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Beirut, Lebanon

Malik M.I.,Pulmonology | Naz H.S.,Jinnah Hospital | Hassan G.U.,Medical Unit 1
Pakistan Journal of Medical and Health Sciences | Year: 2014

Aim: To determine the frequency of ATT induced hepatitis in newly diagnosed pulmonary TB patients.Methods: This descriptive, cross-sectional study was conducted at Department of Pulmonology Jinnah Hospital Lahore from August 2013 to February 2014. Total 95 newly diagnosed pulmonary TB patients were included in this study. Baseline LFTs including ALT, AST, and bilirubin were done in every patient at time of induction and repeated at one month follow up. Data was analyzed by using SPSS 16.Results: Mean age of the patients was 37.95 ± 14.46. Among the participants males were 51(53.7%) and females were 44(46.3%). Out of 95 patients, 34(35.8%) had ALT and AST derangements while 35(36.8%) had hyperbilirubinemia.Conclusion: ATT induced hepatitis is a frequent complication in newly diagnosed cases of Pulmonary Tuberculosis. So, all patients put on ATT must be followed up for at least the initial month. The patients and the doctors have to be well-educated about the adverse effects of the ATT, its early recognition and management. © 2014 Pakistan Journal of Medical and Health Sciences. All Rights Reserved. Source

Thunnissen F.B.,University of Amsterdam | Prinsen C.,Canisius Wilhelmina Hospital | Hol B.,Pulmonology | Van der Drift M.,Radboud University Nijmegen | And 4 more authors.
Lung Cancer | Year: 2012

Background: In a European multicenter prospective study patients with lung cancer were interviewed for smoking history and biological samples centrally collected. The aim of this study was to compare KRAS mutation analysis with smoking status at the time of diagnosis. Methods: A nested case-study was performed on 233 non-small cell lung carcinomas. Cases were selected on the basis of progressive disease or disease-free post surgery based on specific criteria. KRAS mutation analysis was performed with the point-EXACCT method. Results: KRAS mutations were found in 39 adenocarcinomas and 1 squamous cell carcinoma in the 233 NSCLC. The median quitting smoking time (QST) for patients with and without KRAS mutations was 9 years, interquartile range [IQR 16-38] and 3 years, IQR [13-50], respectively (p= 0.039). No difference was found for age at initiation of smoking, duration of smoking, average tobacco consumption, and smoking status at the time of diagnosis. Conclusion: The QST was longer for patients with KRAS mutations, supporting the notion that the presence of a KRAS mutation is a dominant early effect, supporting its role as a driver oncogen. © 2011 Elsevier Ireland Ltd. Source

Dragonieri S.,University of Bari | Porcelli F.,University of Bari | Longobardi F.,University of Bari | Carratu P.,University of Bari | And 6 more authors.
Journal of Breath Research | Year: 2015

Exhaled breath contains thousands of volatile organic compounds (VOCs) in gaseous form, which may be used as markers of airway inflammation and lung disease. Electronic noses enable quick and real-time pattern analysis of VOC spectra. It has been shown that the exhaled breath of patients with obstructive sleep apnoea (OSA) differs from that of non-obese controls. We aimed to assess the influence of obesity in the composition of exhaled VOCs by comparing obese subjects with and without OSA. Moreover, we aimed to identify the discriminant VOCs in the two groups. 19 obese patients with established OSA (OO; age 51.2 6.8; body mass index (BMI) 34.3 3.5), 14 obese controls without OSA (ONO; age 46.5 7.6; BMI 33.5 4.1) and 20 non-obese healthy controls (HC; age 41.1 12.6; BMI 24.9 3.8) participated in a cross-sectional study. Exhaled breath was collected by a previously described method and sampled by using an electronic nose (Cyranose 320) and by gas chromatography-mass spectrometry (GC-MS) analysis. Breathprints were analyzed by canonical discriminant analysis on principal component reduction. Cross-validation accuracy (CVA) was calculated. Breathprints from the HC group were separated from those of OO (CVA = 97.4%) and ONO (CVA = 94.1%). Breathprints from OO were moderately separated from those of ONO (CVA = 67.6%). The presence of OSA alters the exhaled VOC pattern in obese subjects. The incomplete separation of breathprints between OO and ONO may be due to the same underlying inflammation caused by obesity. © 2015 IOP Publishing Ltd. Source

