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Qingdao, China

Guo M.-M.,Shandong University | Duan X.-N.,Peking University | Cui S.-D.,Zhengzhou University | Tian F.-G.,Shanxi Cancer Hospital | And 29 more authors.

The level of total adiponectin, a mixture of different adiponectin forms, has been reported associated with breast cancer risk with inconsistent results. Whether the different forms play different roles in breast cancer risk prediction is unclear. To examine this, we measured total and high molecular weight (HMW) adiponectin in a case-control study (1167 sets). Higher circulating HMW adiponectin was negatively associated with breast cancer risk after adjusting for menopausal status and family history of breast cancer (P=0.024). We analyzed the relationship between adiponectin and breast cancer risk in 6 subgroups. Higher circulating HMW adiponectin was also negatively associated with breast cancer risk (P=0.020, 0.014, 0.035) in the subgroups of postmenopausal women, negative family history of breast cancer, BMI>=24.0. Total adiponectin was positively associated with breast cancer (P=0.028) in the subgroup of BMI<=24.0. Higher HMW/total adiponectin ratio was negatively associated with breast cancer (P=0.019) in the subgroup of postmenopausal women. Interestingly, in the subgroup of women with family history of breast cancer, higher circulating total and HMW adiponectin were positively associated with breast cancer risk (P=0.034, 0.0116). This study showed different forms of circulating adiponectin levels might play different roles in breast cancer risk. A higher circulating HMW adiponectin is associated with a decreased breast cancer risk, especially in postmenopausal, without family history of breast cancer or BMI>=24.0 subgroups, whereas higher circulating HMW adiponectin levels is a risk factor in women with a family history of breast cancer. Further investigation of different forms of adiponectin on breast cancer risk is needed. © 2015 Guo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Source

Wang W.,Qingdao University | Zhao C.,Qingdao University | Ji Q.,Qingdao University | Liu Y.,Weifang Nursing Vocational College | And 2 more authors.
BMC Pediatrics

Backgrounds: Catheter-related infections (CRIs) are one of the severe complications of PICC placement. If treatment is not timely or correct, the incidence of infection and mortality rate can be high. A central line bundle (CLB) guideline was first proposed by the Institute for Healthcare Improvement, and included five key measures. Very low-birth-weight infants (VLBWIs) have a low immune response and indistinct symptoms after infection compared with other populations (Costa P, Kimura AF, de Vizzotto MP, de Castro TE, West A, Dorea E. Prevalence and reasons for non-elective removal of peripherally inserted central catheter in neonates. Rev Gaucha Enferm. 2012;33:126-33). Some reviews have focused on the effect and safety of a CLB in VLBWIs and its preventive effect on bacterial colonization and infection. Methods: Fifty-seven VLBWIs who underwent PICC insertion at a hospital in Qingdao, China, between November 2012 and June 2013, and for whom a CLB guideline and a standard checklist were adopted, were included in the CLB group. In contrast, 53 VLBWIs who underwent PICC insertion, but for whom a CLB guideline and a standard checklist were not adopted, were included in the control group. The incidence of CRIs was compared between before and after the treatment. Results: The incidence of infection showed a statistically significant reduction from 10.0 to 2.20 per 1000 catheter days in the control group (P? Source

Hongying H.,Qingdao Medical College | Ming S.,Rehabilitation Hospital of Sichuan Province | Jhig A.,Capital Medical University | Chushuang C.,Guangzhou University | And 5 more authors.
Chinese Journal of Medical Genetics

