Pyatigorsk State Pharmaceutical Academy

Stavropol kray, Russia

Pyatigorsk State Pharmaceutical Academy

Stavropol kray, Russia
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Agadzhanyan V.S.,Pyatigorsk State Pharmaceutical Academy | Oganesyan E.T.,Pyatigorsk State Pharmaceutical Academy | Abaev V.T.,North Ossetian State University
Pharmaceutical Chemistry Journal | Year: 2010

Indices of reactivity with respect to active oxygen species that resulted from quantum-chemical calculations (PM3 and AM1) have been studied in a series of hydroxyl-and methoxy-derivatives of cinnamic acid. The high antioxidant activity of 4-hydroxy-3,5-di-tert-butylcinnamic acid has been predicted and then experimentally confirmed, which can be of interest for the creation of new drugs. © 2010 Springer Science+Business Media, Inc.


Garanyan G.S.,Pyatigorsk State Pharmaceutical Academy | Khanferyan R.A.,Kuban State Medical University | Oganesyan E.T.,Pyatigorsk State Pharmaceutical Academy
Pharmaceutical Chemistry Journal | Year: 2010

The amino-acid and elemental composition of a hydrolysate based on lactic-acid bacterial cultures has been studied. The quantitative content of amino acids in the hydrolysate is determined and the analytical method is validated with respect to linearity, reproducibility, and accuracy. Investigation of the biological activity of the hydrolysate by three-day cultivation with cells showed evidence for stimulation of the expression of T-lymphocytes (CD3+) and their subpopulation with helper activity (CD4+). © 2010 Springer Science+Business Media, Inc.


Gavrilin M.V.,Pyatigorsk State Pharmaceutical Academy | Sedin A.V.,Pyatigorsk State Pharmaceutical Academy | Senchenko S.P.,Pyatigorsk State Pharmaceutical Academy
Pharmaceutical Chemistry Journal | Year: 2012

Micellar electrokinetic chromatography was used to determine the content of indole-3-carbinol in aerial parts of some plants from the family Brassicaceae. It was established that the herb of Brassica napus L. and the leaves of Brassica rapa L. had high contents of indole-3-carbinol (from 1.4 to 1.9%). In view of the potential use of Brassica napus as a source of anticancer compounds, reversed-phase HPLC was performed and revealed a significant content of flavonoids with the major aglycons quercetin, kaempferol, and isorhamnetin. © 2012 Springer Science+Business Media New York.


Airapetova A.Yu.,Pyatigorsk State Pharmaceutical Academy | Gavrilin M.V.,Pyatigorsk State Pharmaceutical Academy | Dmitriev A.B.,Pyatigorsk State Pharmaceutical Academy | Mezenova T.D.,Pyatigorsk State Pharmaceutical Academy
Pharmaceutical Chemistry Journal | Year: 2010

Agaricinic acid was extracted from the carpophore of Fomitopsis officinalis (Vill. Bond. et Sing). Its structure was established by 1H and 13C NMR spectroscopy and comparison to a standard sample (Sigma-Aldrich). The extraction was carried out using ethanol. The obtained extract was evaporated, cooled (-5°C), and purified by ether. The structure of unbranched alkyl radicals was determined using their proton spectrum. The 13C NMR spectrum and two-dimensional {13C,1H} correlation diagram showed the presence of a hydroxyl (second quaternary C atom) and three types of carboxy groups (first, second, and third C atoms). The spectrum of the extracted sample is identical to that of the standard sample of agaricinic acid. © 2010 Springer Science+Business Media, Inc.


Gavrilin M.V.,Rostov State Medical University | Senchenko S.P.,Pyatigorsk State Pharmaceutical Academy
Pharmaceutical Chemistry Journal | Year: 2014

HPLC with mass spectroscopic detection was used to demonstrate that Forsythia intermedia (Forsythia x intermedia Zabel) flowers contain flavolignans: forsythin, phillygenin, isolariciresinol and, presumptively, its derivative hydroxyisolariciresinol, as well as the phenylethanoid glycoside forsythoside A. Forsythoside A was assayed by two methods - HPLC with spectrophotometric detection and capillary electrophoresis. Forsythoside A contents in flowers reached 1.5%. © 2014, Springer Science+Business Media New York.


