Dun Z.,Shandong University |
Zhu S.,Shandong University |
Jiang H.,Qianfoshan Hospital
Journal of International Medical Research | Year: 2013
ObjectiveFrame-based stereotactic surgical planning systems (SSPSs) have been used for deep brain stimulation and radioneurosurgery. Here, we evaluated the feasibility, safety and efficacy of using a SSPS to aid spontaneous intracerebral haematoma (ICH) treatment.MethodsPatients with moderate spontaneous putamen haematomas were randomized into two groups: treatment (group A) and control (group B). In group B, the catheter for evacuating haematomas was inserted into a target point, located at the centre of the haematoma, using conventional frame-based stereotactics; urokinase thrombolysis was subsequently delivered through the catheter. In group A, this procedure was assisted by a SSPS, which designed both the target point and trajectory in the haematoma through virtual reality. Duration of evacuating haematomas and number of urokinase injections was compared between groups.ResultsIn total, 65 patients were recruited: in group A (n = 30), the duration of evacuating haematomas (35.27 ± 9.17 h) was shorter than in group B (n = 35; 67.77 ± 13.82 h). There were fewer urokinase injections in group A (3.63 ± 1.16) than in group B (6.40 ± 1.29).ConclusionsThe feasibility, efficacy and safety of spontaneous ICH treatment were optimized by the use of a frame-based SSPS. © The Author(s) 2013.
Ling J.,Michigan State University |
Anderson L.M.,State University of New York at Buffalo |
Ji H.,Qianfoshan Hospital
School Psychology International | Year: 2015
This article reviews the results of a school-based self-management intervention for Chinese obese children at risk for metabolic syndrome. Twenty-eight Chinese obese children (M age = 10 years) and their parents participated in the study. Metabolic syndrome risk factors were measured pre- and post-intervention. The risk factors included Body Mass Index, waist circumstance, systolic blood pressure, diastolic blood pressure, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, High-sensitivity C-reactive Protein, fasting plasma glucose, and fasting blood insulin. After 6 months of school-based self-management intervention, all risk factors with the exception of triglycerides and fasting plasma glucose changed significantly in the healthful direction (p < 0.01). This pilot study offers promising implications for school interventions that are delivered by school-based practitioners collaborating with parents, teachers, and children. An individualized program based on a self-care and -management framework may have utility as a relatively cost-effective, school-based intervention to improve children’s health. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav
Human placenta-derived mesenchymal stem cells suppress T cell proliferation and support the culture expansion of cord blood CD34+ cells: A comparison with human bone marrow-derived mesenchymal stem cells
Luan X.,Binzhou Medical University |
Li G.,Qianfoshan Hospital |
Wang G.,Binzhou Medical University |
Wang F.,Binzhou Medical University |
Lin Y.,Red Cross
Tissue and Cell | Year: 2013
Human placenta-derived mesenchymal stem cells (hPMSCs) have been shown to possess immunosuppressive effects against T cells and support the expansion of hematopoietic stem/progenitor cells (HSPCs) from umbilical cord blood (UCB). However, the characteristics of hPMSCs compared with human bone marrow-derived mesenchymal stem cells (hBMSCs) are not fully understood. Here, we show that hPMSCs have similar regulatory effects on T cell activation, proliferation and cytokine secretion as hBMSCs and demonstrate that PDL1 and B7H4, negative co-stimulatory molecules, are involved in the T cell immunosuppressive activities of hPMSCs and hBMSCs, respectively. hPMSCs efficiently enhanced the expansion of CD34+ cells from UCB compared with hBMSCs. Furthermore, hPMSCs maintained the expression of adhesion molecules (CD11a, CD44 and CD49e) in CD34+ cells. Similar effects were observed for both hPMSCs and hBMSCs on CD34+ cell chemotaxis and cytokine production, such as SDF-1α, IL-6 and SCF. Therefore, hPMSCs may be an ideal alternative source of hBMSCs for basic research and clinical applications, which may be significant in future efforts to explore the potential clinical utility of hPMSCs. © 2012 Elsevier Ltd.
