Curitiba, Brazil
Curitiba, Brazil

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PubMed | University of Michigan, Fresenius Medical Care, University of Cologne, Danube University Krems and 7 more.
Type: Journal Article | Journal: Clinical kidney journal | Year: 2016

The aim of this study was to describe the experience of pediatric and young adult hemodialysis (HD) patients from a global cohort.The Pediatric Investigation and Close Collaborative Consortium for Ongoing Life Outcomes for MONitoring Dialysis Outcomes (PICCOLO MONDO) study provided de-identified electronic information of 3244 patients, ages 0-30 years from 2000 to 2012 in four regions: Asia, Europe, North America and South America. The study sample was categorized into pediatric (18 years old) and young adult (19-30 years old) groups based on the age at dialysis initiation.For those with known end-stage renal disease etiology, glomerular disease was the most common diagnosis in children and young adults. Using Europe as a reference group, North America [odds ratio (OR) 2.69; CI 1.29, 5.63] and South America (OR 4.21; CI 2.32, 7.63) had the greatest mortality among young adults. North America also had higher rates of overweight, obesity, hypertension, cardiovascular disease, hospitalizations and secondary diabetes compared with all other regions. Initial catheter use was greater for North American (86.4% in pediatric patients and 75.2% in young adults) and South America (80.6% in pediatric patients and 75.9% in young adults). Catheter use at 1-year follow-up was most common in North American children (77.3%) and young adults (62.9%). Asia had the lowest rate of catheter use. For both age groups, dialysis adequacy (equilibrated Kt/V) ranged between 1.4 and 1.5. In Asia, patients in both age groups had significantly longer treatment times than in any other region.The PICCOLO MONDO study has provided unique baseline and 1-year follow-up information on children and young adults receiving HD around the globe. This cohort has brought to light aspects of care in these age groups that warrant further investigation.


De Castro Avila L.F.,Univille | Martins W.D.,Pontifical Catholic University of Parana | Ignacio S.A.,PUCPR | Bonfim C.M.S.,Federal University of Paraná | De Oliveira Ribas M.,Oral and Maxillofacial Surgery
Cleft Palate-Craniofacial Journal | Year: 2014

Objective: This study is aimed to evaluate craniofacial features in patients with Fanconi anemia (FA) through cephalometric analysis and to classify the facial growth pattern to observe possible facial discrepancies. Design: This is a cross-sectional study which employed a quantitative approach to compare linear and angular measurements of cephalometric analysis in lateral teleradiographic images of a clinical type sample of patients with FA. A retrospective cephalometric study was performed using cephalometric analyses of Ricketts and Steiner; growth patterns according to Ricketts' vertical growth pattern (VERT index) were also analyzed. Patients: Fifty patients diagnosed with FA who were undergoing anti-aplasia treatment at the outpatient Hematology service at the Federal University of Parana , Curitiba, Brazil were included in the study. Interventions: The patients were evaluated in the School of Dentistry of the Pontifical Catholic University of Parana (PUCPR), Curitiba, Brazil. Exclusion criteria included patients who had used or were using growth hormone medication, had undergone bone marrow transplant, or had been previously subjected to dental treatment. Main Outcome Measures: Cephalometric points were plotted in order to set up linear and angular cephalometric measurements. Angular and linear measurements from 17 factors proposed by Ricketts' cephalometric analysis were assessed. Results: Dolicofacial appearance was observed in 52% of individuals; braquifacial in 28%, and mesofacial in 20%. Significant maxillary/mandibular discrepancy was observed. It was concluded that upon anteroposterior evaluation of facial bone structures, the FA sample presented smaller median measurements in most variables evaluated; it also presented mandibular micrognathism and mainly dolicofacial vertical growth pattern. These findings, together with other features such as skin pigmentation and microphthalmia, may lead to a possible recognition of a FA condition from a patient's facial features. © Copyright 2014 American Cleft Palate-Craniofacial Association.


