Pulmuone Holdings Co

Seoul, South Korea

Pulmuone Holdings Co

Seoul, South Korea
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Park H.-J.,Catholic University of Korea | Park H.-J.,Kyung Hee University | Shim H.S.,Kyung Hee University | Ahn Y.H.,Kyung Hee University | And 9 more authors.
Behavioural Brain Research | Year: 2012

The present study examined the effects of Tremella fuciformis (TF) on the learning and memory function and the neural activity in rats with trimethyltin (TMT)-induced memory deficits. The rats were administered saline or TF (TF 25, 50, 100. mg/kg, p.o.) daily for 21 days. The cognitive improving efficacy of TF on the amnesic rats, which was induced by TMT, was investigated by assessing the Morris water maze test and by performing Choline acetyltransferase (ChAT) and cAMP responsive element binding protein (CREB) immunohistochemistry. In order to confirm the underlying mechanisms of the memory enhancing effects of TF, we assessed the neurite outgrowth of PC12 cells. We also administered 18F-fluorodeoxyglucose and performed a PET scan of the frontal lobe.The rats with TMT injection showed impaired learning and memory of the tasks and treatment with TF produced a significant improvement of the escape latency to find the platform in the Morris water maze compared to that of the control group. In the retention test, the TF50 group showed increased time spent around the platform compared to that of the control group. Consistent with the behavioral data, TF50. mg/kg significantly alleviated the loss of ChAT-ir neurons in the hippocampus compared to that of the control group. Treatment with TF significantly increased the CREB positive neurons in the hippocampal CA1 area as compared to that of the control group. In addition, TF treatment (50. mg/kg) increased the glucose uptake approximately sevenfold in the frontal lobe and it significantly promoted neurite outgrowth of the PC12 cells, as compared to that of the controls.These results suggest that TF may be useful for improving the cognitive function via regulation of the CREB signaling pathway and cholinergic system in the hippocampus. © 2011 Elsevier B.V..


Kim G.-S.,Pulmuone Holdings Co. | Min B.-D.,National Water Research Institute | Park S.-J.,National Water Research Institute | Oh J.-H.,WoongjinCoway Co. | And 8 more authors.
Korean Journal of Microbiology | Year: 2013

Biofilm formed on stainless and copper in water treatment plant was investigated for sixteen weeks. Biofilm reactor was specially designed for this study. It was similar to that of a real distribution pipe. Raw water, coagulated, settled, filtered and treated water were used in this study. The average number of heterotrophic bacteria counts was 1.6 × 104 CFU/ml, 5.8 × 103 CFU/ml, 1.8 × 103 CFU/ml, 1.3 × 102 CFU/ml, 1 CFU/ml, respectively. Density of biofilm bacteria formed on stainless and copper pipes in raw, coagulated and settled water increased above 2.9 × 103 CFU/cm2 within second weeks while more biofilm bacteria counts were found on the stainless pipe than on the copper pipe. In case of filtered water (free residue chlorine 0.44 mg/L), there was no significant difference in the number of biofilm bacteria on both pipes and biofilm bacteria below 18 CFU/cm2 were detected on both pipe materials after fifth weeks. Biofilm bacteria were not detected on both pipe materials in treated water (free residue chlorine 0.88 mg/L). According to the results of DGGE analysis, Sphingomonadacae was a dominant species of biofilm bacteria formed on the stainless pipe while the copper pipe had Bradyrhizobiaceae and Sphingomonadaceae as dominant bands. In case of filtered water, a few bands (similar to Propionibacterium sp., Sphingomonas sp., Escherichia sp., and etc.) that have 16S rRNA sequences were detected in biofilm bacteria formed on both pipes after fifth weeks. Stainless pipe had higher species richness and diversity than the copper pipe. © 2013, The Microbiological Society of Korea.


Park J.-M.,CHA Medical University | Kim Y.-J.,Gachon University | Kim J.-S.,Gachon University | Han Y.-M.,CHA Medical University | And 9 more authors.
Nutrition Research | Year: 2013

Increased acid output, accompanied with a defective defense system, is considered a fundamental pathogenesis of duodenal ulcer (DU). However, relapse of DU occurs despite proton pump inhibitors and H2 receptor antagonists, hence imposing the enforcement of the defense system. Dried powder of the yam tuber (Dioscorea spp) has been used in traditional folk medicine as a nutritional fortification. We hypothesized that dried-yam powder would prevent DU through improvement of anti-inflammatory actions and carbonic anhydrase (CA) activity. Therefore, we investigated the preventive effects of dried-yam powder against the cysteamine-induced DU and elucidated the underlying mechanisms. Duodenal ulcers were induced in Sprague-Dawley rats by intragastric administration of 500 mg/kg cysteamine-HCl. The dried-yam powder was used as a pretreatment before the cysteamine-HCl. The number and size of DU were measured. The expressions of inflammation mediators were checked in duodenal tissues, and the expressions of CAs and malondialdehyde levels were also examined. Cysteamine provoked perforated DU, whereas dried-yam powder significantly prevented DU as much as pantoprazole and significantly reduced the incidence of perforation. The messenger RNA expressions of cyclooxygenase-2 and inducible nitric oxide synthase were remarkably decreased in the yam group compared with the cysteamine group, and the serum levels of proinflammatory cytokines including interleukin-1β, interleukin-6, and tumor necrosis factor were significantly attenuated in the yam group. Cysteamine significantly decreased the expression of CAs, whereas yam treatment significantly preserved the expressions of CA IX, XII, and XIV. In conclusion, dried-yam powder exerts a significant protective effect against cysteamine-induced DU by lowering the activity of inflammatory cytokines and free radicals and restoring the activity of CAs, except in CA IV. © 2013 Elsevier Inc.


