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Li L.,Qinghai Provincial Peoples Hospital
International Eye Science | Year: 2012

AIM: To investigate the application of 23-Gauge (23G) vitrectomy system in high altitude area. METHODS: In the applying of 23G vitrectomy system, the vitrectomy had been done for 32 cases (32 eyes), including vitreous hemorrhage, macular hole, macular pucker, posterior dislocation of lens, retinal detachment, Tersonz syndrome, vitreous hemorrhage combining with retinal detachment. RESULTS: The operations were successful, without expanding sclera puncture. The postoperative syndrome mainly was low IOP. CONCLUSION: In 2000, the clinical using of 23G vitrectomy system without conjunctival suture was first reported. It is more efficient than 25G vitrectomy system, which can process the retina around like 20G and has the advantage of healing fast ,seamless, short operation time and less postoperative syndrome as 25G vitrectomy system. So it can be widely applied in the vitrectomy in high altitude area. Source

Pengmao J.,Qinghai Provincial Peoples Hospital | Gao Q.,The 92nd Hospital of PLA
Chinese Journal of Tissue Engineering Research | Year: 2015

BACKGROUND: Osteoporosis is characterized as bone microstructure damage of the whole body and systemic osteopenia. Some scholars believe that the anterior vertebral height of patients with osteoporosis cannot decrease, but shows a trend of increase. OBJECTIVE: To investigate the correlation between degenerative lumbar scoliosis and osteoporosis. METHODS: Thirty-seven patients with degenerative lumbar scoliosis were selected as observation group and another 37 inpatients with no lumbar scoliosis as control group. Modified Cobb method was used to detect the maximum angle between parallel lines to the endplate on the T12-L6 vertebrae, and the vertebrae with these two parallel lines were regarded as upper and lower vertebrae. Dual energy X-ray absorptiometry was used to measure the bone mineral density of L2-L4 segments, femoral neck, Ward’s triangle and femoral trochanter. Linear regression analysis was used to analyze the correlation between osteoporosis and degenerative lumbar scoliosis. RESULTS AND CONCLUSION: There were significant differences in the T values in the L2-L4 segments, femoral neck, Ward’s triangle and femoral trochanter between the observation and control groups (P < 0.05), and the bone density of the femoral parts was lower than that of the lumbar vertebrae (L2-L4). The incidence of osteoporosis in the patients with lumbar scoliosis was significantly higher than that in the patients with no lumbar scoliosis (P < 0.05). Osteoporosis was a risk factor for degenerative lumbar scoliosis, and the T values of the lumbar vertebra and proximal femur had no remarkable correlation with Cobb’s angles. These findings indicate that osteoporosis is the risk factor for degenerative lumbar scoliosis, but it has no correlation with the severity of scoliosis. Source

Li G.,Tianjin Medical University | Sun Y.,Qinghai Provincial Peoples Hospital | Song H.,Tianjin Medical University | Wang Y.,Tianjin Medical University
Clinical and Experimental Nephrology | Year: 2015

Background: Renal artery aneurysm (RAA) is a relatively rare vascular entity. Treatment of ruptured RAA could be either surgical or via an endovascular route with variable prognosis and remain controversial. To evaluate the results of ruptured renal artery aneurysms treated by endovascular treatment and explore the efficacy of selective embolization in ruptured RAAs, controlling hemorrhage, and preserving renal function. Methods: From January 2001 to May 2011, 6 patients presented with gross hematuria or sudden onset severe abdominal or flank pain. This included a number in whom the aneurysm leaked, causing hematuria. Color Doppler ultrasonography (CDU) and contrasted computed tomography (CT) or computed tomography angiography (CTA) demonstrated 6 cases, and all cases were performed emergency angiography and 5 cases treated with selective coil embolization, and one case with trunk artery occlusion. Results: All cases with a follow-up for mean 25 months (range 12–64 months),4 cases with selective coil embolization with complete durable occlusion was achieved in all aneurysms without relapse, patients’ renal function was not significantly deteriorated. The case with trunk occlusion underwent subsequent ischemic parenchymal loss and post-embolization syndrome and with mild kidney atrophy. Conclusions: Superselective coil embolization provides a good therapeutic option for the ruptured RAAs with low mortality rates and good long-term outcome. RAAs have a probability of bilateral and multiple lesions,so attention for the presence of the contralateral RAA is important for medical choice. © 2015, Japanese Society of Nephrology. Source

Zhang X.,Qinghai Provincial Peoples Hospital
Zhonghua nei ke za zhi [Chinese journal of internal medicine] | Year: 2012

To investigate the roles of the chemokine receptor CXCR3 and its ligand I-TAC in the pathogenesis of immune thrombocytopenic purpura (ITP). A total of 48 ITP patients were enrolled in this study: 30 with newly diagnosed or relapse ITP and 18 in remission after treatment, and 24 healthy volunteers were as controls. IFNγ and I-TAC in plasma were detected by ELISA. The mRNA expression of CXCR3 in the peripheral blood mononuclear cells (PBMNCs) was determined by quantitative RT-PCR. The IFNγ level in the plasma of ITP patients before the treatment was obviously increased than those in the remission group and controls [(71.45 ± 17.62) ng/L vs (36.94 ± 14.86) ng/L and (25.28 ± 12.85) ng/L, all P < 0.05] and those in the remission group was higher than in the controls (P < 0.05). In contrast, there were no statistic differences of the levels of I-TAC among the three groups [(455.56 ± 144.70) ng/L, (488.24 ± 164.70) ng/L and (382.97 ± 167.43) ng/L, P > 0.05]. Both ITP patients before the treatment and remission groups expressed more CXCR3 mRNA [6.76 (3.03, 37.00), 1.76 (0.45, 14.18) vs 0.12 (0.04, 0.28), P < 0.05]. After effective therapy, CXCR3 mRNA expression decreased, while it was still higher than that in the controls. Our data demonstrate that Th1 cytokine (IFNγ) dominance is reflected in ITP. Simultaneously, the CXCR3(+) cell may play a role in cell-mediated immunity through chemotaxis in ITP. Source

Li J.,Peking Union Medical College | Yang S.,Peking Union Medical College | Lu S.,Peking Union Medical College | Zhao H.,Tianjin University of Commerce | And 8 more authors.
PLoS ONE | Year: 2012

Aplastic anemia (AA) is generally considered as an immune-mediated bone marrow failure syndrome with defective hematopoietic stem cells (HSCs) and marrow microenvironment. Previous studies have demonstrated the defective HSCs and aberrant T cellular-immunity in AA using a microarray approach. However, little is known about the overall specialty of bone marrow mesenchymal stem cells (BM-MSCs). In the present study, we comprehensively compared the biological features and gene expression profile of BM-MSCs between AA patients and healthy volunteers. In comparison with healthy controls, BM-MSCs from AA patients showed aberrant morphology, decreased proliferation and clonogenic potential and increased apoptosis. BM-MSCs from AA patients were susceptible to be induced to differentiate into adipocytes but more difficult to differentiate into osteoblasts. Consistent with abnormal biological features, a large number of genes implicated in cell cycle, cell division, proliferation, chemotaxis and hematopoietic cell lineage showed markedly decreased expression in BM-MSCs from AA patients. Conversely, more related genes with apoptosis, adipogenesis and immune response showed increased expression in BM-MSCs from AA patients. The gene expression profile of BM-MSCs further confirmed the abnormal biological properties and provided significant evidence for the possible mechanism of the destruction of the bone marrow microenvironment in AA. © 2012 Li et al. Source

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