Qingdao, China
Qingdao, China

Qingdao University is a key provincial research university located in Qingdao, China. Qingdao University traces its origin to 1909, when Deutsch-Chinesische Hochschule, the oldest predecessor institution of Qingdao University, was jointly established by the Chinese and German governments in Qingdao. In 1993, the former Qingdao University, Qingdao Medical College, Shandong Textile Engineering College, and Qingdao Normal College, four higher education institutions with glorious history, merged to form the new Qingdao University. At present, QU is one of the best comprehensive universities in Shandong Province, recognized as a member of the national "Excellent Engineer Education and Training Program." With a strong profile in Medical science, Textile and Design, Business, and liberal arts, QU serves 32,300 full-time undergraduate students, 7,400 graduate students, and 1,100 international students. Wikipedia.

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Wang D.-Q.,Qingdao University | Ding F.,Jiangnan University
IEEE Signal Processing Letters | Year: 2012

This letter focuses on identification problems of a Hammerstein-Wiener system with an output error linear element embedded between two static nonlinear elements. A hierarchical least squares algorithm is presented for the Hammerstein-Wiener system by using the auxiliary model identification idea and the hierarchical identification principle. The major contributions of the present study are that the identification model is formulated by using the auxiliary model identification idea (the estimate of the unknown internal variable is replaced with the output of an auxiliary model) and that the bilinear parameter vectors in the identification model are estimated by using the hierarchical identification principle. The proposed hierarchical identification approach is computationally more efficient than the existing over-parametrization method. © 1994-2012 IEEE.

Yu J.-T.,Qingdao University | Yu J.-T.,Ocean University of China | Tan L.,Qingdao University | Tan L.,Ocean University of China | Hardy J.,University College London
Annual Review of Neuroscience | Year: 2014

The vast majority of Alzheimer's disease (AD) cases are late onset (LOAD), which is genetically complex with heritability estimates up to 80%. Apolipoprotein E (APOE) has been irrefutably recognized as the major genetic risk factor, with semidominant inheritance, for LOAD. Although the mechanisms that underlie the pathogenic nature of APOE in AD are still not completely understood, emerging data suggest that APOE contributes to AD pathogenesis through both amyloid-β (Aβ)-dependent and Aβ-independent pathways. Given the central role for APOE in the modulation of AD pathogenesis, many therapeutic strategies have emerged, including converting APOE conformation, regulating APOE expression, mimicking APOE peptides, blocking the APOE/Aβ interaction, modulating APOE lipidation state, and gene therapy. Accumulating evidence also suggests the utility of APOE genotyping in AD diagnosis, risk assessment, prevention, and treatment response. © Copyright ©2014 by Annual Reviews. All rights reserved.

Tan L.,Qingdao University | Yu J.-T.,Qingdao University
Molecular neurodegeneration | Year: 2014

Parkinson's disease (PD), like many common age-related conditions, has been recognized to have a substantial genetic component. Multiple lines of evidence suggest that Leucine-rich repeat kinase 2 (LRRK2) is a crucial factor to understanding the etiology of PD. LRRK2 is a large, widely expressed, multi-domain and multifunctional protein. LRRK2 mutations are the major cause to inherited and sporadic PD. In this review, we discuss the pathology and clinical features which show diversity and variability of LRRK2-associated PD. In addition, we do a thorough literature review and provide theoretical data for gene counseling. Further, we present the evidence linking LRRK2 to various possible pathogenic mechanism of PD such as α-synuclein, tau, inflammatory response, oxidative stress, mitochondrial dysfunction, synaptic dysfunction as well as autophagy-lysosomal system. Based on the above work, we investigate activities both within GTPase and outside enzymatic regions in order to obtain a potential therapeutic approach to solve the LRRK2 problem.

