Pt. Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya

Mathura, India

Pt. Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya

Mathura, India

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Garg S.K.,Pt. Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya | Garg K.M.,Pt. Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya | Garg K.M.,Veterinary University | Sabir M.,Pt. Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya
Indian Journal of Animal Sciences | Year: 2010

A study was conducted to evaluate the tocolytic effect of selective calcium channel blockers on uterine strips of buffaloes. Prostaglandin F2 alpha (PGF2α), oxytocin, (OT), potassium chloride (CK1) and barium chloride (BaCl2) were used to induce uterine contractions of pregnant and diestrous stage buffaloes. After contracting the tissues, cumulative concentration-response curves of verapamil and diltiazem were constructed and their mean effective concentration (EC50) values were determined and statistically compared. Comparative EC50 values of CCBs revealed the rank order potency of PGF2α> KC1> BaCl2> OT on pregnant uteri while OT > PGF2α > KC1 > BaCl2 on dioestrus animals uteri for verapamil. The rank order potency of diltiazem was different from that of verapamil and it was KCl > OT > PGF2α > BaCl2 on pregnant while KCl > PGF2α > BaCl2 > OT on dioestrus stage uteri. Difference in the rank order potency of verapamil and diltiazem against different spasmogens on the uteri of pregnant or dioestrus stage buffaloes may be attributed to the difference in chemical structure of verapamil and diltiazem or their binding with calcium channels or due to difference in the molecular mechanism of different spasmogens-induced contraction. Further, it may not be unreasonable to state that CCBs appear to be promising tocolytics for buffaloes, however, detailed in-vivo pharmacological studies are warranted to estiablish their clinical utility and safety in farm animals including buffaloes.


Bhattacharyya A.,Pt. Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya | Garg S.K.,Pt. Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya | Kumar V.,Pt. Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya | Roy D.,Pt. Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya | And 2 more authors.
International Journal of Poultry Science | Year: 2013

A study was conducted during the months of December-January involving sixty one week old broiler chickens, distributed into two experimental groups having three replicates of ten birds each. The birds of the first group were fed a basal diet (22.5% CP & 2830 K cal/kg ME) while the second group birds were fed a basal diet supplemented with a liver tonic, Superliv concentrate (Ayurvet Limited product) @ 50g/quintal. Body weight gain was significantly higher (P<0.05) in the Superliv concentrate group compared to the control group at 2nd week, 3rd week, 4th week and 5th week of age. FCR was significantly higher (P<0.05) in the Superliv concentrate group than control group during 1-4 wk period (1.9 vs 2.1) and 1-6 wk period (1.97 vs 2.17). Total immunoglobulins and mercaptoethanol resistant (IgG) antibody titer (log 2) values in response to sheep red blood cells (SRBC) was significantly higher (P<0.05) in the Superliv concentrate group compared to the control group. Further, mercaptoethanol sensitive (IgM) antibody titer (log 2) values in response to sheep red blood cells (SRBC) were apparently higher in the Superliv concentrate group compared to the control group. Cell mediated immune (CMI) response (foot web index) was significantly higher (P<0.05) in the Superliv concentrate group compared to the control group. There was no significant difference in the nutrient retention between the Superliv concentrate group and control group. Hence, it may be concluded that Superliv concentrate may be added to broiler diet during winter to elicit growth performance and immunocompetence traits of commercial broilers. © Asian Network for Scientific Information, 2013.

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