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Sahoo S.,Pulla Reddy Institute of Pharmacy | Mahendra Kumar C.B.,St. Mary's College
Asian Journal of Chemistry | Year: 2016

Based on the outcome of computational docking to the active site of cytochrome P450 14α-demethylase (CYP51), diverse 3,4-disubstituted 5-mercapto-1,2,4-triazoles were prepared and screened for antioxidant and antifungal activities. The docking study of synthesized compounds showed promising binding affinity towards docked enzyme, sterol 14α-demethylase(CYP51) from trypanosome cruzi obtained from a RCSB protein data bank (PDB ID: 3KHM). The synthesized compounds were characterized by IR, 1H NMR and Mass spectral data. Among the novel synthesized compounds IV-6, IV-1 and IV-2 showed maximum antifungal activity against A. Niger and C. albicans organism when compared the standard fluconazole. For antioxidant activity, all the compounds showed moderate activity but compound IV-6 and IV-7 showed significant activity when compared to standard ascorbic acid.


Chungath T.T.,Pulla Reddy Institute of Pharmacy | Kuppusamy K.,Sri Ramakrishna Institute of Paramedical science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2010

The present investigation involves formulation and evaluation of floating microspheres with curcumin as model drug for prolongation of gastric residence time and to evaluate the influence of polymers on the release kinetics. The microspheres were prepared by oil in water (o/w) emulsion / solvent evaporation method using HPMC K100 and Poloxamer 188. Characterization of microspheres followed, to examine the size of microspheres, drug incorporation efficiency, % yield, buoyancy percentage and in vitro drug release. Drug release kinetics was evaluated using linear regression method. The influence of the agitation speed during preparation, polymer concentration, solvent proportion and dissolution medium on the size of the microspheres and drug release were discussed. The prepared microspheres exhibited prolonged drug release (~10h) and remained buoyant for ~ 12 h. The mean particle size increased and the drug release rate decreased at higher polymer concentration. Agitation speed showed minimum significance on drug release profile. In vitro studies demonstrated diffusion controlled drug release of curcumin from the microspheres. Through the study, the developed curcumin loaded floating microspheres could be used as a drug delivery system to improve the absorption kinetics of curcumin. Poloxamer 188 may be further evaluated for claiming the in vivo-in vitro correlation.


Rama Mohan Gupta V.,Pulla Reddy Institute of Pharmacy
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

The direct compression is a modern technique in the tablet manufacturing, many processing steps are limited in direct compression compared to conventional wet granulation method and also wet granulation cannot be used with sensitive drugs. Spherical agglomeration is a modern technique for development of directly compressible pharmaceutical dosage forms where the drug crystals are converted to spherical form to improve flowability, compressibility and packability. The spherical crystallization further developed use with hydrophilic polymers to enhance dissolution rate characteristics of poorly water soluble drugs. The spherical agglomerates evaluated in terms of flow properties, particle size analysis, compression and dissolution behavior. Physical characters of the crystals were studied for the morphology of crystals using scanning electron microscope (SEM), identification of polymorphism done by x-ray powder diffraction (XPRD) and for thermo dynamic properties using differential scanning calorimetry (DSC).


Manvi S.R.,F R and D | Gupta V.R.M.,Pulla Reddy Institute of Pharmacy | Srikanth K.,Pulla Reddy Institute of Pharmacy | Devanna N.,JNTUH College of Engineering
Research Journal of Pharmacy and Technology | Year: 2012

Objective of the present research work is to develop the liquid dosage form (niosomal suspension) of candesartan. Niosomes have been prepared using two different non ionic surfactants by thin film hydration technique and are characterized for size, shape, entrapment efficiency, invitro drug release and stability. SEM studies have been carried out which shown that the niosomes are spherical in shape with smooth surface. All the vesicles appeared in the size range of 8.1- 11.3μm. % entrapment efficiency has been carried out by dialysis method and the results are confirmed with centrifugation method. Niosomes prepared using spans showed good results than the niosomes prepared using tweens. Among all formulations, FS603 has shown highest entrapment efficiency [71.2%]. Diffusion studies were carried out to study the drug release pattern from all formulations and are revealed that increase in the concentration of surfactant decreases the drug release from niosomes, in all formulations prepared using spans and tweens. Among all formulations, FS603 has shown better sustained release, which is desirable for enhancing the bioavailability. Hence, FS603 has been optimized as best formulation and carried stability studies as per ICH guidelines and are revealed that the niosomes are stable for long time at refrigerated temperature. © RJPT All right reserved.