Dorofeyev V.,South Russia State Technical University | Dorofeyev Y.,South Russia State Technical University | Babets A.,South Russia State Technical University | Goncharova T.,South Russia State Technical University | Vodolazhenko R.,Pyatigorsk State Pharmaceutical Academy
International Powder Metallurgy Congress and Exhibition, Euro PM 2013 | Year: 2013

A reduced pure iron powder was used as a basic material in the production of wear resistant iron - molybdenum carbide composites. Content of powders of milled eutectic white iron and molyb-denum or ferromolybdenum was varied as well as the heating conditions of porous preforms prior to hot forging. In the course of the preheating the particles of cast iron fuse and wet the particles of iron and molybdenum (or ferromolybdenum). This is accompanied by carbon diffusion from cast iron parti-cles into the depth of particles of matrix and molybdenous addition as well as by the formation of fine molybdenum carbides, which are variable in stoichiometric composition. The heating conditions' opti-mization together with the performance of the normalization provided for homogenization of material on carbon as well as for absence of "soft" zones poored in carbon. Diffusive pores near carbide parti-cles are not observed. Excessive intermetallic phase at the grain boundaries of iron matrix does not precipitate. Hot forging in the presence of the liquid phase makes possible composites with high wear and thermal shock resistance resulting in a possibility of crack-free quenching in water.


Ishchenko Z.V.,Pyatigorsk State Pharmaceutical Academy | Yunusova S.G.,RAS Institute of Organic Chemistry | Gusakova S.D.,Academy of Sciences of Uzbekistan | Yunusov M.S.,RAS Institute of Organic Chemistry | And 2 more authors.
Chemistry of Natural Compounds | Year: 2013

Neutral (NL) and polar (PL) lipids including glyco- (GL) and phospholipids (PhL) were isolated and their contents were determined from seeds and rhizomes with roots (RR) of Helleborus abchasicus and H. caucasicus in two development phases that were introduced into Pyatigorsk Botanical Garden. The amount of NL in subterranean organs increased from flowering to fruiting phases. The PL content in roots of H. abchasicus increased during fruiting and was independent of the vegetation stage in H. caucasicus. GL dominated in RR. The GL and PhL ratio in seeds was practically identical. The fatty-acid composition of all lipid groups in the two development phases of the introduced plants was determined. Subterranean organs and seeds of the two Helleborus species contained alkaloids, a part of which was extracted with the PL. The alkaloid content in RR during fruiting was 0.63% in H. abchasicus; 0.49%, in seed pulp; 0.26%, in H. caucasicus; and 0.05% in seed pulp of the starting raw material mass. © 2013 Springer Science+Business Media New York.


Vernikovskii B.V.,Pyatigorsk State Pharmaceutical Academy | Stepanova E.F.,Pyatigorsk State Pharmaceutical Academy
Russian Journal of General Chemistry | Year: 2012

Data on the immobilization of proteolytic enzymes for creation of medicines for the first phase of wound healing are summarized. The most common methods of immobilization, media, and pharmaceutical forms are characterized. © Pleiades Publishing, Ltd., 2012.


Dorofeyev V.,South Russia State Technical University | Dorofeyev Y.,South Russia State Technical University | Vodolazhenko R.,Pyatigorsk State Pharmaceutical Academy | Goncharova T.,South Russia State Technical University
Proceedings of the Euro International Powder Metallurgy Congress and Exhibition, Euro PM 2011 | Year: 2011

The structure and properties of iron base powder phosphorous materials, obtained by the hot forging (HF) of porous preforms in the presence of liquid eutectic phase, have been studied. Blends were produced on the base of reduced pure iron PZhV 2.160.26 powder as well as on the base of water atomized low-alloyed iron powder Astaloy A. For alloying by phosphor, powder of milled ferrophosphorus was used. The carbon was mixed in the form of pencil graphite powder. The content of ferrophosphorus and graphite in blend, the temperature of heating of porous preforms before HF and also the temperature of sample annealing after HF were varied. Increasing the time of heating of performs prior to HF is favourable to the diffusion solution of film of liquid phosphide eutectic, which was formed at the initial stage of heating. The values of time of preliminary preform heating should be optimized. These values are heating temperature dependent. The liquid phase presence in the process of HF decrease the energy needed for material densification, but it negatively influences the plasticity and fracture toughness of samples. The performance of the sample annealing after HF provides a means for the solution of eutectic film and for the improvement of these properties.


Dorofeyev V.,South Russia State Technical University | Dorofeyev Y.,South Russia State Technical University | Vodolazhenko R.,Pyatigorsk State Pharmaceutical Academy
Proceedings of the World Powder Metallurgy Congress and Exhibition, World PM 2010 | Year: 2010

The aim of the work is to study the possibility of using of cast iron particles as the car-bonaceous additive in the manufacture of hot-deformed powder steels. Reduced pure iron PZhV 2.160.26 powder was drawn as a basis in the preparation of blends. For alloying by carbon the powders of milled cast irons (Fe-4.3C (I); Fe-3.75C-4.0Si (II); Fe-4.0C-1.2Mn-12.5Ni (III)) were used. The cast iron powder content and the duration as well as the temperature of heating of porous preforms before hot forging were varied. It is found that the increase of heating temperature in excess of 1200 0C is liable to formation of thin eutectic layer on the boundaries of particles of iron and cast iron I, II. This causes the increase of me-chanical properties of produced materials.

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