Tueting P.,Psychiatric Institute |
Davis J.M.,Psychiatric Institute |
Veldic M.,Psychiatric Institute |
Veldic M.,Mayo Medical School |
And 5 more authors.
NeuroReport | Year: 2010
Schizophrenia postmortem brain is characterized by γ aminobutyric acid downregulation and by decreased dendritic spine density in frontal cortex. Protracted L-methionine treatment exacerbates schizophrenia symptoms, and our earlier work (Tremolizzo et al. and Dong et al.) has shown that L-methionine decreases reelin and GAD67 transcription in mice which is prevented by co-administration of valproate. In this study, we observed a decrease in spine density following L-methionine treatment, which was prevented by co-administration of valproate. Together with our earlier findings conducted under the same experimental conditions, we suggest that downregulation of spine density in L-methionine-treated mice may be because of the decreased expression of reelin and that valproate may prevent spine downregulation by inhibiting the methylation induced decrease in reelin. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Bais L.,University of Groningen |
Bais L.,Psychiatric Institute |
Liemburg E.,University of Groningen |
Liemburg E.,Psychiatric Institute |
And 4 more authors.
Progress in Neuro-Psychopharmacology and Biological Psychiatry | Year: 2017
Introduction Efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) targeting the temporo-parietal junction (TPJ) for the treatment of auditory verbal hallucinations (AVH) remains under debate. We assessed the influence of a 1 Hz rTMS treatment on neural networks involved in a cognitive mechanism proposed to subserve AVH. Methods Patients with schizophrenia (N = 24) experiencing medication-resistant AVH completed a 10-day 1 Hz rTMS treatment. Participants were randomized to active stimulation of the left or bilateral TPJ, or sham stimulation. The effects of rTMS on neural networks were investigated with an inner speech task during fMRI. Changes within and between neural networks were analyzed using Independent Component Analysis. Results rTMS of the left and bilateral TPJ areas resulted in a weaker network contribution of the left supramarginal gyrus to the bilateral fronto-temporal network. Left-sided rTMS resulted in stronger network contributions of the right superior temporal gyrus to the auditory-sensorimotor network, right inferior gyrus to the left fronto-parietal network, and left middle frontal gyrus to the default mode network. Bilateral rTMS was associated with a predominant inhibitory effect on network contribution. Sham stimulation showed different patterns of change compared to active rTMS. Conclusion rTMS of the left temporo-parietal region decreased the contribution of the left supramarginal gyrus to the bilateral fronto-temporal network, which may reduce the likelihood of speech intrusions. On the other hand, left rTMS appeared to increase the contribution of functionally connected regions involved in perception, cognitive control and self-referential processing. These findings hint to potential neural mechanisms underlying rTMS for hallucinations but need corroboration in larger samples. © 2017 Elsevier Inc.
Frohlich S.,Mathematical Institute |
Franco C.A.,Psychiatric Institute
Advances in Experimental Medicine and Biology | Year: 2010
This paper is the continuation of a study about Consciousness as a resulting function between attention and luminosity, presented at the Neuroscience International Congress, which was held in the city of Natal, in Brazil, in 2006. There it was described how visual Consciousness is generated by the interaction of the cortical area activity through FFS (Feedforward Sweep Processes), RP (Recurrent Processes) andWSRP (Wide Spread Recurrent Processes), and its relationship with the luminosity that hits the eyes. We have applied the reciprocal interaction model, which says that the eye reacts to luminosity through the regulation of sleep-awake states through EEG wave synchronization; this, in turn, is regulated by the thalamic cortical neural activity from the brainstem monoaminergic and cholinergic nuclei. Such an understanding has led us to construct a consciousness model which can be represented by an orthogonal graph. Through this model, we can represent all states of human consciousness (emotional consciousness, unconsciousness states, dreaming states, awareness states, pre-consciousness states and others) making it possible, in theory, to construct a Consciousness parameter which yields to the understanding of consciousness state observation without a subjective approach to experience. We have also applied on this orthogonal graph the Quantum Orch OR Model. According to it, subjective, phenomenal conscious vision depends on quantum computation in microtubules where the quantum is the smallest quantity of radiant energy, in a scale in which matter and energy interact. This model helps us to build the vertical axe of the consciousness orthogonal graph, a cholinergic-aminergic scale, in which activation triggers the quantum mechanismrelevant to the consciousness phenomenon. © Springer Science+Business Media, LLC 2010.
