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Li Q.,Qianghai Institute for Endemic Disease Prevention and Control | Zhao Z.-J.,Qianghai Institute for Endemic Disease Prevention and Control | Yang P.-Z.,Qianghai Institute for Endemic Disease Prevention and Control | Xu X.-Q.,Qianghai Institute for Endemic Disease Prevention and Control | And 5 more authors.
Biological Trace Element Research | Year: 2015

Selenium deficiency is an important environmental risk factor of Kaschin-Beck disease (KBD), and appropriate selenium supplement can reduce the prevalence of KBD. Guide and Xinghai counties, active endemic areas of KBD in Qinghai Plateau, are characteristic with low level of selenium. The aim of this article was to explore the relationship between selenium content and prevalence of children KBD in some active endemic areas from Guide and Xinghai counties. The historical data of KBD were collected, including the detectable rates of KBD and selenium contents of the hair of children, and then the relationship between the prevalence of KBD and selenium contents of hair was analyzed. In KBD endemic areas of Guide County, the detectable rates of X-ray and metaphysic lesion were declined from 25.00 and 16.96 % in 2000 to 13.75 and 13.75 % in 2010, respectively. Similarly, in KBD endemic areas of Xinghai County, the detectable rates of X-ray and metaphysic lesion were declined from 46.51 and 40.31 % in 2000 to 10.64 and 8.51 % in 2010, respectively. The selenium contents of hair in Xinghai county were increased from 130.01 ± 48.08 μg/kg in 2003 to 211.8 ± 86.64 μg/kg in 2010(t = 2.98, P < 0.05); the selenium content of hair in Guide County were increased from 142.30 ± 62.02 μg/kg in 2003 to 182.09 ± 78.46 μg/kg in 2010 (t = 3.12, P < 0.05). There was a negative correlation between the prevalence of KBD and selenium contents of hair (r = −0.785). There was a close relationship between selenium content and prevalence of KBD. Selenium could reduce the prevalence of KBD, so it is very necessary to supplement selenium appropriately for KBD prevention. © 2015 Springer Science+Business Media New York


Sun L.-Y.,Harbin Medical University | Li Q.,Qianghai Institute for Endemic Disease Prevention and Control | Meng F.-G.,Harbin Medical University | Fu Y.,Harbin Medical University | And 2 more authors.
Biological Trace Element Research | Year: 2012

It has been strongly suggested that two factors are involved in the development of Kaschin-Beck Disease (KBD), namely grains contamination with T-2 toxin and selenium deficiency. So our team undertook a survey about grains and drinking water in three rural KBD endemic villages and one non-KBD village in Qinghai Province. The level of T-2 toxin contamination in 364 grain samples was assayed using an ELISA kit. The selenium concentration in these grains and 15 drinking water samples from three KBD endemic villages were determined using the 2,3-diaminonaphthalene fluorometric assay. The results revealed that the level of T-2 toxin contamination in the samples from three KBD endemic villages was relatively high with an average level of 78.91 ng/g in wheat and 47.47 ng/g in flour. The T-2 toxin level in samples from the non-KBD village (12.23 ng/g) was significantly lower than that of local grains from the three KBD endemic villages. The average selenium content in wheat and flour from KBD areas was 0.0045 and 0.0067 μg/g, respectively. The selenium concentration in local grain samples was significantly lower than that in samples from the non-KBD village (0.0604 μg/g). In addition, the selenium concentration in drinking water from three KBD endemic villages was also low (0.156 μg/L). These results support a potential role of T-2 toxin contamination and selenium deficiency in KBD. Compared with non-KBD endemic areas, health hazards in grains and in the environment of KBD endemic areas were observed. © 2012 Springer Science+Business Media, LLC.


Zhao Z.-J.,Qianghai Institute for Endemic Disease Prevention and Control | Li Q.,Qianghai Institute for Endemic Disease Prevention and Control | Yang P.-Z.,Qianghai Institute for Endemic Disease Prevention and Control | Wang H.,Qianghai Institute for Endemic Disease Prevention and Control | And 3 more authors.
Biological Trace Element Research | Year: 2013

There is a close relationship between selenium deficiency and Kaschin-Beck disease (KBD). Although the etiology of KBD is not known and selenium deficiency is not its actual cause, it is an important environmental risk factor. In particular, in the Qing-Tibet Plateau, a selenium-deficient region, the prevalence of KBD is serious and still increasing and continues to damage public health. By providing selenium to the population in appropriate amounts, and especially to children, KBD can be effectively controlled and prevented. © 2013 Springer Science+Business Media New York.

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