Tasdemir K.,Cardiovascular Surgery | Oymak S.,Pulmonology | Duran M.,Erciyes University | Oguz F.,Erciyes University
Hemodialysis International | Year: 2010

The aim of this prospective study was to evaluate long-term effects of arteriovenous fistula (AVF) on the development of pulmonary arterial hypertension (PAH) and the relationship between blood flow rate of AVF and pulmonary artery pressure (PAP) in the patients with end-stage renal disease (ESRD). This prospective study was performed in 20 patients with ESRD. Before an AVF was surgically created for hemodialysis, the patients were evaluated by echocardiography. Then, an AVF was surgically created in all patients. After mean 23.50 ± 2.25 months, the second evaluation was performed by echocardiography. Also, the blood flow rate of AVF was measured at the second echocardiographic evaluation. Pulmonary arterial hypertension was defined as a systolic PAP above 35 mmHg at rest. Mean age of 20 patients with ESRD was 55.05 ± 13.64 years; 11 of 20 patients were males. Pulmonary arterial hypertension was detected in 6 (30%) patients before AVF creation and in 4 (20%) patients after AVF creation. Systolic PAP value was meaningfully lower after AVF creation than before AVF creation (29.95 ± 10.26 mmHg vs. 35.35 ± 7.86 mmHg, respectively, P: 0.047). However, there was no significant difference between 2 time periods in terms of presence of PAH (P>0.05). Pulmonary artery pressure did not correlate with blood flow rate of AVF and duration after AVF creation (P>0.05). In hemodialysis patients, a surgically created AVF has no significant effect on the development of PAH within a long-term period. Similarly, blood flow rate of AVF also did not affect remarkably systolic PAP within the long-term period. © 2010 The Authors. Hemodialysis International © 2010 International Society for Hemodialysis. Source

Swidsinski A.,Humboldt University of Berlin | Swidsinski A.,Charite - Medical University of Berlin | Dorffel Y.,Charite - Medical University of Berlin | Loening-Baucke V.,Humboldt University of Berlin | And 9 more authors.
Gut | Year: 2011

Background: Acute appendicitis is a local intestinal inflammation with unclear origin. The aim was to test whether bacteria in appendicitis differ in composition to bacteria found in caecal biopsies from healthy and disease controls. Methods and patients: We investigated sections of 70 appendices using rRNA-based fluorescence in situ hybridisation. Four hundred caecal biopsies and 400 faecal samples from patients with inflammatory bowel disease and other conditions were used as controls. A set of 73 group-specific bacterial probes was applied for the study. Results: The mucosal surface in catarrhal appendicitis showed characteristic lesions of single epithelial cells filled with a mixed bacterial population ('pinned cells') without ulceration of the surroundings. Bacteria deeply infiltrated the tissue in suppurative appendicitis. Fusobacteria (mainly Fusobacterium nucleatum and necrophorum) were a specific component of these epithelial and submucosal infiltrates in 62% of patients with proven appendicitis. The presence of Fusobacteria in mucosal lesions correlated positively with the severity of the appendicitis and was completely absent in caecal biopsies from healthy and disease controls. Main faecal microbiota represented by Bacteroides, Eubacterium rectale (Clostridium group XIVa), Faecalibacterium prausnitzii groups and Akkermansia muciniphila were inversely related to the severity of the disease. The occurrence of other bacterial groups within mucosal lesions of acute appendicitis was not related to the severity of the appendicitis. No Fusobacteria were found in rectal swabs of patients with acute appendicitis. Conclusions: Local infection with Fusobacterium nucleatum/necrophorum is responsible for the majority of cases of acute appendicitis. Source

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