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Li N.,Changchun University of Chinese Medicine | Zhao L.,Jilin University | Lin Z.,Changchun University of Chinese Medicine | Li J.,Changchun University of Chinese Medicine | And 7 more authors.
Journal of Liquid Chromatography and Related Technologies | Year: 2015

A metabonomics study using RRLC-Q-TOF/MS was performed to obtain a systematic view of the osteoporosis and anti-osteoporosis effects of velvet collagen hydrolysate. Combined with multivariate statistics, the urinary difference was determined between the model group and control group and between the treatment group and model group. Biochemical and pathway analyses were also performed to validate the osteoporosis model and investigate the anti-osteoporosis effect of velvet collagen hydrolysate. A clear separation trend was observed in the PCA scores plot. A total of five compounds were identified as significantly changed metabolites in the urine samples and may be potential biomarkers. This study demonstrates that the action mechanism of velvet collagen hydrolysate on osteoporosis may involve the regulation of amino acid metabolism and phospholipid metabolism. © Taylor & Francis Group, LLC. Source

Li L.L.,Qianwei Hospital of Jilin Province
Zhonghua nan ke xue = National journal of andrology | Year: 2012

The self-renewal and differentiation of adult stem cells are closely related to their niches. Naturally, spermatogonial stem cells (SSCs) are the only adult stem cells in the body, which can transfer genetic information into the offspring. An insight into the modulation of the self-renewal and differentiation of SSCs can help elucidate the mechanisms of spermatogenesis and investigate the proliferation and differentiation of other adult stem cells. Therefore, the SSC system provides an ideal model for researches on the adult stem cell niche. More and more evidence indicates that the self-renewal and differentiation of SSCs are regulated by their niches. Based on our previous work and other related findings recently reported, this article presents an overview on the biological properties of SSC niches and their relationship with the self-renewal and differentiation of SSCs, focusing on the basic properties and components of SSC niches and various regulatory factors they produce. Source

Sun H.,Jilin University | Zhang L.,Jilin University | Han X.,Qianwei Hospital of Jilin Province | Wang Z.,Jilin University | Xu L.,208th Hospital of Peoples Liberation Army Chinese
Pakistan Journal of Medical Sciences | Year: 2016

Objective: To compare the effects of thoracotomy and total thoracoscopic surgery on coronary artery fistulae complicated with ectasia. Methods: Forty-six patients with coronary artery fistulae complicated with ectasia were randomly divided into a treatment group and a control group (n=23) which were given totally thoracoscopic surgery and thoracotomy respectively. Both groups were followed up. Results: All patients survived the surgeries and were discharged from the hospital. The treatment group had significantly less intraoperative blood loss, earlier postoperative ambulation and shorter postoperative hospitalization stay more than those of the control group (P<0.05). The two groups had similar plasm cortisol and adrenocorticotropic hormone levels one day before and after surgery. These levels peaked on the postoperative 3rd day, but those of the treatment group were significantly lower (P<0.05). The two groups had similar left and right atrial diameters as well as left ventricular ejection fractions (LVEFs) before surgery, but the treatment group had significantly higher postoperative LVEF (P<0.05) as well as significantly smaller left and right atrial diameters in the postoperative 1st and 3rd months (P<0.05). The treatment group was significantly less prone to postoperative complications such as chest pain, atelectasis and pulmonary infection than the control group (P<0.05). Conclusion: Total thoracoscopic surgery promoted the recovery of coronary artery fistulae complicated with ectasia, improved cardiac remodeling and cardiac function, and alleviated stress reaction, with well- proved safety. © 2016, Professional Medical Publications. All rights reserved. Source

Pang L.,Jilin University | Bian M.,Qianwei Hospital of Jilin Province | Zang X.-X.,Jilin University | Wu Y.,Jilin University | And 7 more authors.
Journal of Biochemical and Molecular Toxicology | Year: 2013

The purpose of this study was to evaluate the efficacy of erythropoietin (EPO) for treating patients with carbon monoxide (CO) poisoning. We conducted a randomized, prospective study of 103 patients with CO poisoning in two groups: an EPO group (n = 54; patients received EPO) and a placebo group (n = 49; patients received normal saline). The study endpoints were the functional outcome at day 30 (the Barthel index and neurologic sequelae), National Institutes of Health Stroke Scale (NIHSS) score, and the levels of S-100β. At 18 days, the NIHSS score improved significantly and S-100β levels significantly decreased in patients in the EPO group. At 30 days, patients in the EPO group had a superior Barthel index and fewer patients had delayed neurologic sequelae (DNS). This study demonstrated that early administration of EPO to patients with CO poisoning improved neurological outcomes and reduced the incidence of DNS. © 2013 Wiley Periodicals, Inc. Source

Pang L.,Jilin University | Wu Y.,Jilin University | Dong N.,Jilin University | Xu D.-H.,Jilin University | And 7 more authors.
Clinical Biochemistry | Year: 2014

ObjectiveUbiquitin C-terminal hydrolase-L1 (UCH-L1) has been established as a reliable and potential biomarker of neuronal damage after acute neurologic insults, such as ischemic stroke, subarachnoid hemorrhage, and traumatic brain injury. However, the effect of serum UCH-L1 levels has not been investigated in carbon monoxide (CO)-poisoned patients. The aim of the present study was to evaluate whether serum UCH-L1 levels are a reliable marker of brain damage and the association of UCH-L1 with outcome. Design and methodsThis case-control study enrolled 46 CO-poisoned subjects and 30 controls. Using an enzyme-linked immunosorbent assay (ELISA) kit, we studied the temporal profile of serum UCH-L1 levels at 6, 12, 24 and 48. h after acute CO poisoning. Poisoning severity was assessed using the Glasgow Coma Scale (GCS) score. Long-term outcome was assessed using the Glasgow Outcome Scale (GOS) at 6. months after poisoning. ResultsCompared with controls, CO-poisoned patients had significantly elevated serum levels of UCH-L1 at each time point after poisoning. There were significantly higher levels of UCH-L1 in CO-poisoned patients with a lower GCS score as well as in those with a poor 6-month outcome dichotomized GOS. ConclusionsSerum levels of UCH-L1 appear to have potential clinical utility in providing valuable information about poisoning severity and outcome after CO poisoning. © 2013. Source

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