Li Y.,Shandong University |
Cao F.,Shandong University |
Cao D.,Qianfoshan Hospital |
Wang Q.,Shandong University |
Cui N.,Shandong University
Journal of Pediatric Surgery | Year: 2012
Background/Purpose: Posttraumatic growth (PTG) is a positive psychological change, or benefit, as a result of a major life trauma and/or loss. The role of emotional intelligence (EI), social support, self-efficacy, posttraumatic stress symptoms (PTSS), and resilience in PTG was evaluated in parents of children undergoing a surgical procedure for congenital disease. Methods: A questionnaire survey was conducted in 208 parents of children undergoing inpatient surgery for correction of congenital disease at the Departments of Pediatric Surgery, Qilu and Shandong Province Hospital, China, between May and September. Posttraumatic growth was measured using the Posttraumatic Growth Inventory. The study variables were measured using the Emotional Intelligence Scale, Perceived Social Support Scale, General Self-Efficacy Scale, Posttraumatic Stress Disorder Checklist-Civilian Version, and the 10-item Connor-Davidson Resilience Scale, respectively. Hierarchical multiple regression analyses were used to identify the significant predictors. Results: Posttraumatic growth was reported in 54.3% (113) of parents. Posttraumatic growth was positively associated with EI, self-efficacy, resilience, and PTSS (total P <.05). Social support was positively associated with the domain of relating to others in the Posttraumatic Growth Inventory (r =.208, P <.01). Hierarchical multiple regression analyses indicated EI was the main predictor of posttraumatic growth, whereas resilience and PTSS were the mediators of personal resources (EI and self-efficacy), perceived social support, and the growth. Conclusions: The relationship between PTG and other variables have been examined at only one point in time. Longitudinal studies in exploring the impact of EI and other variables affecting PTG can be used to reduce the impact of bidirectionality that may have impact on the conclusions drawn. Emotional management programs should focus on the use of EI as a proactive measure for enhancing emotional well-being and promoting positive emotions. © 2012 Elsevier Inc.
Liang Z.,Shandong University |
Sun X.-Y.,Reproductive Medical Center |
Xu L.-C.,Yantaishan Hospital |
Fu R.-Z.,Qianfoshan Hospital
Medical Science Monitor | Year: 2014
Background: Increased amounts of soluble E-cadherin (E-cad) have been found in the serum in various cancers, but the role of serum soluble E-cad in the prognosis of breast cancer patients has not been explored in Asian populations. Material/Method: Blood samples from 111 consecutive patients diagnosed with breast cancer and 55 healthy controls were in-vestigated. Serum soluble E-cad expression levels were measured by enzyme-linked immunosorbent assay (ELISA) with an immunoassay kit according to the manufacturer’s directions. Kaplan-Meier analyses were used to evaluate the association between serum soluble E-cad expression level and survival. All statistical tests were 2-sided. Results: The serum levels of soluble E-cad in breast cancer patients were significantly higher than those of the control group (2218.9±319.6 ng/ml vs. 742.8±91.7 ng/ml, p<0.001). Serum levels of soluble E-cad correlated signifi- cantly with TNM stage (P=0.007), tumor grade (P=0.03), and lymph node metastasis (P<0.001). Kaplan-Meier analysis with the log-rank test indicated that high serum levels of soluble E-cad had a significant impact on overall survival (55.4% vs. 81.4%; P=0.032) and disease-free survival (36.8% vs. 67.8%; P=0.002) in breast can- cer. Multivariate analysis revealed that serum levels of soluble E-cad were independently associated with over-all survival and disease-free survival in breast cancer patients. Conclusions: Serum soluble E-cad level is an independent prognostic factor in Asian breast cancer patients. © Med Sci Monit, 2014; 20: 2776-2782.