Pudong New District Gongli Hospital

Shanghai, China

Pudong New District Gongli Hospital

Shanghai, China
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Shi Y.,Tongji University | Xu L.,Tongji University | Tang J.,Tongji University | Fang L.,Tongji University | And 8 more authors.
American Journal of Physiology - Renal Physiology | Year: 2017

Histone deacetylase 6 (HDAC6) inhibition has been reported to protect against ischemic stroke and prolong survival after sepsis in animal models. However, it remains unknown whether HDAC6 inhibition offers a renoprotective effect after acute kidney injury (AKI). In this study, we examined the effect of tubastatin A (TA), a highly selective inhibitor of HDAC6, on AKI in a murine model of glycerol (GL) injection-induced rhabdomyolysis. Following GL injection, the mice developed severe acute tubular injury as indicated by renal dysfunction; expression of neutrophil gelatinase-associated lipocalin (NGAL), an injury marker of renal tubules; and an increase of TdT-mediated dUTP nick-end labeling (TUNEL)-positive tubular cells. These changes were companied by increased HDAC6 expression in the cytoplasm of renal tubular cells. Administration of TA significantly reduced serum creatinine and blood urea nitrogen levels as well as attenuated renal tubular damage in injured kidneys. HDAC6 inhibition also resulted in decreased expression of NGAL, reduced apoptotic cell, and inactivated caspase-3 in the kidney after acute injury. Moreover, injury to the kidney increased phosphorylation of nuclear factor (NF)-ĸB and expression of multiple cytokines/chemokines including tumor necrotic factor-α and interleukin-6 and monocyte chemoattractant protein-1, as well as macrophage infiltration. Treatment with TA attenuated all those responses. Finally, HDAC6 inhibition reduced the level of oxidative stress by suppressing malondialdehyde (MDA) and preserving expression of superoxide dismutase (SOD) in the injured kidney. Collectively, these data indicate that HDAC6 contributes to the pathogenesis of rhabdomyolysis-induced AKI and suggest that HDAC6 inhibitors have therapeutic potential for AKI treatment. © 2017 the American Physiological Society.


Bi X.,Pudong New District Gongli Hospital | Zhao J.,Pudong New District Gongli Hospital | Zhao L.,Pudong New District Gongli Hospital | Liu Z.,Pudong New District Gongli Hospital | And 4 more authors.
Journal of International Medical Research | Year: 2013

Objective: To assess the effect of pelvic floor muscle exercise in patients with chronic low back pain. Methods: Adults (aged ≥18 years) with chronic low back pain (with or without radiculopathy) were randomized to undergo either routine treatment (ultrasonography, short wave diathermy and lumbar strengthening exercises; control group) or routine treatment with pelvic floor exercises (intervention group) for 24 weeks. Pain, disability (Oswestry Disability Index [ODI] score) and trunk muscle function were assessed at baseline and after completion of treatment. Results: The study included 47 patients (control group n=24; intervention group n=23). Pain severity and ODI scores were significantly lower in the intervention group than in the control group after 24 weeks. There were no significant between-group differences in trunk muscle function. Conclusion: Pelvic floor exercise in combination with routine treatment provides significant benefits in terms of pain relief and disability over routine treatment alone. © The Author(s) 2013.


Tang Z.,Branch Hospital in Fengxian of the Shanghai Sixth Peoples Hospital | Chen F.,Branch Hospital in Fengxian of the Shanghai Sixth Peoples Hospital | Shi L.-H.,Pudong New District Gongli Hospital | Fu H.-M.,Pudong New District Mental Health Center | Qu Z.-W.,Pudong New District Mental Health Center
Chinese Journal of Medical Imaging Technology | Year: 2012

Objective: To observe the clinical value of low-dose CT perfusion imaging (CTPI) in the diagnosis of senile dementia. Methods: Totally 95 patients with senile dementia (senile dementia group, including 52 with Alzheimer disease, 43 with vascular dementia) and 30 healthy subjects (control group) underwent low-dose CTPI examination with multi-slice spiral CT after plain scan. CT perfusion images were analyzed using perfusion software. Derived perfusion parameters including cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT) and time to peak (TTP) were measured. The diagnostic value of perfusion parameters was evaluated by ROC curve. Results: CBV and CBF of both of frontal lobe, temporal lobe, hippocampus and basal ganglial area in senile dementia group were much lower than those of control group. MTT and TTP of the above-mentioned areas in senile dementia group were higher than those in the control group (P<0.05). The area under ROC curves of perfusion parameters left temporal lobe MTT, left the basal ganglia MTT and left the hippocampus MTT to diagnose senile dementia was 0.959, 0.920 and 0.916, respectively, indicating higher diagnostic accuracy, while of left frontal MTT, left the basal ganglia CBV was 0.867 and 0.819, respectively, indicating mediate diagnostic accuracy. Conclusion: CTPI is valuable for the diagnosis of senile dementia, and can be used as an effective method. © 2012 by the Press of Chinese Journal of Medical Imaging Technology.