Weine S.,University of Illinois at Chicago |
Weine S.,Psychiatric Institute |
Bahromov M.,Research Center |
Loue S.,Case Western Reserve University |
Owens L.,University of Illinois at Urbana - Champaign
AIDS and Behavior | Year: 2012
Little is known about the role of trauma and PTSD symptoms in the context of migration-associated HIV risk behaviors. A survey of Tajik married male seasonal labor migrants in Moscow was completed by 200 workers from 4 bazaars and 200 workers from 18 construction sites as part of a mixed method (quantitative and qualitative) study. The mean PC-PTSD score was 1.2 with one-quarter of migrants scoring at or above the cutoff of 3 indicating likely PTSD diagnosis. PC-PTSD score was directly correlated with both direct and indirect trauma exposure, but PC-PTSD score did not predict either HIV sexual risk behaviors or HIV protective behaviors. HIV sexual risk behavior was associated with higher indirect trauma exposure. PC-PTSD score was associated with some indicators of increased caution (e.g., more talking with partners about HIV and condoms; more use of condom when drinking). Qualitative findings were used to illustrate the differences between direct and indirect traumas in terms of HIV sexual risk. The study findings call for future efforts to address labor migrant's mental health needs and to integrate trauma dimensions into HIV prevention. © 2012 Springer Science+Business Media, LLC.
Dong E.,Psychiatric Institute |
Chen Y.,Psychiatric Institute |
Gavin D.P.,Psychiatric Institute |
Grayson D.R.,Psychiatric Institute |
Guidotti A.,Psychiatric Institute
Epigenetics | Year: 2010
The methylation and demethylation of CpG dinucleotides that are embedded in promoters play an important role in controlling gene transcription. In the mammalian brain, cpG promoter methylation is a postreplicative process mediated by a group of DNA methyltransferases (DNMT), such as DNMT1 and DNMT3a, DNMT3b. several studies demonstrate that in addition to DNMTs, promoter methylation in the brain can be regulated by a putative DNA demethylation process that specifically removes the methyl group from the carbon-5 of cytosines. To test the existence of a possible active DNA demethylation activity in postmitotic neuronal or glial cells, we incubated an SssI methylated mouse reelin (Reln) promoter fragment (-720 to +140) with nuclear extracts from the mouse frontal cortex (FC). We observed the presence of DNA demethylation activity, which was increased in FC nuclear extracts from mice treated with valproate (VPA, 2.2 mmol/kg, twice a day for 3 days). VPA not only reduces anxiety and cognitive deficits and other symptoms in bipolar disorder (BP) disorder and schizophrenia (SZ) patients but also upregulates Reln and glutamic acid decarboxylase 67 (Gad67) mRNa/protein expression by reducing the methylation of their promoters. We believe that the identification of an enzyme in brain that facilitates DNA-demethylation and an understanding of how drugs induce DNA demethylation are crucial to progress in a new line of pharmacological interventions to treat neurodevelopment, neuropsychiatric and neurodegenerative diseases. © 2010 Landes Bioscience.
PubMed | Leiden University, Clinical Center for Body and Psychiatric Institute
Type: | Journal: Clinical psychology & psychotherapy | Year: 2015
Assessment of psychological distress is important, because it may help to monitor treatment effects and predict treatment outcomes. We previously developed the 48-item Symptom Questionnaire (SQ-48) as a public domain self-report psychological distress instrument and showed good internal consistency as well as good convergent and divergent validity among clinical and non-clinical samples. The present study, conducted among psychiatric outpatients in a routine clinical setting, describes additional psychometric properties of the SQ-48. The primary focus is on responsiveness to therapeutic change, which to date has been rarely examined within psychiatry or clinical psychology. Since a questionnaire should also be stable when no clinically important change occurs, we also examined test-retest reliability within a test-retest design before treatment (n=43). A pre-treatment/post-treatment design was used for responsiveness to therapeutic change, comparing the SQ-48 with two internationally widely used instruments: the Brief Symptom Inventory (n=97) and the Outcome Questionnaire-45 (n=109). The results showed that the SQ-48 has excellent test-retest reliability and good responsiveness to therapeutic change, without significant differences between the questionnaires in terms of responsiveness. In sum, the SQ-48 is a psychometrically sound public domain self-report instrument that can be used for routine outcome monitoring, as a benchmark tool or for research purposes. Copyright 2015 John Wiley & Sons, Ltd. Key Practitioner Message The SQ-48 is developed as a public domain self-report questionnaire, in line with growing efforts to develop clinical instruments that are free of charge. The SQ-48 has excellent test-retest reliability and good responsiveness to therapeutic change or patient progress. There were no significant differences in terms of responsiveness between the SQ-48 and BSI or OQ-45. The SQ-48 can be used as a routine evaluation outcome measure for quality assurance in clinical practice. Providing feedback on patient progress via outcome measures could contribute to the enhancement of treatment outcomes.
