Public Higher Medical Professional School in Opole

Opole Lubelskie, Poland

Public Higher Medical Professional School in Opole

Opole Lubelskie, Poland
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Mazzatenta A.,University of Chieti Pescara | Pokorski M.,Public Higher Medical Professional School in Opole | Pokorski M.,University of Opole | Di Giulio C.,University of Chieti Pescara
Respiratory Physiology and Neurobiology | Year: 2015

A plethora of studies on this model show the complexity of the system. Laboratory studies fail to find a biomarker of senescence. The real time exhaled breath volatile organic compounds (VOCs) has been suggested as a new biomarker to detect and monitor physiological processes in the respiratory system. VOCs exhaled by centenarians have not been studied in the general population and across-age-groups. In the present study we investigated, in real time, the breath properties and VOC exhaled content in healthy centenarians as compared with non-centenarian seniors and young healthy subjects. We found distinctly different breath pattern and distribution profiles of VOCs in the centenarians. Thus, the VOCs measurement allowed to discriminate the differences between the age-groups. We propose a VOCs fingerprint as a biomarker underlying the physiological mechanisms of aging and longevity. Longevity should be considered physiologically as a new phase of life, characteristic of the well adapted subject. © 2014 Elsevier B.V.


Mastalerz-Migas A.,Wroclaw Medical University | Pokorski M.,Public Higher Medical Professional School in Opole | Pokorski M.,University of Opole | Kilis-Pstrusinska K.,Wroclaw Medical University | And 4 more authors.
Advances in Experimental Medicine and Biology | Year: 2015

Toll-like receptors (TLRs) are involved in immunogenicity. However, little information is available on the role of TLRs in the immune response to vaccination against influenza virus. The aim of the study was to analyze the relationship between the immunogenic response to influenza vaccine and the presence of soluble forms of TLRs and selected cytokines in the serum. There were two groups of subjects participating in the main protocol of the study: 55 chronically hemodialyzed patients (Group A) and 55 healthy volunteers (Group B) participated in the study. Both groups were vaccinated against influenza using a subunit Agrippal vaccine. The concentrations of human TNF-α, IL-1β/IL-1F2, IL-6, and IL-10 were measured by a high sensitivity enzyme-linked immunosorbent assay. The soluble forms of TLR-2, TLR-4, and TLR-7 were determined in serum samples by ELISA as well. The findings were that vaccination did not appreciably influence the level soluble TRL-2, TRL-4, and TRL-7 or the cytokines investigated either in patients on hemodialysis or in healthy volunteers. Nor were there any relevant correlations between Toll-like receptors or pro-inflammatory cytokines and the immune response to influenza vaccination. On the other hand, the study showed that Toll-like receptors are increased in hemodialyzed patients, which may enhance the anti-inflammatory IL-10 and counter the downgrade of the immune response to influenza vaccine. © Springer International Publishing Switzerland 2014.


Pokorski M.,Public Higher Medical Professional School in Opole | Klimanska S.,University of Opole
Advances in Experimental Medicine and Biology | Year: 2015

Deafness is a model of brain adaptation to sensory deprivation which entails psychomotor and cognitive domains. This study seeks to determine the level of emotional intelligence, assessed from the ability to discern emotions from facial expressions, visual and mental attention, and non-verbal fluency in the deaf people as compared with the hearing counterparts. Participants were 29 prelingually deaf, hearing loss of >70 dB, communicating only in sign language, and 30 hearing persons. The age range of all subjects was 40-50 years. Psychometric tools consisted of the Emotional Intelligence Scale-Faces, the d2 Test of Attention, and the Figural Fluency Test. Data elaboration took gender into account. The findings were that both deaf women and men defined significantly fewer emotions as known, compared with the hearing persons. However, the deaf men, but not women, were able to properly recognize a higher percentage of emotions associated with a definite face look, among the emotions they knew. There were no appreciable differences in attention indices between the deaf and hearing men, but deaf women’s total performance on attention was worse. By contrast, deaf women, but not men, fared better in non-verbal fluency, compared with their hearing counterparts. We conclude that, on the whole, prelingual deafness does not impede cognitive functioning in adult age. The nature of detecting and executing of cognitive tasks, despite gender and taskspecific variations, is preserved. Brain networks are able to compensate for the missing auditory input. © Springer International Publishing Switzerland 2014.


