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Raipur, India

Singh K.,Pt JNM Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

The inherited disorders of haemoglobin are the commonest single gene disorder of the world population. Sickle cell anaemia being the most widespread and numerically the most important haemoglobinopathy in the world today The major features of sickle cell disease (SCD) in most patients are life-long anaemia and the consequences of recurrent vaso-occlusion. Many complications of SCD involve anaemia, vaso-occlusion etc. Impairment of pulmonary function is a common complication of SCD. The patients suffering from this disease frequently present with complaints referable to the pulmonary system although other systems are also involved. Hence present study was carried out to evaluate the pulmonary function tests in sickle cell disease patients ( HbSS ),sickle cell trait patients(Hb AS) with normal person ( HbAA) non-sicklers.1) To study the pulmonary alterations in cases of homozygous SS & heterozygous AS Sickle Cell Disorder subjects.2) To compare the parameters with normal healthy controls & assess the importance of PFT in "Steady State"(free from complications or crisis)as an objective evidence to predict the risk of "Sickle Cell Chronic Lung Disease'' in future. A cross sectional study was done in 50 cases of SCD (22HbSS & 28HbAS) and age and sex matched normal 50 HbAA controls. From the various measured pulmonary function test( PFT )parameters Forced Vital Capacity( FVC),Forced Expiratory Volume in 1 sec(FEV1),FEV1/FVC, Forced Mid Expiratory Flow(FEF25%-75%) were selected for the study. The data collected was subjected to statistical analysis involving computation of Mean, Standard deviation, Independent T test. Mean value of FVC, FEV1, FEV1/FVC and FEF25%-75% were found to be significantly lower than normal controls, but the difference in FVC between HbAS and HbSS turned out to be statistically non-significant whereas the difference in FEV1, FEV1/FVC,FEF25%-75% between HbAS and HbSS was statistically significant. There were significant reductions in pulmonary function test parameters in sickle cell anaemia patients as compared to normal controls indicative of mixed pattern (both restrictive and obstructive) lung impairment in sickle cell anaemia.

Nigam P.,Pt JNM Medical College
International Journal of Trichology | Year: 2013

Desmogleins (Dsgs) are calcium-dependent, transmembrane glycoproteins belonging to the desmosomal cadherin superfamily, which play significant roles in selective calcium ions (Ca2+) dependent adhesion interactions between cell surfaces. Four subtypes of Dsg have been identified. Recent observations show the distribution of Dsgs can correlate with specific types of keratinization, anchorage of the hair, and hypotrichosis.

Pande B.,Pandit Ravishankar Shukla University | Parganiha A.,Pandit Ravishankar Shukla University | Patra P.K.,Pt JNM Medical College | Pati A.K.,Pandit Ravishankar Shukla University
Indian Journal of Experimental Biology | Year: 2014

The present study aimed to investigate probability of a possible endogenous circadian rhythm in human cognitive attribute to estimate short intervals. Apparently healthy young males and females were selected for our study. Eight subjects prospectively produced the short-time intervals 10 s and 60 s at 2 hourly intervals in 30 h constant routine (CR) study conducted in spring (CR-1). The study was repeated again in autumn (CR-2) in the remaining eight subjects. The established circadian markers, namely serum cortisol, salivary melatonin levels and tympanic temperature were also measured either in CR-1 or CR- 2. Oral temperature was measured simultaneously. Circadian rhythms were validated in serum cortisol, salivary melatonin, oral, and tympanic temperatures. Circadian rhythm in 60 s estimates was observed in a few subjects and in all males at group level in CR-1. The cognitive attribute to perceive short intervals vary as function of season. The results provide evidence in support of interaction among the interval, circadian and circannual timing systems in human.

Patra P.K.,Pt JNM Medical College | Khodiar P.K.,Pt JNM Medical College | Hambleton I.R.,University of the West Indies | Serjeant G.R.,Sickle Cell Trust Jamaica
Journal of Community Genetics | Year: 2015

In India, the Chhattisgarh State screening programme for sickle haemoglobin focuses on children aged 3–15 years and has screened over 1,050,440 subjects over the last 6 years. Commencing in the District around the capital Raipur, this programme has now completed screening in 7 of the 27 Districts of Chhattisgarh State. Screening is initially performed by solubility tests on fingerprick samples in the field and those with positive tests have venipunctures for haemoglobin electrophoresis. The frequency of the sickle cell trait was 9.64 % and of the SS phenotype 0.29 % with only two Districts in Hardy-Weinberg equilibrium, most Districts showing an excess of the SS ‘phenotype’ most readily explained by symptomatic selection. The estimated costs were US$0.28 (solubility tests alone) and US$0.60 (haemoglobin electrophoresis). Of the social groupings commonly used in India, the OBC’s (other backward classes) had the highest frequencies of the sickle cell gene mutations, followed by the Scheduled Tribes and the Scheduled Castes. The objectives of the programme were the detection of sickle cell disease for prospective clinical management and of the sickle cell trait for purposes of genetic counselling. The former objective is being met for diagnosis although the success of referral to clinic services requires audit. The objective of genetic counselling is compromised by the failure of the screening test to detect other genes of potential clinical significance such as HbD Punjab and the beta thalassaemia trait. Despite these exceptions, the detection of HbS appears relatively robust and could be another condition factored into the traditions of partner selection amongst the underprivileged communities of this state. Overall, the Chhattisgarh programme seeks to address the daunting challenges of large populations carrying the sickle cell gene and maybe a useful model for elsewhere. © 2015, Springer-Verlag Berlin Heidelberg.

Abha S.,Pt JNM Medical College | Pratibha R.,Pt JNM Medical College
Journal of Obstetrics and Gynecology of India | Year: 2011

Objective To compare maternal and neonatal outcomes of vacuum versus forceps application in assisted vaginal delivery. Material and Method Women in labor with vertex presentation were delivered by vacuum and forceps. A total of 120 cases were included in this prospective study. Maternal and neonatal morbidity were compared in terms of perineal lacerations, episiotomy extension, post-partum hemorrhage, Apgar score, instrumental injuries, NICU admissions PNM etc. χ2 test was used to analyze the data. Observations Maternal morbidity viz. episiotomy extension as well as first and second degree perineal tear were significant in the forceps group (P = 0.0001 and P = 0.02, respectively). With regards to neonatal morbidity, no statistically significant difference was noted. Conclusion Vacuum and forceps should remain appropriate tools in the armamentarium of the modern obstetrician. However, ventouse may be chosen first (if there is no fetal distress) as it is significantly less likely to injure the mother. . © 2012 Federation of Obstetric & Gynecological Societies of India.

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