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Kovacs A.T.,University of Groningen | Van Hartskamp M.,Purac | Kuipers O.P.,University of Groningen | Kuipers O.P.,Kluyver Center for Genomics of Industrial Fermentation | Van Kranenburg R.,Purac
Applied and Environmental Microbiology | Year: 2010

Bacillus coagulans has good potential as an industrial production organism for platform chemicals from renewable resources but has limited genetic tools available. Here, we present a targeted gene disruption system using the Cre-lox system, development of a LacZ reporter assay for monitoring gene transcription, and heterologous D-lactate dehydrogenase expression. Copyright © 2010, American Society for Microbiology. All Rights Reserved.


News Article | November 7, 2016
Site: www.newsmaker.com.au

Zion Research has published a new report titled “Succinic Acid Market for 1,4-BDO, Resin, Coatings, Dyes & Inks, Pharmaceutical, Polyurethane, Food, Plasticizers, Cosmetics, Solvents & Lubricants and De-Icing Solutions Applications: Global Industry Perspective, Comprehensive Analysis, and Forecast, 2014 – 2020”. According to the report, the global succinic acid market was valued at approximately USD 400.0 million in 2014 and is expected to reach approximately USD 1,000.0 million by 2020, growing at a CAGR of over 20% between 2015 and 2020. In terms of volume, global succinic acid market stood at 100.0 tons in 2014. Succinic acid is an important intermediate chemical witnessing strong demand. It is a building block chemical for producing many specialty and commodity chemicals that are used in a wide range of applications such as polymers, food, metals, pharmaceutical, coatings, fibers, solvents, lubricating oils, diesel fuel oxygenates, cosmetics, etc. This platform chemical is produced through mixed-acid fermentation of carbohydrates in a process that also yields the other valuable chemicals such as lactic acid, acetic acid, formic acid, and alcohols. Succinic acid is also known as amber acid. Succinic acid can be manufactured using conventional (crude oil based) method and by bio-based route as well. Presently, large volume of succinic acid is derived from petroleum feedstock and a small amount is produced from fermentation process. Succinic acid is widely used as a building block chemical in the manufacturing of many other chemicals. Succinic acid yields derivatives such as 1, 4-butanediol (BDO), gamma-butyrolactone (GBL), and tetrahydrofuran (THF), have high potential for use as solvents and fibers such as lycra. In addition, pyrrolidinones and N-methylpyrrolidinone can also be directly produced from succinic acid manufactured by fermentation. These organic chemicals find high demand in pharmacology. Succinic acid market is expected to witness strong growth owing to increasing demand for its derivatives. Strong demand from Asia Pacific is also expected to fuel growth of succinic acid market owing strong growth prospectus of various end-user industries in the region. However, environmental concerns and fluctuations in raw material prices are expected to be major concerns for the manufacturers of petroleum based succinic acid. On the other hand, bio-based succinic acid manufacturers are expected to face challenges such as high initial investment and high production cost as compared to petroleum based succinic acid. 1,4-BDO, resin, coatings, dyes & inks, pharmaceutical, polyurethane, food, plasticizers, cosmetics, solvents & lubricants and de-icing solutions are some of the important application markets for succinic acid. With around 20% share in total volume consumed, coatings, resins, dyes, and inks collectively was the largest application market for succinic acid in 2014. Pharmaceutical is also one of the prominent application markets for succinic acid. Pharmaceutical was the second largest application market for succinic and closely followed by polyurethane and 1, 4-BDO. 1, 4-BDO is expected to exhibit robust growth rate in the years to come. It is mainly used in the production of tetrahydrofuran (THF), polyurethane elastomers, polybutylene terephthalate (PBT), and gamma-butyrolactone. Europe was a leading regional market for succinic acid in 2014. Asia Pacific and Europe accounted for almost similar share of the total succinic acid volume consumed in 2014. However, Asia Pacific is expected to grow at rapid pace and outperform Europe in succinic acid demand by the end of 2020. This strong growth can be attributed to the rising demand for paints and coatings, polyurethane, 1,4-BDO in various end-user industries in the region. China, India, Japan and South Korea are major demand driver in the region. However, Europe will keep dominating bio-based succinic acid market all through the forecast period. Some of the key players in global succinic acid market include BioAmber Inc, Gadiv Petrochemical industries ltd, Kawasaki Kasei Chemicals Ltd, Mitsubishi Chemical Corporation , Mitsui & Co. Ltd , Myriant Corporation , Nippon Shokubai Co. Ltd, PTT Global Chemical Public Co. Ltd , Purac, BASF SE, Reverdia, Roquette Freres S.A and DSM N.V. This report segments the global succinic acid market as follows:


