Qingdao University of Science and Technology is a university located in Qingdao, China, colloquially known as Qingkeda . Having evolved from a college specializing in the chemical industry, it is now a comprehensive, multi-disciplinary university offering academic degrees in Science, Technology, Humanities, Business, Management, Medicine, Law and Arts. The school encompasses three campuses in Sifang and Laoshan districts of Qingdao and Gaomi district of Weifang. Wikipedia.
Jie G.,Qingdao University of Science and Technology
Chemistry (Weinheim an der Bergstrasse, Germany) | Year: 2011
Magnetic electrochemiluminescent Fe(3)O(4)/CdSe-CdS nanoparticle/polyelectrolyte nanostructures have been synthesized and used to fabricate an electrochemiluminescence (ECL) immunosensor for the detection of carcinoembryonic antigen (CEA). CEA is a protein used as a biomarker for several cancers; particularly, to monitor response to treatment in colon and rectal cancer patients. The nanocomposites can be easily separated and firmly attached to an electrode owing to their excellent magnetic properties. This represents a promising advantage for bioassay applications. More importantly, the nanostructures exhibit intense and stable ECL emissions in neutral solution, which makes them ideal for ECL immunosensing. The 3-aminopropyltriethoxysilane (APS) polyelectrolyte shell on the nanostructure surface not only enhances the intensity and stability of the ECL signal, but also acts as a crosslinker for immunosensor fabrication. A CEA antibody immobilized onto a nanocomposite/APS/electrode with gold nanoparticles comprises the ECL immunosensor. The principle of ECL detection for CEA is based on a change in steric hindrance after immunoreaction, which leads to a decrease in ECL intensity. A wide detection range (0.064pg ml(-1)-10ng ml(-1)) and low detection limit (0.032pg ml(-1)) are achieved. The immunosensor is highly sensitive and selective, and exhibits excellent stability and good reproducibility. It thus has great potential for clinical protein detection. In particular, this approach uses a novel class of bifunctional nanocomposites that display both intense ECL and excellent magnetism, which renders them suitable for a large range of bioassay applications. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Wang Y.,Tsinghua University |
Chen C.,Tsinghua University |
Peng J.,Tsinghua University |
Li M.,Qingdao University of Science and Technology
Angewandte Chemie - International Edition | Year: 2013
Three become one: Multiply substituted quinolines were synthesized from diaryliodoniums, alkynes, and nitriles by a CuII-catalyzed method. This cascade annulation is highly regioselective, step-economic, flexible with regard to the functional groups, and could potentially be applied to the synthesis of complex molecules. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Bu Y.,CAS Qingdao Institute of Oceanology |
Chen Z.,CAS Qingdao Institute of Oceanology |
Li W.,Qingdao University of Science and Technology
Applied Catalysis B: Environmental | Year: 2013
Silver (Ag) nanoparticles are successfully modified onto mesoporous graphitic carbon nitride (mg-C3N4) by photo-assisted reduction. Modifying mg-C3N4 with Ag significantly increases the photoelectric conversion performance. The promotion mechanism is studied through electrochemical methods for the first time. Modifying mg-C3N4 with Ag also increases the conductivity and lowers the energy barrier of the interface reactions. A heterojunction electric field, forms on the interface between the modified Ag and mg-C3N4, enhances the separation efficiency of photogenerated electron-hole pairs. The enhanced separation efficiency thus prolongs the lifetime of the photogenerated electrons and significantly improves the photoelectric conversion performance of mg-C3N4. Furthermore, Modifying mg-C3N4 with Ag significantly improves the adsorption capacity and photocatalytic degradation efficiency. Smaller Ag nanoparticles are much more effective than larger ones in improving photoelectric conversion performance. © 2013 Elsevier B.V.
Luo X.,Qingdao University of Science and Technology |
Luo X.,University of Oxford |
Davis J.J.,University of Oxford
Chemical Society Reviews | Year: 2013
Electrical detection methodologies are likely to underpin the progressive drive towards miniaturised, sensitive and portable biomarker detection protocols. In being easily integrated within standard electronic microfabrication formats, and developing capability in microfluidics, the facile multiplexed detection of a range of proteins in a small analytical volume becomes entirely feasible with something costing just a few thousand pounds and benchtop or handheld in scale. In this review, we focus on recent important advances in label free assays of protein using a number of electrical methods, including those based on electrochemical impedance spectroscopy (EIS), amperometry/voltammetry, potentiometry, conductometry and field-effect methods. We introduce their mechanistic features and examples of application and sensitivity. The current state of the art, real world applications and challenges are outlined. © 2013 The Royal Society of Chemistry.
Wang D.,Qingdao University |
Ding F.,Qingdao University of Science and Technology |
Ximei L.,Qingdao University of Science and Technology
Nonlinear Dynamics | Year: 2014
For a Hammerstein input nonlinear system with a subspace state space linear element, this paper transforms the system into a bilinear identification model by using the property of the shift operator to the state space model and presents a recursive and an iterative least squares algorithms to generate parameter estimates and state estimates by using the hierarchical identification principle and by replacing the unknown state variables with their estimates. The proposed approaches are computationally more efficient than the over-parameterization model based least squares method. © 2013 Springer Science+Business Media Dordrecht.