Dong X.-Z.,Qingdao University
International Journal of Systems Science | Year: 2014

In this paper, the problem of admissibility analysis is investigated for linear singular systems through a delta operator method. The delta operator model of a linear singular continuous system is set up first for a special case and then generalised to the common case. It is shown that when the sampling period tends to zero, the delta operator model tends to the corresponding singular continuous system. In order to obtain the above delta operator model, we adopt a linear singular discrete model which contains the sampling period instead of the standard discrete one which contains no sampling period in the modeling process. The relation between the admissibility of the two singular discrete models is analysed and it is proved that the admissibility of one singular discrete model is equivalent to that of the other discrete model. Moreover, based on the relation between the discrete and delta operator models, some admissibility conditions are derived for linear singular delta operator systems. A numerical example is also provided to demonstrate the theoretical results in this paper. © 2013 Taylor & Francis.

Wang D.Q.,Qingdao University
IET Control Theory and Applications | Year: 2011

For parameter estimation of output error moving average (OEMA) systems, this study combines the auxiliary model identification idea with the filtering theory, transforms an OEMA system into two identification models and presents a filtering and auxiliary model-based recursive least squares (F-AM-RLS) identification algorithm. Compared with the auxiliary model-based recursive extended least squares algorithm, the proposed F-AM-RLS algorithm has a high computational efficiency. Moreover, a filtering and auxiliary model-based least squares iterative (F-AM-LSI) identification algorithm is derived for OEMA systems with finite measurement input-output data. Compared with the F-AM-RLS approach, the proposed F-AM-LSI algorithm updates the parameter estimation using all the available data at each iteration, and thus can generate highly accurate parameter estimates. © 2011 The Institution of Engineering and Technology.

Zhisheng Z.,Qingdao University
Expert Systems with Applications | Year: 2010

Quantum-behaved particle swarm optimization algorithm is firstly used in economic load dispatch of power system in this paper. Quantum-behaved particle swarm optimization algorithm is the integration of particle swarm optimization algorithm and quantum computing theory. The superposition characteristic and probability representation of quantum methodology are combined into particle swarm optimization algorithm. This can make a single particle be expressed by several certain probability states. And the quantum rotation gates are used to realize update operation of particles. The algorithm is simulated by two cases, which validates it can effectively solve economic load dispatch problem. Though performance comparison, it is obvious the solution is superior to that of improved particle swarm optimization algorithm and other optimization algorithms. © 2009 Elsevier Ltd. All rights reserved.

Jiang W.,Qingdao University
European journal of epidemiology | Year: 2014

Dairy foods have been linked to Parkinson's disease (PD), and a meta-analysis of prospective cohort studies on dairy foods intake and PD risk was conducted. Eligible studies were identified in a literature search of EMBASE and PubMed up to April 2014. Seven results from prospective studies were included, including 1,083 PD cases among 304,193 subjects. The combined risk of PD for highest vs. lowest level of dairy foods intake was 1.40 (1.20-1.63) overall, 1.66 (1.29-2.14) for men and 1.15 (0.85-1.56) for women. For highest vs. lowest level, the PD risk was 1.45 (1.23-1.73) for milk, 1.26 (0.99-1.60) for cheese, 0.95 (0.76-1.20) for yogurt and 0.76 (0.51-1.13) for butter. The linear dose-response relationship showed that PD risk increased by 17% [1.17 (1.06-1.30)] for every 200 g/day increment in milk intake (Pfor non-linearity = 0.22), and 13% [1.13 (0.91-1.40)] for every 10 g/day increment in cheese intake (Pfor non-linearity = 0.39). The absolute risk differences were estimated to be 2-4 PD cases per 100,000 person-years for every 200 g/day increment in milk intake, and 1-3 PD cases per 100,000 person-years for every 10 g/day increment in cheese intake. Dairy foods (milk, cheese) might be positively associated with increased risk of PD, especially for men.