Succinic Acid Market for 1,4-BDO, Resin, Coatings, Dyes & Inks, Pharmaceutical, Polyurethane, Food, Plasticizers, Cosmetics, Solvents & Lubricants and De-Icing Solutions Applications: Global Industry Perspective, Comprehensive Analysis, and Forecast, 2014 – 2020 The report covers forecast and analysis for the succinic acid market on a global and regional level. The study provides historic data of 2014 along with a forecast from 2015 to 2020 based on both volumes (Tons) and revenue (USD Million). The study includes drivers and restraints of the succinic acid market along with the impact they have on the demand over the forecast period. Additionally, the report includes the study of opportunities available in the succinic acid market on a global level. In order to give the users of this report a comprehensive view on the succinic acid, we have included a detailed value chain analysis, competitive scenario and product portfolio of key vendors. To understand the competitive landscape in the market, an analysis of Porter’s five forces model for the succinic acid market has also been included. The study encompasses a market attractiveness analysis, wherein application segments are benchmarked based on their market size, growth rate and general attractiveness. The study provides a decisive view on the succinic acid market by segmenting the market based on applications and regions. All the segments have been analyzed based on present and future trends and the market is estimated from 2014 to 2020. Key application markets covered under this study includes 1,4-BDO, resin, coatings, dyes & inks, pharmaceutical, polyurethane, food, plasticizers, cosmetics, solvents & lubricants and de-icing solutions. The regional segmentation includes the current and forecast demand for North America, Europe, Asia Pacific, Latin America, and Middle East and Africa with its further bifurcation into major countries including U.S., Germany, France, UK, China, Japan, India and Brazil. This segmentation includes demand for succinic acid based on individual applications in all the regions and countries. The report covers detailed competitive outlook including the market share and company profiles of the key participants operating in the global succinic acid market include BioAmber Inc, Gadiv Petrochemical industries ltd, Kawasaki Kasei Chemicals Ltd, Mitsubishi Chemical Corporation, Mitsui & Co. Ltd, Myriant Corporation, Nippon Shokubai Co. Ltd, PTT Global Chemical Public Co. Ltd, Purac, BASF SE, Reverdia, Roquette Freres S.A and DSM N.V. The detailed description of players includes parameters such as company overview, financial overview, business strategies and recent developments of the company. This report segments the global succinic acid market as follows:


