Gurgaon, India
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Hemashettar B.M.,Pvt. Ltd. | Patil R.N.,Jawaharlal Nehru Medical College | O'Donnell K.,1815 North University Street | Chaturvedi V.,New York State Department of Health | And 2 more authors.
Journal of Clinical Microbiology | Year: 2011

In this article, we describe a chronic case of rhinofacial mucormycosis caused by Mucor irregularis, formerly known as Rhizomucor variabilis var. variabilis, a rare mycotic agent in humans. The infection caused progressive destruction of the nasal septum and soft and hard palate, leading to collapse of the nose bridge and an ulcerative gaping hole. The mucoralean mold cultured from a nasal biopsy specimen was determined by multilocus DNA sequence data to be conspecific with M. irregularis. Copyright © 2011, American Society for Microbiology. All Rights Reserved.


PubMed | Fundacion Ciencia y Vida, Medivation Inc., Andrés Bello University and Pvt. Ltd.
Type: Journal Article | Journal: ACS medicinal chemistry letters | Year: 2016

The aberrant activation of B-cells has been implicated in several types of cancers and hematological disorders. BTK and PI3K are kinases responsible for B-cell signal transduction, and inhibitors of these enzymes have demonstrated clinical benefit in certain types of lymphoma. Simultaneous inhibition of these pathways could result in more robust responses or overcome resistance as observed in single agent use. We report a series of novel compounds that have low nanomolar potency against both BTK and PI3K as well as acceptable PK properties that could be useful in the development of treatments against B-cell related diseases.


Amann F.,ETH Zurich | Button E.A.,Pvt. Ltd. | Evans K.F.,ETH Zurich | Gischig V.S.,ETH Zurich | Blumel M.,University of Graz
Rock Mechanics and Rock Engineering | Year: 2011

The mechanical behavior of clay shales is of great interest in many branches of geo-engineering, including nuclear waste disposal, underground excavations, and deep well drilling. Observations from test galleries (Mont Terri, Switzerland and Bure, France) in these materials have shown that the rock mass response near the excavation is associated with brittle failure processes combined with bedding parallel shearing. To investigate the brittle failure characteristics of the Opalinus Clay recovered from the Mont Terri Underground Research Laboratory, a series of 19 unconfined uniaxial compression tests were performed utilizing servo-controlled testing procedures. All specimens were tested at their natural water content with loading approximately normal to the bedding. Acoustic emission (AE) measurements were utilized to help quantify stress levels associated with crack initiation and propagation. The unconfined compression strength of the tested specimens averaged 6.9 MPa. The crack initiation threshold occurred at approximately 30% of the rupture stress based on analyzing both the acoustic emission measurements and the stress-strain behavior. The crack damage threshold showed large variability and occurred at approximately 70% of the rupture stress. © 2011 Springer-Verlag.


Bhagwat S.,National Health Research Institute | Dalvi V.,National Health Research Institute | Chandrasekhar D.,Institute of Bioinformatics and Applied Biotechnology IBAB | Matthew T.,Institute of Bioinformatics and Applied Biotechnology IBAB | And 7 more authors.
Fertility and Sterility | Year: 2014

Objective To determine the status of α-tubulin acetylation and of testis-specific acetylable α-tubulin isoforms in asthenozoospermia. Design Research study. Setting Research institute and an infertility clinic. Patient(s) 50 men with normal sperm parameters, and 50 men with asthenozoospermia. Intervention(s) None. Main Outcome Measure(s) Western blot analyses of α-tubulin, acetylated α-tubulin, and isoforms TUBA3C, TUBA4A, and TUBA8 in Percoll separated sperm and flow cytometry, real-time reverse-transcription polymerase chain reaction, and immunofluorescent localization. Result(s) A statistically significant decrease in the expression of acetylated α-tubulin in asthenozoosperm was seen with Western blot analysis, double immunostaining by direct immunofluorescence, and flow cytometric analysis. The transcript and protein of testis-specific acetylable α-tubulin isoform TUBA3C was decreased and TUBA4A was statistically significantly increased in asthenozoosperm as compared with normal spermatozoa. TUBA8 was reduced in asthenozoosperm. Similar observations were noted by indirect immunofluorescent localization. The potential transcription factors involved in the differential expression of TUBA4A and TUBA3C have been identified. Conclusion(s) Data suggest an association of α-tubulin acetylation with asthenozoospermia. Ours is the first report to demonstrate α-tubulin isoforms in sperm, implicating their role in motility. The differential expression of TUBA3C and TUBA4A suggests that tubulin acetylation may be governed by the isoform of α-tubulin that is expressed or silenced and that this in turn is transcriptionally controlled. © 2014 by American Society for Reproductive Medicine.