PubMed | Public Higher Medical Professional School in Opole and University of Chieti Pescara
Type: | Journal: Advances in experimental medicine and biology | Year: 2016

Most chemically mediated sexual communication in humans remains uncharacterized. Yet the study of sexual communication is decisive for understanding sexual behavior and evolutive mechanisms in our species. Here we provide the evidence to consider 4,16-androstadien-3-one (AND) as a mans sexual pheromone. Our experiment provides support for the physiological effect of AND on nasal airway resistance (Rna) in women, as assessed by anterior rhinomanometry. We found that AND administration increased the area of turbinate during the ovulatory phase, resulting in an increase of Rna. Thus, we discovered that minute amounts of AND, acting through neuroendocrine brain control, regulate Rna and consequently affect the sexual physiology and behavior. Fascinatingly, this finding provides the evidence of the preservation of chemosexual communication in humans, which it has been largely neglected due to its unconscious perception and concealed nature. Therefore, chemical communication is a plesiomorphic evolutive phenomenon in humans.


Kurpas D.,Wroclaw Medical University | Mroczek B.,Pomeranian Medical University | Karakiewicz B.,Pomeranian Medical University | Kassolik K.,Public Higher Medical Professional School in Opole | And 3 more authors.
Annals of Agricultural and Environmental Medicine | Year: 2013

Introduction and objective: Wind power is employed worldwide as an alternative source of energy. At the same time, however, the health effects of wind turbines have become a matter of discussion. The purpose of this study is a critical review of available reports providing arguments both for and against the construction of wind farms. The authors also attempt to propose recommendations in accordance with the Evidence-Based Medicine (EBM) guidelines. In the case of exposure to wind farms, a randomized controlled trial (RCT) is impossible. To obtain the highest-level recommendations, analysis of case-control studies or cohort studies with control groups should be performed. Preferably, it should include geostatistical analysis conducted with the use of variograms and the kriging technique. Combinations of key words were entered into the Thomson Reuters Web of KnowledgeSM and the Internet search engine Google. Short description of state of the art: The nuisance caused by wind turbines is stereotypically linked with the noise that they produce. Nevertheless, the visual aspect of wind farms, opinions about them, and sensitivity to sound seem to be of the greater importance. To date, the direct correlations between the vicinity of modern wind farms, the noise that wind turbines make, and possible consequences to health have not been described in peer reviewed articles. Health effects are more probably associated with some environmental factors leading to annoyance or frustration. All types of studies share the same conclusion: wind turbines can provoke annoyance. As with any project involving changes in the local environment, a certain level of irritation among the population can be expected. There are elected officials and government representatives who should decide what level of social annoyance is acceptable, and whether wind power advantages outweigh its potential drawbacks. The influence of wind turbines on human emotional and physical health is a relatively new field of research. Further analyses of these issues are justified, especially because none of the studies published in peer-reviewed journals so far meet the criteria for cohort or case-control studies. Summary: Due to methodology, currently available research results do not allow for higher than C-level recommendations. In the case of wind farms, the ideal types of research would be: a retrospective observation of a particular group of residents before and after the wind farm construction, case-control studies or cohort studies with control groups matched in respect of socioeconomic factors, predisposition for chronic diseases, exposure to environmental risk factors, and only one variable which would differentiate cases from controls - the distance between place of residence and a wind farm.