Tang Z.,Branch Hospital In Fengxian Of Shanghai No 6 Peoples Hospital | Chen F.,Branch Hospital In Fengxian Of Shanghai No 6 Peoples Hospital | Huang J.,Branch Hospital In Fengxian Of Shanghai No 6 Peoples Hospital | Shi L.,Pudong New District Gongli Hospital | And 6 more authors.
Archives of Gerontology and Geriatrics | Year: 2013

To evaluate the clinical value of low-dose cerebral CTPI in the diagnosis of senile dementia, as an attempt to develop a new imaging method to diagnose this disease and measure its severity. 95 patients of senile dementia (52 with Alzheimer's disease (AD), 43 with vascular dementia (VD)) and 30 healthy subjects (control group) were underwent low-dose cerebral CTPI examinations with multi-slices spiral CT. The CTPI images were analyzed using perfusion software. Derived perfusion parameters including cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT) and time to peak (TTP) were measured. Diagnostic value of perfusion parameters was evaluated by receiver-operating characteristic (ROC) curve. The CBV and CBF of both of frontal lobe, temporal lobe, hippocampus and basal ganglial area in the patients with senile dementia were much lower than those in the healthy group. And MTT and TTP of the areas above-mentioned in the senile dementia group were higher than those in the control group. There was statistically significant difference between them (p<0.05). The areas under ROC curves of perfusion parameters left temporal lobe MTT, left the basal ganglia MTT and left the hippocampus MTT to diagnose senile dementia were 0.959, 0.920, 0.916, and diagnostic accuracy rate is higher. The areas under ROC curve of the left frontal MTT, the left basal ganglia CBV were 0.867 and 0.819, diagnosis accuracy medium. The results showed that cerebral CTPI is valuable for the diagnosis of senile dementia. © 2012 Elsevier Ireland Ltd.


Tang Z.,Branch Hospital In Fengxian Of Shanghai No 6 Peoples Hospital | Pi X.,Pudong New District Gongli Hospital | Chen F.,Branch Hospital In Fengxian Of Shanghai No 6 Peoples Hospital | Shi L.,Pudong New District Gongli Hospital | And 3 more authors.
American Journal of Alzheimer's Disease and other Dementias | Year: 2012

To evaluate the value of 50% reduced-dose cerebral computed tomography (CT)perfusion imaging (CTPI) to show the perfusion abnormalities in Alzheimer's disease (AD), as an attempt to develop a new imaging protocol with lower radiation dose to track the correlation of AD with regional blood flow abnormalities. A total of 52 patients with AD were assigned to the AD group and 28 healthy volunteers served as the control group. All participants were given a 50% reduced-dose cerebral CTPI (current was reduced from 160 to 80 mA) test by a multislice spiral CT scanner. Perfusion parameters of the bilateral frontal cortex, temporal cortex, hippocampus, and basal ganglia were measured, including the cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), and time to peak (TTP). Both the CBV and CBF values of the measured regions were significantly higher in the healthy control group than in the AD group (P <.05), while the MTT and TTP values of these cerebral areas were significantly lower in the healthy control group than in the AD group (P <.05). Four perfusion parameters, namely the MTT of the left frontal cortex, right temporal cortex, right basal ganglia, and right hippocampus, had the greatest sensitivity and a striking correlation with the incidence of AD. The blood flow per unit of time in the regions of interest was significantly lower in the AD group, which provides new evidence for the existence of microcirculation disturbance and ischemia in AD. The 50% reduced-dose cerebral CTPI scan is valuable to show the regional perfusion abnormalities in the patients with AD. © The Author(s) 2012.


PubMed | Tongji University, Brown University and Pudong New District Gongli Hospital
Type: | Journal: American journal of physiology. Renal physiology | Year: 2017

Histone deacetylase 6 (HDAC6) inhibition has been reported to protect against ischemic stroke and prolong survival after sepsis in animal models. However, it remains unknown whether HDAC6 inhibition offers a renoprotective effect after acute kidney injury (AKI). In this study, we examined the therapeutic effect of tubastatin A (TA), a highly selective inhibitor of HDAC6, on AKI in a murine model of glycerol (GL) injection-induced rhabdomyolysis. Following GL injection, the mice developed severe acute tubular injury as indicated by renal dysfunction, expression of neutrophil gelatinase-associated lipocalin (NGAL), an injury marker of renal tubules and increase of TUNEL positive tubular cells. These changes were companied by increased HDAC6 expression in the cytoplasm of renal tubular cells. Administration of TA significantly reduced serum creatinine and blood urea nitrogen levels as well as attenuated renal tubular damage in injured kidneys. HDAC6 inhibition also resulted in decreased expression of NGAL, reduced apoptotic cell and inactivated caspase-3 in the kidney after acute injury. Moreover, injury to the kidney increased phosphorylation of nuclear factor (NF)-B and expression of multiple cytokines/chemokines including tumor necrotic factor- and interleukin-6, and monocyte chemoattractant protein-1, as well as macrophages infiltration. Treatment with TA attenuated all those responses. Collectively, these data indicate that HDAC6 contributes to the pathogenesis of rhabdomyolysis-induced AKI and suggest that HDAC6 inhibitors have therapeutic potential for AKI treatment.

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