Purnea College

Purnia, India

Purnea College

Purnia, India
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Rao T.V.R.K.,Purnea College | Kumari P.,Purnea College | Yadav A.,Purnea College | Mishra K.K.,Purnea College
Der Pharma Chemica | Year: 2014

Aluminimum uptake by some foods from the aluminium cookware during cooking has been studied. Various food items studied were pulses of green gram (Phaseolus aureus Roxb), red gram (Cajanas cajan) and lentil (Lens escunenta), vegetables of potato (Solanum tuberosum), cabbage (Brassica oleracea), and chutneys of tomato (Lycopersicon esculentum) and tamarind (Tamarindus indica). Affect of the presence of fluoride in the cooking water on the uptake of aluminium by the foods from the aluminium cookware has also been studied. Results revealed an aluminimum uptake of 21.6 to 32.1 mg/100gm by the pulses. The vegetables uptook comparatively lower amount (4.41 to 13.54 mg) of Al. The chutneys uptook larger quantity (18.24 to 22.51 mg) of Al. pH seems to be one of the factor in deciding the quantity of aluminium uptake from the cookware. Other factors such as complexones/chelating agents of the food might also be the factors, ruling the Al uptake. Presence of fluoride (5 ppm) in the cooking water resulted in an enhanced uptake (20.09 to 43.26%) of Al from the cookware.


Rao T.V.R.K.,Purnea College | Kumar A.,Purnea College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

Mixed ligand aluminium complexes involving some natural amino acids viz., glycine, a-alanine, ?-aspartic acid or ?-glutamic acid and some natural hydroxy acids viz., malic, tartaric or citric acid have been synthesized in aqueous medium at room temperature. Analytical results suggest the complexes to be of formulae, [Al(gly)(mal)], [Al(gly)(tart)], [Al(gly)(H.cit)], [Al(aln)(mal)], [Al(aln)(tart)], [Al(aln)(H.cit)], [Al2(asp)2(mal)], [Al2(asp)2(tart)], [Al2(asp)2(H.cit)], [Al2(glu)2(mal)], [Al2(glu)2(tart)] and [Al2(glu)2(H.cit)], where, gly, aln, asp, glu, mal, tart and H. cit are glycinate, a-alaninate, ?-aspartate, ?-glutamate, malate, tartrate and citrate (dibasic) respectively. In the infrared structure, the stretching and bending modes of NH2 group of amino acids have been found to split into two or shift from their position upon complexation. This suggest a coordinated nature of amino group in the complexes. Evidence for additional hydrogen-bonding in the complexes, involving, possibly, the OH groups of hydroxy acids and NH2 groups of amino acids, is also observed in the infrared spectra of complexes. The 1H NMR spectra of the ligands and complexes also suggest coordination of NH2 group of amino acids in the complexes. Utility of the results in aluminium toxicology has been discussed.


Rao T.V.R.K.,Purnea College | Kumar A.,Purnea College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

Aluminium complexes of some natural amino acids viz., glycine, α-alanine, L-aspartic acid and L-glutamic acid have been synthesized in aqueous medium at room temperature. Analytical results suggest the complexes to be of formulae, [Al(gly)3], [Al(aln)3], [Al2(asp)3] and [Al2(glu)3], where, gly, aln, asp, and glu are glycinate, α-alaninate, L-aspartate and L-glutamate respectively. In the infrared structure, the stretching and bending modes of NH2 group of amino acids have been found to split into two or shift from their position upon complexation. This suggests a coordinated nature of amino group in the complexes. Evidence for additional H-bonding in the complexes is also observed in the infrared spectra. The 1H NMR spectra of the ligands and complexes also suggest coordination of NH2 group of amino acids in the complexes. Utility of the results in aluminium toxicology has been discussed.


Rao T.V.R.K.,Purnea College | Kumar A.,Purnea College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

Aluminium uptake by the seeds of green gram (Phaseolus aureus) from the solutions of Al3+, as well as, Al3+ mixed with different inorganic and organic anions viz., fluoride, phosphate, borate, silicate, malate, tartrate, citrate, malonate or succinate, has been studied. Effect of inorganic and organic anions on the aluminium uptake by the seeds has been observed. Percentage germination and morphogenic aspects of the plants germinated (in soil) out of intoxicated seeds has also been studied. Results revealed an expression of toxicity by the seeds upon exposure to the aluminium ions under different chemical milieu. Al uptake by the seeds exposed to 0.01M Al3+ solution has been found to be 2.16 mg/gm. Inorganic and organic anions (0.01M solution) when present in the milieu along with Al3+ were found to inhibit the Al uptake in the range of 0.46-87.5%. Silicate showed a maximum inhibition of 87.5%. Aluminium intoxicated seeds expressed severe toxicity in germination and plant growth in soil culture. Only 10% germination was seen as compared to that of 100% in the control (non-toxicated) set. Presence of different inorganic and organic anions along with Al3+ in the intoxication of seeds, could not exhibit much difference in the seed germination and plant growth as compared to that of Al- only intoxication, except malate ions. The malate had a good amelioration effect on Al toxicity. 70% germination and good plant growth was exhibited by these intoxicated (Al3+ + malate) seeds. Thus, malate seems to be a good ameliorator of aluminium toxicity.

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