Hou X.-J.,Qinhuangdao 066000 |
Wang C.-H.,Qinhuangdao 066000 |
Li L.,Qinhuangdao 066000 |
Lian H.-X.,Qinhuangdao 066000 |
And 2 more authors.
Chinese Journal of Tissue Engineering Research
BACKGROUND: Autologus bones possess the bone guided activity and osteoinductive properties, becoming the gold standard for repair of bone defects. However, the limitation of resources in autogenous bone causes the research fellows to look for bone graft substitutes. OBJECTIVE: To explore the effectiveness of repairing distal femur defects in rabbit with β-calcium phosphate sintered bone. METHODS: A rabbit model of distal femur defects at diameter of 5 mm and depth of 12 mm was prepared. β-calcium phosphate sintered bone was implanted into the experimental side of the model, and nothing to the control side. Operation incision was observed and the pathological section was prepared to observe bone growth after implantation. RESULTS AND CONCLUSION: The incision healed fine after the operation of implanting the test piece of β-calcium phosphate sintered bone into the defect site in the condyles of femur in rabbits; new bone formation could be observed around bone defects in the rabbits of experimental groups after 4 weeks of the operation, the quantity of the new bone increased gradually with the time prolonging, the center of the β-calcium phosphate sintered bone could be found new bone and the materials could be degraded gradually after 12 weeks of the operation. In the other hand, new bone formation could not be found around bone defects until 12 weeks of the operation in the control group. These findings indicate that β-calcium phosphate has a good osteogenesis capacity, and can serve as an excellent bone graft substitute. Source