Punjab Technical University is a state university located at Kapurthala highway, Jalandhar, India.It was established by an act of State Legislature on 16 January 1997, to promote technical, management and pharmaceutical education in the state of Punjab at the degree level and above. Being an education and research university, it has a mandate to set up centers of excellence in emerging technologies for promoting training and research & development in these areas. Wikipedia.
Boparai K.S.,Guru Nanak Institutions |
Singh R.,Punjab Technical University |
Singh H.,Guru Nanak Institutions
Rapid Prototyping Journal | Year: 2016
Purpose - In this study the friction and wear behavior of fused deposition modeling (FDM) parts fabricated with composite material and acrylonitrile butadiene styrene (ABS) material feedstock filament were realized and compared under dry sliding conditions. Design/methodology/approach - The tests were performed by applying the load of 5, 10, 15 and 20 N with sliding velocity of 0.63 m/s for the duration of 5 and 10 min at room temperature. Findings - The results highlight various wear mechanisms such as adhesion, abrasion and fatigue during the investigation. It was observed that the wear volume, friction force, friction co-efficient and temperature were sensitive to the applied load and time duration. The composite material showed a remarkable improvement in wear properties as compared to the ABS material. Research limitations/implications - The investigations reported in the present research work is based on comparative analysis (of composite material and ABS material feedstock filament). The results may be different in practical applications because of different operating conditions. Practical implications - The parts fabricated with proposed composite material feedstock filament are highly wear resistant than basic ABS filament. This may lead to the development of better wear resistance components for numerous field applications. Originality/value - The potential of this research work is to fabricate FDM parts with composite material feedstock filament to cater need of wear resistant industrial components. © 2016 Emerald Group Publishing Limited.
Mukhija M.,Punjab Technical University
Journal of Ethnopharmacology | Year: 2014
Ethanopharmacological relevance Zanthoxylum alatum is used in traditional medicinal systems for number of disorders like cholera, diabetes, cough, diarrhea, fever, headache, microbial infections, toothache, inflammation and cancer. The aim of the present study was to evaluate Zanthoxylum alatum stem bark for its cytotoxic potential and to isolate the bioactive constitiuents. Material and methods Cytotoxicity of the different extracts and isolated compounds was studied on lung carcinoma cell line (A549) and pancreatic carcinoma cell line (MIA-PaCa) using MTT assay. Isolation of compounds from most active extract (petroleum ether) was done on silica gel column. Structure elucidation was done by using various spectrophotometric techniques like UV, IR, 1H NMR, 13C NMR and mass spectroscopy. The type of cell death caused by most active compound C was explored by fluorescence microscopy using the acridine orange/ethidium bromide method. Result Petroleum ether extract of plant has shown significant cytotoxic potential. Three lignans sesamin (A), kobusin (B), and 4'O demethyl magnolin (C) has been isolated. All lignans showed cytotoxic activities in different ranges. Compound C was the novel bioactive compound from a plant source and found to be most active. In apoptosis study, treatment caused typical apoptotic morphological changes. It enhances the apoptosis at IC50 dose (21.72 μg/mL) however showing necrotic cell death at higher dose after 24 h on MIA-PaCa cell lines. Conclusion Petroleum ether extract (60-80 C) of Zanthoxylum alatum has cytotoxic potential. The lignans isolated from the petroleum ether extract were responsible for the cytotoxic potential of the extract. 4'O demethyl magnolin was novel compound from Zanthoxylum alatum. Hence the Zanthoxylum alatum can be further explored for the development of anticancer drug. © 2014 Elsevier Ireland Ltd.