Sigel A.,University of Basel | Operschall B.P.,University of Basel | Matera-Witkiewicz A.,Wroclaw Medical University | Swiatek-Kozlowska J.,Public Higher Medical Professional School in Opole | Sigel H.,University of Basel
Coordination Chemistry Reviews | Year: 2016

The thionucleoside 2-thiocytidine (C2S) as well as the thiouridines (US) occur in Nature, especially in transfer RNAs, and they also receive attention in diverse fields like nanotechnology and drug research. If (C2)O in cytidine (Cyd) is replaced by (C2)S to give the thio analogue C2S, the release of H+ from (N3)H in H(C2S)+ (pK a =3.44) is facilitated somewhat [H(Cyd)+; pK a =4.24], yet, the deprotonation of the (C4)NH2 group is much more affected: the pK a decreases from ca. 16.7 in Cyd to 12.65 in C2S. This is because the amino-thione tautomer dominating in the neutral C2S, transfers into the imino-thioate form, which has the charge largely localized on (C2)S-. As a consequence, the M(C2S)2+ species (M2+ =Zn2+ or Cd2+) transfer very easily into their deprotonated M(C2S-H)+ forms. This reaction is extremely facilitated by M2+coordination at (C2)S- and occurs already at a pH slightly above 3. It is shown that the (C2)SM2+ coordination dominates to more than 99% in both the M(C2S)2+ and the M(C2S-H)+ complexes; their structures, including chelate formation with the participation of N3, are evaluated. In 2-thiouridine (U2S), 4-thiouridine (U4S), and 2,4-dithiouridine (U2S4S), the release of H+ from (N3)H, compared to Urd (pK a =9.18), is facilitated by ca. 1 to 2 pK units, the charge being largely localized on the (C)S sites; this leads with (U4S-H)- and (U2S4S-H)- to the reduction of Cu(II) to Cu(I), transforming the thiolate into a disulfide. In Cu(U2S-H)+ Cu(II) is stable, most likely due to steric constraints inhibiting disulfide formation. The stability of the M(US-H)+ complexes with Ni2+, Cu2+ or Cd2+ is enhanced by about 1.3 to 2log units compared to the corresponding uridinate complexes. The properties of the biologically relevant Zn(US-H)+ are expected to be between those with Ni2+ and Cd2+. The relatively high affinity of the (C)S sites for these M2+ is reflected in the 2-thiouridine 5'-monophosphate (U2SMP2-) and 4-thiouridine 5'-monophosphate (U4SMP2-) complexes, M2+ being located to more than 99% at the thiouracil residue and only traces are coordinated at the phosphate group. In the N3-deprotonated Cu[(U2S-H)MP]- species the anti conformer is partly turned into the syn one allowing thus a formation degree of about 60% of the macrochelate formed by (C2)S- and the phosphate group. The corresponding coordination pattern also seems to hold for Cd[(U2S-H)MP]-, though the formation degree of the macrochelate is lower. No macrochelate formation is detected for Ni[(U2S-H)MP]-, as well as for Ni[(U4S-H)MP]- and Cd[(U4S-H)MP]-. The reasons for the indicated coordination patterns are discussed, as well as the biological implications of the summarized results, especially with regard to tRNAs. © 2016 Elsevier B.V.


Halski T.,Public Higher Medical Professional School in Opole | Ptaszkowski K.,Wroclaw Medical University | Slupska L.,Wroclaw Medical University | Dymarek R.,Wroclaw Medical University
BioMed Research International | Year: 2013

Objectives. The main objective was to determine how the depth of probe placement affects functional and resting bioelectrical activity of the PFM and whether the recorded signal might be dependent on the direction in which the probe is rotated. Participants. The study comprised of healthy, nulliparous women between the ages of 21 and 25. Outcome Measures. Bioelectric activity of the PFM was recorded from four locations of the vagina by surface EMG and vaginal probe. Results. There were no statistically significant differences between the results during functional sEMG activity. During resting sEMG activity, the highest bioelectrical activity of the PFM was observed in the L1 and the lowest in the L4 and a statistically significant difference between the highest and the lowest results of resting sEMG activity was observed (P=0.0043). Conclusion. Different electrodes placement during functional contraction of PFM does not affect the obtained results in sEMG evaluation. In order to diagnose the highest resting activity of PFM the recording plates should be placed toward the anterior vaginal wall and distally from the introitus. However, all of the PFM have similar bioelectrical activity and it seems that these muscles could be treated as a single muscle. © 2013 Tomasz Halski et al.


