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Yan Y.,Southern Medical University | Sha Y.-H.,Southern Medical University | Li X.-Z.,Puyang Oilfield General Hospital | Wang S.-G.,Southern Medical University | And 3 more authors.
Chinese Journal of Evidence-Based Medicine | Year: 2015

To systematically review the efficacy and safety of laparoscopic Roux-en-Y gastric bypass (LRYGB) versus laparoscopic sleeve gastrectomy (LSG) for obesity and type 2 diabetes mellitus (T2DM). Methods We searched PubMed, EMbase, The Cochrane Library (Issue 8, 2014), CNKI and WanFang Data from inception to December 2014, to collect randomized controlled trials (RCTs) of LRYGB vs. LSG for obesity and T2DM. Two reviewers independently screened literature, extracted data and evaluated the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.2 software. Results A total of 8 RCTs including 828 patients were included. The results of meta-analysis showed that: There were no significant differences between the LRYGB group and the LSG group in body mass index (MD= –1.02, 95%CI –2.90 to 0.86, P=0.29), remission rate of T2DM (OR=1.11, 95%CI 0.71 to 1.73, P=0.64), reoperation rate (OR=2.74, 95%CI 1.01 to 7.42, P=0.05), level of fasting plasma glucose (MD=2.71, 95%CI -0.80 to 6.21, P=0.13), and level of serum low density lipoprotein (MD= –23.85, 95%CI –47.20 to –0.50, P=0.05). However, the LSG group had lower postoperative complication rate (OR=2.28, 95%CI 1.43 to 3.62, P=0.000 5) than that of the LRYGB group. Conclusion In short term, both LRYGB and LSG were equally efficient in the treatment of obesity and T2DM, but LSG has lower postoperative complication rate than LRYGB. Due to the limited quality and quantity of the included studies, more high quality studies are needed to verify the above conclusion. © 2015 Editorial Board of Chin J Evid-based Med. Source

Lu C.,Henan University of Traditional Chinese Medicine | Jia H.,Henan University of Traditional Chinese Medicine | Xu A.,Zhengzhou University | Tang J.,Zhengzhou University | And 3 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2014

Helicobacter pylori (Hp) infection is known to alter levels of pepsinogens (PG) and is correlated with several disease states, including gastric and cardiovascular diseases. This study sought to assess whether Hp infection is associated with hypertension as well as to identify the value of assessing the PG I/PG II ratio in patients with hypertension. The study included 396 individuals with hypertension who were assessed for infection with Hp by colloidal gold assay. Participants’ weight, height, blood pressure, and serum lipids were measured, and participants were examined for the presence of renal or ocular damage. H. pylori infection status or PG I/PG II ratio were compared against other variables (e.g., body mass index, serum cholesterol, diastolic blood pressure) by t-test or (Formula presented.) test, and Pearson’s correlation analysis was used to identify associations. Consistent with other studies, the PG I/PG II ratio of patients with Hp infection was significantly lower than that of patients without Hp infection (P < 0.001). The serum total cholesterol and triglycerides of patients with Hp infection were significantly higher than those of patients without Hp infection (P < 0.001), and the PG I/PG II ratio was negatively correlated with total cholesterol (r=-0.61) and triglycerides (r=-0.56) levels. However, there was no significant difference in hypertension severity by Hp infection status or PG I/PG II ratio. Interestingly, the PG I/PG II ratio was significantly lower in patients with hypertensive nephropathy or hypertensive retinopathy than in patients without these symptoms (P < 0.05). The areas under the receiver-operating characteristic curve were 0.77 and 0.83 in the diagnosis of nephropathy and retinopathy, respectively. These findings indicate that the PG I/PG II ratio is lower in individuals with hypertensive nephropathy and hypertensive retinopathy. Thus, the detection of the PG I/PG II ratio may be valuable for diagnostic screening for hypertensive organ damage. © 2014, E-Century Publishing Corporation. All rights reserved. Source

Zhang S.,Puyang Oilfield General Hospital | Wang X.,Zhengzhou University | Ju C.,Zhengzhou University | Zhu L.,Zhengzhou University | And 2 more authors.
International Immunopharmacology | Year: 2016

Objective To investigate the effects of Ca2 + activated potassium channel KCa3.1 and voltage-gated potassium channel Kv1.3 of B lymphocyte on inflammatory monocytes chemotaxis and the potential mechanisms. Materials and methods Thanswell test was used to detect the inflammatory monocyte (Ly-6Chi) chemotaxis caused by the B lymphocyte. Enzyme-linked immunosorbent assay (ELISA) was applied to detecting the C-C motif ligand 7 (CCL7) in cultured media. Cell counting kit-8 (CCK) was used to detect the proliferation of B lymphocytes after activation and blockage of both KCa3.1 and Kv1.3 channels. Western blot was used to detect the expression of phosphorylated extracellular signal-regulated kinase (P-ERK) of the B lymphocytes. Results When activated, B lymphocytes significantly proliferated. After application of KCa3.1 channel-specific inhibitor TRAM-34 and potent Kv1.3 channel inhibitor ShK, both B lymphocytes proliferation and Ly-6Chi monocyte chemotaxis were significantly inhibited. The expression of chemotaxis related factor CCL7 decreased remarkably. Conclusion The opening of KCa3.1 and Kv1.3 channels promote B lymphocyte activation, proliferation and Ly-6Chi monocyte chemotaxis. The increase of CCL7 secretion by B lymphocyte may explain the pro migration effects. © 2016 Elsevier B.V. All rights reserved. Source