News Article | December 2, 2016
Site: www.newsmaker.com.au

MarketStudyReport.com adds “2017 Top 5 Anaerobic Digester Manufacturers in North America, Europe, Asia-Pacific, South America, Middle East and Africa" new report to its research database. The report spread across 122 pages with table and figures in it. This report studies Anaerobic Digester in Global market, especially in North America, Europe, Asia-Pacific, South America, Middle East and Africa, focuses on the top 5 Anaerobic Digester Players in each region, with sales, price, revenue and market share for top 5 manufacturer, covering Paques Veolia GE Water & Process Technologies Purac Bossco Environmental Protection Technology Shandong Meiquan Degremont ADI Systems Voith Best Environmental Technology Browse full table of contents and data tables at  https://www.marketstudyreport.com/reports/2017-top-5-anaerobic-digester-manufacturers-in-north-america-europe-asia-pacific-south-america-middle-east-and-africa/ Market Segment by Regions, this report splits Global into several key Regions, with sales, revenue, market share of top 5 players in these regions, from 2012 to 2017 (forecast), like North America (United States, Canada and Mexico) Asia-Pacific (China, Japan, Southeast Asia, India and Korea) Europe (Germany, UK, France, Italy and Russia etc. South America (Brazil, Chile, Peru and Argentina) Middle East and Africa (Egypt, South Africa, Saudi Arabia) Split by Product Types, with sales, revenue, price, market share of each type, can be divided into Up flow anaerobic sludge blanket (UASB) Internal circulation reactor(IC reactor) Expanded granular sludge bed digestion (EGSB) Others Split by applications, this report focuses on sales, market share and growth rate of Anaerobic Digester in each application, can be divided into Paper Industry Food & Beverage Industry Chemical Industry Others 9 Global Anaerobic Digester Players Profiles/Analysis 9.1 Paques 9.1.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 9.1.2 Anaerobic Digester Product Types, Application and Specification 9.1.2.1 Type 1 9.1.2.2 Type 2 9.1.3 Paques Anaerobic Digester Sales, Revenue, Price and Gross Margin (2012-2017) 9.1.4 Main Business/Business Overview 9.2 Veolia 9.2.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 9.2.2 Anaerobic Digester Product Types, Application and Specification 9.2.2.1 Type 1 9.2.2.2 Type 2 9.2.3 Veolia Anaerobic Digester Sales, Revenue, Price and Gross Margin (2012-2017) 9.2.4 Main Business/Business Overview 9.3 GE Water & Process Technologies 9.3.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 9.3.2 Anaerobic Digester Product Types, Application and Specification 9.3.2.1 Type 1 9.3.2.2 Type 2 9.3.3 GE Water & Process Technologies Anaerobic Digester Sales, Revenue, Price and Gross Margin (2012-2017) 9.3.4 Main Business/Business Overview 9.4 Purac 9.4.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 9.4.2 Anaerobic Digester Product Types, Application and Specification 9.4.2.1 Type 1 9.4.2.2 Type 2 9.4.3 Purac Anaerobic Digester Sales, Revenue, Price and Gross Margin (2012-2017) 9.4.4 Main Business/Business Overview 9.5 Bossco Environmental Protection Technology 9.5.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 9.5.2 Anaerobic Digester Product Types, Application and Specification 9.5.2.1 Type 1 9.5.2.2 Type 2 9.5.3 Bossco Environmental Protection Technology Anaerobic Digester Sales, Revenue, Price and Gross Margin (2012-2017) 9.5.4 Main Business/Business Overview 9.6 Shandong Meiquan 9.6.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 9.6.2 Anaerobic Digester Product Types, Application and Specification 9.6.2.1 Type 1 9.6.2.2 Type 2 9.6.3 Shandong Meiquan Anaerobic Digester Sales, Revenue, Price and Gross Margin (2012-2017) 9.6.4 Main Business/Business Overview 9.7 Degremont 9.7.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 9.7.2 Anaerobic Digester Product Types, Application and Specification 9.7.2.1 Type 1 9.7.2.2 Type 2 9.7.3 Degremont Anaerobic Digester Sales, Revenue, Price and Gross Margin (2012-2017) 9.7.4 Main Business/Business Overview 9.8 ADI Systems 9.8.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 9.8.2 Anaerobic Digester Product Types, Application and Specification 9.8.2.1 Type 1 9.8.2.2 Type 2 9.8.3 ADI Systems Anaerobic Digester Sales, Revenue, Price and Gross Margin (2012-2017) 9.8.4 Main Business/Business Overview 9.9 Voith 9.9.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 9.9.2 Anaerobic Digester Product Types, Application and Specification 9.9.2.1 Type 1 9.9.2.2 Type 2 9.9.3 Voith Anaerobic Digester Sales, Revenue, Price and Gross Margin (2012-2017) 9.9.4 Main Business/Business Overview 9.10 Best Environmental Technology 9.10.1 Company Basic Information, Manufacturing Base, Sales Area and Its Competitors 9.10.2 Anaerobic Digester Product Types, Application and Specification 9.10.2.1 Type 1 9.10.2.2 Type 2 9.10.3 Best Environmental Technology Anaerobic Digester Sales, Revenue, Price and Gross Margin (2012-2017) 9.10.4 Main Business/Business Overview To receive personalized assistance write to us @ [email protected] with the report title in the subject line along with your questions or call us at +1 866-764-2150


