Qingdao Stomatological Hospital

Qingdao, China

Qingdao Stomatological Hospital

Qingdao, China

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PubMed | Qingdao Stomatological Hospital and Peking University
Type: | Journal: Drug design, development and therapy | Year: 2016

This study aimed to evaluate the efficacy and safety of topical treatment with natural herbal medicines on recurrent aphthous stomatitis (RAS). Nine electronic databases were searched to identify the randomized controlled trials and clinical controlled trials that reported the potential effect of natural herbal medicines on RAS published in Chinese or English. Ulcer size and duration, and remission of pain were assessed as main outcome measures. The methodological quality of the studies was evaluated using the Cochrane Handbook for Systemic Review of Interventions and Rev Man software. Thirteen trials with a total of 1,515 patients were included in the present analysis, which showed that topical treatment with natural herbal medicines seemed to benefit RAS patients by reducing ulcer size, shortening ulcer duration, and relieving pain without severe side effects. In conclusion, there is some evidence of the efficacy of topically applied natural herbal medicines with regards to improved RAS outcome measures and fewer side effects. However, given the limitations of this study, the evidence remains insufficient. Well-designed and high-quality randomized controlled trials are required for further exploration.


PubMed | Qingdao Stomatological Hospital and Qingdao Hiser Medical Group
Type: Journal Article | Journal: Molecular medicine reports | Year: 2015

The present study aimed to investigate the effect of -anhydroicaritin on the expression levels of tumor necrosis factor (TNF)- and matrix metalloproteinase (MMP)-3, and the pathological changes in the periodontal tissue of diabetic rats. Male Wistar rats (n=40; three months old) were randomly divided into four groups: Normal control group, diabetes group, diabetes + -anhydroicaritin group and diabetes + urate group, (n=10 in each group). Following an overnight fast, diabetes was induced by intraperitoneal injection of streptozocin. The rats were maintained for 12 weeks and the blood sugar, urine sugar and body weight were assessed in week 12. Histological changes of the periodontal tissues were observed by hematoxylin and eosin staining, and the expression levels of TNF- and MMP-3 were observed by immunohistochemistry. Following 12 weeks, the TNF- grey value in the diabetes group was significantly lower compared with that in the control group (P<0.05), while no significant difference was observed between TNF- levels in the diabetes + -anhydroicaritin group, diabetes + urate group and the control group (P>0.05). However, TNF- levels in the diabetes + -anhdroicaritin group and diabetes + urate group were significantly higher compared with those in the diabetes group (P<0.05), and those in the diabetes + -anhydroicaritin group were lower compared with those in the diabetes + urate group (P<0.05). The MMP-3 grey value in the diabetes group was significantly lower compared with that in the control group (P<0.05), while no significant difference was observed between MMP-3 levels in the diabetes + -anhydroicaritin group, diabetes + urate group and the control group (P>0.05). However, MMP-3 levels the diabetes + -anhydroicaritin group and diabetes + urate group were significantly higher compared with those in the diabetes group (P<0.05), and those in the diabetes + -anhydroicaritin group were lower compared with those in the diabetes + urate group (P<0.01). -anhydroicaritin normalized the expression levels of TNF- and MMP-3 in the periodontal tissue of diabetic rats and led to the recovery of the changes in the morphological structure of the periodontal tissue.


Xu M.,Jiangxi Province Peoples Hospital | Zhang Q.,Guangzhou University | Qiu H.,Qingdao Stomatological Hospital
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology | Year: 2013

Loss of anterior tooth impairs patients physically and emotionally as well as presents a challenge for dentists. This article presented a method of replacing one anterior tooth that was extracted because of periodontitis. The proposed method involves the use of the natural crown as pontic with fiber-reinforced composite resin-bonded fixed partial denture.


Sun J.,Shandong University | Sun J.,Qingdao Stomatological Hospital | Zhang T.,Shandong University | Zhang P.,Shandong University | And 6 more authors.
Journal of Molecular Histology | Year: 2014

