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Beijing, China

Wardzynska A.,Medical University of Lodz | Kubsik B.,Public Health Care Center | Kowalski M.L.,Medical University of Lodz
Geriatrics and Gerontology International | Year: 2015

Aim: The incidence of concomitant conditions increases with age. In elderly patients, the presence of comorbidities has been related to the course and severity of asthma. The aim of the present study was to assess the impact of comorbidities and concomitant treatment on asthma control and severity in older adults. Methods: A total of 93 elderly (age >65 years) and 78 younger (age 30-50 years) asthmatic patients were randomly selected from a database including 1755 asthmatics. Evaluation consisted of a questionnaire, spirometry and skin prick testing. Results: In elderly asthmatics, a higher incidence of chronic comorbidities (mean 8.4 vs 4.7; P<0.001) and a higher number of prescribed medicines (7.4 vs 4.5, P<0.001) were observed, but the severity of asthma and the intensity of anti-asthma treatment were similar to that seen in younger patients. Asthma control was not strikingly different between the groups. There was no correlation between the presence of comorbid conditions and asthma control, severity or frequency of exacerbations in older patients. Elderly patients treated with statins had a lower risk of asthma exacerbation (OR 0.39, 95% CI 0.18-0.84, P=0.017), whereas treatment with proton pump inhibitors was associated with a higher risk of exacerbations in older adults (OR 1.84, 95% CI 1.07-3.18, P=0.029) and higher disease severity in younger patients (OR 2.49, 95% CI 1.1-5.67, P=0.029). Conclusion: The higher prevalence of comorbidities observed in elderly asthmatics under specialist care do not seem to be associated with worsened asthma control or severity. However, concomitant medications can significantly affect asthma control in both elderly and younger asthmatics. © 2014 The Authors. Geriatrics & Gerontology International published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Geriatrics Society. Source


Malara P.,Silesian University of Technology | Czech Z.,West Pomeranian University of Technology | Swiderski W.,Public Health Care Center
Archives of Materials Science and Engineering | Year: 2014

Purpose: The aim of the work was to test hardness of composite dental materials with different resins in relation to different light-curing parameters. Design/methodology/approach: The following article provides and insight into factors influencing hardness of composite materials. Standardized samples made of Herculite XRV based on a methacrylate resin and Filtek Silorane based on silorane resin were tested using two types of Light Curing Units (LCUs) – halogen and LED. The distance of light source and time of curing differed between samples. Findings: Filtek Silorane composite compared to Herculite XRV composite guarantees higher hardness, regardless of the used LCU type. Using LED LCU compared to halogen LCU allows to obtain higher hardness both for Herculite XRV and Filtek Silorane composite. The lower the distance of light source the higher the hardness of composite material. Research limitations/implications: Further studies will provide additional information on other properties such as compressive strength, wear resistance and light transmission. Practical implications: This article presents important comparison between older and newer composite technology. It provides practical information on polymerization methods. Originality/value: Article shows broad spectrum of different curing methods, important to the composite use in dentistry. © Copyright by International OCSCO World Press. All rights reserved. 2014. Source


Sima J.,Aerospace Central Hospital | Sima J.,Peking University | Sima J.,Shandong University | Sima J.,Public Health Care Center | And 16 more authors.
Tumor Biology | Year: 2015

The objective of the study was to investigate the impact of Numb on cell growth, cell migration, and invasion in human clear cell renal cell carcinoma (ccRCC). Endogenous expression of Numb was evaluated in the ccRCC cell lines (786-O, Caki-1, and Caki-2) and control reference human renal proximal tubular epithelial cells. Numb expression was decreased in the ccRCC cells compared with the control cells (P < 0.01). Then, 786-O and Caki-1 cells described as suitable transfection hosts were used in transfection to carry out biological function studies. The three experimental groups were as follows: Numb-ORF (transfected with Numb-ORF plasmid), blank-vector (transfected with pCMV6-entry), and cell-alone group (no DNA). Numb expression in the Numb-ORF groups was significantly higher than that in the controls (P < 0.01). Cell growth was remarkably reduced (P < 0.01), and the number of migrating or invading cells was reduced (P < 0.01) in the Numb-ORF groups compared with controls. Furthermore, the ratio of G0/G1 phase in the Numb-ORF group of 786-O cells was increased, and the S phase fraction and proliferation index was decreased (P < 0.01). Cyclin D1 and MMP-9 expression was reduced in the Numb-ORF groups compared with controls. Here, we have provided data for attenuated Numb expression in the ccRCC cells. Overexpression of Numb could induce G0/G1 phase arrest and inhibit cell proliferation, migration, and invasion. The suppressive effects might be due to downregulation of cyclin D1 or MMP-9 expression. Taken together, our data suggest that Numb may possibly function as a tumor suppressor involved in the carcinogenesis of ccRCC. © 2014, International Society of Oncology and BioMarkers (ISOBM). Source

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