This report studies Renewable Chemicals in Global market, especially in North America, Europe, China, Japan, India and Southeast Asia, focuses on top manufacturers in global market, with sales, price, revenue and market share for each manufacturer, covering  Bioamber Inc.  Genomatica Inc.  Myriant Corporation  Dupont Tate & Lyle Bio Products Company, LLC  Cobalt Technologies Inc.  Biomethanol Chemie Nederland B.V.  Metabolix Inc.  Corbion Nv (Purac)  Natureworks LLC  Mitsubishi Chemical Corp.  Biome Technologies PLC  Reverdia  Braskem  BASF SE Market Segment by Regions, this report splits Global into several key Regions, with sales, revenue, market share and growth rate of Renewable Chemicals in these regions, from 2011 to 2020 (forecast), like  North America  China  Europe  Japan  India  Southeast Asia Split by product types, with sales, revenue, price, market share and growth rate of each type, can be divided into Alcohols  Organic Acids  Ketones  Platform Chemicals  Biopolymers  Others Split by applications, this report focuses on sales, market share and growth rate of Renewable Chemicals in each application, can be divided into  Transportation  Textiles  Food safety  Environment  Communication  Housing&Recreation  Health & Hygiene  Bio-Medical  Agriculture  Other Applications 1 Renewable Chemicals Overview  1.1 Product Overview and Scope of Renewable Chemicals  1.2 Renewable Chemicals Segment by Types  1.2.1 Global Sales Market Share of Renewable Chemicals by Types in 2015  1.2.2 Alcohols  1.2.3 Organic Acids  1.2.4 Ketones  1.2.5 Platform Chemicals  1.2.6 Biopolymers  1.2.7 Others  1.3 Renewable Chemicals Segment by Applications/End Users  1.3.1 Transportation  1.3.2 Textiles  1.3.3 Food safety  1.3.4 Environment  1.3.5 Communication  1.3.6 Housing&Recreation  1.3.7 Health & Hygiene  1.3.8 Bio-Medical  1.3.9 Agriculture  1.3.10 Other Applications  1.4 Renewable Chemicals Market by Regions  1.4.1 North America Status and Prospect (2011-2020)  1.4.2 China Status and Prospect (2011-2020)  1.4.3 Europe Status and Prospect (2011-2020)  1.4.4 Japan Status and Prospect (2011-2020)  1.4.5 India Status and Prospect (2011-2020)  1.4.6 Southeast Asia Status and Prospect (2011-2020)  1.5 Global Market Size (Value and Volume) of Renewable Chemicals (2011-2020)  1.5.1 Global Renewable Chemicals Sales and Revenue (2011-2020)  1.5.2 Global Renewable Chemicals Sales and Growth Rate (2011-2020)  1.5.3 Global Renewable Chemicals Revenue and Growth Rate (2011-2020) 2 Global Renewable Chemicals Market Competition by Manufacturers  2.1 Global Renewable Chemicals Sales and Share by Manufacturers (2015 and 2016)  2.2 Global Renewable Chemicals Revenue and Share by Manufacturers (2015 and 2016)  2.3 Manufacturers Renewable Chemicals Manufacturing Base Distribution and Product Types  2.4 Competitive Situation and Trends  2.4.1 Expansions  2.4.2 New Product Launches  2.4.3 Acquisitions  2.4.4 Other Developments 3 Global Renewable Chemicals Analysis by Regions  3.1 Global Renewable Chemicals