Background: Differentiated thyroid carcinoma (DTC) with rising thyroglobulin (Tg) level and negative radioiodine whole body scan results has been observed in follow-up studies. The management of this condition remains controversial. Most studies support blind 131I treatment while others oppose this approach. Aims: To assess the effects of 131I therapy for DTC with rising Tg and negative scan results. Selection criteria: Randomised controlled clinical trials, prospective controlled clinical trials and any trials using 131I treatment or no treatment for Tg-positive and radioiodine-negative disease were included in this review. Results: Due to the lack of any suitable randomised or prospective controlled trials in this area, it was not possible to undertake a meta-analysis. Eighteen trials were retrieved for further overall assessment. Of 438 patients from 16 studies who were treated empirically with 131I for Tg-positive and radioiodine-negative disease, 267 (62%) displayed pathological uptake in the thyroid bed, lungs, bone, mediastinum and lymph nodes. In studies in which data were available for serum Tg levels during thyroid-stimulating hormone (TSH) suppression therapy or TSH withdrawal, 188 of 337 patients (56%) showed a decrease in serum Tg. Of 242 patients from five studies who received no specific treatment for Tg-positive and radioiodine-negative disease, 106 (44%) showed spontaneous normalisation and a significant decrease in serum Tg. Conclusions: The currently available evidence is insufficient for reliable assessment of the potential of 131I treatment for DTC with elevated Tg and negative scan results. A decrease in serum Tg in 62% of patients with DTC with elevated Tg and negative scan results suggests that 131I therapy has a therapeutic effect for more than one-half of patients when the Tg level is considered an index of tumour burden. However, considering that 44% of patients with DTC with elevated Tg and negative scan results showed spontaneous normalisation and a significant reduction in serum Tg without any specific treatment, 131I therapy should be individualised according to clinical characteristics. Other diagnostic techniques are strongly recommended for patients with Tg-positive and radioiodine-negative disease. If these diagnostic results are positive, treatment options such as surgery, external radiotherapy and tumour embolisation should be considered. If diagnostic results are negative, one course of 131I treatment may be considered in high-risk patients with serum Tg >10ng/mL after TSH withdrawal or >5ng/mL under recombinant human TSH stimulation. No further 131I therapy is indicated for patients with a negative post-therapy radioiodine scan. © 2010 The Royal College of Radiologists.

Chu T.,Qingdao University
Journal of Computational Chemistry | Year: 2010

The time-dependent quantum wave packet and the quasi-classical trajectory (QCT) calculations for the title reactions are carried out using three recent-developed accurate potential energy surfaces of the 1 1A', 1 3A', and 1 3A" states. The two commonly used polarization-dependent differential cross sections, dr00/dxt, dr20/dxt, with xt being the polar coordinates of the product velocity x0, and the three angular distributions, P(hr), P(Fr), and P(hr, Fr), with hr, Fr being the polar angles of the product angular momentum, are generated in the center-of-mass frame using the QCT method to gain insight into the alignment and the orientation of the product molecules. Influences of the potential energy surface, the collision energy, and the isotope mass on the stereodynamics are shown and discussed. Validity of the QCT calculation has been examined and proved in the comparison with the quantum wave packet calculation. © 2009 Wiley Periodicals, Inc.

Tan L.,Qingdao University
Current Alzheimer research | Year: 2015

Prevalence estimates of depression in AD vary greatly across studies, and a reliable result is crucial for further interventions. A systematic review and meta-analysis was conducted to identify the prevalence of depression in AD patients. We searched PubMed and Embase, followed by data extraction, quality assessment, prevalence estimates and subgroup analyses. A total of 63 studies were included in the review. The prevalences of depression were 12.7% (CI, 8.8-17.8) and 42% (CI, 38-45) according to the DSM criteria for major depression and the specific criteria for dementia respectively. Subgroup analyses stratified by case identification showed that the prevalences of population-based stud ies were 5% (CI: 2-15) and 35% (CI: 29-41) according to the DSM criteria and the specific criteria respectively, while those of single source were 17% (CI: 11-25) and 43% (CI: 37-49). Subgroup analyses stratified by MMSE score revealed that the prevalences of severe AD were 8% (CI: 5-15) and 48% (CI: 41-54) according to the DSM criteria and the specific criteria respectively, while those of mild AD were 14% (CI: 8-24) and 40% (CI: 32- 47). In conclusion, the prevalence of depression according to the DSM criteria was lower than that of the specific criteria. Prevalence estimates conducted in population-based studies were lower compared with those in single-source studies irrespective of the screening tools. Patients with severe AD tended to have higher prevalence of depression according to the specific criteria, while the trend was opposite according to the DSM criteria. Thus, different settings and diagnostic approaches should be taken into account before estimates of depression and further interventions.

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