Jamwal S.,Punjab Technical University
Physiology and Behavior | Year: 2016
Aim and Background: Spermidine, a naturally occurring polyamine, is involved in various internal biological functions, due to its antioxidant and anti-inflammatory properties. A decreased level of polyamines is associated with aging and neurodegenerative disorders including Huntington disease (HD). 3-Nitropropanoic acid (3-NP) induces a spectrum of HD-like neuropathologies in rat striatum and thus serves as a good experimental model of HD. Therefore, the aim of the present study was to investigate whether spermidine confers neuroprotection against 3-NP-induced striatal toxicity and to explore its possible mechanism. Methods: Rats were administered 3-NP (10 mg/kg/day, i.p.) for 21 days. Spermidine (5 and 10 mg/kg/day, p.o.) was administered once a day 1 h before 3-NP treatment for 21 days. Body weight and behavioral observations were recorded at weekly intervals after continuous 3-NP treatment. On the 22nd day, the animals were sacrificed, and the rat striatum was isolated for the estimation of biochemical parameters (lipid peroxidation (LPO), glutathione (GSH), and nitrite), determination of pro-inflammatory cytokine levels (tumor necrosis factor (TNF)-α and interleukin (IL)-6 and IL-1β), and neurochemical analysis (gamma-aminobutyric acid (GABA), glutamate, dopamine (DA), norepinephrine (NE), 5-HT, 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), adenosine, inosine, and hypoxanthine). Results: The findings of the present study demonstrate significant alterations in motor coordination, oxidative defense, and the levels of pro-inflammatory mediators (TNF-α, IL-6, and IL-1β) and striatal neurotransmitters upon 3-NP treatment. Pretreatment with spermidine significantly attenuated 3-NP-induced alterations in motor coordination, oxidative stress, and the levels of neuroinflammatory markers and striatal neurotransmitters. Conclusion: Our findings suggested that spermidine exerted a potential neuroprotective effect in a 3-NP model of HD, which may provide insight into the therapeutic potential of spermidine for HD. © 2015 Elsevier Inc.
Jamwal S.,JKK Nataraja Dental College and Hospital |
Jamwal S.,Punjab Technical University |
Kumar P.,JKK Nataraja Dental College and Hospital
European Journal of Pharmacology | Year: 2015
Huntington Disease (HD), which is characterized by abnormal dance-like movements, is a neurodegenerative disorder caused by a genetic mutation that results in an expanded polyglutamine stretch in the NH2 terminus of huntingtin protein (HTT). The principal neuropathological hallmarks of disease include loss of striatal and cortical projection neurons. HTT is ubiquitously expressed and is implicated in several cellular functions including neurogenesis, cell trafficking and brain-derived neurotrophic factor (BDNF) production. Major depression is the most common symptom among pre-symptomatic HD carriers and numerous pieces of preclinical evidence have suggested the use of antidepressants in HD not only elevates mood but also slows down the disease progression by activating different neuroprotective mechanism like BDNF/TrkB pathway, MAPK/ERK signalling, neurogenesis and Wnt signalling. HTT plays major role in neurogenesis, a physiological phenomenon that is implicated in some of the behavioral effects of antidepressants. Currently, there is no clinically available treatment that can halt or slow down the progression of HD except tetrabenazine (the only FDA approved drug); however, this drug also induces depression and sedation in patients. In this review, a brief discussion has been made about the mutant HTT that induced various cellular and molecular mechanisms underlying behavioral disorders in HD. Further, an attempt has been made to understand the various cellular mechanisms involved in mediating the neuroprotective effects of antidepressants in HD. © 2015 Elsevier B.V. All rights reserved.
Chatha S.S.,Punjabi University |
Sidhu H.S.,Punjabi University |
Sidhu B.S.,Punjab Technical University
Surface and Coatings Technology | Year: 2012
80Ni-20Cr and 75Cr 3C 2-25(Ni-20Cr) coatings were deposited on T91 boiler tube steel by high velocity oxy-fuel (HVOF) process to enhance high-temperature corrosion resistance. Hot corrosion studies were conducted on bare and HVOF-coated steel specimens after exposure to a molten salt (Na 2SO 4-60%V 2O 5) environment at 750°C under cyclic conditions. Each cycle consisted 1h of heating in the silicon carbide tube furnace followed by 20min of cooling in air. The weight change measurements were performed after each cycle to establish the kinetics of corrosion using thermogravimetric technique. X-ray diffraction (XRD), scanning electron microscopy/energy dispersive X-ray analysis (SEM/EDAX) and X-ray mapping techniques were used to analyse the corrosion products. The bare steel experienced higher weight gain, which may be attributed to the formation of unprotective Fe 2O 3 dominated oxide scales. The 80Ni-20Cr coating was found to be more protective than the 75Cr 3C 2-25(Ni-20Cr) coating. The phases revealed in the oxide scale of the coated specimens were mainly oxides and spinels of nickel and chromium, which are reported to be protective against the hot corrosion. © 2012 Elsevier B.V.
