Tuam, Ireland
Tuam, Ireland
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A subject is inoculated from a disease by exposing a biopsy of a tumor or other abnormal growth to a nanosecond pulsed electric field (nsPEF). A sufficient treatment can be confirmed by detecting calreticulin on the tumor cell membranes, which indicates apoptosis occurring in the tumor cells. Treated tumor cells from the biopsy are then reintroduced into the subject. The calreticulin-exhibiting tumor cells activate the subjects immune system against the tumor, and any other like tumors in the body, and effectively vaccinates the subject against the disease. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. The immune response may be measured at a later time. Specific electrical characteristics of the nsPEF treatments can be based on the type and/or strength of the tumor.


Various embodiments of ultrasonic testing systems are disclosed herein. In one embodiment, an ultrasonic testing system includes a plurality of ultrasonic arrays. The individual ultrasonic arrays include a transducer support extending along a length of the corresponding ultrasonic array, and a plurality of ultrasonic transducers. The individual ultrasonic transducers are mounted to the corresponding transducer supports, and are operable to generate ultrasonic sound waves. The system also includes an adjustable mount supporting the plurality of ultrasonic arrays and operable to adjust a position of the plurality of ultrasonic arrays along two non-parallel axes.


Patent
Pulse Inc | Date: 2016-11-08

A PEMF web using immersive, flux-guided, micro-coils to direct intense, deeply penetrating, magnetic flux into a subject from each micro-coil capable of pointing in an arbitrary direction. Micro-coils are spooled around iron cores, insulated properly, and soldered to connecting wires, all embedded in a polymeric resin, such as cold-cured silicone resin. Nodes protect, enclose, insulate electrically, and otherwise protect the micro-coils. Connectors between nodes provide mechanical stability against breaking of wires, while permitting folding, bending, buckling, and otherwise deflecting to position the nodes as desired with three degrees of freedom.


A high-voltage coaxial cable with a hollow inner conductor is described. The hollow region can be filled with a non-conducting filler. The inner conductor is surrounded by a dielectric, which is surrounded by an outer conductor and jacket. Methods and systems for designing these very high voltage coaxial cables with matching system impedance and minimal cable cross sections are provided. Embodiments include coaxial cables, systems, and methods for designing coaxial cables with high standoff voltage capacity, greater flexibility than standard coaxial cable, and a given impedance. Embodiments provide setting the requirements for an insulator of a coaxial cable driving the dimensions of the other components of the coaxial cable.


This disclosure relates to an in vivo treatment of a skin lesion of a mammal comprising application of electrical energy to the skin lesion in a form of electrical pulses. At least one electrical pulse is applied. The pulse duration may be at least 1 nanosecond at the full-width-half-maximum. Surface of a tissue surrounding the skin lesion may be marked to guide the device to deliver the electric pulses at substantially precise locations on the lesion surface. This treatment may prevent at least growth of the lesion.


Patent
Pulse Inc | Date: 2016-01-28

A system and method of transmitting measurement-while-drilling (MWD) data while drilling a wellbore in a subterranean formation are provided. The system utilizes a transmission sub located uphole of the drill bit which transmits an electromagnetic signal through the surrounding drilling fluid to a receiver assembly located farther uphole at a position suitable for relaying the signal to the surface.


Patent
Pulse Inc | Date: 2015-06-17

A biocompatible, implantable electrode for electrically active medical devices. The implantable medical electrode has a surface geometry which optimizes the electrical performance of the electrode, while mitigating the undesirable effects associated with prior art porous surfaces. The electrode has an optimized surface topography for improved electrical performance. Such a electrode is suitable for devices which may be permanently implanted in the human body as stimulation electrodes, such as pacemakers, or as sensors of medical conditions. Such is achieved by the application of ultrafast high energy pulses to the surface of a solid, monolithic electrode material for the purpose of increasing the surface area and thereby decreasing its after-potential polarization. In addition, the electrode material comprises a biocompatible metal having a minimal or eliminated amount of metal oxides which are detrimental to electrode performance.


Patent
Pulse Inc | Date: 2015-06-24

A biocompatible, implantable electrode for electrically active medical devices. The implantable medical electrode has a surface geometry which optimizes the electrical performance of the electrode, while mitigating the undesirable effects associated with prior art porous surfaces. The electrode has an optimized surface topography for improved electrical performance. Such a electrode is suitable for devices which may be permanently implanted in the human body as stimulation electrodes, such as pacemakers, or as sensors of medical conditions. Such is achieved by the application of ultrafast high energy pulses to the surface of a solid, monolithic electrode material for the purpose of increasing the surface area and thereby decreasing its after-potential polarization.


A titanium based, ceramic reinforced alloy ingot for use in producing medical implants. An ingot is formed from an alloy having comprising from about 5 to about 35 wt. % niobium, from about 0.5 to about 3.5 wt. % silicon, and from about 61.5 to about 94.5 wt. % of titanium. The alloy has a hexagonal crystal lattice phase of from about 20 vol % to about 70 vol %, and a cubic body centered crystal lattice phase of from about 30 vol. % to about 80 vol. %. The ingot has an ultimate tensile strength of about 940 MPa or more, and a Youngs modulus of about 150 GPa or less. A molten substantially uniform admixture of a niobium, silicon, and titanium alloy is formed, cast into a shape, and cooled into an ingot. The ingot may then be formed into a medical implant and optionally annealed.


This disclosure relates to an in vivo treatment of a skin lesion of a mammal comprising application of electrical energy to the skin lesion in a form of electrical pulses. At least one electrical pulse is applied. The pulse duration may be at least 1 nanosecond at the full-width-half-maximum. Surface of a tissue surrounding the skin lesion may be marked to guide the device to deliver the electric pulses at substantially precise locations on the lesion surface. This treatment may prevent at least growth of the lesion.

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