Liu C.,Puyang Oilfield General Hospital
International Eye Science | Year: 2015

AIM: To observe the clinical effect of on-flap and off-flap epipolis laser in situ keratomileusis (EPi-LASIK) in ametropia. METHODS: Sixty-eight myopia patients (136 eyes) receiving surgical treatment were selected and divided into research group and control group according to different therapies. The patients in research group adopted off-flap EPi-LASIK and those in control group adopted on-flap EPi-LASIK. The index like uncorrected visual acuity, diopter and Haze of two groups before surgery, 1wk, 1 and 4mo after surgery was observed. RESULTS: One month after surgery, the uncorrected visual acuity of research group was 1.33±0.22 while that of control group was 1.22±0.19 (P<0.05); Cylindrical diopter of research group was 0.10±0.55D while that of control group was 0.30±0.82D (P<0.05). One week after surgery, Haze of research group was 0.22±0.15 while that of control group was 0.23±0.18 (P<0.05). CONCLUSION: On-flap and off-flap EPi-LASIK are safe and effective surgery approaches in the clinical treatment of ametropia. The presence of corneal epithelial flap has a certain effect in the postoperative clinical outcome at early stage. The impact will be gradually reduced over time. Copyright 2015 by the IJO Press. Source

Jiang T.,Capital Medical University | Tang G.-F.,Anhui Medical University | Lin Y.,Liaoning Medical University | Peng X.-X.,Capital Medical University | And 9 more authors.
Chinese Medical Journal | Year: 2011

Background Although the first leading cause of death in China was malignant neoplasms (mortality, 374.1 per 100 000 person-years), the full impact of primary brain tumors (PBT) on the healthcare system is not completely described because there are a few well documented reports about the epidemiologic features of brain tumors. This study aimed to report a comprehensive assessment on the prevalence of PBT. Methods A multicenter cross-sectional study on brain tumor (MCSBT) in China was initiated in five regional centers: Daqing (northeast), Puyang (north of China), Shiyan (center of China), Ma'anshan (center of China) and Shanghai (southeast). Prevalence rate was calculated by counting the number of people living with a PBT between October 1, 2005 and September 30, 2006 and dividing by the total population of the five communities at January 1, 2006. Estimates of prevalence were expressed as percentages and grouped according to gender and to age in fifteen-year categories. Within these strata, the rates were estimated with 95% confidence intervals (CI) using the accurate calculation of CI for Poisson distribution. A chi-square test was used to compare the various frequencies with α <0.05. Age-standardized prevalence with the direct method was calculated with the ten-year age-specific prevalence and the age distribution of population prospects: the 2008 revision.Results We estimated that the overall prevalence of PBT was 24.56 per 100 000 (95% CI, 14.85 to 34.27), and the overall prevalence of PBT in female population (30.57 per 100 000 and its 95% CI ranged from 19.73 to 41.41) was higher than that in male population (18.84 per 100 000 and its 95% CI ranged from 10.33 to 27.35). However, the discrepancy between genders was not statistically significant because the 95% CI overlapped. Of 272 cases of newly diagnosed PBT, the proportion of histological subtypes by age groups, gender was statistically different (χ 2=52.6510, P <0.0001). More than half of all reported tumors (52.57%) were either gliomas or meningiomas. For the youngest (aged from 0-19) strata of the population, glioma appeared to occur more than other subtypes, accounting for 55.56% of all of cases. The majority of brain tumors presented in those aged from 20 to 59 years was pituitary adenomas (45.12%) and gliomas (31.10%). Opposed to brain tumors in adults and teenage, gliomas only accounted for 22.22%. Meanwhile, the median ages at diagnosis of the patients with PBT were similar between males and females except for pituitary adenomas (male: 59 years old; female: 45 years old). Conclusions Age standardized prevalence of PBT is 22.52 per 100 000 (95% CI, 13.22 to 31.82) for all populations, 17.64 per 100 000 (95% CI, 9.41 to 25.87) for men, and 27.94 per 100 000 (95% CI, 17.58 to 38.30) for women. Age standardization to China's 2010 population yielded an estimated population of 304 954 cases with PBT. Our prevalence estimates provide a conservative basis on which to plan health care services and to develop programmatic strategies for surviving. In the future, it would be helpful to have long-term observed survival rates that would make the assumptions and the resulting imprecision in the current estimates unnecessary. Source

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