Sales, Revenue and Market Share by Regions (2011-2020)  3.1.1 Global Renewable Chemicals Sales Market Share by Regions (2011-2020)  3.1.2 Global Renewable Chemicals Revenue Market Share by Regions (2011-2020)  3.2 North America  3.2.1 North America Renewable Chemicals Sales, Revenue and Price (2011-2020)  3.2.2 North America Renewable Chemicals Sales, Revenue and Growth Rate (2011-2020)  3.3 Europe  3.3.1 Europe Renewable Chemicals Sales, Revenue and Price (2011-2020)  3.3.2 Europe Renewable Chemicals Sales, Revenue and Growth Rate (2011-2020)  3.4 China  3.4.1 China Renewable Chemicals Sales, Revenue and Price (2011-2020)  3.4.2 China Renewable Chemicals Sales, Revenue and Growth Rate (2011-2020)  3.5 Japan  3.5.1 Japan Renewable Chemicals Sales, Revenue and Price (2011-2020)  3.5.2 Japan Renewable Chemicals Sales, Revenue and Growth Rate (2011-2020)  3.6 India  3.6.1 India Renewable Chemicals Sales, Revenue and Price (2011-2020)  3.6.2 India Renewable Chemicals Sales, Revenue and Growth Rate (2011-2020)  3.7 Southeast Asia  3.7.1 Southeast Asia Renewable Chemicals Sales, Revenue and Price (2011-2020)  3.7.2 Southeast Asia Renewable Chemicals Sales, Revenue and Growth Rate (2011-2020) 4 Global Renewable Chemicals Analysis by Types  4.1 Global Renewable Chemicals Sales, Revenue, Market Share and Growth Rate by Types (2011-2020)  4.1.1 Global Renewable Chemicals Sales and Market Share by Types (2011-2020)  4.1.2 Global Renewable Chemicals Revenue, Market Share and Growth Rate by Types (2011-2020)  4.2 Alcohols Sales, Revenue, Price and Growth (2011-2020)  4.3 Organic Acids Sales, Revenue, Price and Growth (2011-2020)  4.4 Ketones Sales, Revenue, Price and Growth (2011-2020)  4.5 Platform Chemicals Sales, Revenue, Price and Growth (2011-2020)  4.6 Biopolymers Sales, Revenue, Price and Growth (2011-2020)  4.7 Others Sales, Revenue, Price and Growth (2011-2020) 6 Global Renewable Chemicals Manufacturers Analysis  6.1 Bioamber Inc.  6.1.1 Company Basic Information, Manufacturing Base and Competitors  6.1.2 Renewable Chemicals Product Overview and End Users  6.1.2.1 Alcohols  6.1.2.2 Organic Acids  6.1.2.3 Ketones  6.1.3 Renewable Chemicals Sales, Revenue, Price of Bioamber Inc. (2015 and 2016)  6.2 Genomatica Inc.  6.2.1 Company Basic Information, Manufacturing Base and Competitors  6.2.2 Renewable Chemicals Product Overview and End Users  6.2.2.1 Alcohols  6.2.2.2 Organic Acids  6.2.2.3 Ketones  6.2.3 Renewable Chemicals Sales, Revenue, Price of Genomatica Inc. (2015 and 2016)  6.3 Myriant Corporation  6.3.1 Company Basic Information, Manufacturing Base and Competitors  6.3.2 Renewable Chemicals Product Overview and End Users  6.3.2.1 Alcohols  6.3.2.2 Organic Acids  6.3.2.3 Ketones  6.3.3 Renewable Chemicals Sales, Revenue, Price of Myriant Corporation (2015 and 2016)  6.4 Dupont Tate & Lyle Bio Products Company, LLC  6.4.1 Company Basic Information, Manufacturing Base and Competitors  6.4.2 Renewable Chemicals Product Overview and End Users  6.4.2.1 Alcohols  6.4.2.2 Organic Acids