Patil P.B.,Net Pharmacy College | Gupta V.R.M.,Pulla Reddy Institute of Pharmacy | Udupi R.H.,Net Pharmacy College | Srikanth K.,Pulla Reddy Institute of Pharmacy | Prasad B.S.G.,Pulla Reddy Institute of Pharmacy
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2010

Mefenamic acid, a non steroidal anti-inflammatory drug is poorly water soluble. Addition of surfactant to the dissolution medium improves the dissolution of pure drug by facilitating the drug release process at the solid/liquid interface and micelle solubilization in the bulk. In the present study a dissolution medium was developed. The composition of the dissolution medium was selected on the basis of solubility data of Mefenamic acid at 37° C. The solubility data revealed that water consisting of 2% w/v sodium lauryl sulphate shall be suitable dissolution medium. The discriminating power of the selected dissolution medium (2% w/v sodium lauryl sulphate in water.) relative to the other dissolution medium was evaluated. The results further justified that the usage of 2% w/v sodium lauryl sulphate in water serves as most suitable dissolution medium for Mefenamic acid.


PubMed | Vishnu Institute of Pharmaceutical Education and Research and Pulla Reddy Institute of Pharmacy
Type: | Journal: Journal of drug delivery | Year: 2015

Diabetes mellitus (DM) and hypertension are two common diseases that often coexist. The most common cause of death in the diabetic patient is heart disease. In the present investigation we combine Nebivolol and Nateglinide for better patient compliance. IR layer was formulated using various superdisintegrants like Crospovidone, Croscarmellose sodium, and sodium starch glycolate and SR layer was formulated using polymers and gums like HPMC E15, ethyl cellulose, Gaur gum, and Xanthan gum. The disintegration and dissolution study of both layers showed that inclusion of surfactant (sodium lauryl sulphate) to the tablet formulation (IR) and dissolution medium (SR) enhanced the release of drugs from both layers. Kinetic studies of optimized IR layer (NBL8) and SR layer (N9) showed good linearity with regression coefficient of 0.9714 (Higuchi model) and 0.9931 (zero order kinetics), respectively. The above results reveal that the optimized IR layer of Nebivolol (NBL8) and SR layer of Nateglinide (N9) might be suitable for the treatment of diabetes and hypertension by sequential release of the two drugs in a bilayer tablet. IR-immediate release, SR-sustain release, NBL8-Nebivolol 8, N9-Nateglinide 9.


Chennaboina S.,Pulla Reddy Institute of Pharmacy | Narsimha Reddy Y.,Kakatiya University | Mayasa V.,Pulla Reddy Institute of Pharmacy | Hussain M.A.,Pulla Reddy Institute of Pharmacy
International Journal of Pharmacy and Technology | Year: 2016

Murraya koenigii (MK) is a tropical or sub tropical plant belonging to family of Rutaceae used in cancer, inflammatory, liver disorders and blood disorders. Liver is the principle functional organ for the metabolism of different drugs and foods. In the present study, protective effect of Murraya koenigii methanolic leaf extract (MMK) was investigated against paracetamol induced hepatotoxicity and compared with silymarin, a standard drug. Five groups of rats (n= 6) were used and they were administered orally once daily with 1.0% CMC (1ml/kg, body weight), 100mg/kg silymarin (positive control), or MMK (200 and 400mg/kg) for 7 days, followed by the hepatotoxicity induction using paracetamol (2gm/kg, po). On the 7th day, the blood samples and livers were collected and subjected to biochemical parameters like (ALP, ALT, AST), total protein, total bilirubin levels and histopathological studies. Hepatotoxic rats were pretreated with silymarin or methanolic extract of MK for seven days. Silymarin and MMK treated groups exhibited significant (p<0.05) decrease in ALT and AST enzyme and converse was observed in toxicant group. Histological examination of the liver tissues supported the hepatoprotective effect of the MMK and it is comparable to standard silymarin. To conclude, that the methanolic extract of leaves of Murrya koenigii plant possesses good hepatoprotective activity. © 2016, International Journal of Pharmacy and Technology. All rights reserved.


