12, C14, C16) by N-alkylation to get N,N'-dialkyl ethylenediamine (1a-e), 1a-e was further reacted with chloroacetyl chloride by N-acylation to get N,N'-(ethane-1,2-diyl)bis(2-chloro-N-alkylacetamide) (2a-e), which was further reacted respectively with 1-methyl imidazole by quaternized to form the surfactant molecule, N,N'-((ethane-1,2-diyl)bis(alkyl-azanediyl)bis(2-oxoethane-2,1-diyl)) bis(1-methyl-1H-imidazol-3-ium) dichloride. The structures of intermediates (1a-e) and (2a-e) were characterized by IR and 1H NMR. The structures of the surfactants (3a-e) were characterized by IR, 1H-NMR and 13C-NMR and element analysis. The critical micelle concentrations (CMC) of 3a-e were determined by the conductivity method at 25 °C. The CMC values decreased with increasing the length of the hydrophobic chain. The surfactants (3a-e) showed good foaming stability, emulsion ability and wetting ability. The surfactants (3a-e) also have good antimicrobial activity against Staphylococcus aureus, Escherichia coli and Bacillus subtilis. © 2014 AOCS.


Wang Y.,Qiqihar First Hospital | Song Y.,Qiqihar First Hospital | Meng L.,Qiqihar First Hospital | Chen Z.,Qiqihar First Hospital | And 5 more authors.
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] | Year: 2016

OBJECTIVE: To analyze the correlation between skeletal muscle mass and age among check-up adults.METHODS: The study objects were those who aged 18-87 years old and came to a city hospital of Qiqihar for health examination from December, 2013 to September, 2014, excepted those with coronary heart disease, infectious disease, endocrine system disease, hypertension, anemia, cancer, liver disease, kidney disease and those carrying with heart pacemaker. A total of 1 836 respondents were finally enrolled into analysis. Appendicular Skeletal Muscle (ASM) was measured by a Body Composition Analyzer, and relative skeletal muscle index (RSMI) was calculated. The relationship among ASM, RSMI and age was assessed by linear regression analysis. The difference of height, weight, BMI, waist-hip-ratio (WHR), total muscle mass and percentage of body fat between genders were tested by t-test. The difference of ASM and total skeletal muscle mass between genders and among age groups was tested by multi-factor variance analysis. The difference of the muscle decline between genders was compared by Chi-square test.RESULTS: The total muscle mass in males was (52.22 ± 6.65) kg, which was significantly higher than that in females ((38.05 ± 4.39) kg) (t=28.20, P<0.001). ASM in 18-29, 30-39, 40-49, 50-59, 60-69, 70-87 years was (24.64 ± 3.23), (24.00 ± 3.12), (24.35 ± 3.03), (23.33 ± 2.97), (22.54 ± 2.91) and (21.40 ± 3.36) kg (F=16.12, P<0.001) in males, respectively, and (16.48 ± 3.14), (16.72 ± 1.93), (16.75 ± 1.93), (16.84 ± 2.28), (16.52 ± 2.35) and(14.70 ± 2.37)kg (F=4.38, P=0.001) in females, respectively. ASM in males ((23.72 ± 3.16) kg) was higher than that in females ((16.65 ± 2.25) kg) (t=55.97, P<0.001). There was a negative correlation between age and ASM in males after 50 years old, the regression equation was y=28.31-0.09x (P<0.001). While a negative correlation between age and ASM in females occurred after 60 years old, the regression equation was y=27.69-0.18x (P<0.001). The prevalence of low ASM was 16.85% (124/736) in females, which was significantly higher than that in males (8.73%, 96/1 100) (χ(2)=27.57, P<0.001).CONCLUSION: A negative correlation was found between age and ASM in males after 50 years old and in females after 60 years old. The prevalence of low RSMI in females was significantly higher than that in males.

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