Aires S.B.K.,Federal Technological University of Paraná | De Freitas C.O.A.,PUCPR | Oliveira L.S.,Federal University of Paraná
Proceedings - 2015 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2015 | Year: 2015

The paper contributes to the CBIR systems applied to trademark retrieval. The proposed model uses Scale Invariant Feature Transform (SIFT) and includes aspects from visual perception of the shapes, by means of feature extractor associated to a non-symmetrical perceptual zoning mechanism based on the Principles of Gestalt. We carried out experiments using four different zonings strategies for matching and retrieval tasks. The proposed method achieved the normalized recall (Rn) equal to 0.84. Experiments show that the non-symmetrical zoning could be considered as a tool to build more reliable trademark retrieval systems. © 2015 IEEE.


de Carvalho R.I.N.,Pontifical Catholic University of Parana | Biasi L.A.,Federal University of Paraná | Zanette F.,Federal University of Paraná | Pereira G.P.,PUCPR
Revista Brasileira de Fruticultura | Year: 2010

The objective of this research was to evaluate the dormancy dynamic of peach tree 'Chimarrita' and plum tree 'Poli Rosa' buds in a region of low chill occurrence. The stems were collected in an orchard in Fazenda Rio Grande, State of Parana, Brazil, from April to August of 2007 and 2008. In the last date, an additional group of stems was collected and maintained in a refrigerator (4 to 7°C) by 672 hours. The evaluation of dormancy was observed by the biological test of single node cuttings under controlled conditions of temperature (25°C) and photoperiod (16 h). The quantification of chilling hours (CH) and the chilling units (CU) occurred in the region were performed. The two species were evaluated separately, as two separate experiments. The experimental design was completely randomized, with 9 treatments for peach tree buds and 11 treatments for plum tree buds, both with four replications. The two years were analyzed individually. The more intense endodormancy period of peach tree buds occurred in May 2007 and 2008. The more intense endodormancy period of plum tree buds occurred in May 2007, and it was extended until June 2008.


Varela P.,PUCPR | Justino E.,PUCPR | Oliveira L.S.,Federal University of Paraná
Proceedings of the International Joint Conference on Neural Networks | Year: 2011

In this work we present a methodology to select syntactic attributes for authorship attribution. The approach takes into account a multi-objective genetic algorithm and a Support Vector Machine classifier and it operates in a wrapper mode. Through a series of comprehensive experiments on a database composed of 3000 short articles written in Portuguese we show that the proposed methodology is able to provide a concise subset of attributes, which increases the recognition rate in about 15 percentage points. © 2011 IEEE.


This article presents an in-depth bibliographic study about the creation, principles, evolution, and practices of the lean philosophy oriented to the services sector. More than 70 papers about "lean thinking" - specially with focus on services - have been carefully reviewed. It presents the principles of lean service in an organized way, companies applying lean service, and best practices and tools in the implementation of lean service. It shows that lean service does not have a single or specific model of tools, practices or standards. In fact, it is a mix of tools and practices that must be applied according the situation found to be improved. Despite the lack of a standards and methodology for use in services, its best practices, inherited from manufacturing, when applied to services can generate large economic and financial results, as well as improvement of workers' behavior. But, like any change process, this study shows that the application of lean in services also suffers resistance. There might be limitations when evaluating lean practices and principles to services, specially those that have not yet been well defined and reported. Other limitations are due to the scarce articles in the literature. However, this research showed that the use of the lean philosophy in services proved to be effective and quite worthwhile. Several cases analyzed presented significant gains and confirmed an increasing and promising future for service companies "thinking lean".


Understanding value creation mechanisms for producing goods and services occupies a special place in enterprises' agenda. The renaissance of Resource Based Theory is a sign of this research intensification, which is focused on organizational resources, capabilities and the role of competences in operations systems value creation. This work develops an integration model based on the intellectual capital concept, to articulate resources, capabilities and competences. The model is built using the resources, capabilities, competences and intellectual capital variables definition, addressing them in their different levels of analysis. The structure of the integration model construction used is based on the Skandia navigator model, taking into account their performance dimensions for developing this study. The result is a model that explains the integrative dynamics of resources, capabilities and competences for assessing value creation from the perspective of intellectual capital.


da Costa F.D.A.,PUCPR | Takkenberg J.J.M.,Erasmus Medical Center | Fornazari D.,PUCPR | Filho E.M.B.,PUCPR | And 7 more authors.
European Journal of Cardio-thoracic Surgery | Year: 2014