Periodontal ligament-associated protein-1 (PLAP-1) is a newly discovered member of the extracellular matrix family of proteins known as proteoglycans and is a negative regulator that plays a crucial role in the homeostasis of periodontal tissues. It can protect the periodontal ligament from excessive osteogenesis. However, the molecular mechanisms of PLAP-1 during osteogenic differentiation and osteogenesis remain unclear. In this study, we constructed a PLAP-1 recombinant retroviral plasmid vector named pBABE-hygro-PLAP-1. We transfected this plasmid into rat bone marrow stromal cells (rBMSCs) to obtain a stable cell line with overexpression of PLAP-1 to verify whether PLAP-1 also acts as an inhibitory factor in rBMSCs during bone mineralization. A rBMSC line stably overexpressing PLAP-1 was established successfully as determined by the mRNA levels of PLAP-1, which were measured by real time-qPCR (RT-qPCR), and protein expression, which was measured by immunocytochemistry and western blot analysis. At the same time, a Cell Counting Kit-8 assay did not reveal any statistically significant changes in the transfected cells (P > 0.05). Then, mineral-inducing cultures were performed, and mineralized nodules were observed at weeks 2, 3 and 4 under a microscope. Alizarin Red (Sigma) staining was performed at 4 week to illustrate calcium accumulation. The mineralized nodules in the PLAP-1-transfected rBMSC group were fewer than those in the control groups. The time span of the formation of the mineralized nodules was prolonged. Meanwhile, osteogenic genes were also detected in the mineral-inducing cells by RT-qPCR. An RT-qPCR analysis demonstrated that the levels of the osteoblast markers of rBMSCs that were transfected with pBABE-hygro-PLAP-1, including Runx2, Osterix, alkaline phosphatase, bone sialoprotein and osteocalcin, were lower than those in the non-transfected rBMSCs and rBMSCs that were transfected with empty vector (P < 0.01). These results suggest that PLAP-1 has an inhibitory function in rBMSCs when they differentiate into osteoblast-like cells. © 2014 Springer Science+Business Media Dordrecht.


Song Y.,Qingdao Stomatological Hospital | Zhang X.,Capital Medical University | Gao Y.,Qingdao Stomatological Hospital | Hou F.,Qingdao Stomatological Hospital | Yu Y.,Qingdao Stomatological Hospital
International Journal of Clinical and Experimental Medicine | Year: 2016

The purpose of this study was to evaluate the condylar morphology parameters using cone beam computed tomography (CBCT). 180 adult female patients with skeletal Class II division 1 were recruited in this study. Then the participants were divided into three groups according to the values of GoGn-SN and S-Go/N-Me. Mimics 10.01 software was used to reconstruct the CBCT images and measure the parameters including condylar volume, surface area, morphological index, inner-outer and front-back diameters on the sagittal and coronal sections. Our results showed that there were no significant difference by condylar morphological parameters in patients with the same vertical skeletal pattern (P>0.05). All the measured parameters in the low angle group were significantly different with those in the average angle group (P<0.05). Similarly, all the measured parameters except the morphological index in the low angle group were significantly different with those in the high angle group (P<0.05). Significant difference was found between the high angle group and the low angle group regarding the parameters including condylar MI, inner-outer and front-back diameters (P<0.05). In conclusion, our study demonstrated that there was significant difference regarding the condylar morphology among females of skeletal Class II division 1 malocclusion with various vertical skeletal features. The data was important and valuable for radiological diagnosis, orthodontic treatments and orthognathic surgery. © 2016, E-Century Publishing Corporation. All rights reserved.


Gao Y.,Qingdao Stomatological Hospital | Zhang M.,Qingdao Stomatological Hospital | Gong C.-M.,Weifang Medical University
Chinese Journal of Tissue Engineering Research | Year: 2015

BACKGROUND: There are two ways to treat the enamel before bracket bonding: etching and sandblasting, but the few studies focus on the direct us of sandblasting technology on untreated enamel surface. OBJECTIVE: To observe the damage of etching versus sandblasting to the enamel surface, and to compare the bonding strength of metal brackets adhesive to isolated teeth with these two kinds of surface treatments. METHODS: (1) Nine premolar teeth removed for orthodontic treatment were randomized into three groups: sandblasting, acid etching and polishing treatment groups. Surface roughening effects of these three kinds of treatments were observed under scanning electron microscope. (1) Another 40 premolar teeth removed for orthodontic treatment were randomized intt two groups: sandblasting and acid etching groups. Ait 24 hours after bracket bonding, the shear strength was detected using mechanical testing machine, and the adhesive residue index of tooth surface was statistically calculated. RESULTS AND CONCLUSION: (1) Under the scanning electron microscope, polishing treatment had no damage to the enamel surface; but in the other two groups, the enamel surface was damaged to varying degrees, especially in the sandblasting group. (2) The bonding strength in the sandblasting group was significantly higher than that in the acid etching group (P < 0. 05), but there was no difference in the adhesive residue index of tooth surface between the two groups (P > 0. 05). These findings indicate that compared with the acid etching technology, the sandblasting technology can increase the bonding strength between the enamel and metal bracket, but it also results in more damage. © 2015, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.