Sanjeeva Kumar A.,Raghavendra Institute of Pharmaceutical Education and Research | Raveendra Reddy J.,Raghavendra Institute of Pharmaceutical Education and Research | Rama Mohan Gupta V.,Pulla Reddy Institute of Pharmacy
International Journal of Pharma and Bio Sciences | Year: 2014

Porana paniculata is an ever green creeper belongs to family Convolvulaceae which is widely grown in tropical countries like India. Porana paniculata whole plant is used in ayurveda and folklore for treatment of various disorders including pain and inflammations. Present study was aimed to evaluate preliminary phytochemical studies and analgesic and anti-inflammatory activities of Porana paniculata whole plant. Plant material was subjected to extraction by maceration by using ethanol and water mixture as solvent and subjected to preliminary phytochemical screening. For Analgesic activity, hot plate, tail immersion and acetic acid induced writhing models were used where as for anti inflammatory activity, carrageenan and histamine induced model were employed. A thick green viscous matter about 28.9 gm was obtained from 1000 gm of plant material and the percentage was found to be 2.89% w/w. Preliminary phytochemical screening of whole plant of Porana paniculata revealed the presence of alkaloids, carbohydrates, saponins, tannins and flavonoids. In hot plate and tail immersion methods, plant extract showed significant increase in reaction time and it showed 50.09 % inhibition of the writhing caused by acetic acid (p < 0.05). In anti inflammatory activity, plant extract showed 25.86, 43.10 % inhibition in carrageenan induced model and 13.41, 54.87 % inhibition in histamine induced model at its lower and higher dose levels respectively. From the above findings, it can be concluded that Porana paniculata whole plant possesses significant analgesic and anti inflammatory activities. Present study supports the folklore claim of the plant for pain and inflammation.


Sanjeeva Kumar A.,Raghavendra Institute of Pharmaceutical Education and Research | Raveendra Reddy J.,Raghavendra Institute of Pharmaceutical Education and Research | Rama Mohan Gupta V.,Pulla Reddy Institute of Pharmacy
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Present study is designed with an aim to establish thin layer chromatographic profile of an ethnomedicinally important plant, Ipomoea quamoclit, belongs to Convolvulaceae family. Plant was collected, shade dried and mechanically made into powder. This powder was subjected to cold maceration and preliminary phytochemical screening by standard methods. Thin layer chromatography study was conducted by using different mobile phases and detecting agents according to standard literature. In detection of alkaloids, three spots were identified whose Rf values were found to be 0.39, 0.46 and 0.73. In detection of carbohydrates, four spots were identified whose Rf values were found to be 0.41, 0.52, 0.79 and 0.87. In detection of saponins, four spots were identified whose Rf values were found to be 0.46, 0.59, 0.73 and 0.91. In detection of tannins, two spots were identified whose Rf values were found to be 0.41 and 0.79. In detection of flavonoids, four spots were identified whose Rf values were found to be 0.39, 0.45, 0.57 and 0.86. In detection of amino acids, five spots were identified whose Rf values were found to be 0.32, 0.52, 0.61, 0.68 and 0.81. In detection of phytosterols, four spots were identified whose Rf values were found to be 0.21, 0.42, 0.65 and 0.95.


Pati N.B.,Pulla Reddy Institute of Pharmacy | Gupta V.R.M.,Pulla Reddy Institute of Pharmacy | Velivela S.,Pulla Reddy Institute of Pharmacy | Mayasa V.,Pulla Reddy Institute of Pharmacy
International Journal of Pharmacy and Technology | Year: 2016

Purpose: The aim of the present work was to develop an extended-release dosage form of Tapentadol Hydrochloride (HCl) with various types of polymers and to compare them. Tapentadol is a centrally-acting opioid analgesic indicated for the management of moderate to severe chronic pain and neuropathic pain associated with diabetic peripheral neuropathy in adults. Tapentadol is a BCS class-I drug having biological half-life of 4-5 hours, its systemic bioavailability is 32%, is a suitable candidate for extended release dosage form. Method: Matrix tablets were prepared using different types of hydrophilic and hydrophobic polymers like PEG 6000, Xanthum gum, Guar gum, HPMC K100M, HPMC 15 cps, Carbapol 974, Carbapol 971, Eudragit EPO, Eudragit S-100, CAP, Ethyl Cellulose, Polyox WSR 303, Compritol ATO 888, Gelucire 43/02, 50/1, Geleol and Kollidon SR, by direct compression method and evaluated for various physical and chemical parameters. Results and Discussion: Most hydrophilic polymers failed to prolong the drug release in comparision to hydrophobic polymers based matrix tablets. Among all the polymers HPMC K100M (hydrophilic synthetic cellulose derivative), Carbopol 971NF (hydrophilic synthetic hydrogel), Polyox WSR 303 (water soluble resin) and Gelucire 43/01 (hydrophobic waxy polymer) were found to give optimum and consistent sustained release of drug. All the four formulations showed first order kinetics with non-fickian diffusion controlled release mechanism. © 2016, International Journal of Pharmacy and Technology. All rights reserved.

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