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Qingdao, China

Duan S.-R.,Harbin Medical Colleges | Wang J.,Harbin Medical Colleges | Teng W.,Qingdao Fuwai Hospital | Xu R.,Harbin Medical Colleges
Neurological Research | Year: 2010

Objectives: We investigated the relationship between glial cell line-derived neurotrophic factor (GDNF), nestin, and the activation of endogenous neural stem cells (NSCs) following cerebral infarction in humans. Methods: Post-mortem brain specimens from patients who died following cerebral infarction were examined. Results: Compared with the controls, the number of nestin-positive cells was increased at 4•5-10 hours in the subgranular zone of the hippocampus dentate gyrus and at 24-72 hours in the subventricular zone, reaching maximum levels at 120-144 hours. Cell numbers decreased at 216-326 hours, but remained elevated compared with controls. Similar results were found when examining the expression of GDNF following ischemia. Furthermore, the expression of nestin and GDNF showed a statistically significant positive correlation over time. Conclusions: Our results indicate that, as in other mammals, proliferation of endogenous neural stem cells in the subventricular zone and subgranular zone of the hippocampus dentate gyrus of humans is activated by cerebral infarction and may be related to increases in GDNF expression. © 2010 Maney Publishing.

Liao Z.,Chinese Academy of Sciences | Chang Y.,Qingdao Fuwai Hospital | Ma J.,Chinese Academy of Sciences | Fang P.,Chinese Academy of Sciences | And 8 more authors.
Circulation: Arrhythmia and Electrophysiology | Year: 2012

Background: We sought to investigate the feasibility of radiofrequency catheter ablation of atrioventricular node reentrant tachycardia and the ideal site for slow pathway (SP) ablation in congenitally corrected transposition of the great arteries. Methods and Results: Nine patients with congenitally corrected transposition of the great arteries referred for catheter ablation of atrioventricular node reentrant tachycardia were studied. A single His potential was recorded in 8 patients (89%, 6 {S,L,L} and 2 {I,D,D}). The earliest atrial activation during retrograde atrioventricular node conduction occurred at His bundle region (HBE; n=7) or shifting from HBE to coronary sinus ostium (n=1, {S,L,L}). Two anatomically separate His potentials were recorded in 1 patient (11%, {S,L,L}), one at the anteroseptum (HBE-1) and the other at the confluence of the pulmonary and mitral annulus (HBE-2). In 8 cases with a single His potential recorded, SP was abated at the posterior-midseptum, 2 ({S,L,L}) at the right posteroseptum, 1 ({S,L,L}) at the left posteroseptum, and 5 (3 {S,L,L} and 2 {I,D,D}) at the midseptum after failure of energy application at the posteroseptum. Junctional rhythm was observed during radiofrequency catheter ablation in all 8 of the cases. In the remaining patient with 2 anatomically separate His potentials recorded, SP was successfully ablated from the confluence of the pulmonary and mitral annulus, slightly below the HBE-2. Junctional rhythm was also induced during radiofrequency catheter ablation. Conclusions: In {S,L,L} or {I,D,D}, radiofrequency catheter ablation of atrioventricular node reentrant tachycardia is feasible. SP input region can mainly be found in the posterior midseptum, especially in patients with single penetrating atrioventricular nodes. SP could usually be successfully ablated in these regions. © 2012 American Heart Association, Inc.

Yang C.-W.,Qingdao Fuwai Hospital | Li J.-Y.,Qingdao Fuwai Hospital
Chinese Journal of Medical Imaging Technology | Year: 2013

Intramural hematoma (IMH) is defined as localized hemorrhage within the aortic wall, which is included in the acute aortic syndrome spectrum with aortic dissection and penetrating atherosclerotic aortic ulcer. The epidemiological, pathological and imaging features of IMH were reviewed in this article.

Shang X.,Peking Union Medical College | Li J.,Qingdao Fuwai Hospital | Tao Q.,Peking University | Li J.,Peking Union Medical College | And 9 more authors.
PLoS ONE | Year: 2013

Objective:To determine whether educational level and overweight/obesity was associated with the development of diabetes among Chinese adult men and women.Methods:A cohort (2000-2011) of 10 704 participants aged 18-59 years (8 238 men, 2 466 women) in Qingdao Port Health Study (QPHS) were recruited in this study. The personal lifestyle, height, weight, waist circumference, resting heart rate, blood pressure, fasting blood glucose, total cholesterol, triglycerides and plasma uric acid were collected annually in a comprehensive health checkup program. Cox proportional hazards regression models were used to estimate the association of factors and incidence of diabetes.Results:During 110 825 person-years of follow-up, 1 056 new onset cases (9.5 per 1 000 person-years) of diabetes were identified. With normal weight as reference, the multiple-adjusted hazard ratio (HR) (95%CI) of diabetes was 1.69(1.38-2.09) for overweight and 2.24(1.66-3.02) for obesity among men, which was 1.81(1.12-2.92) and 2.58(1.37-4.86) among women, respectively. Compared with the participants with high educational level, those with low educational level had a higher risk of diabetes (multiple-adjusted HR (95%CI): 1.43(1.11-1.86)) among men. The association was not found among women and the adjusted HR (95%CI) of diabetes was 1.56(0.89-2.76). The increased risks of low educational level were independent of mediators among men, through normal weight (P for trend = 0.0313) and overweight (P for trend = 0.0212) group but not obesity group (P for trend = 0.0957).Conclusion:Baseline overweight/obesity was an independent risk factor for diabetes for both men and women. Low educational level was adversely associated with incidence of diabetes through normal weight, overweight and obesity groups, with the association being substantially attenuated by mediating factors only in the obesity group among men. The association was not found among women. © 2013 Shang et al.

Wang G.,Qingdao University | Xu P.,Qingdao University | Feng W.,Beijing Fuwai Hospital | Jiang X.,Qingdao Fuwai Hospital | And 2 more authors.
Iranian Journal of Basic Medical Sciences | Year: 2015

Objective(s): To investigate the association of single nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptors gamma (PPARG) with essential hypertension (EH) and additional role of gene- high-density lipoprotein cholesterol (HDL) interaction. Materials and Methods: A total of 1640 patients with EH (806 males, 834 females), with a mean age of 52.5±12.6 years, were selected, including 816 EH patients and 824 controls, who were enrolled from the community. Three SNPs were selected for genotyping in the case-control study: rs10865710, rs709158, rs1805192. Logistic regression model was used to examine the interaction between SNP and HDL on EH, odds ratio (OR) and 95% confidence interval (95% CI) were also calculated. Results: All genotypes were distributed according to Hardy-Weinberg equilibrium in controls. Logistic regression analysis showed an association between genotypes of variants in rs1805192 and decreased EH risk, EH risk was significantly lower in carriers of Ala allele of the rs1805192 polymorphism than those with Pro/Pro (Pro/Ala+ Ala/Ala versus Pro/Pro, adjusted OR (95% CI) =0.65 (0.53-0.83), after covariate adjustment. In addition, the Ala allele of the rs1805192 polymorphism was also associated with diastolic blood pressure (DBP), but not systolic blood pressure (SBP), we also found, by interaction analysis, combined effect of rs1805192 and HDL on EH risk after covariate adjustment. Conclusion: Our results support an important association between rs1805192 minor allele (Ala allele) of PPARG and lower EH risk, the interaction analysis showed a combined effect of Ala- HDL on lower EH risk. © 2015, Mashhad University of Medical Sciences. All rights reserved.

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