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Medak District, India

Sanjeeva Kumar A.,Raghavendra Institute of Pharmaceutical Education and Research | Raveendra Reddy J.,Raghavendra Institute of Pharmaceutical Education and Research | Rama Mohan Gupta V.,Pulla Reddy Institute of Pharmacy
International Journal of Pharma and Bio Sciences | Year: 2014

Porana paniculata is an ever green creeper belongs to family Convolvulaceae which is widely grown in tropical countries like India. Porana paniculata whole plant is used in ayurveda and folklore for treatment of various disorders including pain and inflammations. Present study was aimed to evaluate preliminary phytochemical studies and analgesic and anti-inflammatory activities of Porana paniculata whole plant. Plant material was subjected to extraction by maceration by using ethanol and water mixture as solvent and subjected to preliminary phytochemical screening. For Analgesic activity, hot plate, tail immersion and acetic acid induced writhing models were used where as for anti inflammatory activity, carrageenan and histamine induced model were employed. A thick green viscous matter about 28.9 gm was obtained from 1000 gm of plant material and the percentage was found to be 2.89% w/w. Preliminary phytochemical screening of whole plant of Porana paniculata revealed the presence of alkaloids, carbohydrates, saponins, tannins and flavonoids. In hot plate and tail immersion methods, plant extract showed significant increase in reaction time and it showed 50.09 % inhibition of the writhing caused by acetic acid (p < 0.05). In anti inflammatory activity, plant extract showed 25.86, 43.10 % inhibition in carrageenan induced model and 13.41, 54.87 % inhibition in histamine induced model at its lower and higher dose levels respectively. From the above findings, it can be concluded that Porana paniculata whole plant possesses significant analgesic and anti inflammatory activities. Present study supports the folklore claim of the plant for pain and inflammation. Source


Sanjeeva Kumar A.,Raghavendra Institute of Pharmaceutical Education and Research | Raveendra Reddy J.,Raghavendra Institute of Pharmaceutical Education and Research | Rama Mohan Gupta V.,Pulla Reddy Institute of Pharmacy
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Present study is designed with an aim to establish thin layer chromatographic profile of an ethnomedicinally important plant, Ipomoea quamoclit, belongs to Convolvulaceae family. Plant was collected, shade dried and mechanically made into powder. This powder was subjected to cold maceration and preliminary phytochemical screening by standard methods. Thin layer chromatography study was conducted by using different mobile phases and detecting agents according to standard literature. In detection of alkaloids, three spots were identified whose Rf values were found to be 0.39, 0.46 and 0.73. In detection of carbohydrates, four spots were identified whose Rf values were found to be 0.41, 0.52, 0.79 and 0.87. In detection of saponins, four spots were identified whose Rf values were found to be 0.46, 0.59, 0.73 and 0.91. In detection of tannins, two spots were identified whose Rf values were found to be 0.41 and 0.79. In detection of flavonoids, four spots were identified whose Rf values were found to be 0.39, 0.45, 0.57 and 0.86. In detection of amino acids, five spots were identified whose Rf values were found to be 0.32, 0.52, 0.61, 0.68 and 0.81. In detection of phytosterols, four spots were identified whose Rf values were found to be 0.21, 0.42, 0.65 and 0.95. Source


Chungath T.T.,Pulla Reddy Institute of Pharmacy | Kuppusamy K.,Sri Ramakrishna Institute of Paramedical science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2010

The present investigation involves formulation and evaluation of floating microspheres with curcumin as model drug for prolongation of gastric residence time and to evaluate the influence of polymers on the release kinetics. The microspheres were prepared by oil in water (o/w) emulsion / solvent evaporation method using HPMC K100 and Poloxamer 188. Characterization of microspheres followed, to examine the size of microspheres, drug incorporation efficiency, % yield, buoyancy percentage and in vitro drug release. Drug release kinetics was evaluated using linear regression method. The influence of the agitation speed during preparation, polymer concentration, solvent proportion and dissolution medium on the size of the microspheres and drug release were discussed. The prepared microspheres exhibited prolonged drug release (~10h) and remained buoyant for ~ 12 h. The mean particle size increased and the drug release rate decreased at higher polymer concentration. Agitation speed showed minimum significance on drug release profile. In vitro studies demonstrated diffusion controlled drug release of curcumin from the microspheres. Through the study, the developed curcumin loaded floating microspheres could be used as a drug delivery system to improve the absorption kinetics of curcumin. Poloxamer 188 may be further evaluated for claiming the in vivo-in vitro correlation. Source


Sahoo S.,Pulla Reddy Institute of Pharmacy | Mahendra Kumar C.B.,St. Marys College
Asian Journal of Chemistry | Year: 2016

Based on the outcome of computational docking to the active site of cytochrome P450 14α-demethylase (CYP51), diverse 3,4-disubstituted 5-mercapto-1,2,4-triazoles were prepared and screened for antioxidant and antifungal activities. The docking study of synthesized compounds showed promising binding affinity towards docked enzyme, sterol 14α-demethylase(CYP51) from trypanosome cruzi obtained from a RCSB protein data bank (PDB ID: 3KHM). The synthesized compounds were characterized by IR, 1H NMR and Mass spectral data. Among the novel synthesized compounds IV-6, IV-1 and IV-2 showed maximum antifungal activity against A. Niger and C. albicans organism when compared the standard fluconazole. For antioxidant activity, all the compounds showed moderate activity but compound IV-6 and IV-7 showed significant activity when compared to standard ascorbic acid. Source


Rama Mohan Gupta V.,Pulla Reddy Institute of Pharmacy
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

The direct compression is a modern technique in the tablet manufacturing, many processing steps are limited in direct compression compared to conventional wet granulation method and also wet granulation cannot be used with sensitive drugs. Spherical agglomeration is a modern technique for development of directly compressible pharmaceutical dosage forms where the drug crystals are converted to spherical form to improve flowability, compressibility and packability. The spherical crystallization further developed use with hydrophilic polymers to enhance dissolution rate characteristics of poorly water soluble drugs. The spherical agglomerates evaluated in terms of flow properties, particle size analysis, compression and dissolution behavior. Physical characters of the crystals were studied for the morphology of crystals using scanning electron microscope (SEM), identification of polymorphism done by x-ray powder diffraction (XPRD) and for thermo dynamic properties using differential scanning calorimetry (DSC). Source

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