Wang Y.,Qingdao Stomatological Hospital | Guan Q.,Qingdao Stomatological Hospital | Li Y.,Qingdao Stomatological Hospital | Guo J.,Qingdao Stomatological Hospital | And 3 more authors.
Shanghai kou qiang yi xue = Shanghai journal of stomatology | Year: 2013

PURPOSE: To study the clinical effect of "gelatamp" colloidal silver gelatin sponge on preventing dry socket after extracting the mandibular impacted teeth.METHODS: 1350 teeth extracted from 976 patients who needed to extract the mandibular impacted teeth were divided into group A, group B and group C randomly. "Gelatamp" colloidal silver gelatin sponge was implanted into alveolar socket after teeth extraction in group A, with absorbable gelatin sponge was implanted into alveolar socket in group B and nothing was implanted into alveolar socket in group C. The incidence of dry socket was observed, the data was analyzed using SPSS10.0 software package.RESULTS: The incidence of dry socket was 0.44% in group A, 2% in group B and 4.44% in group C. There was significant difference in the incidence of dry socket between group A and group C(P<0.01). There was also significant difference between group B and group C(P<0.05) and between group A and group B(P<0.05).CONCLUSIONS: The results demonstrate that "gelatamp" colloidal silver gelatin sponge can prevent the occurrence of dry socket after teeth extraction, which is of wide clinical use.


Wang W.,Qingdao Stomatological Hospital | Yang Y.,Qingdao Stomatological Hospital | Zhang W.,Qingdao Stomatological Hospital | Wu W.,Qingdao University
Oral Oncology | Year: 2014

Objectives Epidemiological studies evaluating the association of tea consumption and the risk of oral cancer risk have produced inconsistent results. Thus, we conducted a meta-analysis to assess the relationship between tea consumption and oral cancer risk. Methods Pertinent studies were identified by a search in PubMed, Web of Knowledge and Wan Fang Med Online. The fixed or random effect model was used based on heterogeneity test. Publication bias was estimated using Egger's regression asymmetry test. Results Finally, 14 articles with 19 studies comprising 4675 oral cancer cases were included in this meta-analysis. The relative risk (95% confidence interval) of oral cancer for the highest versus the lowest category of tea consumption was 0.853 (0.779-0.934), and the association was significant between oral cancer risk and green tea consumption [0.798 (0.673-0.947)] but not in the black tea consumption [0.953 (0.792-1.146)]. The associations were also significant in Asian and Caucasian. Conclusions Our analysis indicated that tea consumption may have a protective effect on oral cancer, especially in green tea consumption.


Xin B.C.,Chongqing Medical University | Xin B.C.,The Affiliated Stomatological Hospital of Zunyi Medical College | Xin B.C.,Qingdao Stomatological Hospital | Luo A.H.,The Affiliated Stomatological Hospital of Zunyi Medical College | And 6 more authors.
Oral Diseases | Year: 2013

Objective: This study aimed to identify the oral microbial diversity of healthy Chinese Han children. Methods: Dental plaques were sampled from the oral cavity of ten healthy Chinese Han children. The oral microbiome was examined using the 16S rRNA-based Human Oral Microbe Identification Microarray. The microbial diversity and similarity were analyzed using the Chao-Jaccard similarity index. Results: A total of 112 species, which belonged to nine bacterial phyla and 41 genera, were detected. Each individual harbored an average of 54.1 microbial species (ranging from 37 to 69) and 26.2 genera (ranging from 21 to 31), with interindividual variations both at the species and genus level. Thirteen genera were conserved among all individuals. The Chao-Jaccard similarity index averages, at the genus and species level, were 0.642 (ranging from 0.485 to 0.871) and 0.506 (ranging from 0.338 to 0.676), respectively, suggesting that the healthy oral community was more conserved at the genus level than at the species level. Conclusion: Although there was interindividual variation in the oral microflora, some bacterial genera were conserved among individuals, supporting the existence of a core microbiome in the oral cavity of healthy Chinese Han children. © 2012 John Wiley & Sons A/S.


PubMed | Qingdao Stomatological Hospital and Qingdao University
Type: Journal Article | Journal: Oral oncology | Year: 2014

Epidemiological studies evaluating the association of tea consumption and the risk of oral cancer risk have produced inconsistent results. Thus, we conducted a meta-analysis to assess the relationship between tea consumption and oral cancer risk.Pertinent studies were identified by a search in PubMed, Web of Knowledge and Wan Fang Med Online. The fixed or random effect model was used based on heterogeneity test. Publication bias was estimated using Eggers regression asymmetry test.Finally, 14 articles with 19 studies comprising 4675 oral cancer cases were included in this meta-analysis. The relative risk (95% confidence interval) of oral cancer for the highest versus the lowest category of tea consumption was 0.853 (0.779-0.934), and the association was significant between oral cancer risk and green tea consumption [0.798 (0.673-0.947)] but not in the black tea consumption [0.953 (0.792-1.146)]. The associations were also significant in Asian and Caucasian.Our analysis indicated that tea consumption may have a protective effect on oral cancer, especially in green tea consumption.

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