Objective: To study polymorphisms of catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAO-B) genes among Chinese patients with Parkinson' s disease. Methods: Genotypes of the COMT and MAO-B genes of 1408 patients with Parkinson's disease was sequenced using Sanger method. And these patients were recruited by Chinese Parkinson Study Group from 29 research centers throughout the country. Results: The genotypic frequencies of COMT rs4680 AA, AG, GG were 8. 9%, 42.0% and 49. 1%. Those of rs4818 CC, CG, GG were 42. 5%, 45. 6% and 11. 9%, respectively. The genotype frequencies of MAOB rsl799836 A/AA, AG, G/GG were 74. 4%, 14. 1% and 11. 5%, respectively. The haplotype formed by COMT rs4680 (GG) and MAO-B rsl799836 (A/AA) genotype has a frequency of 36. 86%. Conclusion: Polymorphisms of COMT and MAO-B genes has a unique characteristics among Chinese patients with Parkinson's disease. They may he related with differences in drug response in such patients. Source

Zhang T.-T.,Qingdao Medical College | Yao Y.-S.,Qingdao Medical College | Zhang J.,Qingdao Medical College | Qi Y.-Y.,Qingdao Medical College | And 2 more authors.
Chinese Journal of Cancer Biotherapy

Objective: To explore the expressions of EGFR (epidermal growth factor receptor), serine/threonine kinase ERK, extracellar signal regulated kinase AKT mRNA in epithelial ovarian cancers and their relevant clinical significance. Methods: Sixty-one samples were obtained from epithelial ovarian cancer ESCC patients who were diagnosed in Affiliated Hospital of Qingdao Medical College from Dec. 2008 to Apr. 2010. The expressions of EGFR, ERK and AKT mRNA in epithelial ovarian cancer, benign ovarian tumor and normal ovarian tissues were detected by RT-PCR, and their clinical significance was evaluated using the clinicopathological parameters of the epithelial ovarian cancers. Results: The positive rates of EGFR, ERK and AKT mRNA expressions in epithelial ovarian cancer tissues (78.7% vs 14.3%, 31.3%, 80.3% vs 35.7%, 35.7%, 90.2% vs 21.4%, 25.0%; P < 0.01, respectively) were significantly higher than those in the benign ovarian tumor and normal ovarian tissues. The expressions of EGFR and AKT mRNA were correlated with the tumor stage, differentiation degree, and lymphatic metastasis of epithelial ovarian cancers (P <0.05), but not with their histological types and patient ages (P >0.05). The expression of ERK mRNA was correlated with the differentiation degree of epithelial ovarian cancers (P <0.05). Conclusion: The expressions of EGFR, AKT and ERK are correlated with the development and progression of epithelial ovarian cancers. Source

Sun J.,Qingdao Medical College | Li Y.,Qingdao Medical College | Chen L.,Qingdao Medical College | Yang J.,Qingdao Medical College | And 3 more authors.
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology

Objective: The purpose of this study was to develop a new method to regenerate articular cartilage of the temporomandibular joint (TMJ) by transplantation of free autogenous costal perichondrium (PC). Study design: In the study, 50 adult rabbits received the operation. For the surgery in the test group, the rabbits were randomly matched in pairs within the group and underwent the surgery of cross transplantation of costal PC after trimming the articular surface of the condyle. Operations were carried out in the same way in the experimental group except for PC transplantation. Instead, the suture was stitched in stratified order in the control group. Examination methods included observation of sections under the microscope, observation of specimens under the electron microscope, proliferating cell nuclear antigen (PCNA) staining, and biochemical analysis of glucuronic acid (GA) content and collagen content. The results of different groups were compared with ANOVA. Results: The transplanted homologous PC escaped observable immune repulsion so that it could survive to form new joint cartilage with approximately normal tissue structure and biochemical constitution. The reproduction process was similar to the normal one, but was prolonged a little. At the later stage, the degeneration and calcification in the basal layer increased. However, because of its limited scope, no apparent effect on cartilage growth and function was observed. Conclusions: Homologous xenografting of free costal PC will not result in an apparent immunorejection of the host. Instead, the grafts can maintain their existence by obtaining nutrition from surrounding tissues and regenerate cartilage tissue. © 2010 Mosby, Inc. All rights reserved. Source

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