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Wang X.,University of Sichuan | Zhang L.,University of Sichuan | Zhang L.,Chongqing Medical University | Luo J.,University of Sichuan | And 6 more authors.
Journal of Clinical Pharmacology | Year: 2015

In this randomized, controlled clinical trial to compare efficacy and safety, 41 patients with labial discoid lupus erythematosus (DLE) were randomized to 2 groups, either receiving tacrolimus 0.03% ointment (n = 22) or triamcinolone acetonide 0.1% cream (n = 19). Each patient was treated with 3, 2, and 1 daily doses in the first, second, and third weeks, respectively, for 1 course. After the 3 week treatment, patients with complete disappearance of erosion were followed up for 3 months. After the 3 week application, 20 participants in the tacrolimus group and 19 in the triamcinolone acetonide group completed the study. The rates of complete response were 70% and 89.5% in tacrolimus-treated and triamcinolone acetonide-treated patients, respectively, with no significant difference (P =.235). Reduction in erosion and erythema showed no significant difference between groups (P >.05). Final reduction in reticulation areas and numeric rating scale scores were significantly greater in the tacrolimus group than in the triamcinolone acetonide group (P =.013; P =.048, respectively). Only 1 patient receiving tacrolimus presented with slight discomfort. There was no significant difference in 3 month recurrence rate between the groups (P >.05). Topical tacrolimus is considered as effective as triamcinolone acetonide for the management of labial DLE. © 2015, The American College of Clinical Pharmacology.

Yang S.-F.,Qingdao University | Wu S.-Y.,Qingdao Stomatological Hospital
Chinese Journal of Tissue Engineering Research | Year: 2013

BACKGROUND: Long-term high-dose radiation therapy is important to prevent the recurrence of cancer. But the radioactive rays can also make hurt to the normal tissues. So, researchers focus on the protection of the surrounding normal tissues in the radiotherapy. OBJECTIVE: To study the impact of radiation on the rat masseter muscle and the revasularization ability of the irradiated tissue by vascular endothelial growth factor gene transfection. METHODS: The Wistar rats were radiated by linear accelerator at a dose of 40 Gy. And then the irradiated muscle tissues were transfected with pcDNA4-HisMax-C/vascular endothelial growth factor 165 or empty plasmids. After 2 weeks of gene therapy, transforming growth factor β1 and vascular endothelial growth factor protein were determined using immunohistochemical staining, and the pathological change of the rat masseter muscles was observed under a light microscope. RESULTS AND CONCLUSION: Transforming growth factor β1 protein was highly expressed in the irradiated tissue than the control tissue. Vascular endothelial growth factor protein was significantly increased in the gene transfected group than the radiation group, empty plasmid DNA transfection group and normal control group. These findings indicate that transforming growth factor β1 can improve damaged tissue repair, and vascular endothelial growth factor gene therapy can resume the ability of revasularization of irradiated tissue, thereby promoting irradiated tissue repair.

Xu M.,Jiangxi Province Peoples Hospital | Zhang Q.,Guangzhou University | Qiu H.,Qingdao Stomatological Hospital
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology | Year: 2013

Loss of anterior tooth impairs patients physically and emotionally as well as presents a challenge for dentists. This article presented a method of replacing one anterior tooth that was extracted because of periodontitis. The proposed method involves the use of the natural crown as pontic with fiber-reinforced composite resin-bonded fixed partial denture.

Gao Y.,Southern Medical University | Deng Y.,Qingdao Stomatological Hospital | Zhao Y.,Inner Mongolia Peoples Hospital | Lai C.,Southern Medical University | And 3 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

Alveolar defects of a critical size cannot heal completely without grafting. Thus, they represent a major clinical challenge to reconstructive surgery. Numerous types of grafts have been used to improve bone regeneration. In the case of particle grafts, the capacity for volume rebuilding and space maintaining is still not ideal, particularly for critical-sized bone defects. Although porous block grafts can overcome the above problems of particle grafts, they are still not widely used for critical-sized alveolar defects, because of their reduced efficacy in blood vessel and bone formation. Thus, in the present study, nano-hydroxyapatite/coralline (nHA/coral) blocks were pre-vascularized by coating them with vascular endothelial growth factor (VEGF), and then implanted in dogs with critical-sized mandibular defects. This model has possible applications in orthopedic and implant surgery. In vivo results indicate that the nHA/coral blocks allow cell and collagen ingrowth because of their suitable pore size and interconnectivity of pores. In addition, pre-vascularization properties were obtained by coating the scaffolds with VEGF. Histological and immunohistochemical examinations, as well as fluorescence analysis, revealed that the local delivery of VEGF can significantly improve neovascularization and mineralization of newly formed bone at the early stages of bone healing in this dog implantation model. Our data collectively show that nHA/coral blocks have possible applications in bone tissue engineering, and excellent results can be achieved by pre-vascularization with VEGF. © 2015, E-Century Publishing Corporation. All rights reserved.

Wang W.,Qingdao Stomatological Hospital | Yang Y.,Qingdao Stomatological Hospital | Zhang W.,Qingdao Stomatological Hospital | Wu W.,Qingdao University
Oral Oncology | Year: 2014

Objectives Epidemiological studies evaluating the association of tea consumption and the risk of oral cancer risk have produced inconsistent results. Thus, we conducted a meta-analysis to assess the relationship between tea consumption and oral cancer risk. Methods Pertinent studies were identified by a search in PubMed, Web of Knowledge and Wan Fang Med Online. The fixed or random effect model was used based on heterogeneity test. Publication bias was estimated using Egger's regression asymmetry test. Results Finally, 14 articles with 19 studies comprising 4675 oral cancer cases were included in this meta-analysis. The relative risk (95% confidence interval) of oral cancer for the highest versus the lowest category of tea consumption was 0.853 (0.779-0.934), and the association was significant between oral cancer risk and green tea consumption [0.798 (0.673-0.947)] but not in the black tea consumption [0.953 (0.792-1.146)]. The associations were also significant in Asian and Caucasian. Conclusions Our analysis indicated that tea consumption may have a protective effect on oral cancer, especially in green tea consumption.

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