Bhattacharjee S.,Pvt. Ltd.
2011 Technical Symposium at ITU Telecom World, ITU WT 11 | Year: 2011

While ICT is necessary ingredient and catalyst for achieving global development objectives, advances in and proliferation of technology in itself cannot cause desired social and economic change to occur. Technology needs to be used and manifested intelligently and judiciously to provide for a platform and a mechanism where the initiatives and inspirations for social advances can thrive. One such model of adoption of ICT, particularly mobile technology, for developing and delivering a solution framework to address the problem of unemployment through skills development in rural India, is reported in this paper. Author's objective is to compile and encapsulate the experience and present this model as a replicable unit project deployable anywhere in the world by anybody. © 2011 ITU.


Blank D.A.,HCRI Technologies International | Blank D.A.,Pvt. Ltd
SAE Technical Papers | Year: 2011

A preliminary study is made of the effectiveness of internally generated "Radical Ignition (RI) species" for NOx reduction in a NG (natural gas) Spark-Ignition (SI) 4-stroke test engine operating under lean fuel conditions at a typical SI compression ratio. The study includes both experimental and simulation analysis components. Investigated in this study is the potential for augmenting SI using a controlled presence of these RI species. The aim of their use is to lower the heat required for flame propagation under leaner than otherwise attainable fuel conditions. This lowers the NOx production. The primary generating site for these species is a set of passive mini-chambers located within the cylinder head. A modified single cylinder SI engine is used for the experimental studies. The simulation involves the chemical-kinetics of 32 species and 97 chemical reactions: solved simultaneously within the mini and main chambers as these chambers interact with each other, with the engine housing and with the manifold (exchanging energy, momentum, mass and chemical species). The study suggests that significant NOx reductions can be accomplished. Copyright © 2011 SAE International and Copyright © 2011 SIAT, India.


A method of obtaining one or more fractions from one or more plants is disclosed. The method includes subjecting one or more parts of the one or more plants to hydro-alcoholic extraction in presence of a water-insoluble solvent to obtain one or more extracts. The method further includes subjecting the one or more extracts to one or more of de-pigmentation, de-fatting and detoxification process to obtain the one or more fractions. The one or more fractions thus obtained contain a desired pharmacologically active ingredient in concentration greater than concentrations of other pharmacologically active ingredients present in the at least one fraction. Further, the one or more fractions are less toxic as compared with corresponding one or more fractions obtained by conventional methods. In addition, the one or more fractions are therapeutically more effective in various diseases as compared to one or more fractions obtained by conventional methods.


PubMed | Chiral Technologies Europe and Pvt Ltd
Type: Journal Article | Journal: Molecules (Basel, Switzerland) | Year: 2016

The chromatographic resolution of pregabalin enantiomers has been often achieved by derivatization of the molecule, in order to reach enough sensitivity at low concentrations of the minor enantiomer present in the active principle. In the present article, the development and optimization of two liquid chromatographic methods are presented for the direct resolution of pregabalin enantiomers on a chiral stationary phase (CSP) containing a zwitterionic selector derived from cinchona alkaloid and sulfonic acid (CHIRALPAK ZWIX). The key parameters for the separation as well as the compatibility of chromatographic conditions with different detection modes (ultraviolet and mass spectrometry) were investigated. The resulting methods were found to be selective, of high performance and low limits of detection (2 g/mL by UV and 1 ng/mL by MS, respectively) and quantification (6 g/mL by UV and 5 ng/mL by MS, respectively) for the minor enantiomer which is considered as a chiral impurity.


PubMed | Pfizer, Now Pfizer Inc. and Pvt. Ltd.
Type: | Journal: Bioorganic & medicinal chemistry letters | Year: 2017

The ATR pathway is a critical mediator of the replication stress response in cells. In aberrantly proliferating cancer cells, this pathway can help maintain sufficient genomic integrity for cancer cell progression. Herein we describe the discovery of 19, a pyrazolopyrimidine-containing inhibitor of ATR via a strategic repurposing of compounds targeting PI3K.


PubMed | MEDCON Pvt Ltd and Pvt Ltd
Type: | Journal: International journal of pediatric otorhinolaryngology | Year: 2016

This manuscript presents a translation and adaptation of the Common Object Token (COT) test, which assesses speech perception, into the Sinhalese language and an attempt to validate it for use on children with normal hearing (NH) and children with a cochlear implant (CI).Ninety-five children (70 with NH, 25 with a CI) participated in the study. The COT test was translated, back-translated, and evaluated by a team of experts until the Sinhalese translation was deemed acceptable. Data of Sinhalese children with NH and values of children with a CI were analysed. Internal reliability and consistency of the COT total score were determined. Lastly, a quick version of the COT test was created.The total mean scores and subtest mean scores improved with age for children with NH. For children with a CI, a strong relationship between the COT total score and device experience, i.e. hearing age, was found. A Quick Sinhalese COT test version, suitable for children with a CI, could be created from Subtests 2, 3, and 4.The Sinhalese COT test is valid for assessing the age-related development of speech perception and identification skills of children with NH. Results suggest that the COT is valid for use in children with a CI.

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