Puericulture Institute and Neonatal Section Azienda Ospedaliero

Monserrato, Italy

Puericulture Institute and Neonatal Section Azienda Ospedaliero

Monserrato, Italy
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Dessi A.,Puericulture Institute and Neonatal Section Azienda Ospedaliero | Pravettoni C.,Puericulture Institute and Neonatal Section Azienda Ospedaliero | Cesare Marincola F.,University of Cagliari | Schirru A.,Puericulture Institute and Neonatal Section Azienda Ospedaliero | Fanos V.,Puericulture Institute and Neonatal Section Azienda Ospedaliero
Expert Review of Proteomics | Year: 2015

Adipose tissue is no longer considered as inert; the literature describes the role it plays in the production of many substances, such as adiponectin, visfatin, ghrelin, S100B, apelin, TNF, IL-6 and leptin. These molecules have specific roles in humans and their potential as biomarkers useful for identifying alterations related to intrauterine growth retardation and large for gestational age neonates is emerging. Infants born in such conditions have undergone metabolic changes, such as fetal hypo- or hyperinsulinemia, which may lead to development of dysmetabolic syndrome and other chronic diseases in adulthood. In this review, these biomarkers are analyzed specifically and it is discussed how metabolomics may be an advantageous tool for detection, discrimination and prediction of metabolic alterations and diseases. Thus, a holistic approach, such as metabolomics, could help the prevention and early diagnosis of metabolic syndrome. © Informa UK, Ltd.


PubMed | Puericulture Institute and Neonatal Section Azienda Ospedaliero
Type: Journal Article | Journal: Expert review of proteomics | Year: 2015

Adipose tissue is no longer considered as inert; the literature describes the role it plays in the production of many substances, such as adiponectin, visfatin, ghrelin, S100B, apelin, TNF, IL-6 and leptin. These molecules have specific roles in humans and their potential as biomarkers useful for identifying alterations related to intrauterine growth retardation and large for gestational age neonates is emerging. Infants born in such conditions have undergone metabolic changes, such as fetal hypo- or hyperinsulinemia, which may lead to development of dysmetabolic syndrome and other chronic diseases in adulthood. In this review, these biomarkers are analyzed specifically and it is discussed how metabolomics may be an advantageous tool for detection, discrimination and prediction of metabolic alterations and diseases. Thus, a holistic approach, such as metabolomics, could help the prevention and early diagnosis of metabolic syndrome.

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