Remus D.M.,TI Food and Nutrition | Remus D.M.,NIZO food research | Remus D.M.,Wageningen University | van Kranenburg R.,Purac | And 16 more authors.
Microbial Cell Factories | Year: 2012

Background: Bacterial cell surface-associated polysaccharides are involved in the interactions of bacteria with their environment and play an important role in the communication between pathogenic bacteria and their host organisms. Cell surface polysaccharides of probiotic species are far less well described. Therefore, improved knowledge on these molecules is potentially of great importance to understand the strain-specific and proposed beneficial modes of probiotic action.Results: The Lactobacillus plantarum WCFS1 genome encodes 4 clusters of genes that are associated with surface polysaccharide production. Two of these clusters appear to encode all functions required for capsular polysaccharide formation (cps2A-J and cps4A-J), while the remaining clusters are predicted to lack genes encoding chain-length control functions and a priming glycosyl-transferase (cps1A-I and cps3A-J). We constructed L. plantarum WCFS1 gene deletion mutants that lack individual (Δcps1A-I, Δcps2A-J, Δcps3A-J and Δcps4A-J) or combinations of cps clusters (Δcps1A-3J and Δcps1A-3I, Δcps4A-J) and assessed the genome wide impact of these mutations by transcriptome analysis. The cps cluster deletions influenced the expression of variable gene sets in the individual cps cluster mutants, but also considerable numbers of up- and down-regulated genes were shared between mutants in cps cluster 1 and 2, as well as between mutant in cps clusters 3 and 4. Additionally, the composition of overall cell surface polysaccharide fractions was altered in each mutant strain, implying that despite the apparent incompleteness of cps1A-I and cps3A-J, all clusters are active and functional in L. plantarum. The Δcps1A-I strain produced surface polysaccharides in equal amounts as compared to the wild-type strain, while the polysaccharides were characterized by a reduced molar mass and the lack of rhamnose. The mutants that lacked functional copies of cps2A-J, cps3A-J or cps4A-J produced decreased levels of surface polysaccharides, whereas the molar mass and the composition of polysaccharides was not affected by these cluster mutations. In the quadruple mutant, the amount of surface polysaccharides was strongly reduced. The impact of the cps cluster mutations on toll-like receptor (TLR)-mediated human nuclear factor (NF)-κB activation in host cells was evaluated using a TLR2 reporter cell line. In comparison to a L. plantarum wild-type derivative, TLR2 activation remained unaffected by the Δcps1A-I and Δcps3A-J mutants but appeared slightly increased after stimulation with the Δcps2A-J and Δcps4A-J mutants, while the Δcps1A-3J and Δcps1A-3J, Δcps4A-J mutants elicited the strongest responses and clearly displayed enhanced TLR2 signaling.Conclusions: Our study reveals that modulation of surface glycan characteristics in L. plantarum highlights the role of these molecules in shielding of cell envelope embedded host receptor ligands. Although the apparently complete cps clusters (cps2A-J and cps4A-J) contributed individually to this shielding, the removal of all cps clusters led to the strongest signaling enhancement. Our findings provide new insights into cell surface glycan biosynthesis in L. plantarum, which bears relevance in the context of host-cell signaling by probiotic bacteria. © 2012 Remus et al.; licensee BioMed Central Ltd.


Lutz M.,University Utrecht | Van Krieken J.,Purac
Acta Crystallographica Section C: Crystal Structure Communications | Year: 2010

The dimeric condensation product of lactic acid, namely (S,S)-2-[(2-hy-droxy-propano-yl)-oxy]propanoic acid, C6H 10O5, (I), crystallizes with two independent mol-ecules in the asymmetric unit, which both have an essentially planar backbone. The trimeric condensation product, namely (S,S,S)-3-hy-droxy-but-3-en-2-yl 2-[(2-hy-droxy-propano-yl)-oxy]propano-ate, C9H14O 7, (II), has one mol-ecule in the asymmetric unit and consists of two essentially planar parts, with the central C - O bond in a gauche conformation. Both mol-ecules of the dimer are involved in inter-molecular hydrogen bonds, forming chains with a C(8) graph set. These chains are connected by D(2) hydrogen bonds to form a two-dimensional layer. The trimer forms hydrogen-bonded C(10) and C22(6) chains, which together result in a two-dimensional motif. The Hooft method [Hooft, Straver & Spek (2008). J. Appl. Cryst. 41, 96-103] was successfully applied to the determination of the absolute structure of (I). © 2010 International Union of Crystallography.

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