Kong Y.-H.,Pulmuone Holdings Co. | Choi K.-B.,Pulmuone Holdings Co. | Kim T.-S.,Pulmuone Holdings Co. | Yeo I.-H.,Pulmuone Holdings Co.
Journal of the Korean Society of Food Science and Nutrition | Year: 2013

This study was performed to investigate anti-oxidant of red pepper and Zanthoxylum schinifolium ethanol extract, main ingredient of mara source. Anti-obesity effects of red pepper and Zanthoxylum schinifolium ethanol extract were investigated with mice fed high fat diet for 8 weeks. Sixty mice were classified to 6 groups of ND (normal diet), HFD (high fat diet), RP (high fat diet+red pepper (0.1 g/60 kg)), CP (high fat diet+Chinese pepper (0.1 g/60 kg)), RCP (high fat diet+red pepper: Chinese pepper=1:1 (0.1 g/60 kg)), HCA (high fat diet+HCA (0.1 g/60 kg)) experiments. This research showed that final weight, weight gain, food efficiency ratio, and river weight were decreased by the addition of red pepper and Zanthoxylum schinifolium ethanol extract comparing to those of HFD group. The plasma triglyceride and LDL cholesterol concentration of red pepper ethanol extract and Zanthoxylum schinifolium ethanol extract group was lower than that of high fat diet group. HDL-cholesterol concentration of red pepper ethanol extract and Zanthoxylum schinifolium ethanol extract group was higher than those of high fat diet group. These results suggested that red pepper and Zanthoxylum schinifolium ethanol extract might be useful for obesity control and good source of functional materials.


Cho J.Y.,Korea Food Research Institute | Choi E.H.,Korea Food Research Institute | Choi E.H.,Pulmuone Holdings Co. | Kang J.I.,Pulmuone Holdings Co. | And 3 more authors.
Food Science and Biotechnology | Year: 2013

The objective of this study was to investigate the possible protective effects of maca (Lepidium meyenii) extract (MLE) by supercritical fluid extraction on dextran sodium sulfate (DSS)-induced colitis. Experimental colitis was induced by giving male BALB/c mice 3% DSS in drinking water, and MLE (30 mg/kg BW), sulfasalazine (100 mg/kg BW) or vehicle were administered orally. DSS challenge caused significant body weight loss, rectal bleeding, diarrhea, shortened colon length, histological changes, and increased myeloperoxidase (MPO) activity in DSS-treated mice. Oral administration of MLE significantly relieved the symptoms of diarrhea and rectal bleeding, and reduced colonic MPO activity (p<0.05). MLE treatment inhibited expression of several colonic proteins related to inflammatory responses, such as interleukin (IL)-1β, tumor necrosis factor-α, IL-6, and S100 calcium-binding protein A8, whose expressions were increased significantly by DSS treatment. These results suggest that MLE can alleviate DSS-induced colitis in mice by modulating colonic inflammatory mediators. © 2013 The Korean Society of Food Science and Technology and Springer Science+Business Media Dordrecht.


Choi E.H.,Korea Food Research Institute | Kang J.I.,Pulmuone Holdings Co. | Cho J.Y.,Korea Food Research Institute | Lee S.H.,Pulmuone Holdings Co. | And 3 more authors.
Journal of Functional Foods | Year: 2012

The effect of lipid-soluble extract from maca (. Lepidium meyenii), which contains macamides, on swimming endurance capacity, as an indicator of fatigue, in weight-loaded forced swimming rats was investigated. The swimming times to exhaustion of rats supplemented for 3. weeks with 30 and 100. mg/kg of maca extract increased by 25% and 41%, respectively. Supplementation with 100. mg/kg of maca extract reduced serum lactate dehydrogenase activity and muscle lipid peroxidation, and increased hepatic and muscle total glutathione compared with those values in controls. The levels of energy sources and serum lactate remained unchanged despite the longer swimming time in the supplemented rats than those in controls. These results suggest that supplementation with lipid-soluble maca extract improved swimming endurance capacity and this effect can be explained partly by attenuation of exercise-induced oxidative stress. © 2012 Elsevier Ltd.


Patent
Pulmuone Holdings Co. and Pulmuone Foods United States Inc. | Date: 2014-04-07

An improved tofu having reduced beany flavor, whiter color, more elasticity, reduced porosity and more consistent characteristics than traditional tofu.


Trademark
Pulmuone Holdings Co. | Date: 2013-03-18

bean curd (tofu); soft tofu; soybean milk; toasted laver; seasoned toasted laver in small pack; toasted green laver; dried edible seaweed (wakame); pickled cucumber; pickled radish; fried tofu pouches; dried beans; fermented vegetables (kimchi); sliced and pickled oriental radish wraps (pickled daikon slice wraps). soybean paste (doenjang); seasoned soybean paste mixed with red pepper paste (ssamjang); instant chewy noodles with seasoning; instant cold buckwheat noodles with a broth pouch; instant thick udon noodles with seasoning; instant Chinese-style noodles with spicy seafood seasoning (jjamppong); instant wide noodles in soup (kalguksu); instant noodles with black-bean sauce (jajanymyeon); instant buckwheat noodle with spicy seasoning; instant noodle mixed with spicy seasoning; Korean-style dumplings (mandu); dried thin noodles (Korean vermicelli); instant noodle with spicy red pepper paste seasoning; instant noodle soup with seasoning (ramen); cooked dish consisting primarily of sliced oval rice cakes with broth (tteokguk); sliced rice cake with spicy red pepper paste seasoning; polished rice; processed mixed grains; brown rice; unpolished sweet rice; uncracked barley; beef-flavored seasoning paste for soft tofu stew; seafood-flavored seasoning paste for soft tofu stew. Fruit beverages; fruit flavored drinks; vegetable juice; vegetable-fruit juices.

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