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Bit A.,National Institute of Technology Raipur | Bissoyi A.,National Institute of Technology Raipur | Sinha S.K.,National Institute of Technology Raipur | Patra P.K.,Pt Jnm Medical College Raipur | Saha S.,SUNY Downstate Medical Center
Proceedings - 32nd Southern Biomedical Engineering Conference, SBEC 2016 | Year: 2016

Colonization of bacteria such as Staphylococus or microbial growth forming layer of bio-film on the surface of implants inhibits osteo-integration on the surface of implants, and simultaneously resists the host defence mechanism on these bacteria. It leads to prognosis of surgical intervention. Titanium based implant (Ti6Al4V) provides the surface for enhanced osteo-integration, and it is biocompatible. But adhesion of bio-film on the surface of Ti-based implant never had been restricted. However, in case of low-cost metallic implant like SS 316, corrosion is another critical phenomenon. Graphene based composite multi-layer coating is therefore introduced on both Ti and SS 316 based implant using electrophoretic deposition process. Multi-layer thickness of graphene is ensured by Raman Spectroscopy. Coated implants made up of both types of metal are tested in simulated body fluid (SBF) for invitro study, and at invivo condition. Integration of graphene in micro-environment with enhancement of osteo-integration, and inhibition of bio-film adhesion and corrosion phenomena was characterised by Adhesion assay, Biofilm assay. Tests reveal enhanced osteogenic differentiation. Simultaneously, it shows restrict bio-film formation, corrosion activity, preventing bacterial adhesion and biofilm formation on both metallic implants. © 2016 IEEE. Source

Joshi U.,Pt Jnm Medical College Raipur | Raut P.D.,Pt Jnm Medical College Raipur
Journal of Clinical and Diagnostic Research | Year: 2011

Objective: Free radicals have important role in the pathogenesis of diabetes mellitus. In diabetes, free radical production is increased whereas capacity of antioxidant system is reduced. This study was, therefore designed to determine and evaluate the serum selenium level in patient with uncomplicated diabetes mellitus and a control group of non-diabetic individuals. Study design: Hospital based non randomized, multistage, stratified, cross-sectional comparative study. Material and Method: 50 uncomplicated diabetic patients (23 male, 27 female) with mean age of49.10±6.48 years were enrolled in the study. Control group was composed of 50 healthy individual (22 male, 28 female) with mean age of 52.74 ±7.5 years. Serum selenium level was determined by using Hydride generation atomic absorption spectrometry in diabetic patients and controls. Result: Mean serum- selenium concentration measured in uncomplicated diabetic patients (51.9±8.23 μg/lit) were significantly lower than those determined in control group (130.66±37.18 μg/lit) (p<0.05).There was significant decrease in mean serum selenium level with increasing age. (p<0.05).No significant differences in serum selenium levels were found in relation to the sex of the patient (p> 0.05). Conclusion: The result of this comparative evaluation confirms the relation between low serum selenium and diabetes. Significant reduction in selenium levels are indicators of metabolic response to oxidative stress in patient with diabetes. Hence, selenium can be used in diabetic patientto prevent the late complications. The present study indicates that since it is a hospital based study, the same study should be conducted in general population (community based) to further evaluate the effect of serum-selenium in diabetes. Source

Abha S.,Pt Jnm Medical College Raipur | Chandrashekhar S.,Pt Jnm Medical College Raipur | Sonal D.,Pt Jnm Medical College Raipur
Journal of Obstetrics and Gynecology of India | Year: 2016

Background: MMR has always been recognized as an important indicator of quality of health services. The MMR in India has so far not reached up to the required MDG 2015. If we look into this matter with the eagle’s eye view, then there are certain gray areas which need attention. For this, it is not the maternal mortality but the maternal near miss which has to be focused. Objectives: To audit the maternal near miss in our institution and to review the pathways that lead to severe maternal morbidity and death. Methods: Prospective observational study from September 2013 to August 2015 in Dr. Bhim Rao Ambedkar Memorial Hospital, Raipur. Maternal near miss cases were identified based on WHO criteria 2009, recorded, and studied. Results: There were 13,895 live births, 211 maternal near miss, and 102 maternal deaths. Maternal near miss to mortality ratio was 2:1. Maternal near miss incidence ratio was 15.18/1000 live births. Mortality index was 32.58 %. Hemorrhage and hypertensive disorders of pregnancy toped the list of the leading causes of near miss morbidity. The near miss events were more common in the primipara (39 %), with age group 21–30 years and in the third trimester at the time of admission. Conclusion: Auditing maternal near miss can help in reducing their morbidity and mortality in our institution. Similar audit between other institute, state, and countries may help to hasten the slow progress of reducing maternal mortality. © 2016 Federation of Obstetric & Gynecological Societies of India Source

Sanjay V.,Pt Jnm Medical College Raipur | Gupta G.B.,Pt Jnm Medical College Raipur | Yogendra M.,Pt Jnm Medical College Raipur | Khare R.L.,Pt Jnm Medical College Raipur | And 3 more authors.
Indian Journal of Forensic Medicine and Toxicology | Year: 2014

Lead acts as cumulative metabolic poison. Occupational lead poisoning occurs frequently in developing country as it has many industrial uses like manufacture of pipes, storage batteries, ship building. Toxic effect of lead on the body is known as Plumbism. It affects multiple organs, specifically bones, blood, brain, increased risk of cardiovascular disease, coronary artery disease and platelet dysfunction. Lead encephalopathy is rare in adults due to the capacity of the mature brain to sequestrate lead away from its mitochondrial site of action within the cerebral and cerebellar neurons. It is a life threatening condition and should be treated as an emergency. Here by, we present a case of 18 year old young man with lead encephalopathy with brief review of literature. © 2014, Indian Journal of Forensic Medicine and Toxicology. All rights reserved. Source

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