PubMed | Public Higher Medical Professional School in Opole and Wroclaw Medical University
Type: | Journal: Surgical and radiologic anatomy : SRA | Year: 2016

The falcine sinus in the falx cerebri is rarely encountered in adults, appearings in approximately 2.1% of CT examinations of adult patients. Some authors have studied the plexus rather than the sinus, a rare form of the venous pathway between the layers of the cerebral falx, which connects the superior sagittal sinus with the inferior sagittal sinus and the straight sinus. The aim of this study was to analyse the anatomy of the falcine sinus in the prenatal period, which will fill a gap in the literature.This study consisted of 50 foetuses with a v-tube length of 89-229mm and the equivalent of 15-28weeks of intrauterine development on the Scammon and Calkins scale.Blood vessels were filled with latex LBS 3022, and analysis was performed using the Scion Image for Windows 4.0.3.2 and Image J. We used various linear and nonlinear transformations.In 20 cases, intraventricular and periventricular haemorrhages were detected. The other cases showed sinuses in the cerebral falx, specifically in the back parts of the falx, and were described as oblique, straight, wavy, or network. A very rich venous network is located around the superior sagittal sinus; the middle section grew twice its length and the back section grew three times its width, reaching the lowest areas of the cerebral falx, the inferior sagittal sinus, and the straight sinus. Anastomotic intersinual loops appeared. There were three forms of venous weave crescents: isolated limited to the area adjacent to the superior sagittal sinus, partly merging with the straight sinus and a fully developed falcine sinus, which appeared in the older age groups with the most primitive forms being plexiform. Their remains a plurality of channels within the same superior sagittal sinus that show a predominance in the posterior segment.The location of the falcine sinus has been mostly associated with the rear one-third of the cerebral falx and should be considered during neurosurgery, because the front two-thirds of the cerebral falx are called the safe zone. Knowledge of the falcine sinus anatomy is important for descriptions in neuroimaging examinations.


PubMed | Wroclaw Medical University and Public Higher Medical Professional School in Opole
Type: | Journal: BioMed research international | Year: 2014

The main objective was to determine how the depth of probe placement affects functional and resting bioelectrical activity of the PFM and whether the recorded signal might be dependent on the direction in which the probe is rotated.The study comprised of healthy, nulliparous women between the ages of 21 and 25.Bioelectric activity of the PFM was recorded from four locations of the vagina by surface EMG and vaginal probe.There were no statistically significant differences between the results during functional sEMG activity. During resting sEMG activity, the highest bioelectrical activity of the PFM was observed in the L1 and the lowest in the L4 and a statistically significant difference between the highest and the lowest results of resting sEMG activity was observed (P = 0.0043).Different electrodes placement during functional contraction of PFM does not affect the obtained results in sEMG evaluation. In order to diagnose the highest resting activity of PFM the recording plates should be placed toward the anterior vaginal wall and distally from the introitus. However, all of the PFM have similar bioelectrical activity and it seems that these muscles could be treated as a single muscle.


PubMed | Public Higher Medical Professional School in Opole
Type: | Journal: Advances in experimental medicine and biology | Year: 2014

Deafness is a model of brain adaptation to sensory deprivation which entails psychomotor and cognitive domains. This study seeks to determine the level of emotional intelligence, assessed from the ability to discern emotions from facial expressions, visual and mental attention, and non-verbal fluency in the deaf people as compared with the hearing counterparts. Participants were 29 prelingually deaf, hearing loss of >70 dB, communicating only in sign language, and 30 hearing persons. The age range of all subjects was 40-50 years. Psychometric tools consisted of the Emotional Intelligence Scale-Faces, the d2 Test of Attention, and the Figural Fluency Test. Data elaboration took gender into account. The findings were that both deaf women and men defined significantly fewer emotions as known, compared with the hearing persons. However, the deaf men, but not women, were able to properly recognize a higher percentage of emotions associated with a definite face look, among the emotions they knew. There were no appreciable differences in attention indices between the deaf and hearing men, but deaf womens total performance on attention was worse. By contrast, deaf women, but not men, fared better in non-verbal fluency, compared with their hearing counterparts. We conclude that, on the whole, prelingual deafness does not impede cognitive functioning in adult age. The nature of detecting and executing of cognitive tasks, despite gender and task-specific variations, is preserved. Brain networks are able to compensate for the missing auditory input.

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