Sharma H.,Punjab Technical University |
Singh R.,Max Planck Institute for Solid State Research
Journal of Physics Condensed Matter | Year: 2011
We investigate the ferromagnetism in ZnO clusters due to vacancy defects and C impurities doped at substitutional O or Zn sites, and interstitial sites. The total energy calculations suggest C at the O site is more stable than that at the Zn site in ZnO clusters. The total magnetic moments of Zn nOn-mCm clusters are 2.0μB/C. However, when two C atoms are bonded to the same Zn atom they interact antiferromagnetically and the total magnetic moment becomes less than 2.0μB/C. The interstitial C defects in ZnO clusters induce small magnetic moments. The combination of substitutional and interstitialC defects in ZnO clusters leads to magnetic moments of 0.0-2.0μB/C. The presence of vacancy defects in addition to substitutional C defects gives magnetic moments of greater than 2.0μB/C. These results suggest that the experimentally observed sample dependence of magnetic moments in ZnO systems is largely due to the different concentrations of substitutional and interstitial C impurities and the presence of vacancy defects in ZnO samples prepared under different growth conditions. © 2011 IOP Publishing Ltd.
Chandok S.,Punjab Technical University
Tamkang Journal of Mathematics | Year: 2012
Some common fixed point theorems for Ćirić type contraction mappings have been obtained in convex metric spaces. As applications, invariant approximation results for these type of mappings are obtained. The proved results generalize, unify and extend some of the results of the literature.
Sharma J.,Malout Institute of Management and Information Technology |
Sidhu B.S.,Punjab Technical University
Journal of Cleaner Production | Year: 2014
Millions of gallons of metal working fluids are used each day in industry for cutting, milling, drilling, stamping, and grinding. But Metal working fluids has been found causing very much damage to employee health and environmental pollution. High production volume, the large number of occupationally-exposed workers, and the lack of carcinogenicity and chronic toxicology data of metal working fluids demands a careful scrutiny. The aim of this research is to investigate the effects of dry and near dry machining (NDM) on AISI D2 steel by using an environmental friendly vegetable oil as a lubricant and to completely eliminate the mineral and petroleum based harmful lubricants from turning process. The high carbon high chromium AISI D2 steel was turned at various feed and speed combinations by using Tungsten carbide insert (CNMG12408). The results have been compared with dry machining and near dry machining. The experimental results indicate that near dry machining shows promising results over dry machining in terms of work-tool interface temperature and surface roughness. In order to obtain a good cutting performance by NDM, it is considered that at higher speeds better surface finish properties are obtained. Therefore, it is suggested that near dry machining, provides environment friendliness, cleaner production and can also help to improve the desirable machinability characteristics up to certain extent. © 2013 Elsevier Ltd. All rights reserved.
Talwar V.,Punjab Technical University |
Singh O.,Guru Nanak Dev University |
Singh R.C.,Guru Nanak Dev University
Sensors and Actuators, B: Chemical | Year: 2014
A novel route for the synthesis of polyaniline nanofibers in the presence of varying amounts of zinc oxide has been reported in this paper. The homogeneous PANI nanofibers were prepared through template approach, in which the ZnO nanoparticles were used as template. Structural, optical and morphological analysis of synthesized nanofibers was carried out using X-ray diffraction, UV-vis, IR spectroscopy and FESEM techniques. The thick films of the synthesized polyaniline powder were deposited on alumina substrate and their sensing response to ammonia gas was investigated. Optimum sensing response was achieved with PANI nanofibers synthesized in the presence of 30 wt% ZnO powder. The sensing response of fabricated sensor was proportional to the ammonia gas concentration and exhibited excellent selectivity toward ammonia gas. © 2013 Elsevier B.V.
Mittal R.,Malout Institute of Management and Information Technology |
Sidhu B.S.,Punjab Technical University
Journal of Materials Processing Technology | Year: 2015
Shielded metal arc welding (SMAW), gas tungsten arc welding (GTAW) and their combination are processed by using austenitic and nickel based diverse welding electrodes/filler wires to prepare the dissimilar weldments. The comparative evaluation of an appropriate welding process and welding consumable is based on microstructural features, micro-hardness variation, tensile testing and fracture morphology. The martensitic morphology is found responsible for the higher micro-hardness of HAZ of T91 side of all the weldments. Higher tensile strength (638.2 MPa) of GTAW, ERNiCr3 combination is observed than other weldments. The fractography corroborates the highest ductility of GTAW, ERNiCr3 combination with an elongation of 28.33% and the ductility of all the combinations of weldments except GTAW, ERNiCr3 is observed to be less than their base metals. Hence, it can be concluded that GTAW process, using nickel based weld metal offered the better results for the dissimilar joint between T91 and 347H. © 2015 Elsevier B.V. All rights reserved.