News Article | November 3, 2016
HERSHEY, Pa., Nov. 03, 2016 (GLOBE NEWSWIRE) -- Penn State Health has selected Cerner Millennium Revenue Cycle™, a patient-centric financial management platform designed to optimize provider and user workflow. The new platform will be integrated with the existing Cerner electronic health record (EHR) at the Milton S. Hershey Medical Center, resulting in a Clinically Driven Revenue Cycle™ across the health system, including more than 60 clinics. As part of the expanded relationship, Cerner will also extend the clinical and financial health information technology system to Penn State Health St. Joseph, previously St. Joseph Regional Health Network. “Having one integrated platform will support our efforts to create seamless coordination and collaboration among our departments and venues of care,” said Stephen Massini, chief financial officer, Penn State Health. “Incorporating clinical data into our revenue cycle processes will enable a better experience for our patients and providers and enhance our ability to holistically manage our patient’s financial responsibility.” Cerner’s Clinically Driven Revenue Cycle is designed to support clinicians and staff to update the billing process throughout the patient’s visit, enhance clinical documentation to help improve reimbursement and limit claims errors. Patients will benefit by having direct access to their clinical results and a streamlined financial experience, including visibility of their financial liability from a single source. “This expanded relationship makes Penn State Health a robust academic client with an integrated health IT system that supports the delivery of high quality care across the continuum,” said Dick Flanigan, president of Cerner HS. “We look forward to providing Penn State Health with a platform that works for the organization versus the organization working around a disrupted and disparate system.” About Penn State Health Penn State Health is a not-for-profit, tax-exempt corporation, established by Penn State for oversight of its health care enterprises and jointly owned health care organizations, to help meet the health needs of people and communities across Pennsylvania. Penn State Health includes several hospitals, including St. Joseph Medical Center in Reading, Pa., and the Milton S. Hershey Medical Center in Hershey, Pa., as well as their respective outpatient medical group practices. The system also includes Penn State Children’s Hospital and Penn State Cancer Institute, and jointly owned health care providers, including Hershey Outpatient Surgery Center, Hershey Endoscopy Center, Horizon Home Healthcare and the Pennsylvania Psychiatric Institute. Penn State Health shares an integrated strategic plan and operations with Penn State College of Medicine, the University’s medical school. About Cerner Cerner’s health information technologies connect people, information and systems at more than 25,000 provider facilities worldwide. Recognized for innovation, Cerner solutions assist clinicians in making care decisions and enable organizations to manage the health of populations. The company also offers an integrated clinical and financial system to help health care organizations manage revenue, as well as a wide range of services to support clients’ clinical, financial and operational needs. Cerner’s mission is to contribute to the systemic improvement of health care delivery and the health of communities. Nasdaq: CERN. For more information about Cerner, visit cerner.com, read our blog at blogs.cerner.com, connect with us on Twitter at twitter.com/cerner and on Facebook at facebook.com/cerner. Our website, blog, Twitter account and Facebook page contain a significant amount of information about Cerner, including financial and other information for investors.
News Article | September 1, 2016
The legacy of World War II and the Holocaust continues to be unearthed, 70 years after the final bombs were dropped, the gates to the extermination camps opened. Body parts and brains of the victims of Nazi doctors were found at the Max Planck Psychiatric Institute during renovations last year, according to The Daily Mail. The remains are believed to have come from the work of Josef Mengele, the “Angel of Death” of Auschwitz infamous for his sadistic experiments on twins and children. The gruesome discovery was found during renovation work at the Munich facility. In a separate ongoing dig, skulls and bones with glue on them have been found in Berlin, about 100 yards away from what was the Kaiser Wilhelm Institute for Human Heredity and Eugenics during the Nazi regime, according to The Associated Press. Mengele, the most infamous SS doctor at the death camp in Poland from 1943 until the end of World War II, escaped Allied investigators and justice for decades, until his remains were disinterred in Brazil and identified in 1985. The Munich and Berlin discoveries also follow a revelation in France: the identification of the remains of 86 victims of the Holocaust on the shelves of the University of Strasbourg last year. Some of those victims were identified, based on tattoos and biometrics on file in the World War II records. The Mack Planck Society ordered a complete review of its specimens, since the discovery of the brains in its Munich-based collection. "The Max Planck Society has accepted a difficult legacy of its predecessor organziation, the Kaiser Wilhelm Society," said Martin Stratmann, the current president of the organization. "We are well aware of the special responsibility that it entails." Mengele remained in Germany and under the radar of war crimes prosecutors until 1949, when he crossed the border to Austria and then fled to Argentina. He lived under his real name in Buenos Aires for about a decade, until the Israeli capture of fellow Nazi Adolf Eichmann prompted his escape to Paraguay and then Brazil. German sympathizers hosted him and kept his identity a secret. Mengele had a stroke and drowned while swimming in 1979. He was buried under the pseudonym Wolfgang Gerhard. His remains were identified in 1985. The Nazi doctor's remains have been stored in a sack at a Brazilian police moruge for decades. In a twist, they are going to be used to teach medical students in the South American country, a doctor announced earlier this year.