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Hao Z.,Qingdao Agricultural University | Zhao Y.,Qingdao Continent Pharmaceutical Co. | Wu H.,China Institute of Veterinary Drug Control | Hao L.,China Institute of Veterinary Drug Control | And 3 more authors.
Journal of Animal and Veterinary Advances | Year: 2012

The aim of the study was to investigated the influence of dietary inclusion of tulathromycin at 5mg kg-1 die on haematological to provide an experiment support for the clinical use of this drug. Eighteen pigs were randomly allocated to three treatment groups. A further six pigs were left untreated as controls (group NTXL). Tulathromycin was administered twice by the oral route administrations of 5, 15, 25mg kg-1 B. W. in three treatment groups on the 1 st and the 4th day, respectively. Blood samples were taken from all animals on days 1, 17, 14 for serum chemical and hematology evaluation. Weight and temperature were measured from all animals at the same time. Comparisons of mean physical examination parameters between treatment and control groups over the 14 day study period revealed no significant differences (p>0.05). All pigs did not show any signs of discomfort after Premix. Hematology evaluation indicated that comparisons of RBC, WBC, HGB, HCT, MCV, MCH, MCHC and PLT between treatment and control groups also revealed no significant differences (p>0.05). AST, ALT, ALP, ALB, BUN were significantly higher in treated groups when compared with the control group (p<0.05) post-treatment. No significant differences as time goes on suggesting that a slight effect of injury on liver was caused by tulathromycin. The safety of tulathromycin Premix in target animal swine indicated that pigs were administered of 5-25mg kg-1 B. W. via the oral route satisfied clinicians' demands. © Medwell Journals, 2012. Source


Hao Z.,Qingdao Agricultural University | Zhao Y.,Qingdao Continent Pharmaceutical Co. | Qu B.,Qingdao Agricultural University | Wu H.,China Institute of Veterinary Drug Control | And 4 more authors.
Journal of Animal and Veterinary Advances | Year: 2012

The objective of this study was to campare different pharmacokinetic parameters of a locally manufactured (Tulathromycin Injection, CONTINENT, China) and reference (Draxxin, Pfizer, USA) formulation of tulathromycin 2.5 mg injection after intramuscular administration of a single dose. Twelve pigs were randomly allocated to two treatment groups. Blood samples were collected by venipuncture of the jugular vein or anterior vena cava, plasma samples were analyzed by High-Performance Liquid Chromatography (HPLC) with tandem mass spectrometry detection (LC-MS/MS) using ESI. Mean puis or minus Standard Deviation (SD) of peak plasma Concentration (Cmax) Area Under the serum Concentration-time curve (AUC0-t), Area Under the serum Concentration-time curve (AUCinf), serum concentration half-life (t1/2) were 4.32±1.52 and 5.86±1.28ugmL-1,3.98±1.63and4.24±1.30ughmL-1,4.04±1.67 and4.65±2.01 ugh mL-1, 83.55±12.84 and 79.25±10.64 h for the locally manufactured (tested) and reference formulation, respectively. The 90% confidence intervals of the mean of the difference between log-transformed values for AUC0-360, AUC0-∝ and Cmax were within the bioequivalence accepted range of 80-125%. The results indicate that tulathromycin was rapidly absorbed, eliminated slowly and highly bioavailable following a single dose which make tulathromycin likely to be effective in swine. © Medwell Journals, 2012. Source


Hao Z.,Qingdao Agricultural University | Zhao Y.,Qingdao Continent Pharmaceutical Co. | Qu B.,Qingdao Agricultural University | Wu H.,China Institute of Veterinary Drug Control | And 3 more authors.
Journal Wuhan University of Technology, Materials Science Edition | Year: 2013

Gelatin ceftiofur alkali microsphere was prepared to observe its characteristics and evaluate preservation conditions. The glutaraldehyde was increased and the carboxylic methyl chitosan was added to improve the microsphere. The experimental results show microspheres have a better morphology surface and fairly regular structure with 4% glutaraldehyde. The average particle size is 15.84 urn and particle size distribution is narrow which shows a good uniformity. Microsphere size was affected by the stirrer speed, dosing ratio and curing degree. The greater drug loaded is, the better microspheres loading is; but with the increase of drug loading rate, the entrapment efficiency increases first and then decreases. The drug release rate of the microsphere is 24.90% in 0.5 h and 84.90% in 48 h, when CMC-GMs with 4% curing agent is 32.03% in 0.5 h and 88.44% in 48 h. So Gms embedding of ceftiofur alkali are better than CMC-GM. The stability tests show that strong light, high temperature, high humiditv have a great influence on the microspheres. © Wuhan University of Technology and SpringerVerlag Berlin Heidelberg 2013. Source

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