Entity

Time filter

Source Type


Coscolla C.,Center for Public Health Research | Yahyaoui A.,Ligair Surveillance Of La Qualite Of Lair En Region Center | Colin P.,Ligair Surveillance Of La Qualite Of Lair En Region Center | Robin C.,Ligair Surveillance Of La Qualite Of Lair En Region Center | And 7 more authors.
Atmospheric Environment | Year: 2013

This work presents first data on the particle size distributions of current-used pesticides in the atmosphere. Ambient air samples were collected using a cascade impactor distributed into four size fractions in a rural site of Centre Region (France). Most pesticides were accumulated in the fine (0.1-1μm) particle size fraction such as cyprodinil, pendimethalin, fenpropidin, fenpropimorph and spiroxamine. Other pesticides such as acetochlor and metolachlor presented a bimodal distribution with maximum concentrations in the ultrafine (0.03-0.1μm)-coarse (1-10μm) and in the ultrafine-fine size ranges, respectively. No pesticides were detected in the size fraction 7gt;10μm. © 2013 Elsevier Ltd. Source


Yusa V.,Foundation for the Promotion of Health and Biomedical Research in the Valencian Region | Yusa V.,Public Health Laboratory of Valencia | Yusa V.,University of Valencia | Millet M.,CNRS The Institute of Chemistry and Processes for Energy, Environment and Health | And 4 more authors.
Chemosphere | Year: 2015

Biomonitoring has been used in many types of investigations, including national programmes and epidemiological studies, to explore the occurrence of biomarkers of pesticide exposure in the general population or relevant groups. This review discusses recent studies that measure levels of biomarkers of pesticide exposure in non-invasive human specimens such as urine, breast milk, meconium and hair. Specific and non-specific metabolites of organophosphate and pyrethroid insecticides have been widely investigated in urine, where some of the suitable biomarkers present rates of detection higher than 80%, which stand for an ongoing chronic exposure to traces of these chemicals. Hair is a promising emerging matrix, but some issues on its suitability and the biological relevance needs further research. Breast milk was used in research investigations focused mainly on legacy pesticides, which provide useful information about time trends. © 2015 Elsevier Ltd. Source


Yusa V.,Foundation for the Promotion of the Health and Biomedical Research in the Valencian Region | Yusa V.,Public Health Laboratory of Valencia | Yusa V.,University of Valencia | Millet M.,CNRS The Institute of Chemistry and Processes for Energy, Environment and Health | And 4 more authors.
Analytica Chimica Acta | Year: 2015

Biomonitoring of both currently-used and banned-persistent pesticides is a very useful tool for assessing human exposure to these chemicals. In this review, we present current approaches and recent advances in the analytical methods for determining the biomarkers of exposure to pesticides in the most commonly used specimens, such as blood, urine, and breast milk, and in emerging non-invasive matrices such as hair and meconium. We critically discuss the main applications for sample treatment, and the instrumental techniques currently used to determine the most relevant pesticide biomarkers. We finally look at the future trends in this field. © 2015 Elsevier B.V. Source


Lopez A.,Foundation for the Promotion of Health and Biomedical Research in the Valencian Region | Lopez A.,Public Health Laboratory of Valencia | Yusa V.,Foundation for the Promotion of Health and Biomedical Research in the Valencian Region | Yusa V.,University of Valencia | And 4 more authors.
Talanta | Year: 2016

A new methodology for the retrospective screening of pesticide metabolites in ambient air was developed, using liquid chromatography coupled to Orbitrap high-resolution mass spectrometry (UHPLC-HRMS), including two systematic workflows (i) post-run target screening (suspect screening) and (ii) non-target screening. An accurate-mass database was built and used for the post-run screening analysis. The database contained 240 pesticide metabolites found in different matrixes such as air, soil, water, plants, animals and humans. For non-target analysis, a "fragmentation-degradation" relationship strategy was selected. The proposed methodology was applied to 31 air samples (PM10) collected in the Valencian Region (Spain). In the post-target analysis 34 metabolites were identified, of which 11 (3-ketocarburan, carbofuran-7-phenol, carbendazim, desmethylisoproturon, ethiofencarb-sulfoxide, malaoxon, methiocarb-sulfoxide, N-(2-ethyl-6-methylphenyl)-L-alanine, omethoate, 2-hydroxy-terbuthylazine, and THPAM) were confirmed using analytical standards. The semiquantitative estimated concentration ranged between 6.78 and 198.31 pg m-3. Likewise, two unknown degradation products of malaoxon and fenhexamid were elucidated in the non-target screening. © 2015 Elsevier B.V. Source


Sanchis Y.,Foundation for the Promotion of the Health and Biomedical Research in the Valencia Region | Sanchis Y.,Public Health Laboratory of Valencia | Coscolla C.,Foundation for the Promotion of the Health and Biomedical Research in the Valencia Region | Coscolla C.,Public Health Laboratory of Valencia | And 5 more authors.
Talanta | Year: 2015

An analytical strategy including both the quantitative target analysis of 8 regulated primary aromatic amines (PAAs), as well as a comprehensive post-run target screening of 77 migrating substances, was developed for nylon utensils, using liquid chromatography-orbitrap-high resolution mass spectrometry (LC-HRMS) operating in full scan mode. The accurate mass data were acquired with a resolving power of 50,000 FWHM (scan speed, 2 Hz), and by alternating two acquisition events, ESI+ with and without fragmentation. The target method was validated after statistical optimization of the main ionization and fragmentation parameters. The quantitative method presented appropriate performance to be used in official monitoring with recoveries ranging from 78% to 112%, precision in terms of Relative Standard Deviation (RSD) was less than 15%, and the limits of quantification were between 2 and 2.5 μg kg-1. For post-target screening, a customized theoretical database was built for food contact material migrants, including bisphenols, phthalates, and other amines. For identification purposes, accurate exact mass (<5 ppm) and some diagnostic ions including fragments were used. The strategy was applied to 10 real samples collected from different retailers in the Valencian Region (Spain) during 2014. Six out of eight target PAAs were detected in at least one sample in the target analysis. The most frequently detected compounds were 4,4′-methylenedianiline and aniline, with concentrations ranging from 2.4 to 19,715 μg kg-1 and 2.5 to 283 μg kg-1, respectively. Two phthalates were identified and confirmed in the post-run target screening analysis. © 2015 Elsevier B.V. All rights reserved. Source

Discover hidden collaborations