Qingdao Medical College

Qingdao, China

Qingdao Medical College

Qingdao, China
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Wang W.,Qingdao University | Zhao C.,Qingdao University | Ji Q.,Qingdao University | Liu Y.,Weifang Nursing Vocational College | And 2 more authors.
BMC Pediatrics | Year: 2015

Backgrounds: Catheter-related infections (CRIs) are one of the severe complications of PICC placement. If treatment is not timely or correct, the incidence of infection and mortality rate can be high. A central line bundle (CLB) guideline was first proposed by the Institute for Healthcare Improvement, and included five key measures. Very low-birth-weight infants (VLBWIs) have a low immune response and indistinct symptoms after infection compared with other populations (Costa P, Kimura AF, de Vizzotto MP, de Castro TE, West A, Dorea E. Prevalence and reasons for non-elective removal of peripherally inserted central catheter in neonates. Rev Gaucha Enferm. 2012;33:126-33). Some reviews have focused on the effect and safety of a CLB in VLBWIs and its preventive effect on bacterial colonization and infection. Methods: Fifty-seven VLBWIs who underwent PICC insertion at a hospital in Qingdao, China, between November 2012 and June 2013, and for whom a CLB guideline and a standard checklist were adopted, were included in the CLB group. In contrast, 53 VLBWIs who underwent PICC insertion, but for whom a CLB guideline and a standard checklist were not adopted, were included in the control group. The incidence of CRIs was compared between before and after the treatment. Results: The incidence of infection showed a statistically significant reduction from 10.0 to 2.20 per 1000 catheter days in the control group (P?


PubMed | Weifang Nursing Vocational College, Qingdao Medical College and Qingdao University
Type: | Journal: BMC pediatrics | Year: 2015

Catheter-related infections (CRIs) are one of the severe complications of PICC placement. If treatment is not timely or correct, the incidence of infection and mortality rate can be high. A central line bundle (CLB) guideline was first proposed by the Institute for Healthcare Improvement, and included five key measures. Very low-birth-weight infants (VLBWIs) have a low immune response and indistinct symptoms after infection compared with other populations (Costa P, Kimura AF, de Vizzotto MP, de Castro TE, West A, Dorea E. Prevalence and reasons for non-elective removal of peripherally inserted central catheter in neonates. Rev Gaucha Enferm. 2012;33:126-33). Some reviews have focused on the effect and safety of a CLB in VLBWIs and its preventive effect on bacterial colonization and infection.Fifty-seven VLBWIs who underwent PICC insertion at a hospital in Qingdao, China, between November 2012 and June 2013, and for whom a CLB guideline and a standard checklist were adopted, were included in the CLB group. In contrast, 53 VLBWIs who underwent PICC insertion, but for whom a CLB guideline and a standard checklist were not adopted, were included in the control group. The incidence of CRIs was compared between before and after the treatment.The incidence of infection showed a statistically significant reduction from 10.0 to 2.20 per 1000 catheter days in the control group (P<0.05). The incidence of catheter-related bloodstream infections decreased from 3.1 to 0 per 1000 catheter days, and that of colonization infections decreased from 6.9 to 2.2 per 1000 catheter days (P<0.05), both of which indicated a statistically significant difference. The indwelling catheter time was 24.87.4 days in the control group and 31.915.0 days in the study group (P<0.05), and these values were significantly different.The use of a CLB guideline with a standard checklist could be effective and feasible for preventing CRIs in VLBWIs and prolonging indwelling catheter time.


Zhang T.-T.,Qingdao Medical College | Yao Y.-S.,Qingdao Medical College | Zhang J.,Qingdao Medical College | Qi Y.-Y.,Qingdao Medical College | And 2 more authors.
Chinese Journal of Cancer Biotherapy | Year: 2011

Objective: To explore the expressions of EGFR (epidermal growth factor receptor), serine/threonine kinase ERK, extracellar signal regulated kinase AKT mRNA in epithelial ovarian cancers and their relevant clinical significance. Methods: Sixty-one samples were obtained from epithelial ovarian cancer ESCC patients who were diagnosed in Affiliated Hospital of Qingdao Medical College from Dec. 2008 to Apr. 2010. The expressions of EGFR, ERK and AKT mRNA in epithelial ovarian cancer, benign ovarian tumor and normal ovarian tissues were detected by RT-PCR, and their clinical significance was evaluated using the clinicopathological parameters of the epithelial ovarian cancers. Results: The positive rates of EGFR, ERK and AKT mRNA expressions in epithelial ovarian cancer tissues (78.7% vs 14.3%, 31.3%, 80.3% vs 35.7%, 35.7%, 90.2% vs 21.4%, 25.0%; P < 0.01, respectively) were significantly higher than those in the benign ovarian tumor and normal ovarian tissues. The expressions of EGFR and AKT mRNA were correlated with the tumor stage, differentiation degree, and lymphatic metastasis of epithelial ovarian cancers (P <0.05), but not with their histological types and patient ages (P >0.05). The expression of ERK mRNA was correlated with the differentiation degree of epithelial ovarian cancers (P <0.05). Conclusion: The expressions of EGFR, AKT and ERK are correlated with the development and progression of epithelial ovarian cancers.

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