Pulmonary and Sleep Research Laboratory

Head of Westport, MA, United States

Pulmonary and Sleep Research Laboratory

Head of Westport, MA, United States

Time filter

Source Type

Huang J.,Pulmonary and Sleep Research Laboratory | Xie T.,Pulmonary and Sleep Research Laboratory | Wu Y.,Pulmonary and Sleep Research Laboratory | Wu Y.,Hebei Medical University | And 8 more authors.
Respiratory Physiology and Neurobiology | Year: 2010

To test the hypothesis that central changes in sympathoregulation might contribute to sympathoexcitation after cyclic intermittent hypoxia (CIH) we exposed male Sprague-Dawley rats to CIH or to room air sham (Sham) for 8 h/d for 3 weeks. After completion of the exposure we assessed heart rate, mean arterial pressure and renal sympathetic nerve activity in conscious animals before and after intracerebroventricular (i.c.v.) administration of endothelin-1 (ET-1, 3 pmol). CIH-exposed animals had a significantly greater sympathetic response to ET-1 than did Sham-exposed animals (CIH 137.8 ± 15.6% of baseline; Sham 112.2 ± 10.0% of baseline; CIH vs. Sham, P = 0.0373). This enhanced sympathetic response to i.c.v. ET-1 was associated with greater expression of endothelin receptor A (ETA) protein in the subfornical organs of CIH-exposed relative to Sham-exposed rats. We conclude that 3-week CIH exposure enhances central ET-1 receptor expression and the sympathetic response to i.c.v. ET-1 suggesting central endothelin may contribute to the sympathetic and hemodynamic response to cyclic intermittent hypoxia. © 2010 Elsevier B.V. All rights reserved.

Loading Pulmonary and Sleep Research Laboratory collaborators
Loading Pulmonary and Sleep Research Laboratory collaborators