Objectives: The purpose of the study was to assess the 18-year outcome of the Ross operation (RO), with emphasis on survival, reoperations, and late function of the pulmonary autografts (PAs) and the right-sided pulmonary allografts. Methods: Between May 1995 to July 2013, 414 patients with a mean age (mean ± standard deviation) of 30.8 ± 13.1 years were submitted to an RO with the root replacement (n = 356) or the inclusion (n = 58) technique. The most prevalent aetiology was bicuspid valve (n = 206, 49.8%). Patients were divided in four groups depending on the type of allograft used on the right side. The mean follow-up was 8.2 ± 5.2 years and was 97.7% complete. In addition to longitudinal outcomes determined by means of the Kaplan-Meier analysis, log-rank test and Cox regression analysis were used to identify predictors of valve failure. Results: The early mortality rate was 2.7% and the late survival rate was 89.3% at 15 years, similar to an age- and sex-matched population. There were 22 reoperations on the PA (90.7% freedom at 15 years) and 15 on the pulmonary allografts (92.5% freedom at 15 years). The freedom rate from more than mild aortic insufficiency (AI) was 73.1% at 15 years. Thirty-three patients presented with a late root diameter >45 mm, corresponding to a freedom rate of 72.4% at 15 years. Patients with AI and a dilated annulus, especially males, are at greater risk for these complications. Among the right-sided allografts, fresh decellularized allografts showed significantly superior freedom from structural valve dysfunction. Conclusions: The RO was associated with excellent long-term survival and low incidence of reoperations up to 15 years. Male patients with AI and dilated annulus are at increased risk for late insufficiency and root dilatation. Fresh decellularized allografts presented the best results for reconstruction of the right ventricular outflow tract. © The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.


Moser A.D.L.,Pontifical Catholic University of Parana | Knaut L.A.M.,University of Montréal | Zotz T.G.,PUCPR | Scharan K.O.,PUCPR
Revista Brasileira de Reumatologia | Year: 2012

Introduction: The American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form (ASES), often used in research in Brazil, although translated and adapted to the Portuguese language, had not had its validity and reliability tested yet. Objective: To assess the validity, reliability, and internal consistency of the ASES-PT for shoulder dysfunction. Materials and methods: Fifty individuals (26 women; mean age, 39 ± 13 years) participated in the validity assessment, and 38 (19 women; mean age, 37 ± 13 years old) in the reliability assessment, all having shoulder dysfunction. The participants completed the 36-Item Short-Form Health Survey (SF-36), the Disabilities of the Arm, Shoulder and Hand Questionnaire (DASH), and the ASES-PT on two occasions with an interval of seven days. The convergent validity was assessed by use of the Spearman's rank correlation coefficient (ρ), and the analysis of the intrarater reliability used the intraclass correlation coefficient (ICC). The internal consistency was assessed by using Cronbach's alpha. Results: The ASES-PT scores correlated with the DASH scores (ρ = -0.69, P = 0.000) and with the "physical functioning" (ρ = 0.50, P = 0.000), "role limitation due to physical health" (ρ = 0.43, P = 0.002) and "bodily pain" domains (ρ = 0.60, P = 0.000) of the SF-36. The intrarater reliability of the ASES-PT proved to be adequate (ICC = 0.75, P = 0.000). The internal consistency (0.794) was satisfactory. Conclusion: The validity and reliability study of the ASES-PT supports its use for assessing shoulder dysfunction. © 2012 Elsevier Editora Ltda. All rights reserved.


Myszczuk A.P.,PUCPR.
Revista de derecho y genoma humano = Law and the human genome review / Cátedra de Derecho y Genoma Humano/Fundación BBV-Diputación Foral de Bizkaia | Year: 2012

This study discusses the possibility of patenting inventions based on human genes and the need for an effective adaptation of the Patent Law system to enable the patenting of material derived from human genes. Furthermore, to allow for the inclusion of human gene-based inventions in the current patent system, many more amendments are required than those that have already become law during and since the twentieth century. It should be emphasized that one of the main characteristics of Patent Law is this changeability that requires the law to constantly respond to economic needs, advances in science and their resulting challenges in order to protect the product of human ingenuity. Therefore, new adaptations are required. In this context, the present paper adopts the understanding that human genes may serve as a basis for patentable inventions provided that the traditional requirements of novelty, inventiveness, utility and descriptive adequacy are adapted to the specific nature of living human matter. They should also be in line with the principles of legality and morality and not infringe human dignity, personality rights and should fulfill their social and environmental functions. Therefore, a bio-patent has a threefold function: economic, social and environmental. The economic function lies in the exclusive right to exploit an invention; the social function is implicit because there is no reason for the existence of a patent that solely benefits, its owner without society also enjoying its benefits and; the environmental function is that which guarantees that a bio-patent should preserve biodiversity and social diversity.

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